• 한국융합학회논문지
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• 제13권2호
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• pp.349-356
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• 2022

본 연구의 목적은 국민건강보험공단 자료를 이용하여 조현병 진단 후 1년 이내 자살과 관련된 요인을 규명하는 것이다. 연구대상 자료는 맞춤형 데이터베이스에서 2007년부터 2010년 사이에 조현병으로 진단받은 대상자 102,540명으로 통계청 사망자료를 확인한 후 조현병 코호트를 구축하였다. 연구결과 조현병 진단 후 1년 이내 자살 사망자는 615명(0.60%)이고, 1년 이내 자살 위험은 25-34세 집단(adjusted OR, 1.40; 95% CI, 1.06-1.86)과 중하(adjusted OR, 1.86; 95% CI, 1.38-2.50)부터 상위(adjusted OR, 1.89; 95% CI, 1.42-2.51)집단의 경제상태에서 높았다. 남성은 45-54세 집단(adjusted OR, 1.60; 95% CI, 1.05-2.43)과 중하(adjusted OR, 2.66; 95% CI, 1.79-3.95)부터 상위(adjusted OR, 2.18; 95% CI, 1.45-3.28)집단의 경제상태에서 자살 위험이 높았다. 여성은 상위집단(adjusted OR, 1.51; 95% CI 1.01-2.27)에서 자살 위험이 높았다. 따라서 조현병 진단 후 1년 이내 자살 예방을 위한 중재 시 연령과 경제상태를 고려해야 하며, 성별에 따른 자살 관련 요인에 초점을 두어야 할 것이다.

• 한국간호교육학회지
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• 제20권3호
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• pp.372-381
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• 2014

Purpose: This study aims to investigate the effects of a peer gatekeeper training program on existential spiritual well-being, interpersonal relationship with friends, and suicide probability for middle school students. Methods: The participants were fifty students who were at a vocational middle school in D city from october 13, 2012 to november 10, 2012. To test the effects of the peer gatekeeper training program, the participants were divided into two groups in the way of matching distribution, an experimental group(24) and a control group(26). Data were analyzed by Chi-square test, t-test, and Fisher exact probability test using the SPSS/WIN 12.0 program. Results: After attending the peer gatekeeper training program, significant differences between the experimental group and the control group were found in existential spiritual well-being(t=2.80, p=.007) and interpersonal relationship with friends scores(t=2.67, p=.010). However, there was no statistically significant difference in suicide probability between the two groups. Conclusion: The results indicate that the peer gatekeeper training program enhance existential spiritual well-being and interpersonal relationship with friends of middle school students. Therefore, this program could be a good strategy that teachers and community mental health nurses can use for suicide prevention of middle school students.

• 생물정신의학
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• 제25권3호
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• pp.72-78
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• 2018

Objectives The high suicide rate has risen as a main concern in South Korea. Given the complexity of the mechanism resulting in complete suicide, studies targeting various populations are needed for broader understanding of its risk factors. This study aims to analyze the factors affecting the suicidal tendency in the population of the elderly living alone in Seoul depending on basic elderly-care services. Methods A total number of 415 people participated in the study. Home-visit interviews were administered by trained interviewers. Suicidal tendency was measured by the Korean version of mini international neuropsychiatric interview (K-MINI). Health-related quality of life was measured by a brief version of the World Health Organization Quality-of-life Scale (WHOQOL-BREF). Alcohol problem was assessed by the Korean version of the alcohol use disorders identification test (AUDIT-K). Among total subjects of 415 interviewees, the actual responses of 408 people were used for the final analysis. Results The result showed that the suicide risk was high in persons isolated from social support [odds ratio (OR) = 4.49], having depression (OR = 14.85), and having low quality of life (OR = 4.39). Conclusions We found that social support, depression and health-related quality of life are associated with suicidal tendency in the elderly living alone on basic services. Our evidence will contribute to suicide prevention policy for the elderly living alone on care services.

