• Journal of Periodontal and Implant Science
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• 제50권1호
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• pp.56-66
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• 2020

Purpose: A stability-measuring device that utilizes damping capacity analysis (DCA) has recently been introduced in the field of dental implantology. This study aimed to evaluate the sensitivity and reliability of this device by measuring the implant stability of ex vivo samples in comparison with a resonance frequency analysis (RFA) device. Methods: Six implant beds were prepared in porcine ribs using 3 different drilling protocols to simulate various implant stability conditions. Thirty-six pork ribs and 216 bone-level implants measuring 10 mm in height were used. The implant beds were prepared using 1 of the following 3 drilling protocols: 10-mm drilling depth with a 3.5-mm-diameter twist drill, 5-mm drilling depth with a 4.0-mm-diameter twist drill, and 10-mm drilling depth with a 4.0-mm-diameter twist drill. The first 108 implants were external-connection implants 4.0 mm in diameter, while the other 108 implants were internal-connection implants 4.3 mm in diameter. The peak insertion torque (PIT) during implant placement, the stability values obtained with DCA and RFA devices after implant placement, and the peak removal torque (PRT) during implant removal were measured. Results: The intraclass correlation coefficients (ICCs) of the implant stability quotient (ISQ) results obtained using the RFA device at the medial, distal, ventral, and dorsal points were 0.997, 0.994, 0.994, and 0.998, respectively. The ICCs of the implant stability test (IST) results obtained using the DCA device at the corresponding locations were 0.972, 0.975, 0.974, and 0.976, respectively. Logarithmic relationships between PIT and IST, PIT and ISQ, PRT and IST, and PRT and ISQ were observed. The mean absolute difference between the ISQ and IST values on a Bland-Altman plot was -6.76 (-25.05 to 11.53, P<0.05). Conclusions: Within the limits of ex vivo studies, measurements made using the RFA and DCA devices were found to be correlated under a variety of stability conditions.

• 농촌의학ㆍ지역보건
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• 제25권1호
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• pp.65-83
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• 2000

본 연구는 일부 전라북도 지역에 거주하는 노인을 대상으로 1999년 6월에서 12월까지 ADL, IADL의 정도와 이에 영향을 줄 수 있는 일반적 특성과의 관련성을 알아보고자 시도되었다. 조사대상 노인은 전체 281명이었고 이중 여자가 195명(69.6%)이었고 남자가 85명(30.4%)이었다. 남성과 여성의 평균연령은 70.8세와 71.9세 이었다. 질병유무에 있어서는 있다가 81.1%이었고 없다가 18.9%이었다. 질병의 유병률에 있어서는 운동 골관절질환은 50.1%, 기타가 15.0%, 순환기 질환이 10.5%, 소화기 질환이 9.4%, 치과질환이 8.5%, 호흡기 질환이 6.3%이었다. 최근에 이용한 의료기관에서는 병의원이 40.0%, 한방병의원이 16.8%, 보건소가 14.5% 약국이 10.9%, 기타가 10.0%, 치과의원이 7.8%이었다. 증상의 호전여부에 대해서는 보통이다가 62.3%, 호전되었다가 19.4%, 호전되지 않았다가 18.2%이었다. 건강상태에 있어서는 나쁘다가 37.1%, 좋다가 35.7%, 보통이다가 27.1%이었다. 일상생활동작능력(ADL)은 6점이 67.1%, 5점이 27.9%, 4점이 2.1%이었고 여성의 ADL이 남성보다 낮은 경향이 있었다. 수단적 일상생활동작능력(IADL)은 5점이 50.4%, 3점이 19.3% 4점이 12.1%이었고 여성의 IADL이 남성보다 낮은 경향이 있었다. 일상생활동작능력(ADL)에 있어 장해빈도가 높은 순으로 보면 실금 28.9%, 목욕 6.1%, 식사 2.9%, 집안 걸어다니기 2.5%, 화장실 1.8%, 옷 갈아입기 1.4%이었고 6항목 모두 남성보다 여성의 장해빈도가 높았다. 일상생활동작능력에서 고 ADL 67.1%, 중 ADL 32.5%, 저 ADL 0.4%로 연령의 증가에 따라 고 ADL은 감소하는 경향이 있었고 중 IADL은 증가하는 경향이 있었다. 수단적 일상생활동작능력(IADL)에 있어 장해빈도가 높은 순으로 보면 현금출납 42.9%, 청구서 지불(납부) 31.8%, 시장보기 21.1%, 식사준비 16.4%, 버스이용 11.8%이었다. 식사준비를 제외한 모든 항목에서 여성이 남성보다 IADL에 있어 장해빈도가 높았다. 수단적 일상생활동작능력에서 고 IADL 50.4%, 중 IADL 42.5%, 저 IADL 7.1%로 연령증가에 따라 고 IADL은 감소하는 경향이었고 중 IADL은 증가하는 경향이 있었다. 일반적 특성에 따른 ADL의 평균은 5.56이었고 학력과 건강상태가 통계학적으로 유의한 변수이었다. 일반적 특성에 따른 IADL의 평균은 3.76이었고 연령, 성별, 학력, 직업, 배우자 유무, 동거가족, 생활비 부담, 건강상태, ADL 분류가 통계학적으로 유의성있는 변수이었다. 단계적 중회귀분석결과 일상생활동작지수(ADL)와 종교, 건강상태 그리고 수단적 일상생활동작지수(IADL)와 교육수준, 동거가족, 생활비, 건강상태가 통계학적으로 관련성이 있는 설명변수이었다.

