• 한국수산과학회지
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• 제32권4호
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• pp.476-480
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• 1999

조개류 유생의 동해방지제 독성에 대한 내성을 평가하기 위해 진주조개, Pinctada fucata martensii와 참굴, Crassostrea gigas의 담륜자를 4종류의 동해방지제에 침지하여 생존율을 조사하였다. 실험에 사용된 동해방지제는 각각 0.01$\~$2.0 M의 DMSO, ethylene glycol, glycerol 과 1,2-propanediol이었으며, 침지시간은 5$\~$20분으로 설정하였다. 모든 동해방지제에 진주조개와 참굴 담륜자를 침지하였을 때, 농도가 낮을수록 침지시간이 짧을수록 생존율이 높아지는 경향을 보였으며, 동해방지제의 종류에 따라 담륜자의 생존율이 다르게 나타났다. DMSO와 ethylene glycol에서는 참굴 담륜자의 생존율이, glycerol과 1,2-propanediol에서는 진주조개 담륜자의 생존율이 상대적으로 높게 나타났다. 그러나 참굴에서는 4종류의 동해방지제에 0.2 M sucrose를 첨가하였을 때 생존율이 유의하게 높아졌다.

• Journal of Chest Surgery
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• 제53권6호
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• pp.361-367
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• 2020

Background: Malignant primary cardiac tumors are extremely rare, but have a poor prognosis. This study evaluated the surgical outcomes of patients with this disease. Methods: Forty patients who underwent surgery for malignant primary cardiac tumors between January 1998 and December 2018 were enrolled. Participants were divided into 3 groups based on resection margins (R0, 14 patients; R1, 11 patients; and R2, 11 patients) and their surgical outcomes were compared. Heart transplantation was performed in 4 patients with unresectable tumors. Results: Early mortality was reported in 2 cases (5%) due to postoperative bleeding and cerebral hemorrhage secondary to brain metastasis. The 1- and 2-year survival rates were 67.5% and 42.5%, respectively. The median survival time of the patients was 20.3 months (range, 9.2-37.6 months). The median survival time was 48.7, 20.3, and 4.8 months in patients with R0, R1, and R2 resections, respectively (p=0.023). Tumor recurrence occurred in 21 patients (61.7%), including 4 cases of local recurrence and 17 cases of distant metastasis. In patients who underwent heart transplantation, the median survival time was 29.5 months, with 3 cases of distant metastasis. Conclusion: Although surgery for malignant primary cardiac tumors has a poor prognosis, complete resection of the tumor may improve surgical outcomes.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2369-2373
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• 2015

Objective: To analyze efficacy of neoadjuvant chemotherapy for advanced ovarian cancer. Materials and Methods: A total of 107 patients with advanced ovarian cancer undergoing cytoreductive surgery were divided into a neoadjuvant chemotherapy group (n=61) and a primary debulking group (n=46) and retrospectively analyzed. Platinum-based adjuvant chemotherapy was applied to both groups after cytoreductive surgery ande overall and progression-free survival times were calculated. Results: No significant difference was observed in duration of hospitalization ($20.8{\pm}6.1$ vs. $20.2{\pm}5.4$ days, p>0.05). The operation time of neoadjuvant chemotherapy group was shorter than the initial surgery group ($3.1{\pm}0.7$ vs. $3.4{\pm}0.8$ h, p<0.05). There were no significant differences in median overall survival time between neoadjuvant chemotherapy group and surgery group (42 vs. 55 months, p>0.05). Similarly, there was no difference in median progression-free survival between neoadjuvant chemotherapy group and surgery group (16 vs. 17 months, p>0.05). The surgical residual tumor size demonstrated no significant difference between initial surgery and neoadjuvant chemotherapy groups (p>0.05). Multivariate analysis showed that more than 3 cycles of regimen with neoadjuvant chemotherapy was associated with more resistance to chemotherapy compared with patients without receiving neoadjuvant chemotherapy (OR: 5.962, 95%CI: 1.184-30.030, p<0.05). Conclusions:Neoadjuvant chemotherapy can shorten the operation time. However, it does not improve survival rates of advanced ovarian cancer patients.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6415-6419
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• 2014