• 대한불안의학회지
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• 제14권2호
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• pp.88-98
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• 2018

Objective : The purpose of this study was to establish a school-based mental health intervention. The success of which was indexed by its effects on the social anxiety symptoms of the enrolled adolescents. Methods : This program for promoting mental health among adolescents in the community was adopted by three middle schools that volunteered to participate in the project. The program included screening for emotional problems related to social anxiety, depression, suicide, and post-traumatic stress disorder. Case management was provided for groups considered high-risk for depression, suicide, or post-traumatic stress disorder; cognitive-behavior therapy was provided for those at high-risk of developing social anxiety. Additionally, educational programs for the prevention of suicide, a "loving life" module, and mental health promotional campaigns were also included. In total, 1,100 middle school students completed self-report questionnaires. Twenty-five students in the high-risk group for social anxiety participated in a cognitive-behavior therapy program, comprising eight sessions, and conducted by two clinical psychologists. Results : Following the suicide prevention education program, suicide awareness among students increased and coping strategies were improved. In addition, the loving life program was associated with positive self-perceptions by many students. Furthermore, social anxiety symptoms showed a statistically significant difference after the cognitive-behavior therapy program. After the therapy, not only did social anxiety symptoms improve, depressive symptoms and suicidal ideation decreased significantly, while self-esteem and psychological resilience significantly increased. Conclusion : A school-based mental health intervention was successfully implemented in three middle schools and improved the mental health of the participating students. Therefore, this intervention could be widely implemented to promote positive mental health among middle school students.

• 정신신체의학
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• 제26권2호
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• pp.127-134
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• 2018

연구목적 본 연구는 일 종합병원 입원 환자를 대상으로 우울, 불안, 디스트레스 등을 비교 분석하여 자살 고위험군을 선별하고, 이들의 임상적 특징을 파악하고자 하였다. 방 법 일 종합병원에 2016년 1월로부터 2017년 12월까지 입원한 전체 환자를 대상으로 하여, 최종 41,249명의 정서상태, 통증, 기저질환 및 기능수준과 관련된 의무기록을 분석하였다. 정서상태 평가를 위해 디스트레스 온도계, 병원 불안-우울 척도를 사용하였다. 자살에 대한 고위험군은 디스트레스 온도계 점수 4점 이상이면서, 병원 불안-우울 척도의 불안, 우울 하위 척도 중 하나라도 8점 이상인 환자로 정의하였다. 결 과 대상자 중 자살에 대한 고위험군 기준에 부합하는 환자는 3,603명(8.7%)였다. 자살 고위험군은 일반군에 비해 더 심한 통증을 경험하고 있었으며, 기저질환을 가진 경우가 더 많은 것으로 나타났다. 통증을 보고한 환자들에서는 디스트레스 온도계 점수, 병원 불안-우울 척도의 불안, 우울 하위 척도 모두에서 통증이 없다고 보고한 환자들에 비해 더 높은 점수를 보였다. 결 론 자살 고위험군은 더 심한 통증과, 더 많은 기저질환을 갖는 것으로 나타났다. 따라서 입원 시 환자의 위험도에 따른 선별 및 선별된 환자들을 대상으로 하는 적극적인 자살 예방 방안이 필요하다.

• 한국심리학회지 : 문화 및 사회문제
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• 제16권2호
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• pp.179-195
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• 2010