• 생명과학회지
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• 제33권2호
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• pp.138-148
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• 2023

본 연구는 Peucedanum insolens Kitagawa의 잎과 뿌리에서 추출한 용매 분획물들의 항산화 활성을 비교 분석하기 위해 수행되었다. 본 연구를 위해 P. insolens Kitagawa의 건조된 잎과 뿌리를 각각 70% 에탄올로 먼저 추출한 후 hexane, chloroform, ethyl acetate, n-butanol, 물의 순서로 분획하였다. 실험 결과 유기용매 분획별 총 폴리페놀 함량은 P. insolens Kitagawa의 잎과 뿌리 모두에서 동일한 분포 양상을 보였다. 유기용매 분획 중 총 폴리페놀 함량은 에틸아세테이트 분획(101.1±1.0 ㎍ vs 128.8±15.6 ㎍ GAE/mg)에서 가장 높게 나타났으며, 헥산 분획에서 가장 낮은 함량(9.51±0.2 ㎍ vs 6.8±0.8 ㎍ GAE/mg)을 보였다. P. insolens Kitagawa의 잎과 뿌리 모두에서 유기용매 분획에 의한 총 플라보노이드 함량 분포는 총 폴리페놀 함량과 동일한 양상을 보였다. P. insolens Kitagawa 잎과 뿌리의 유기용매 추출물을 DPPH, ABTS, FRAP assay를 통해 활성산소 소거 활성을 측정한 결과, 잎과 뿌리 추출물에서도 동일한 패턴으로 활성산소 소거 활성을 보였으며, 유기용매 분획 중 에틸아세테이트 분획이 가장 높은 자유 라디칼 소거 활성을 보였다. P. insolens Kitagawa의 잎과 뿌리의 유기용매 분획물에서 총 페놀 함량과 자유 라디칼 소거 활성 사이에 유의한 상관 관계(R=0.903, p<0.0001, DPPH 라디칼, R=0.891, p<0.001, ABTS 라디칼, R=0.745, p<0.05, FRAP 라디칼)와 P. insolens Kitagawa의 잎 또는 뿌리의 용매 분획물에서 DPPH, ABTS 및 FRAP assay들 사이에서도 중요한 상관관계(R=0.867, p<0.001, DPPH vs ABTS 라디칼, R=0.882, p<0.0001, DPPH vs FRAP 라디칼, R=0.973, p<0.0001, ABTS vs FRAP 라디칼)가 있음이 확인되었다. 본 연구 결과에서 얻은 결론은 왕산방풍 식물의 뿌리에서와 마찬가지로 왕산방풍의 잎에서도 강한 항산화 활성을 가지고 있으며, 잎을 주요 항산화 물질의 소재로 사용할 수 있다.

