• 한국멀티미디어학회논문지
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• 제11권3호
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• pp.386-397
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• 2008

본 연구는 HL7 버전 3의 객체지향 분석 및 개발 방법론인 HL7 개발 프레임워크(HDF)를 이용하여 투약관리의 임상문서구조의 개발을 통해 임상활동의 표준화 데이터 모델을 구현하는 것을 제안한다. 투약관리는 의료현장에서 임상전문가가 행하는 가장 중요한 업무이다. 표준화 된 데이터 모델 및 구조화된 병원정보시스템은 근거기반 임상 활동을 이루기 위해 상당히 중요한 과제이다. 임상문서구조를 생성하기 위해서 HDF와 제공된 도구들을 사용하였다. 본 연구자들은 투약관리활동에서 HDF의 각 단계의 다이어그램을 생성할 수 있었다. 그 결과, 임상 활동 중 하나인 투약관리에 대한 표준화 정보모델을 생성하였다. 이 모델은 보건의료정보시스템을 모델링하기 위한 정보통신개발자들에게 국제 표준방법론을 이해하기 위한 기본적 개념모델이 될 것이다.

• 한국콘텐츠학회논문지
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• 제10권7호
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• pp.122-132
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• 2010

다양한 모바일 장비의 등장으로 인하여 해당 장비에서 실행 가능한 응용 프로그램의 요구가 증가하고 있다. 플랫폼 독립적이란 특성을 가지는 자바 언어는 이러한 환경에 최적의 프로그래밍 언어로 급부상하고 있다. 그러나 자바는 가상 기계에 의해 실행되므로 플랫폼 의존적인 기능을 제공하지 못하는 단점을 가진다. 썬 마이크로시스템즈에서는 이러한 문제점을 해결하기 위해 자바 네이티브 메소드라는 JNI 기술을 제시하였다. JNI 기술을 이용하기 위해서는 JVM의 내부구조와 JNI에 대한 풍부한 지식이 필요하다. 또한 수많은 JNI 함수의 사용으로 인하여 프로그램 개발 생산성과 품질의 저하를 초래하고 있다. JNI에 대한 지식 없이 쉽고 빠르게 네이티브 프로그래밍이 가능 하도록 도와주는 지원 도구의 필요성 대두되고 있다. 이를 위해서는 자바 언어와 C/C++ 언어 사이에 존재하는 구문과 의미상 차이점을 자동적으로 처리해 주어야 한다. 본 연구에서 자바와 C/C++언어 간에 차이점과 이를 극복하기 위한 방안을 제시하고 이를 바탕으로 개발한 JNI 통합 개발 환경을 소개한다.

• Biomolecules & Therapeutics
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• 제19권3호
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• pp.331-335
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• 2011

In this study, we determined the anti-inflammatory activity and mechanism of action of a hexane fraction (hWRF) obtained from white Rosa hybrida flowers by employing various assays such as quantitative real-time PCR, Western blotting, and Electrophoretic-Mobility Shift Assay (EMSA). The results revealed that the hWRF had excellent anti-inflammatory potency by reducing inflammatory repertoires, such as inducible nitric oxide synthase (iNOS), interleukin-$1{\beta}$, and cyclooxygenase-2 (COX-2) in RAW264.7 cells when stimulated with lipopolysaccharide (LPS), a pro-inflammatory mediator. The reduction of nitric oxide (NO) release from RAW 264.7 cells supported the anti-inflammatory effect of hWRF. Interestingly, hWRF effectively inhibited LPS-mediated nuclear factor-${\kappa}B$ (NF-${\kappa}B$) p65 subunit translocation into the nucleus and extracellular signal-regulated kinase (ERK)1/2 phosphorylation, suggesting that hWRF anti-inflammatory activity may be based on inhibition of the NF-${\kappa}B$ and MAPK pathways. Based on the findings described in this study, hWRF holds promise for use as a potential anti-inflammatory agent for either therapeutic or functional adjuvant purposes.

• Journal of Microbiology and Biotechnology
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• 제19권10호
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• pp.1153-1160
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• 2009

Lactosucrose ($4^G-\beta$-D-galactosylsucrose) is an oligosaccharide consisting of galactose, glucose, and fructose. In this study, we prepared lactosucrose from lactose and sucrose using a levansucrase derived from Zymomonas mobilis. Optimum conditions for lactosucrose formation were $23^{\circ}C$, pH 7.0, 18.0% (w/v) lactose monohydrate, and 18% (w/v) sucrose as substrates, and 1 unit of enzyme/ml of reaction mixture. Under these conditions, the lactosucrose conversion efficiency was 28.5%. The product was purified and confirmed to be O-$\beta$-D-galactopyranosyl-($1{\rightarrow}4$)-O-$\beta$)-D-glucopyranosyl-($1{\rightarrow}2$)-$\beta$-D-fructofuranoside, or lactosucrose. A mixed-enzyme system containing a levansucrase and a glucose oxidase was applied in order to increase the efficiency of lactose and sucrose conversion to lactosucrose, which rose to 43.2% as a result.

