• 대한의용생체공학회:의공학회지
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• 제16권4호
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• pp.395-402
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• 1995

자기공명 영상 시스템에서 영상을 얻고자 하는 물체내의 자화율 차이는 복셀내의 스핀들의 위상을 변화시킨다. 또한 스핀들 상호간의 위상변화로 인하여 영상 신호는 감쇄된다. 이러한 신호 세기의 감쇄는 자기공명 영상분야에서 자화율 효과라 알려져 왔고 이런 효과를 억제시키거나 또는 이용하는 연구가 심도있게 논의되어왔다. 본 논문에서 자화율 효과로 인한 신호의 변화를 분석할 수 있는 새로운 스펙트럼 분해법과 영상법을 제안하였다. 그리고 자화율 스펙트럼 분해법을 위한 펄스시퀀스를 개발하였고, 이것을 상자성(paramagnetic) 성질 때문에 자화율 효과가 생기는 정맥영상에 적용하였다. 컴퓨터 모의 실험과 팬텀(phantom)을 대상으로 한 실험 결과로 스펙트럼 분해법의 타당성을 보였다.

• 대한의용생체공학회:의공학회지
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• 제17권4호
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• pp.525-534
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• 1996

We have developed a fast steady state free precession interferometry (SSFPI) technique which is useful for the fMRl (functional Magnetic Resonance Imaging). As is known, SSFP sequence with a suitable adjustment of Vadient (readeut) allows us to measure precession angle 6 which in tw relates to the field inhomogeneity. Combining the two pulses (known as FID and Echo) in FADE (Fast Acquisition Double Echo) sequence, for example, one can obtain the interference term which is directly related to the precession angle It has been known that a fast high resolution magnetic field mapping is possible by use of the modified FADE sequence or SSFPI, and we have attempted to use the SSFPI technique for the susceptibility-induced fMRl. When the method is applied to the susceptibility effect based functional magnetic resonance imaging (fMRl), it was found that the direct susceptibility effect measurement was possible without perturbations such as the backgrounds and inflow effect. In this paper, simulation results and experimental results obtained with 2.0 Tesla MRI system are presented.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1995년도 추계학술대회
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• pp.173-176
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• 1995

We have developed a fast steady state free precession interferometry (SSFPI) technique which is useful for the fMRI (functional Magnetic Resonance Imaging). As is known, SSFP sequence with a suitable adjustment of gradient (readout) allows us to measure precession angle $\theta$ which is in turn related to the field inhomogeneity [1-3]. When the method is applied to the susceptibility effect based functional magnetic resonance imaging (fMRI), it was found that the direct susceptibility effect measurement was possible without perturbations such as the backgrounds and inflow effect. In this paper, simulation results and experimental results obtained with 2.0 Tesla MRI system are also presented.

• 대한디지털의료영상학회논문지
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• 제15권1호
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• pp.27-31
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• 2013

Perfusion MR imaging is how to use exogenous and endogenous contrast agent. Exogenous perfusion MRI methods which are dynamic susceptibility contrast using $T2^*$ effect and dynamic contrast-enhanced using T1 weighted image after injection contrast media. An endogenous perfusion MRI method which is arterial spin labeling using arterial blood flow in body. In order to exam perfusion MRI in human, technical access are very important according to disease conditions. For instance, dynamic susceptibility contrast is used in patients with acute stroke because of short exam time, while dynamic susceptibility contrast or dynamic contrast enhancement provides the various perfusion information for patients with tumor, vascular stenosis. Arterial spin labeling is useful for children, women who are expected to be pregnant. In this regard, perfusion MR imaging is required to understanding, and the author would like to share information with clinical users

• 대한의용생체공학회:의공학회지
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• 제20권2호
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• pp.165-172
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• 1999

본 연구에서는 MRI 영상에서 위상을 조절하여 영상 대조를 증가 시키는 방법을 제안 하였다 영상하고자 하는 물체 자체가 갖는 위상에 따라 영상의 대조가 변하기 때문에 본 방법은 자화율 영상이나 유속 영상에 유용하게 쓰일 수가 있다. 본 논문에서는 위상 분포에 따른 영상의 대조를 증가 시키기 위하여 RF 펄스를 복셀 내에서 위상을 갖도록 디자인 하였다. 따라서 복셀에서의 신호의 크기는 물체자체의 위상과 RF 펄스에의하여 가해준 위상이 결합에 의하여 결정된다. 외부위상 변화에 따른 신호의 변화를 분석하였고 그때 디자인된 RF 펄스를 이용하여 자화율만의 영상과 유속만의 영상을 얻었다. 컴퓨터 시뮬레이션의 결과는 제안된 알고리즘이 복셀내에 위상을 갖는 물체의 영상에 유용하고 그런 물체만을 영상하는데 유용함을 보였다.

