• 공업화학
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• 제10권1호
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• pp.85-92
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• 1999

고정층 촉매 반응기를 이용하여 ${\gamma}$-알루미나에 담지한 크롬산화물 촉매상에서 vinyl chloride의 완전산화잔응을 $240{\sim}300^{\circ}C$의 온도와 600~3,500 ppm의 농도범위에서 조사하였다. 반응은 vinyl chloride의 농도에 대하여 비선형적으로 변하였으며, 산소의 농도에 대하여는 0차 거동을 보였다. 또한 반응 생성물인 $H_2O$와 HCl를 반응물에 첨가하였을 때 vinyl chloride의 전환율에 영향이 거의 없었다. Vinyl chloride의 산화반응에 대한 몇 가지 반응모델을 가정하고 실험결과와 상관시켜 가장 잘 일치하는 모델을 도출하였다. 속도식의 해석결과 vinyl chloride의 산화반응은 산소로 피복된 촉매표면에 vinyl chloride가 흡착한 후 산화분해되며, vinyl chloride가 촉매표면에 흡착하여 반응을 방해한다는 가정하에서 도출된 반응속도 모델이 실험결과를 가장 잘 표현하였다. 실험치와 예측치간의 표준편차 백분율은 약 5.2% 정도였으며 활성화에너지는 18.9 kcal/mol으로 계산되었다.

• Korean Journal of Acupuncture
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• 제21권4호
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• pp.101-115
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• 2004

Objective : The present studies investigated the effects of 120 Hz high frequency electroacupuncture (EA) on the stress-induced stomach dysfunction in relation to its effect on the level of stress hormones and gastric mucosal damages. The gastric mucosal injury was induced by cold-restraint stress and two acupoints corresponding to Zusanli and Sanyinjiao in man were used. Methods : Cold-restraint stress produced typical gastric lesions in all rats of the stressed groups, but the number of ulcers as well as the mean ulcer diameter were reduced by 120 Hz EA pre-treatment. Results : The degranulation value of gastric mast cell was significantly higher in cold-restrained rats than in control ones. However, with the significant reduction of degranulation values of gastric mast cells in EA pre-treated rats compared with cold-restrained rats. Cold-restarint stress induced an elevated mRNA expression of pro-inflammatory gene such as cyclooxygenases-2 and tumor necrosis factor $(TNF)-{\alpha}$, but these expression were down-regulated in EA pre-treated rats. Immunohistochemical analysis showed that while the $inhibitory-{\kappa}B{\alpha}$ and $TNF-{\alpha}$ immunorection in the surface epithelium of the stomach tended to increase, both reactions in the EA pre-treated rats showed similar pattern as observed in controls. Conclusion : These results suggest that 120 Hz EA may act as a therapeutical means for gastric mucosal damages through an activation of pituitary adrenal system. It could be concluded that 120 Hz high frequency electroaucupuncture affords a good protective potential against stress-induced gastrointestinal dysfunction.

• BMB Reports
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• 제37권3호
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• pp.330-338
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• 2004

Different types of cardiotoxin (I-V and n) were isolated and purified from the venom of the Taiwan cobra (Naja naja atra). The effects of these cardiotoxins were studied on membrane-bound acetylcholinesterase, which was isolated from a sheep's brain cortex. The results showed that cardiotoxins I-III, V, and n activated the enzyme by modification of substrate inhibition, but cardiotoxin IV's reaction was different. The inhibition and activation of acetylcholinesterase were linked to the functions of the hydrophobicity index, presence of a cationic cluster, and the accessible arginine residue. Our results indicate that Cardiotoxins have neither a cationic cluster nor an arginine residue in their surface area of loop I; therefore, in contrast to fasciculin, cardiotoxins are attached by loop II to the peripheral site of the enzyme. As a result, fasciculin seems to stabilize nonfunctional conformation, but cardiotoxins seem to stabilize the functional conformation of the enzyme. Based on our experimental and theoretical findings, similar secondary and tertiary structures of cardiotoxins and fasciculin seem to have an opposite function once they interact with acetylcholinesterase.