• The Korean Journal of Physiology and Pharmacology
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• 제13권3호
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• pp.257-263
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• 2009

This study aimed to investigate whether selective serotonin reuptake inhibitors (SSRIs) attenuate brain injury and facilitate recovery following photothrombotic cortical ischemia in mice. Male ICR mice were anesthetized and systemically administered Rose Bengal. Permanent focal ischemia was induced in the medial frontal and somatosensory cortices by irradiating the skull with cold light laser. The animals were treated with fluoxetine or sertraline once a day for 14 d starting 1 h after ischemic insult. Treatment with fluoxetine and sertraline significantly reduced the infarct size. The Evans blue extravasation indices of the fluoxetine- and sertraline-treated groups were significantly lower than that of the vehicle group. Treatment with fluoxetine and sertraline shifted the lower limit of the mean arterial blood pressure for cerebral blood flow autoregulation toward normal, and significantly increased the expression of heme oxygenase-1 (HO-1) and hypoxia-inducible factor-1 ${\alpha}$ (HIF-1 ${\alpha}$) proteins in the ischemic region. These results suggest that SSRIs, such as fluoxetine and sertraline, facilitate recovery following photothrombotic cortical ischemia via enhancement of HO-1 and HIF-1 ${\alpha}$ proteins expression, thereby providing a benefit in therapy of cerebral ischemia.

• 대한치과보철학회지
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• 제30권2호
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• pp.167-189
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• 1992

Frictional heat produced by cutting tools during dental implantation procedure may destroy the surrounding bone tissue and regenerative capacity and interfere ossointegration by formation of undifferentiated connective tissue. To study the effect of frictional heat according to various rotational speeds on the regenerative capacity of surrounding bone tissue, 13 ITI HS implants (8 mm) were inserted at 4 mongrel dogs. Temperatures were measured using thermocouple located 6 mm below from the marginal crest and 0.5 mm from the periphery of trephine mill during implant bed preparation. After 4 and 9 months, animals were sacrificed and specimens were examined using x-rays and light microscope. Results were as follows: 1. With drill speeds of 300, 800, 2,000, 3,500 rpm and saline irrigation, temperatures of surrounding bone were decreased from $-2.9^{\circ}\;to\;-1.7^{\circ}C$. Temperature rises of $2.0^{\circ}\;and\;2.1^{\circ}C$ were recorded with a drill speed of 5,000 rpm and irrigation. 2. With drill speeds of 800, 3,500, 5,000 rpm and no irrigation, temperatures of surrounding bone rose from $+1.5^{\circ}\;to\;+6.8^{\circ}C$, but maximum temperature was $40^{\circ}C$ at 5,000 rpm. 3. On radiographic examination, bone resorptions were observed at the upper half of implant of 5,000 rpm without irrigation and one case of 5,000 rpm with irrigation. 4. Osseointegration was unsuccessful in cases of 3,500, 5,000 rpm without irrigation due to fibrous connective tissue formation to the outer surface and hollow, but it was successful in a case of 800 rpm without irrigation. 5. Osseointegration was successful in cases of 300, 800, 2,000 and 3,500 rpm with irrigation. But fibrous connective tissue formation was observed at the hollow of implant inserted with 5,000 rpm with irrigation.

• Biomolecules & Therapeutics
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• 제21권6호
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• pp.454-461
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• 2013

The neuroprotective effects of a butanol fraction of white rose petal extract (WRPE-BF) were investigated in a middle cerebral artery occlusion (MCAO) model. Seven week-old male rats were orally administered WRPE-BF for 2 weeks and subjected to MCAO for 2 h, followed by reperfusion. Twenty-four h later, MCAO-induced behavioral dysfunctions were markedly improved in a dose-dependent manner by pretreatment with WRPE-BF. Moreover, higher dose of WRPE-BF not only decreased infarction area but also effectively reduced astrogliosis. The expression of inducible nitric oxide synthase, cyclooxygenase-2, and glial fibrillary acidic protein in MCAO model were markedly inhibited by WRPE-BF treatment. Notably, WRPE-BF decreased nitricoxide and malondialdehyde levels in the striatum and subventricular zone of stroke-challenged brains. These data suggested that WRPE-BF may exert its neuroprotective effects via anti-oxidative and anti-inflammatory activities against ischemia-reperfusion brain injury and could be a good candidate as a therapeutic target for ischemic stroke.

