• Journal of Gifted/Talented Education
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• v.20 no.3
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• pp.967-984
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• 2010

This study purposed to examine the effects of the Feuerstein's cognitive mediated learning for gifted children on attention control and attention shift. For the study, 40 gifted students were chosen from the 3rd graders in elementary schools and divided into test and control groups using K-WISC-III and Torrance Tests of Creative Thinking. The mediated learning program that is targeted to improve the executive functions of gifted children has used the tools of Organization of Dots, Analytic Perception and Comparisons among Feuerstein's Instrumental Enrichment(FIE). According to the results of this study, a significant improvement has been observed in selective attention, self-control, sustained attention, and attention shift through cognitive mediated learning. Therefore, it has been proven that the cognitive mediated learning is effective in reducing gifted children's problematic behaviors that are caused by a lack of attention control and attention shift and improving their cognitive functions and potentials.

• Journal of Microbiology
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• v.45 no.2
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• pp.122-127
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• 2007

Factors indicating culture status of two Spirulina platensis strains were monitored in a batch mode cultivation for 36 days. Changing mode in all factors showed a common turning point, indicating shift of cell or culture status. Mean biomass productivity was highly sustained until day 22, chlorophyll a concentration peaked on day 22, pH value was > 12 on day 22, coil number was abruptly shortened on day 22, and floating activity was sustained at greater than 79% after day 22, indicating that day 22 is a criterion reflecting phase-transfer in cell physiology in a batch culture system. Many of these changes may have been caused by increased pH, suggesting that pH control is essential for mass production of S. platensis. Fluctuations in floating activity were likely induced by the number of cellular gas vacuoles. Consequently, coil number per trichome and floating activity of S. platensis could readily act as simple indicators for determination of culture status or harvesting time of cells.

• The Korean Journal of Physiology and Pharmacology
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• v.10 no.3
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• pp.137-141
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• 2006

The systolic and diastolic pressures in anesthetized Sprague-Dawley male rats were greatly decreased after single-dose of Cd treatment without significant changes in heart rate. There was a fluid-shift into the third space and/or -loss through the kidney, since plasma $Na^+$ concentration and hematocrit ratio were significantly increased by acute Cd exposure. The present study showed that the sustained hypotensive effect of single-dose Cd on the cardiovascular system might have resulted from the systemic hypovolemia. Furthermore, renal excretion of electrolytes, including $Na^+$ and $K^+$, and urine flow rate were increased by Cd intoxication. Interestingly, the ratio of $Na^+/K^+$ excretion was increased and reached the maximum level 3 hours after Cd injection and returned to the normal level after 7 hours. Nevertheless, there was no difference in the regression analysis of $Na^+$ excretion and urine flow rate in both groups. Therefore, the increase in the urine volume seemed to enhance the excretion of $Na^+$. This study strongly suggest that the hypotensive effect of Cd is mediated by systemic $Na^+$ loss through the kidney and/or hypovolemia via fluid-shift.

• Journal of Power Electronics
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• v.18 no.3
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• pp.766-777
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• 2018

In this paper, a sliding mode and proportional plus integral (SM-PI) control combined with self-sustained phase shift modulation (SSPSM) for LLC resonant converters is presented. The proposed control scheme improves the transient response while preserving good steady-state performance. An averaged large signal model of an LLC converter with the ZVS modulation technique is developed for the SM control design. The sliding surface is obtained based on the input-output linearization concept. A system identification method is adopted to obtain the transform function of the LLC resonant converter, which is used to design the PI control. In order to reduce the inherent chattering problem in the steady state, the combined SM-PI control strategy is derived with fuzzy control, where the SM control is responsive during the transient state while the PI control prevails in the steady state. The combination of SSPSM and the SM-PI control provides ZVS operation, robustness and a fast transient response against step load variations. Simulation and experimental results validate the theoretical analysis and the attractive features of the proposed scheme.

• Korean Journal of Clinical Pharmacy
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• v.34 no.1
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• pp.1-20
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• 2024

This review examines the pivotal clinical trials that evaluated the efficacy and safety of semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in the management of obesity. The reported findings underscore significant and sustained weight loss achieved with semaglutide in diverse patient groups, although gastrointestinal disorders occurred frequently, leading to therapy discontinuation. Overall, the studies demonstrated the potential of semaglutide as a therapeutic option not only for type 2 diabetes but also for obesity. The treatment landscape in obesity is evolving, as reflected in changing regulatory approvals and clinical guidelines, suggesting a paradigm shift toward personalized approaches in this chronic disease states to achieve optimal treatment outcomes for patients.

