• Asian Pacific Journal of Cancer Prevention
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• v.17 no.3
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• pp.1433-1436
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• 2016

Background: Cholangiocarcinoma (CCA), a major problem of health in Thailand, particularly in Northeastern and Northern regions, is generally incurable and rapidly lethal because of presentation in stage 3 or 4. Early diagnosis of stage 1 and 2 could allow better survival. Therefore, this study aimed to provide a distribution map of populations at risk for CCA in BuaYai district of Nakhon Ratchasima province, Northeast Thailand. Materials and Methods: A cross-sectional survey was carried out in 10 sub-districts and 122 villages, during June and November 2015. The populations at risk for CCA were screened using the Korat CCA verbal screening test (KCVST) and then risk areas were displayed by using Google map (GM). Results: A total of 11,435 individuals from a 26,198 population completed the KCVST. The majority had a low score of risk for CCA (1-4 points; 93.3%). High scores with 6, 7 and 8 points accounted for 1.20%, 0.13% and 0.02%. The population at risk was found frequently in sub-district municipalities, followed by sub-district administrative organization and town municipalities, (F=396.220, P-value=0.000). Distribution mapping comprised 11 layers: 1, district; 2, local administrative organization; 3, hospital; 4, KCVST opisthorchiasis; 5, KCVST praziquantel used; 6, KCVST cholelithiasis; 7, KCVST raw fish consumption; 8, KCVST alcohol consumption; 9, KCVST pesticide used; 10, KCVST relative family with CCA; and 11, KCVST naive northeastern people. Geovisual display is now available online. Conclusions: This study indicated that the population at high risk of CCA in Bua Yai district is low, therefore setting a zero model project is possible. Key success factors for disease prevention and control need further study. GM production is suitable for further CCA surveillance and monitoring of the population with a high risk score in this area.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.3
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• pp.1293-1297
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• 2016

Cholangiocarcinoma (CCA) is a serious problem in Thailand, particularly in the northeastern and northern regions. Database of population at risk are need required for monitoring, surveillance, home health care, and home visit. Therefore, this study aimed to develop a geographic information system (GIS) database and Google map of the population at risk of CCA in Mueang Yang district, Nakhon Ratchasima province, northeastern Thailand during June to October 2015. Populations at risk were screened using the Korat CCA verbal screening test (KCVST). Software included Microsoft Excel, ArcGIS, and Google Maps. The secondary data included the point of villages, sub-district boundaries, district boundaries, point of hospital in Mueang Yang district, used for created the spatial databese. The populations at risk for CCA and opisthorchiasis were used to create an arttribute database. Data were tranfered to WGS84 UTM ZONE 48. After the conversion, all of the data were imported into Google Earth using online web pages www.earthpoint.us. Some 222 from a 4,800 population at risk for CCA constituted a high risk group. Geo-visual display available at following www.google.com/maps/d/u/0/edit?mid=zPxtcHv_iDLo.kvPpxl5mAs90&hl=th. Geo-visual display 5 layers including: layer 1, village location and number of the population at risk for CCA; layer 2, sub-district health promotion hospital in Mueang Yang district and number of opisthorchiasis; layer 3, sub-district district and the number of population at risk for CCA; layer 4, district hospital and the number of population at risk for CCA and number of opisthorchiasis; and layer 5, district and the number of population at risk for CCA and number of opisthorchiasis. This GIS database and Google map production process is suitable for further monitoring, surveillance, and home health care for CCA sufferers.

• The Journal of Korean Medicine
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• v.31 no.1
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• pp.81-92
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• 2010

Objectives: The objective of this study was to assess bra in activation and difference by LI11 or ST36 acupuncture stimulation using functional MRI (fMRI). Methods: A total of 10 healthy right-handed volunteers were studied. LI11 acupuncture and ST36 acupuncture stimulations were applied in order on the left. The block design paradigm of RARARA was used for the task, with R representing rest and A representing stimulation, and each period lasted 30 seconds. fMRI data were analyzed using SPM2. Results: The left LI11 acupuncture stimulation activated both sides of the inferior parietal lobule, the left side of the extra-nuclear, culmen and inferior semi-lunar lobules. On the right side, the nodule and midbrain regions were activated by the left LI11 acupuncture stimulation. The left ST36 acupuncture stimulation activated the right side of the superior frontal gyrus, middle frontal gyrus, superior parietal lobule, inferior semi-lunar lobule and pyramis. On the left side, the sub-gyral, middle temporal gyrus, fusiform gyrus, supramarginal gyrus, extra-nuclear, cingulate gyrus and fastigium regions were activated by the left ST36 acupuncture stimulation. Besides, both sides of the paracentral lobule, inferior parietal lobule, culmen, cerebellar tonsil and midbrain regions were activated. Conclusions: In conclusion, brain signal activation patterns according to acupoints were observed to differ, and ST36 acupuncture stimulation activated more regions than LI11. It is supposed that LI11 and ST36 acupuncture stimulations have an influence on motor function and sensory aphasia, and these stimulations thus represent potential for ocular motor dysfunction, discriminative touch or position sense disorder. Moreover, ST36 acupuncture stimulation activated the cingulate gyrus of the limbic system, so it seems to have an influence over autonomic functions.