• 한국운동역학회지
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• 제22권2호
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• pp.193-199
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• 2012

The purpose of this study was to investigate the activities of the serratus anterior (SA) and upper trapezius (UT) muscles during scapular protraction exercise with a dumbbell. Twenty-one healthy subjects with no medial history of shoulder pain or upper extremity disorders were recruited for this study. Subjects performed scapular protraction at $90^{\circ}$ and $130^{\circ}$ shoulder flexion with a dumbbell in supine and standing positions. The activities of the SA and UT were measured via surface electromyography (EMG) during 4 scapular protraction exercises. A 2 (angle) ${\times}$ 2 (position) repeated-measures analysis of variance (ANOVA) was used to compare the normalized activities of the SA and UT and the UT/SA ratio. The results showed that activities of both the SA and UT were the highest for the scapular protraction exercise at $130^{\circ}$ shoulder flexion in the standing position. However, the UT/SA ratio was the lowest for the exercise at $90^{\circ}$ shoulder flexion in supine position. Therefore, for selective activation of the SA muscle, we recommend performing the scapular protraction exercise with a dumbbell in the supine position at $90^{\circ}$ shoulder flexion.

• 한국균학회지
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• 제30권1호
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• pp.31-36
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• 2002

렉틴은 T-cell 자극 분열효과 및 항종양효과 이외에도 당특이성에 의한 세포표면이나 용액내에 존재하는 당류의 확인 및 연구에 유용하게 쓰이고 있어 최근들어 특히 흥미의 대상이 되고 있다. 렉틴은 주로 식물을 대상으로 연구되어져 왔으며, 이러한 연구결과, 렉틴은 단백질성 물질이라는 공통점을 제외하고는 생화학적, 면역학적 성질이 매우 다양한 것으로 나타났다. 본 연구에서는 표고버섯을 부위별로 구분하여 그 화학적 조성분석과 단백질 분리를 실시하고, 렉틴을 정제하여 생리활성의 특성을 구명하였다. 표고버섯은 신선한 것일수록 단백질 추출이 용이하며, 균산이 균병에 비해 단백질 량이 2배 정도 많았다. 렉틴은 $40^{\circ}C$ 이하에서 그리고 산성보다는 알칼리성에 더 안정하였다. 당 특이성에 있어서는 galactose, fucose, glucosamine, lactose, N-aretyl-D-galactosamine에 특이성을 지니는 것으로 나타났으며, 분리한 렉틴은 당단백질임을 알 수 있었다.

• The Journal of Korean Physical Therapy
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• 제25권5호
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• pp.337-342
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• 2013

Purpose: This study was conducted in order to determine the effect of visual and tactile feedback on muscle activity of the gluteus maximus (Gmax) and abdominal muscles and the motion of pelvic rotation during performance of clam exercise (CE). Methods: Thirteen subjects without low back pain were recruited for this study. Each subject was instructed to perform the CE without and with feedback. The subjects were instructed to keep pelvic from rotating backwards by palpating the ASIS and monitoring the pelvic movement by themselves during performance of CE with feedback. The electromyographic (EMG) activities of Gmax and abdominal muscles were collected using surface EMG. Angles of pelvic rotation were measured using a 3-dimensional motion-analysis system. Paired t-tests were used for comparison of EMG activities in each muscle and the angle of pelvic rotation. Results: The EMG activities of all abdominal muscles were not significant between CM without and CM with feedback (p>0.05). The EMG activity of Gmax was significantly greater in CM with feedback compared with CM without feedback (without vs. with feedback; 14.2% vs. 20.7%MVIC) (p<0.05). The angle of pelvic rotation was significantly less in CM with feedback compared with CM without feedback (without vs. with feedback; $15.3^{\circ}$ vs. $10.8^{\circ}$ ) (p<0.05). Conclusion: Therefore, these findings suggest that CM with the visual and tactile feedback is effective in activation of the Gmax and correcting of the uncontrolled lumbopelvic rotation during CE.

• The Journal of Korean Physical Therapy
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• 제32권3호
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• pp.157-162
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• 2020

Purpose: This study was to evaluate several tasks performed at a high intensity in terms of their ability to elicit EMG activity in the serratus anterior by comparing the EMG activities of the serratus anterior, upper trapezius, and lower trapezius muscles during six tasks combined shoulder flexion with rotation. Methods: Fifteen healthy males were recruited to this study. Each subject was instructed to assume a sitting position without back support and asked to flex (90° or 120°) the right shoulder and protract the scapula in the sagittal plane with maximal external rotation; to assume a neutral position; or to internally rotate the glenohumeral joint. The EMG data were collected from the serratus anterior (SA), upper trapezius (UT), and lower trapezius (LT) muscles were normalized to maximum voluntary isometric contraction. The UT/LT and UT/SA muscle activity ratios in each task were assessed by calculating the surface EMG. Data were analyzed by two-way repeated-measures analysis of variance, with the level of significance set at p<0.05. Results: The results of this study, shoulder flexion with external rotation resulted in low upper trapezius/serratus anterior and upper trapezius/lower trapezius ratios and a relatively high level of serratus anterior activation. Conclusion: Shoulder flexion with external rotation used herein may be considered as important for clinical interventions aimed at selectively increasing SA strengthen and clinical selection of exercises for improving glenohumeral joint and scapulothoracic control.