• Atmosphere
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• v.27 no.2
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• pp.177-188
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• 2017

The development mechanisms of an unusual heavy snowfall event, which occurred in the coast of Jeju Island on 23 January 2016 were investigated through a thermodynamic approach. The formation of heavy snowfall was attributed to the enhanced thermal convection in two ways. First, the convection was enhanced by the air-sea temperature difference between the cold air advection in low-troposphere associated with the strengthening of the Siberian High and abnormal warm sea surface temperature, which is $1{\sim}2^{\circ}C$ higher than normal year over the Yellow Sea (YS). Second, the convective instability was increased by the vertical temperature gradient between the 7 days-sustained cold air advection in low-troposphere and the abrupt cold air intrusion in mid-troposphere induced by the southward shift of a cold cut-off vortex ($-45^{\circ}C$) at the formation stage. Compared to the twelve hours prior to the formation, the low-level moisture increased by 5% through the moisture supply from the YS, and the air-sea temperature difference increased from $18.5^{\circ}C$ to $28.5^{\circ}C$. Furthermore, the upward sensible (latent) heat flux increased 1.5 (1.2) times over the YS before the twelve hours prior to the formation. Thereafter, the sustained moisture supply and upward turbulent heat flux helped to maintain the snowstorm.

• 한국생물공학회:학술대회논문집
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• 2000.11a
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• pp.393-395
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• 2000

We studied to improve the stability of retrovirus during freeze-drying. Through selection of the additives, we chose the trehalose, trehalose-PVP colyophilized mixture which were most effective additive on retrovirus storage. Through thermal analysis by DSC. in case of adding trehalose, thermal change shift to $15^{\circ}C$ from $10^{\circ}C$. As a result, we found it that Tg have important role to improve the stability of retrovirus. When retrovirus was storaged at the different temperature, the activity of freeze-dried retrovirus with trehalose sustained for 8 week below $4^{\circ}C$, But freeze-dried retrovirus without additives showed the activity less than 40% at all temperature.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.21 no.4
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• pp.329-335
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• 2018

Loss of response to anti-tumor necrosis factor (anti-TNF) agents in the treatment of inflammatory bowel disease (IBD) is a major consideration to maintain sustained response. Reversal of immunogenicity can re-establish response and increase the durability of these agents. Strategies to reverse immunogenicity include dose-intensification and/or the addition of an immunomodulator. However, there is a relative paucity of data on the efficacy of such interventions in pediatric IBD patients. Available reports have not strictly utilized homogenous mobility shift assay, which reports on anti-drug antibodies even in the presence of detectable drug, whereas prior studies have been confounded by the use of drug sensitive assays. We report four pediatric inflammatory bowel disease patients with successful reversal of immunogenicity on an anti-TNF agent using dose intensification and/or addition of an immunomodulator.

• Speech Sciences
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• v.10 no.1
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• pp.15-25
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• 2003

A laryngograph was developed to measure the open and closed movements of vocal folds in our laboratory. This study attempted to evaluate its performance by comparing its glottal data with that of the original laryngograph. Ten normal Korean adults Participated in the experiment. Each subject produced a sustained vowel /a/ for about five seconds. This study compared f0 values, contact quotients of the duration of closed vocal folds over one glottal pulse, and area quotients of the closed over open vocal folds derived from glottal waves using both the original and new laryngographs. Results showed that the mean and standard deviation of the two laryngographs were almost comparable with a correlation coefficient 0.662 but minor systematic shift below those of the original laryngograph was observed. The absolute mean difference converged into 1 Hz, which indicates a possibility of adopting some threshold of rejecting inappropriate pitch values beyond a threshold value. The contact quotient of the normal subjects came out slightly over the 50% in a citation speech. Finally, the area quotient converged into 1. We will pursue further studies on the abnormal patients in the future.

• 한국신재생에너지학회:학술대회논문집
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• 2006.06a
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• pp.478-481
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• 2006

Energy is vital to global prosperity, yet dependence on fossil fuels as our primary energy source contributes to global climate change environmental degradation, and health problems. Hydrogen $(H_2)$ offers tremendous potential as a clean renewable energy currency. Hydrogen has the highest gravimetric energy density of any known fuel and is compatible with electrochemical and combustion processes for energy conversion without producing carbon-based emission that contribute to environmental pollution and climate change. Numerous methodologies have been developed for effective hydrogen production. Among them, the biological hydrogen production has gained attention, because hydrogen can be produced by cellular metabolismunder the presence of water and sunlight. The green alga Chlamydomonas reinhardtii is capable of sustained $H_2$ photoproduction when grown under sulfur deprived condition. Under sulfur deprived conditions, PSII and photosynthetic $O_2$ evolution are inactivated, resulting in shift from aerobic to anaerobic condition in the culture. After anaerobiosis, sulfur deprived algal cells induce a reversible hydrogenase and start to evolve $H_2$ gas in the light. According to above principle, we investigated the effect of induction parameters such as cell age, cell density. light intensity, and sulfate concentration under sulfur deprived condition We also developed continuous hydrogen production system by sulfate re-addition under sulfur deprived condition.