Purpose: To explore the relationship between SER (time between the start of any treatment and the end of radiation therapy) and the survival of patients with limited-stage small cell lung cancer. Materials and Methods: Between 2008 and 2013, 135 cases of limited-stage small cell lung cancer (LS-SCLC) treated with consecutively curative chemoradiotherapy were included in this retrospective analysis. In terms of SER, patients were divided into early radiotherapy group (SER<30 days, n=76) and late radiotherapy group ($SER{\geq}30$ days, n=59) with a cut-off of SER 30 days. Outcomes of the two groups were compared for overall survival. Results: For all analyzable patients, median follow-up time was 23.8 months and median overall survival time was 16.8 months. Although there was no significant differences in distant metastasis free survival between the two groups, patients in early radiotherapy group had a significantly better PFS (p=0.003) and OS (p=0.000). Conclusions: A short SER may be a good prognostic factor for LD-SCLC patients treated with concurrent chemoradiotherapy.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.647-650
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• 2014

Objective: To explore the efficiency of single application of lobaplatin in tran-scatheter arterial chemoembolization (TACE) for patients with a primary hepatic carcinoma who were unable or unwilling to undergo surgery. Methods: 173 patients with primary hepatic carcinoma diagnosed by imaging or pathology were randomly divided into experimental and control groups and respectively treated with lobaplatin and pirarubicin hydrochloride as chemotherapeutic drugs for TACE. The amount of iodipin was regulated according to the tumor number and size, and then gelatin sponge or polyvinyl alcohol particles were applied for embolisms. The efficiency of treatment in the two groups was compared with reference to survival time and therapeutic response. Results: The experimental group (single lobaplatin as chemotherapy drug) was superior to control group (single pirarubicin hydrochloride as chemotherapy drug) in the aspects of survival time and therapeutic response, with statistical significance. Conclusions: Single lobaplatin can be as a chemotherapy drug in TACE and has better efficiency in the aspects of mean survival time and therapeutic response, deserving to be popularized in the clinic.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5073-5076
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• 2013

Objective: This study aimed to investigate whether the miR-198 expression level is related to clinicopathological factors and prognosis of esophageal cancer. Methods: MicroRNA was extracted from esophageal cancer patients who underwent surgery for assessment using the Taqman@ MicroRNA assay. The correlation between miR-198 expression and clinicopathological features was analyzed, and the significance of miR-198 as a prognostic factor and its relationship with survival was determined. Results: MicroRNA-198 (miR-198) expression was higher in patients with poor prognosis than those with good prognosis (P<0.05). Kaplan-Meier analysis results showed that the miR-198 expression level had a significant correlation with survival time (P=0.030) and that patients with a higher expression of miR-198 had a shorter survival time. Cox multi-factor model analysis showed that patient prognosis (P=0.014), tumor length (P=0.040) and expression (P=0.012), and survival time had a significant correlation; the corresponding risks were 7.268, 1.246, and 3.524, respectively. Conclusion: miR-198 overexpression is involved in the poor prognosis of esophageal cancer and can be used as a biomarker for selection of cases requiring especial attention.

• Journal of Preventive Medicine and Public Health
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• 제38권1호
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• pp.9-15
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• 2005

Objectives : To analyze medical expenses by cancer site and survival time among cancer patients in their last year of life. Method : The study subjects were 45,394 people that had died of cancers in 2002, were registered by the Korea Central Cancer Registry and received National Health Insurance benefit in the last year (360 days) of life. Personal identification data, general characteristics, dates of death and cancer incidence, and site of cancer were collected from the National Statistical Office and the Korea Central Cancer Registry, and merged with the data of the individual medical expenses of the Health Insurance Review Agency. Results : Average monthly cost curves were U-shaped with high costs near the time of diagnosis and death, and lower costs in between. Medical expenses in the last year of life were around 30.3, 16.7, 13.0, and 12.1 million won among leukemia, lymphoma, ovarian cancer, and breast cancer patients, respectively. Digestive organ cancers including stomach, esophagus, liver, pancreas, and colorectal cancers had relatively low medical expenses. Medical expenses in the last year of life were inverse U-shaped with high expenses near one year of survival. Average monthly cost in the 12 months before death among the patients who had survived $10{\sim}15$ years were more than two-fold greater than the cost before diagnosis among those who had survived for less than one year. Conclusions : Leukemia was the most expensive cancer. It is possible that once diagnosed as cancer, medical expenses do not return to the level before diagnosis. Further research will be needed to understand the magnitude and change of the medical expenses among cancer patients with long term follow up data.