• Asian-Australasian Journal of Animal Sciences
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• v.31 no.3
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• pp.327-334
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• 2018

Objective: The objective of the present study was to validate genes and genomic regions associated with carcass weight using a low-density single nucleotide polymorphism (SNP) Chip in Hanwoo cattle breed. Methods: Commercial Hanwoo steers (n = 220) were genotyped with 20K GeneSeek genomic profiler BeadChip. After applying the quality control of criteria of a call rate ${\geq}90%$ and minor allele frequency (MAF) ${\geq}0.01$, a total of 15,235 autosomal SNPs were left for genome-wide association (GWA) analysis. The GWA tests were performed using single-locus mixed linear model. Age at slaughter was fitted as fixed effect and sire included as a covariate. The level of genome-wide significance was set at $3.28{\times}10^{-6}$ (0.05/15,235), corresponding to Bonferroni correction for 15,235 multiple independent tests. Results: By employing EMMAX approach which is based on a mixed linear model and accounts for population stratification and relatedness, we identified 17 and 16 loci significantly (p<0.001) associated with carcass weight for the additive and dominant models, respectively. The second most significant (p = 0.000049) SNP (ARS-BFGL-NGS-28234) on bovine chromosome 4 (BTA4) at 21 Mb had an allele substitution effect of 43.45 kg. Some of the identified regions on BTA2, 6, 14, 22, and 24 were previously reported to be associated with quantitative trait loci for carcass weight in several beef cattle breeds. Conclusion: This is the first genome-wide association study using SNP chips on commercial Hanwoo steers, and some of the loci newly identified in this study may help to better DNA markers that determine increased beef production in commercial Hanwoo cattle. Further studies using a larger sample size will allow confirmation of the candidates identified in this study.

• BMB Reports
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• v.43 no.2
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• pp.133-139
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• 2010

We have performed analyses using ancient DNA extracted from 25 excavated human bones, estimating around the 1st century B.C. Ancient human bones were obtained from Nukdo Island, which is located off of the Korean peninsula of East Asia. We made concerted efforts to extract ancient DNA of high quality and to obtain reproducible PCR products, as this was a primary consideration for this extensive kind of undertaking. We performed PCR amplifications for several regions of the mitochondrial DNA, and could determine mitochondrial haplogroups for 21 ancient DNA samples. Genetic information from mitochondrial DNA belonged to super-haplogroup M, haplogroup D or its sub-haplogroups (D4 or D4b), which are distinctively found in East Asians, including Koreans or Japanese. The dendrogram and principal component analysis based on haplogroup frequencies revealed that the Nukdo population was close to those of the East Asians and clearly distinguished from populations shown in the other regions. Considering that Nukdo is geologically isolated in the southern part of the Korean peninsula and is a site of commercial importance with neighboring countries, these results may reflect genetic continuity for the habitation and migration of ethnic groups who had lived in a particular area in the past. Therefore, we suggest that phylogenetic analyses of ancient DNA have significant advantages for clarifying the origins and migrations of ethnic groups, or human races.

• Journal of Environmental Impact Assessment
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• v.26 no.5
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• pp.376-384
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• 2017

Bangladesh is a South Asian country with subtropical monsoonal climate between the intersection of the Indo-Himalayan and Indo-Chinese sub-regions, is known as biodiversity hotspot of the Asian region. The country has different types of forest like deciduous forest, evergreen forest, mixed forest, haor (wetlands) and mangrove forest. The natural beauty of the country is increased with the presence of so many rivers, longest sea beach of the world, green plants, critical hilly regions and green agricultural forest widely spread here and there. Sundarbans is the world largest mangrove forest and world natural heritage site declared by UNESCO in 1999 situated in Bangladesh and India. About 62 percent of this mangrove forest is situated in Bangladesh and there are so many plants and animals are found in this forest. To meet the increasing demand of the large population most of the natural ecosystem is now altered, deforestation rate is increased, natural habitat of the species is disturbed. Due to the imbalance of the climate and natural system many of the rare species of the world found this region is now endangered and some of the species are extinct. Directly or indirectly they are benefited from natural resources. At present time community, based ecotourism is also an important source of income for rural poor peoples. To protect the natural resources the government is now developed so many conservation acts and policy as well NGOs are also doing work for the conservation of ecosystem and biodiversity. At present transboundary pollutants and so many natural disasters also destruct the natural resources of Bangladesh.