• 생명과학회지
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• 제19권5호
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• pp.671-675
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• 2009

Prostate cancer has been a critical health problem due to an increase of prostate cancer-related deaths worldwide. Also, a frequent treatment option for prostate cancer is androgen ablation, but this treatment has a limited scope, especially for hormone-refractory cancer. There is an urgent need for the identification of alternative therapeutic strategies for prostate cancer. Previously, over one hundred species of dried-plant methanol extracts were tested for inhibitory effects on proliferation. One of them, Piper longum Linn. was selected based on its potent anti-proliferation effect. The dried root of P. longum Linn. was extracted with 100% methanol for 2-3 days and its extract was fractionated using chloroform. The chloroform layer was then subjected to column chromatography on silica gel, reverse phase-18 (RP-18) and Sephadex LH-20, in turn. Finally, the pure compound was obtained and identified as pipernonaline by NMR spectroscopic and physico-chemical analysis. In this study, anti-proliferation and cell cycle arrest effects of pipernonaline on human prostate cancer PC-3 cells were investigated using the MTT and PI staining, respectively. Our findings suggest that pipernonaline represents a dose-dependent growth inhibition pattern on PC-3 cells and, moreover, its growth inhibition is associated with sub-G1 and G0/G1 cell cycle accumulation in PC-3 cells. Also, these results provide an anticancer candidate for human prostate cancer.

• 한국환경과학회지
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• 제24권1호
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• pp.81-96
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• 2015

The characteristics of atmospheric dispersion of radioactive material (i.e. $^{137}Cs$) related to local wind patterns around the Kori nuclear power plant (KNPP) were studied using WRF/HYSPLIT model. The cluster analysis using observed winds from 28 weather stations during a year (2012) was performed in order to obtain representative local wind patterns. The cluster analysis identified eight local wind patterns (P1, P2, P3, P4-1, P4-2, P4-3, P4-4, P4-5) over the KNPP region. P1, P2 and P3 accounted for 14.5%, 27.0% and 14.5%, respectively. Both P1 and P2 are related to westerly/northwesterly synoptic flows in winter and P3 includes the Changma or typhoons days. The simulations of P1, P2 and P3 with high wind velocities and constant wind directions show that $^{137}Cs$ emitted from the KNPP during 0900~1400 LST (Local Standard Time) are dispersed to the east sea, southeast sea and southwestern inland, respectively. On the other hands, 5 sub-category of P4 have various local wind distributions under weak synoptic forcing and accounted for less than 10% of all. While the simulated $^{137}Cs$ for P4-2 is dispersed to southwest inland due to northeasterly flows, $^{137}Cs$ dispersed northward for the other patterns. The simulated average 137Cs concentrations of each local wind pattern are $564.1{\sim}1076.3Bqm^{-3}$. The highest average concentration appeared P4-4 due to dispersion in a narrow zone and weak wind environment. On the other hands, the lowest average concentration appeared P1 and P2 due to rapid dispersion to the sea. The simulated $^{137}Cs$ concentrations and dispersion locations of each local wind pattern are different according to the local wind conditions.

