• Journal of Korean Neurosurgical Society
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• 제59권4호
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• pp.392-399
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• 2016

Objective : Brain metastases in gynecologic cancer (ovarian, endometrial, and cervical cancer) patients are rare, and the efficacy of Gamma Knife Radiosurgery (GKRS) to treat these had not been evaluated. We assessed the efficacy of GKRS and prognostic factors for tumor control and survival in brain metastasis from gynecologic cancers. Methods : This retrospective study was approved by the institutional review board. From May 1995 to October 2012, 26 women (mean age 51.3 years, range 27-70 years) with metastatic brain tumors from gynecologic cancer were treated with GKRS. We reviewed their outcomes, radiological responses, and clinical status. Results : In total 24 patients (59 lesions) were available for follow-up imaging. The median follow-up time was 9 months. The mean treated tumor volume at the time of GKRS was $8185mm^3$ (range $10-19500mm^3$), and the median dose delivered to the tumor margin was 25 Gy (range, 10-30 Gy). A local tumor control rate was 89.8% (53 of 59 tumors). The median overall survival was 9.5 months after GKRS (range, 1-102 months). Age-associated multivariate analysis indicated that the Karnofsky performance status (KPS), the recursive partitioning analysis (RPA) classification, and the number of treated lesions were significant prognostic factors for overall survival (HR=0.162, p=0.008, HR=0.107, p=0.038, and HR=2.897, p=0.045, respectively). Conclusion : GKRS is safe and effective for the management of brain metastasis from gynecologic cancers. The clinical status of the patient is important in determining the overall survival time.

• 한국양식학회지
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• 제16권4호
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• pp.229-232
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• 2003

이 연구에서는 인공종묘 생산된 북방대합 치패를 대상으로 수온, 염분 및 공기 중 노출에 따른 생존율과 방류를 위한 잠사 능력을 조사하였다. 수온 4∼28$^{\circ}C$ 범위에서 10일간 치패의 수온에 따른 생존율은 차이가 없었으며 ,염분 22 psu 이상에서는 50% 이상의 생존율을 보였다. 또한 기온 2$0^{\circ}C$이하의 공기 중 노출에서 12시간 이내에는 생존율에 차이가 없었으나 $25^{\circ}C$에서는 16시간 이상에서 50% 이하의 생존율을 보였다 각 장에 따른 잠사능력은 각 장이 증가할수록 잠입시간은 길어지고 잠입률은 감소하였으며, 각장 15mm 이하의 치패는 10분 이내에 90% 이상 잠입하였다. 저질모래 크기에 따른 잠입시간과 잠입률에는 차이가 나타나지 않았다.

• Journal of Korean Neurosurgical Society
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• 제61권6호
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• pp.737-746
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• 2018

Objective : The purpose of this study was to compare the cosmetic outcome and complications after cranioplasty (CP) due to three different implant materials, and analyze the mean implant survival and cumulative survival rate based on these results. Methods : We reviewed 108 patients retrospectively who underwent CP between January 2014 and November 2016. Autologous bone (AB; 45 patients) and synthetic materials with porous polyethylene (PP; 32 patients) and custom-made 3-dimensional printed titanium mesh (CT; 31 patients) were used as implants. Results : Regardless of implanted materials, more than 89.8% of the CP patients were satisfied with the cosmetic outcome. No statistically significant difference was observed among the three groups. The overall postoperative complication rates of each group were 31.1% in the AB group, 15.6% in the PP group and 3.2% in the CT group. The CT group showed lower complication rates compared with AB and PP groups (${\chi}^2$-test : AB vs. PP, p=0.34; AB vs. CT, p=0.00; PP vs. CT, p=0.03). The AB and PP groups demonstrated a higher post-CP infection rate (11.1% and 6.3%) than the CT group (3.2%). However, no significant difference in the incidence of post-CP infection was observed among the three groups. The PP and CT groups demonstrated a higher mean implant survival time and cumulative survival rate than the AB group at the last follow-up (p<0.05). Conclusion : In comparison with AB and PP, cranioplasty with CT shows benefits in terms of lower post-CP complication, less intraoperative bleeding loss, shorter operation time and in-hospital stay. The PP and CT groups showed higher implant survival time and cumulative survival rate compared with the AB group.

• 한국항해항만학회지
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• 제37권1호
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• pp.85-89
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• 2013

Sometimes, an evacuation should be executed from a ship for many reasons. This study considers on emergency evacuation on fire in a ship, one of the many reasons for evacuation. Due to the characteristic of fire, the most loss of life is known to be caused by suffocation resulted by smoke. To reduce the suffocation by smoke, the time available for evacuation should be improved for the higher survival rate of crews. In this study, crews' survival times and Evacuation time are analyzed quantitatively in during fire in the same sealed space in two different cases of the natural ventilation and the forced ventilation.