기존의 논문들은 미디어의 자살보도와 시·공간적으로 근접한 자살사건 간의 관련성을 보고하고 그 영향에서의 사회학습적 효과를 제안했지만, 구체적인 심리적 과정을 확인하지 못하였다. 본 연구는 미디어의 자살보도가 우리나라 성인들의 지각, 기억, 태도에 영향을 미치고 결국 자살에 대한 태도와 인식을 변화시켜 모방자살을 증가시키게 된다는 사회학습과정에서의 인지적 기제를 확인하고자 진행되었다. 이를 위해 300명의 일반 성인들을 대상으로 자살보도에 대한 지각, 기억, 태도, 그리고 자살보도의 부정적인 영향과 긍정적인 영향에 대한 인식을 측정하고 마지막으로 자살에 대한 태도와 행동을 측정하였다. 분석결과에 따르면 일반인들은 보도내용 중에서 모방자살을 증가시키는 역할을 하는 것으로 알려진 내용들을 더 많이 기억하고 있었으며, 자살보도로 인한 부정적 영향과 국민의 알권리에 대한 이중적인 인식을 가지고 있는 것으로 밝혀졌다. 그리고 자살보도로 인해서 자살자가 얻는 보상에 대한 지각이 모방자살에 대한 긍정적 생각과 태도를 일으키는 것으로 밝혀져 모방자살에서의 사회학습적 기제의 역할을 지지하는 결과를 얻었다. 이러한 결과들을 종합하여 향후 미디어의 자살보도에 대한 심리학적 접근의 방향과 자살보도의 제한에 대한 함의점을 논하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.2121-2127
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• 2012

Objective: Deoxyribonucleoside kinase of Drosophila melanogaster (Dm-dNK) mutants have been reported to exert suicide gene effects in combined gene/chemotherapy of cancer. Here, we aimed to further evaluate the capacity of the mutanted enzyme and its potential for inhibiting cancer cell growth. Methods: We altered the sequence of the last 10 amino acids of Dm-dNK to perform site-directed mutagenesis and constructed active site mutanted Dm-dNK (Dm-dNKmut), RT-PCR and western bloting studies were used to reveal the expression of lentivirus mediated Dm-dNKmut in a breast cancer cell line (Bcap37), a gastric cancer cell line (SGC7901) and a colorectal cancer cell line (CCL187). [3H]-labeled substrates were used for enzyme activity assays, cell cytotoxicity was assessed by MTT assays, cell proliferation using a hemocytometer and apoptosis induction by thenannexin-V-FITC labeled FACS method. In vivo, an animal study was set out in which BALB/C nude mice bearing tumors were treated with lentivirus mediated expression of Dm-dNKmut with the pyrimidine nucleoside analog brivudine (BVDU, (E)-5-(2-bromovinyl)-(2-deoxyuridine). Results: The Dm-dNKmut could be stably expressed in the cancer cell lines and retained its enzymatic activity. Moreover, the cells expressing Dm-dNKmut exhibited increased sensitivity in combination with BVDU, with induction of apoptosis in vitro and in vivo. Conclusion: These findings underlined the importance of BVDU phosphorylated by Dm-dNKmut in transduced cancer cells and the potential role of Dm-dNKmut as a suicide gene, thus providing the basis for future intensive research for cancer therapy.

• 지역사회간호학회지
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• 제32권3호
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• pp.292-302
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• 2021

Purpose: Suicide among adolescents is a serious problem worldwide, and especially, the suicide rate of teenagers is increasing rapidly in South Korea. This study was conducted to investigate the factors affecting the respective suicidal behavior in terms of home-environment characteristics, health behavior characteristics, and psychological health characteristics in Korean adolescents. Methods: The data of the Web-based Survey of the Youth Risk Behavior from 2015 to 2017 collected by the Korea Centers for Disease Control and Prevention (KCDC) was analyzed using multivariable logistic regression analysis. Results: The influential factors by depression and suicidal behavior (suicidal ideation (SI), suicidal plan (SP), and suicidal attempt (SA)) were female(adjusted odds ratios [aOR], 1.45, 1.69, 1.30, 2.19), age (aOR 1.03, 0.98, 0.97, 0.90), no family members (aOR 1.21, 1.36, 2.11, 2.32), living with only the father (aOR 1.05, 1.06, 1.07, 1.11), high economic status (aOR 1.15, 1.22, 1.34, 1.46), residence in relatives' home (aOR 1.6, 1.36, 2.34, 1.97), drinking experience (aOR 1.35, 1.47, 1.57, 1.76), smoking experience (aOR 1.28, 1.30, 1.31, 1.94), hospital treatment experience due to violence (aOR 2.18, 3.33, 6.24, 8.40), bad health status (aOR 1.23, 1.48, 2.00, 2.15), unhappiness (aOR 2.49, 6.14, 6.72, 8.89), and a lot of stress (aOR 6.05, 10.40, 4.86, 5.52). Conclusion: The suicidal behavior risk screening and prevention program for adolescents should be developed considering the subjective happiness and hospital treatment experience status due to violence that affects suicidal behavior.