• Journal of Yeungnam Medical Science
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• 제33권1호
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• pp.13-20
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• 2016

Background: Prevalence of adenoma in males aged 40-49 years in Korea was higher than expected. The aim of this study was to investigate the prevalence and risk factors of colorectal adenoma in males aged 40-49 years. Methods: Total 1,902 asymptomatic subjects with a mean age of $47.9{\pm}6.7years$, who underwent a screening colonoscopy in a health promotion center of Myongji Hospital from 2010 to 2013 were enrolled in this study. We conducted a case-control study to determine the risk factors for adenoma. The subjects were classified into two groups (adenoma vs. controls). To validate the diagnostic value of carcinoembryonic antigen (CEA) for adenoma, area under the receiver operating characteristic curve (AUROC) was calculated. Results: At least one colorectal adenoma was identified in 385 subjects (20.2%). Among these 385 subjects, 372 subjects were found to have a non-advanced adenoma, 13 subjects had an invasive adenoma. One subject had cancer. Male sex, age, smoking, metabolic syndrome, and elevated CEA level were significantly associated with a colorectal adenoma in univariate analysis. However, metabolic syndrome was not significant in multivariate analysis. In the male group, the AUROC of CEA for colorectal adenoma was 0.600 (0.543 to 0.656) in non-smokers under 50 years of age, and 0.615 (0.540 to 0.690) in smokers under 50 years of age. Conclusion: Male sex, smoking, and high levels of CEA seem to be associated with colorectal adenoma. High levels of CEA and smoking may be diagnostic markers for any colorectal adenoma in Korean males aged 40-49 years.

• Journal of Microbiology and Biotechnology
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• 제25권12호
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• pp.2146-2152
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• 2015

Apios americana Medik (hereinafter Apios) has been reported to treat diseases, including cancer, hypertension, obesity, and diabetes. The therapeutic effect of Apios is likely to be associated with its anti-inflammatory activity. This study was conducted to evaluate the protective effects of Apios in animal models of acute lung injury induced by lipopolysaccharide (LPS) or pandemic H1N1 2009 influenza A virus (H1N1). Mice were exposed to LPS or H1N1 for 2-4 days to induce acute lung injury. The treatment groups were administered Apios extracts via oral injection for 8 weeks before LPS treatment or H1N1 infection. To investigate the effects of Apios, we assessed the mice for in vivo effects of Apios on immune cell infiltration and the level of pro-inflammatory cytokines in the bronchoalveolar lavage (BAL) fluid, and histopathological changes in the lung. After induction of acute lung injury, the numbers of neutrophils and total cells were lower in the Apios-treated groups than in the non-Apios-treated LPS and H1N1 groups. The Apios groups tended to have lower levels of tumor necrosis factor-a and interleukin-6 in BAL fluid. In addition, the histopathological changes in the lungs were markedly reduced in the Apios-treated groups. These data suggest that Apios treatment reduces LPS- and H1N1-induced lung inflammation. These protective effects of Apios suggest that it may have therapeutic potential in acute lung injury.

• 대한간호학회지
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• 제21권1호
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• pp.89-116
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• 1991