• 아동학회지
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• 제28권2호
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• pp.217-233
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• 2007

The present study investigated the effects of individual, family, school, and community factors on the onset of adolescent runaway behavior. Using the Korean Youth Panel data(n=3,118), discrete-time survival analysis was applied for research purposes. Results showed that the likelihood of onset of adolescent runaway behavior increased sharply during the early middle school years. The variables of self-control, aggression, parents' divorce, paternal abuse, attachment with parents, and number of delinquent peers were associated with the likelihood of runaway behavior. These results suggest that special attention should be paid to adolescents in the early middle school years and that various preventive programs, e.g., aggression and stress management, and peer relations programs, should be developed and implemented.

• Communications for Statistical Applications and Methods
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• 제24권2호
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• pp.115-127
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• 2017

This paper proposes a Bayesian test for the equivalence of survival functions in multiple groups. Proposed Bayesian test use the model of Cox's regression with time-varying coefficients. B-spline expansions are used for the time-varying coefficients, and the proposed test use only the partial likelihood, which provides easier computations. Various simulations of the proposed test and typical tests such as log-rank and Fleming and Harrington tests were conducted. This result shows that the proposed test is consistent as data size increase. Specifically, the power of the proposed test is high despite the existence of crossing hazards. The proposed test is based on a Bayesian approach, which is more flexible when used in multiple tests. The proposed test can therefore perform various tests simultaneously. Real data analysis of Larynx Cancer Data was conducted to assess applicability.

• The Korean Journal of Ecology
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• 제17권2호
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• pp.223-235
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• 1994

The transfer of plasmid-borne genes coding for resistance to antibiotics (Ampicillin, Carbenicillin, and tetracycline) among 16 strains isolated from Mankyong River was examined. The survival of donors, recipient, and transformants in sterile and nonsterile soil (the soil was amended with 12% vol/vol with the clay mineral, montmorillonite) was also studied. In sterile soil, the survival was prolonged in the order of donors, transformants, and recipient. The survival of donors, transformants, and recipient increased when the soil was amended with 12% montmorillonite, but not in nonsterile soil. In nonsterile soil, donors survived longer than transformants and recipient, but the survival of transformants and recipient showed no significant differences. The results of these studies suggest that genes can be transferred by transformation, and transferred genes can survive in soil for a considerable time.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6253-6255
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• 2014

Background: Colorectal cancer (CRC) is considered to be a main cause of malignancy-related death in the world, being commonly diagnosed in both men and women. It is the third leading cause of cancer dependent death in the world and there are one million new cases diagnosed per year. In Iran the incidence of colorectal cancer has increased during the last 25 years and it is the fifth cause of cancer in men and the third in women. Materials and Methods: In this article we analyzed the survival of 475 colorectal patients of Taleghani hospital in Tehran with the semi-parametric competing-risks model. Results: There were 55% male cases and at the time of the diagnosis most of the patients were between 48 and 67years old. The probability of a patient death from colorectal cancer with survival of more than 25 years was about 0.4. Body mass index, height, tumour site and gender had no influence. Conclusions: According to these data and by using semi-parametric competing-risks method, we found out that only age at diagnosis has a significant effect on these patient survival time.

• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.3169-3173
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• 2014

Background: To investigate factors associated with overall survival in patients with newly diagnosed metastatic nasopharyngeal carcinoma. Materials and Methods: Two hundred and two consecutive patients with pathologically confirmed nasopharyngeal carcinoma with distant metastasis at diagnosis seen between December 2007 and May 2011 were reviewed. Patient, tumor and treatment factors were analyzed for their significance regarding overall survival. Results: The median follow-up time was 22 months. At the time of this report, 116 patients had died. For 112 patients, cause of death was nasopharyngeal carcinoma. The 1, 2, 3, and 4-year overall survival rates were 75.6%, 50.2%, 39.2%, and 28.2%, respectively. Cox regression multivariate analysis showed that T-stage (p=0.045), N-stage (p=0.014), metastasis number (p<0.001) and radiotherapy for nasopharynx and neck (p<0.001) were significant factors for overall survival. Conclusions: Early T-stage and N-stage, solitary metastasis in a single organ were good prognostic factors for patients with newly diagnosed metastatic nasopharyngeal carcinoma. Radiotherapy should be strongly recommended in systemic treatment.

• 응용통계연구
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• 제11권2호
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• pp.269-285
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• 1998

임상시험연구의 설계에서 적절한 표본수의 결정은 매우 중요한 문제 중의 하나이다. 본 논문에서는 생존분포를 비교하기 위한 여러 가지 방법들을 소개하고, 각 방법에서의 가정들을 고찰하였다. 또한 다양한 상황에서의 표본수와 검정력 등을 비교제시하고 모의실험을 통해 각 방법들의 이론상의 검정력과 실제 검정력을 알아보았다 그 결과로서 의학연구자들이 처한 여러 상황에 적합한 표본수의 결정방법을 제시하였다.