• 한국학교보건학회지
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• 제32권2호
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• pp.105-115
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• 2019

Purpose: The purpose of this study was to compare the mental health factors related to health risk behaviors between multicultural and monocultural adolescents. Methods: The study subjects were selected from the 2018 Korea Youth Risk Behavior Web-Based Survey Dataset. A total of 60,040 multicultural and monocultural adolescents were included in the analysis. A $x^2$ test and logistic regression were conducted, using SPSS 18.0, to compare the general characteristics, mental health, and health risk behaviors of the multicultural and monocultural adolescents. This process involved a complex sample design. Results: There was a significant difference in the rates of suicidal behaviors. Multicultural adolescents showed a significantly higher rate of suicidal ideation (8.6% vs. 8.5%, p=.004), suicidal plan (3.2% vs. 2.4%, p=.004), and suicidal attempt (5.0% vs 3.1%, p=.04) than monocultural adolescents. Perceived stress had a significant impact only on monocultural adolescents. Monocultural adolescents with high levels of perceived stress were at a greater risk of drinking (high stress=reference; low stress OR=0.91, p=.025) and smoking (high stress=reference; low stress OR=0.90, p=.029) than those with low stress. Multicultural adolescents who had made suicide attempts were at a higher risk of drinking (multicultural OR=7.879, p<.001; monocultural OR=2.481, p<.001) and smoking (multicultural OR=4.011, p=.015; monocultural OR=2.800, p<.001) than monocultural adolescents. Conclusion: To implement an effective smoking and drinking prevention program, it is necessary to consider how we can reduce the risk factors. Stress management is important for monocultural adolescents and a proactive suicide-screening program and a suicide prevention program should be included in the program for both multicultural and monocultural adolescents.

• 대한통합의학회지
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• 제8권4호
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• pp.67-77
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• 2020

Purpose : Recently, Korea has entered an aging society due to the steadily increasing proportion of the elderly population. Additionally, elderly suicidal rate in Korea is the highest among OECD member countries. Because old age is a time when all functions are weakened physically, mentally, and socially, negative experiences, including depression and poor quality of life in the elderly, may lead to suicidal intentions. This study attempts to understand the relationship between depression and quality of life experienced by the elderly and their suicidal intentions. Methods : The survey was conducted from January 2 to March 31, 2019 by administering a questionnaire targeting people aged ≥ 65 years, who were registered at public health centers located in U-city, Gyeonggi-do. In total, 1,015 copies of data were used for the final analysis. The collected data were analyzed using the SPSS/WIN 23.0 program. The χ2 test was performed to investigate the relationship between the demographic characteristics and the suicidal intentions of the elderly subjects. The t-test was performed to determine the relationship between suicidal intentions, depression, and quality of life in elderly subjects. Results : The study results revealed that 168 people (16.6 %) had thought of suicide and 3.2 % had actually tried to commit suicide. The reasons for suicidal thoughts were family problems in 60 (5.6 %), economic problems in 49 (4.6 %), and physical illness in 44 (4.1 %). Those with suicidal intentions had higher levels of depression (t=11.712, p<.001) and higher quality of life scores (t=-9.565, p<.001). Conclusion : Based on these results, it is proposed that a suicide prevention policy and program that can improve the elderly's depression and quality of life is necessary.