• Land and Housing Review
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• v.6 no.2
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• pp.89-99
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• 2015

What is a role of the studies on spatial planning of Korean peninsular and its cities in the process of cooperation between and unification of South and North Korea? Where should the basic perspectives be oriented for the process? Can a comprehensive plan of North Korea have practical implications although South-North cooperation does not get into its stride? If it can, which contents should the plan cover? This study aims to contemplate these issues and to suggest a preliminary land development approach of North Korea, which would contribute academic and practical debates on the issues, at this juncture of the cascade of studies on spatial planning in North Korea. It assume South-North relation would evolve from 'reconciliation and cooperation' and 'confederation' into 'unification' of South and North Korea which is based on the official plan of South Korea. We suggest, as the basic perspectives of development approach, cooperation(or co-evolution), future-oriented sustainability, and parallel development of industry and physical infrastructure. The development potential of North Korea is explained by detail fields and sub-regions, which is used to analyse SWOT and to subsequently extract the basic directions(vision and strategies) of North Korea development. These directions are followed by the spatial structure plan to improve North Korea using the potential of the regions. Based on the plan, the development directions of detail fields are suggested.

• Journal of the Korean earth science society
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• v.28 no.7
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• pp.878-890
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• 2007

This study aimed to provide a fundamental basis for the development and promotion of a Korea windchill temperature index model in the field of human biometeorology. For this, a sensitivity model currently being used by KMA (Korea Meteorological Administration) was analyzed. The results of the analysis showed that the Korean peninsula could be divided into the urban area, the coastal/island area, the inland area, and the mountain area. The average temperature was highest in the coastal/island area, while it was lowest in the mountain regions. The lowest temperature in the urban and coastal/island areas was 20 degrees below zero and that in the inland and mountain regions were 30 degrees below zero. As for wind speed, both average and maximum wind speed were highest in the coastal/island area. The distribution of temperature and wind speed in winter was similar to that of the entire period. The results of the JAG/Tl and Missenard model sensitivity showed that temperature tends to have more influence on sensitivity than any other factors. In sub-zero temperature, however, the influence of wind speed tends to increase.

• Korean Journal of Agricultural and Forest Meteorology
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• v.19 no.2
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• pp.62-72
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• 2017

Spatio-temporal projection of evapotranspiration over croplands would be useful for assessment of climate change impact and development of adaptation strategies in agriculture. Potential evapotranspiration (PET) and dryness index (DI) during rice growing seasons were calculated using climate change scenario data provided by the National Institute of Meteorological Research (NIMR). A data processing tool for gridded climate data files, readGrADSWrapper, was used to calculate PET and DI during the current (1986-2005) and future (2006-2100) periods. Scripts were written to implement the formulas of PET and DI in R, which is an open source statistical data analysis tool. Evapotranspiration in rice fields ($PET_{Rice}$) was also determined using R scripts. The Spatio-temporal patterns of PET differed by regions in Korean Peninsula under current and future climate conditions. Overall, PET and $PET_{Rice}$ tended to increase throughout the $21^{st}$ century. Those results suggested that region-specific water resource managements would be needed to minimize the risk of water loss in the regions where considerable increases in PET would occur under the future climate conditions. For example, a number of provinces classified as a humid region were projected to become a sub-humid region in the future. The Spatio-temporal assessment of water resources based on PET and DI would help the development of climate change adaptation strategies for rice production in the 21st century. In addition, the studies on climate change impact would be facilitated using specialized data tools, e.g., readGrADSWrapper, for geospatial analysis of climate data.

• The Journal of Industrial Distribution & Business
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• v.10 no.8
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• pp.55-65
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• 2019

Purpose - Recently, the fourth industrial revolution is rapidly progressing, and the central government-led innovation system is not able to flexibly cope with changes in science and the economy and society. To solve these problems, it is necessary for local governments, which can easily identify and flexibly respond to local sites, to become self-centered and ready to respond more quickly to massive changes. Through this research, this study investigated the awareness of the elements of Jeonnam Province's capabilities in the field of science and technology policy, the importance of R&D, and how network cooperation among the base institutions might affect performance. Research design, data, and methodology - In fact, the data used in this study only 115 people were polled, excluding five who did not respond to the necessary variables. The methods of the survey were sampled, and the means of the survey were investigated via a self-contained electronic file (e-mail). Statistical analysis, including hypothesis verification, was performed by SPSS 19. The regression analysis was used. Results - All factors significantly affect performance by dividing them into five sub-fields: R&D strategic establishment, R&D demand survey, R&D planning, R&D evaluation, and R&D project management. These results suggest the importance and need for local scientific technology policy capabilities. Besides, it was confirmed that the relationship between regional science and technology policy capabilities and performance was moderated by the recognition of the importance of science technology and network cooperation among the core organizations. Conclusions - As a result, independent variables regarding the capabilities of each scientific technology policy were found to be statistically significant and have a significant effect on performance. Second, the regression analysis has shown the moderation effects of R&D importance awareness between the capabilities of science and technology policies and their performance. On the other hand, a regression analysis showing that the capabilities of science and technology policies and network cooperation between the base regions were not significant, indicating that there is no effect of moderation of network cooperation between the base regions between the capabilities of science and technology policies and performance.