• 한국식품영양과학회지
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• 제39권2호
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• pp.186-192
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• 2010

피부의 주름은 노화과정의 결과로 유도되어지는데, 비효소적 glycation 반응은 주름생성의 원인 중에 하나로 단백질의 비가역적 가교결합에 의해 생성된 최종당화산물(AGEs)이라고 불리는 갈색화합물을 생성한다. 비교적 반감기가 긴 collagen은 쉽게 glycation이 일어나고 collagen의 가교결합(cross-linking)이 일어나면서 여러 단계의 반응을 거쳐 최종적으로 생성된 AGEs가 피부에 축적되어 피부의 탄력감소 및 주름을 일으킨다고 알려져 있다. 피부 내에 glycation된 collagen의 축척은 피부의 탄력성을 유지하는 것을 방해한다. 수종의 식용작물로부터 항주름소재를 개발하기 위하여 메탄올 및 열수추출물을 조제한 후 AGEs 형성을 억제하는 활성을 검색하였다. 먼저 서양향신료 중에서는 월계수잎, 계피, 정향, 오레가노, 로즈마리, 사보리, 팔각과 한약재 중에서는 복분자, 달개비, 삼지구엽초, 가자와 해당화의 메탄올 및 열수추출물에서 최종당화산물 생성 억제활성이 높았다. 그러나 국내 식물 중에서는 단지 참취 및 녹차 추출물의 메탄올과 열수추출물만이 높은 활성을 보였으며 해조류 중에서는 활성이 높은 시료는 없었다.

• 한국의류산업학회지
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• 제18권6호
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• pp.869-877
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• 2016

This study looks into the dyeing properties and functionality of cotton fabrics dyed in both the Spirodela polyrhiza extract and the extract resulting from the mixture of Salvia plebeia R. Br. and Spirodela polyrhiza. Since the UV-Vis Spectrum of the methanol extract of Spirodela polyrhiza shows absorption peaks at 256, 268nm, and 345nm, it can be inferred that the compound that Spirodela polyrhiza contains is a flavonoid. In addition, it can also be presumed that, by analyzing the infrared absorption spectrum of Spirodela polyrhiza, the plant contains flavonoid compounds, just like Salvia plebeia R. Br.. The UV protection factors of the cotton fabrics dyed in both the Spirodela polyrhiza extract and the extract from the mixture of Salvia plebeia R. Br. and Spirodela polyrhiza were 50+, presenting outstanding UV protection factors. The deodorization rate of the cotton dyed in the Spirodela polyrhiza extract was between 30 and 120 minutes, and the rate rose from 92% to 97% as time passed. The deodorization rate of the cotton dyed in the extract from the mixture of Salvia plebeia R. Br. and Spirodela polyrhiza increased from 88% to more than 91%. The result also revealed that overall the fastness of color, including color fastness to washing related to change in color, as well as the color fastness to light of the fabric dyed in the extract from the mixture of the two plants improved, compared to the cloth dyed only in Spirodela polyrhiza extract. Furthermore, the antibacterial activity was also strengthened.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.2979-2982
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• 2013

Cervical cancer is a commonly-encountered malignant tumor in women. Cervical screening is particularly important due to early symptoms being deficient in specificity. The main purpose of the study is to assess the application value of cervical thinprep cytologic test (TCT) and human papillomavirus (HPV) detection in screening for cervical cancer and precancerous lesions. In the study, cervical TCT and HPV detection were simultaneously performed on 12,500 patients selected in a gynecological clinic. Three hundred patients with positive results demonstrated by cervical TCT and/or HPV detection underwent cervical tissue biopsy under colposcopy, and pathological results were considered as the gold standard. The results revealed that 200 out of 12,500 patients were abnormal by TCT, in which 30 cases pertained to equivocal atypical squamous cells (ASCUS), 80 cases to low squamous intraepithelial lesion (LSIL), 70 cases to high squamous intraepithelial lesion (HSIL) and 20 cases to squamous cell carcinoma (SCC). With increasing pathological grade of cervical biopsy, however, TCT positive rates did not rise. Two hundred and eighty out of 12,500 patients were detected as positive for HPV infection, in which 50 cases were chronic cervicitis and squamous metaplasia, 70 cases cervical intraepithelial neoplasia (CIN) I, 60 cases CIN II, 70 cases CIN III and 30 cases invasive cervical carcinoma. Two hundred and thirty patients with high-risk HPV infection were detected. With increase in pathological grade, the positive rate of high-risk HPV also rose. The detection rates of HPV detection to CIN III and invasive cervical carcinoma as well as the total detection rate of lesions were significantly higher than that of TCT. Hence, HPV detection is a better method for screening of cervical cancer at present.