• Investigative Magnetic Resonance Imaging
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• 제1권1호
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• pp.66-74
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• 1997

혈액의 산소화와 불 산소화에 따른 국부적인 자화율 효과의 변화에 의한 자장의 불 균일성에 민감한 경사 자장 에코 기법은 현재의 뇌기능 MR 영상의 기본이 되고 있다. 일반적으로 이러한 경사 자장 에코기법은 $T2^{*}$ 혹은 BOLD효과에 의한 자장의 불 균일성의 증가가 신호의 감소로 나타난다. BOLD 효과는 주자장에 대한 핏줄의 방향이나 영상 형식, 즉, 횡단면, 관상면, 또는 시상면에 따라 달라진다. 그래서 영상 형식과 영상면에 대한 기울임 각에 따른 신호의 변화와 BOLD 효과의 변화에 대한 정량적인 연구를 하였다. 연구는 자화율 효과에 대해 다른 민감도를 가지는 TRFGE 와 CGE 기법으로 이루어졌다. 컴퓨터 모의 실험과 실험 결과를 본 논문에 나타내었다.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 추계학술대회
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• pp.571-574
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• 1997

fMRI, functional MRI introduced recently appears based on the gradient echo technique which is sensitive to the field inhomogeneity developed due to the local susceptibility changes of blood oxygenation and deoxygenation. Common to all the gradient echo techniques is that the signal due to the susceptibility effects is generally decreased with increasing inhomogeneity due to the $T2^*$ effect or conventionally known as blood oxygenation level dependent (BOLD) effect. It is, also found that the BOLD sensitivity is also dependent on the imaging modes, namely whether the imaging is in axial, or coronal or sagittal mode as well as the directions of the vessels against the main magnetic field. We have, therefore, launched a systematic study of imaging mode dependent signal change or BOLD sensitivity as well as the signal changes due to the tilting angle of the imaging planes. Study has been made or both TRFGE sequence and CGE sequence to compare the distinctions of the each mode since each technique has different sensitivity against susceptibility effect. Method of computation and both the computer simulations and their corresponding experimental results are presented.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1993년도 추계학술대회
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• pp.23-26
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• 1993

In MR functional imaging, it is shown that the signal change during photic activation is composed of two terms, i.e. the inflow effect and the susceptibility effect. Relatively the inflow effect affects the data obtained by CGE on the condition of short $T_E$(15ms) and large $\alpha$(90degree). The susceptibility effect, however, mainly contributes to the data on the condition of large $T_E$(35ms) and small $\alpha$(30degree). In this apper, we will discriminate the susceptibility effect for the intermingled data affected both flow effect and susceptibility effect. Finally susceptibility only functional imaging is proposed by using TRFGE.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1992년도 춘계학술대회
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• pp.85-91
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• 1992

In MRI, an image contrast can be developed as a result of the susceptibility effect if an object has paramagnetic substances. This is mainly due to the non-uniform phase distribution or linear gradient developed by the magnetic susceptibility within a voxel, which in turn reduces the signal intensity; e.g., spin phases are dephased and thereby cancel each other resulting in a reduced signal. In this paper, a new concept for manipulating the susceptibility effect through the use of tailored RF pulses is proposed. As potential applications of the method, two different types of tailored RF pulses are introduced: one for susceptibility artifact correction and the other for contrast enhancement. The latter, for example, can be applied to angiography utilizing the paramagnetic property of deoxygenated blood. Both a theoretical study of the method and experimental results are reported.

• Investigative Magnetic Resonance Imaging
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• 제22권1호
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• pp.37-49
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• 2018

Purpose: The effect of global inhomogeneity on quantitative susceptibility mapping (QSM) was investigated. A technique referred to as Simultaneous Unwrapping Phase with Error Recovery from inhomogeneity (SUPER) is suggested as a preprocessing to QSM to remove global field inhomogeneity-induced phase by polynomial fitting. Materials and Methods: The effect of global inhomogeneity on QSM was investigated by numerical simulations. Three types of global inhomogeneity were added to the tissue susceptibility phase, and the root mean square error (RMSE) in the susceptibility map was evaluated. In-vivo QSM imaging with volunteers was carried out for 3.0T and 7.0T MRI systems to demonstrate the efficacy of the proposed method. Results: The SUPER technique removed harmonic and non-harmonic global phases. Previously only the harmonic phase was removed by the background phase removal method. The global phase contained a non-harmonic phase due to various experimental and physiological causes, which degraded a susceptibility map. The RMSE in the susceptibility map increased under the influence of global inhomogeneity; while the error was consistent, irrespective of the global inhomogeneity, if the inhomogeneity was corrected by the SUPER technique. In-vivo QSM imaging with volunteers at 3.0T and 7.0T MRI systems showed better definition in small vascular structures and reduced fluctuation and non-uniformity in the frontal lobes, where field inhomogeneity was more severe. Conclusion: Correcting global inhomogeneity using the SUPER technique is an effective way to obtain an accurate susceptibility map on QSM method. Since the susceptibility variations are small quantities in the brain tissue, correction of the inhomogeneity is an essential element for obtaining an accurate QSM.