• 한국응용과학기술학회지
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• 제20권3호
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• pp.212-220
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• 2003

Electrical properties of carbon filler/PVdF [poly(vinylidene fluoride)] composite were investigated as a funtion of carbon filler/PVdF ratio in the range of 0.2${\sim}$0.5. Three kinds of comercialzied conductive carbon blacks such as Hiblack 41Y, KE300J, and KE600J, and carbon nanofibers prepared by the catalytic chemical vapor deposition of $C_2H_4$ over Ni-Cu catalysts were used as the carbon fillers. The electrical conductivity of carbon filler/PVdF composites were in the range of 0.65 to 13.5 S/cm depending the fillers' electrical conductivity ranging from 5.6 to 23.1 S/cm. Among the carbon fillers used, the KE600J carbon black showed the highest conductivity both in the composite and filler itself because of its high degree of graphitization due to the high-temperature thermal treatment and its high surface area due to the activation treatment.

• 대한의용생체공학회:의공학회지
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• 제34권4호
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• pp.212-217
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• 2013

Falling is one of the major public problems to the elderly, resulting in limitations of daily living activities. It can be induced by the functional loss of the balance ability and muscle strength in the elderly. It has been, however, not well investigated to suggest an effective methodology improving the balance ability and muscle strength for the prevention of the falling due to lack of information about the characteristics of the balance and muscle activations responded to the dynamic motions. The aim of the current study is, therefore, to identify the characteristics of the balance and muscle activations responded to the dynamic motions in Anterior-Posterior(AP) and Medial Lateral(ML) directions. For that, a motion capture system with eight infrared cameras, surface electromyogram system and Wii Fit system with a customized variable unstable base were used and kinematic and kinetic data obtained from the systems were analyzed for five healthy male($24.8{\pm}3.3years$, $177.4{\pm}2.0cm$, $73.9{\pm}12.9kg$, $23.5{\pm}4.0kg/m$). The results showed that the characteristics of the balance and muscle activations were differently responded to between the dynamic motions in Anterior-Posterior(AP) and Medial Lateral(ML) directions. These findings may indicate that customized dynamic motions should be applied to the training of the balance ability and muscle strength for the effective prevention of the falling. This study may be meaningful to providing basic information to establish a guideline improving effectively the balance ability and muscle strength.

• Journal of Microbiology and Biotechnology
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• 제23권9호
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• pp.1339-1346
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• 2013

Conventional chemotherapeutic regimens often accompany severe side effects and fail to induce complete regression of chemoresistant or relapsing metastatic cancers. The need for establishing more efficacious anticancer strategies led to the development of a combined modality treatment of chemotherapy in conjunction with immunotherapy or radiotherapy. It has been reported that poly-gamma-glutamate (${\gamma}$-PGA), a natural polymer composed of glutamic acids, increases antitumor activity by activating antigen-presenting cells and natural killer (NK) cells. Here, we investigated the antitumor effect of ${\gamma}$-PGA in combination with cyclophosphamide in a murine melanoma model. Whereas cyclophosphamide alone directly triggered apoptosis of tumor cells in vitro, ${\gamma}$-PGA did not show cytotoxicity in tumor cells. Instead, it activated macrophages, as reflected by the upregulation of surface activation markers and the secretion of proinflammatory factors, such as nitric oxide and tumor necrosis factor ${\alpha}$. When the antitumor effects were examined in a mouse model, combined treatment with cyclophosphamide and ${\gamma}$-PGA markedly suppressed tumor growth and metastasis. Notably, ${\gamma}$-PGA treatment dramatically increased the NK cell population in lung tissues, coinciding with decreased metastasis and increased survival. These data collectively suggest that ${\gamma}$-PGA can act as an immunotherapeutic agent that exhibits a synergistic antitumor effect in combination with conventional chemotherapy.