• 한국해양환경ㆍ에너지학회지
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• 제10권4호
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• pp.211-217
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• 2007

새로운 공격 무기들의 등장과 적과의 전투환경 변화로 현대의 함정설계에 있어 생존성의 향상은 가장 중요한 요소가 되었으며, 특히 적에게 쉽게 노출되는 수상함에 있어서는 생존성의 취약성에 대비한 감소대책이 보다 강조되고 있다. 생존성을 고려한 함정설계를 위하여 우선 적절한 공격 시나리오를 설정하고 이에 따라 폭발해석을 수행하여야 한다. 폭발은 함의 국부 손상 및 대변형 손상을 야기시키며 이 때 손상된 함정에 대한 적절한 생존성 평가가 중요하다. 본 연구에서는 구조-유체 연성기법 중 하나인 ALE기법을 적용하여 폭발해석을 수행하고 함정의 붕괴거동을 조사하였으며 이 손상된 함정에 대하여 정량적으로 생존시간을 계산할 수 있는 간략계산법을 제시하였다.

• 대한수의학회지
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• 제35권3호
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• pp.635-641
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• 1995

The purpose of this study was to investigate the effects of developmental stage and equilibration time on survival of rabbit embryos following freezing by vitrification. Adult New Zealand White female rabbits were superovulated with PMSG and hCG. The 8-cell stage embryos were collected from 40 to 45 hours after hCG injection by flushing oviducts with Dulbecco's phosphated buffered saline and in vitro cultured in TCM-199 containing 10% fetal calf serum(FCS). Each embryos developed in vitro to 16-cell, compact morula and blastocyst was cryopreserved and cultured following thawing to examine their developmental potential to expanded blastocyst stage in vitro. The frozen-thawed-cultured embryos were stained with Hoechst 33342, and their nuclei were counted using a fluorescence microscope. On the toxicity test of EFS solution as cryopreservation, the survival rates of 8-cell stage embryos was decreased in reverse to increasing of exposure time over 5 minutes. The post-thaw survival rates of embryos on equilibration times was significantly(P<0.05) higher for 2 min. than for 5 or 10 minutes. From morula to blastocyst of rabbit embryos was more suitable than 8-cell stage for cryopreservation by vitrification. The higher post-thaw survival rate of embryos can be achieved by keeping the cryoprotectant at $4^{\circ}C$ than at $20^{\circ}C$. The mean number of nuclei per embryo following freezing by vitrification and in vitro culture to expanded blastocyst at compacted morula and blastcyst was not significantly differ from fresh blastocyst.

• 대한한방내과학회지
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• 제28권3호
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• pp.531-543
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• 2007

배 경 : 위암은 세계적으로 암으로 인한 사망의 가장 많은 원인 중 하나이다. 위암 환자들은 진단시 자주 원격전이를 나타내고, 아직까지 수술이나 전이와 재발을 막기 위한 화학요법 후의 표준화된 요법은 없다. 목 적 : 연구 목적은 ‘수레바퀴 암치료법(WBT)’으로 치료받은 환자들에 있어서의 전체생존율과 무병생존율을 WBT 단독 혹은 기존 통상요법과 병용치료한 환자들을 비교하고 두 그룹의 생존율에 있어 유의성이 있는지를 관찰하는 것이다. 세팅과 디자인 : 대전대학교 둔산한방병원 동서암센터; 후향적 연구. 자료와 방법 : WBT를 시행하기 2개월 이전까지 수술이나 화학요법을 받은(혹은 어떠한 통상치료도 받지 않은) III기(40명)와 IV기(22명)의 62명의 위암 환자들을 후향적으로 분석했다. 환자들은 전이와 재발을 방지하는 PSM 캡슐, OnePlus 시럽, 항암단과 같이 한약을 포함한 WBT 계획을 따랐다. 전체생존율과 무병생존율을 분석했으며 환자들은 III기와 IV기 각각 89.55주와 49.27주(평균치) 동안 치료를 받았다. 통계분석 : 전체생존율과 무병생존율은 Kaplan-Meier법으로 측정하고 WBT 단독 및 병행 치료는 log rank test로 비교했다. 결 과 : III기에서 3년 전체생존율은 78.5%이고, 무병생존율은 78.3%였다. 40명 중 13명의 환자(32.5%)에게 전이와 재발이 있었다. IV기에서 2년 전체생존율은 18.2%이고, 무병생존율은 또한 18.2%였다. 22명 중 19명(86.4%)에게서 전이와 재발이 있었다. WBT 단독 및 병행치료법 중 병행치료의 효과가 높게 나타났지만 통계적으로 유의한 차이를 보이지는 않았다(전체생존율 p=0.5093, 무병사망율 p=0.5175 ). 결 론 : WBT는 위암 환자들에게 생존기간을 늘이고 전이를 방지하는 만족할 만한 결과를 산출했다. WBT의 주된 치료법은 한약(항암단, PSM 캡슐, OnePlus 시럽)으로 구성되어 있으며 향후에는 무작위의 전향적인 연구가 이 치료법만을 이용해서 수행되어야 할 것이다.