The purpose of this study was to describe mother -infant interacting behavior patterns related to newborn infant feeding and to explore the mother's cultural belief about their infant. The data collection was conducted by observation and interview. Twenty-five mothers and their newborn infants who were normally delivered and were also planned to breast feed were comprised as the subjects of this study. All subjects were interviewed and observed individuaily at 1 to 5 days after the delivery at the hospital, mid -wife's clinic, Maternal Child Health Center and their home throughout the country from remote area to big city, The observation data were recorded with symbolic letter on a recording sheet newly developed as a result of preliminary study. The interview data were taperecorded and then recorded in narrative form. Mother - infant interaction behaviors in early feeding period were analyzed based on 19 analytic sub-categories and their composing elements. Unit of analysis were mother, infant and mother -infant dyad. 8 analytic categories draw from the data. Each were preparation, instrument, interaction inducing, evaluation referred to mother's behavior, preparation, instrument, interaction inducing referred to infant's behavior and synchronic behaviors referred to mother - infant dyad. Frequencies of behavior items based on the categories were converted to percent. The result showed that in mother's preparation behavior, the breast condition of Korean mother can be an affecting factor for mother - infant interaction during feeding, and vocalization behavior was observed most frequently in interaction inducing behavior while the least frequent behavior observed was contacting. Subcultural characteristics of mother - infant interaction behaviors were analyzed for their relationships between groups of mothers who have lived in remote area vs urban area, and who were multipara vs primipara. Using a chi -square test, there were statistically significant relationships in the activity of psychological readiness in preparation behavior and the movement of extremities for the position of instrumental behavior in both groups. However, interaction inducing behaviors were not related with statistical significance in any set of groups. Accomplishment of marriage, bonding and emotional mediation of family members were the categories related to mother's cultural belief about the infant in aspect of functional values. Infant at birth is considered little more than a biological organism without social capabilities. Although the newborn infant is still be attached to his mother, he makes his mother extend her territoriality. The mother's interacting behavior toward her infant based on those beliefs appeared task oriented, separative behavioral series. On the other hand, it was seen that infant reacted independently to his mother's behavior by the in-nate perceptual abilities. Those independent behavioral series of mother and infant on the feeding situation were synchronized at any moment. Nurses are In a unique position to teach mothers about their infant's capabilities and help reducing some of uncertainty about infant's behaviors. Study results indicated that the informations infant's social capabilities and breast feeding should be given to the mothers. The results of this study have several implications for nursing. First, the study results will be used as fundamental resources for the development of the assessment tool about the early mother - infant interaction. Second, the results could be a relevant information in the fied. I of maternal child nursing education as real and useful data. Third, the behavioral patterns of early mother - infant interaction which were classified based on the qualitative analysis could be used for nursing theory development as very fundamental data.

• 한국산학기술학회논문지
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• 제21권10호
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• pp.222-230
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• 2020

본 연구는 보육교사의 회복탄력성과 관련하여 지난 10여년 간 국내에서 연구된 석·박사 학위논문과 학술지 논문을 중심으로 관련요인들의 효과크기를 메타분석을 통해 검증하였다. 검증결과는 다음과 같다. 첫째, 보호요인의 전체효과크기는 큰효과크기를 보였고, 보호요인군 별 효과크기는 모두 큰 효과크기로 개인특성요인군이 가장 큰 것으로 나타났고 그다음 직무특성요인군, 조직특성요인군 순이었다. 둘째, 보호요인군 중 개인특성요인군의 하부요인의 효과크기는 모두 큰효과크기를 보였고, 조직특성요인군과 직무특성요인군은 중간효과크기를 보인 원장리더십과 정서노동을 제외한 모든 하부요인이 큰효과크기를 보였다. 셋째, 위험요인 전체효과크기는 큰효과크기를 보였고, 직무특성 위험요인군인 소진은 큰효과크기, 직무특성 위험요인군인 직무스트레스는 중간효과 크기로 소진이 상대적으로 직무스트레스보다 더 큰 효과크기를 보였다. 결론적으로 본 연구는 지난 20년간의 보육교사의 회복탄력성과 관련하여 선행된 연구들을 통합적으로 정리하여 객관적 결과를 살피기 위한 수량적 통합을 시도했다는데 의의가 있으며, 보육교사의 회복탄력성 증진을 위한 프로그램 개발과 정책수립에 기초적 자료를 제공하였다는데 의의가 있다.

• 대한한의학방제학회지
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• 제16권2호
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• pp.133-144
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• 2008

Recently, people are becoming fatter in most parts of the world. Obesity is regarded as an important risk factor to adversely affect the health of humans, associated with hypertension, hyperlipidemia, diabetes, and cardiovascular diseases. In the present study, therefore, we tested the short time efficiency and safety of Bangpoongtongsungsan as a drug to decrease body weight in subjects with obesity. A total 48 volunteers (24 man, 24 woman) with body mass index (BMI : weight in kg divided by square of height in meters) of $23㎏/m^2$ participated in clinical study for 12 weeks, from 2008, March 01 to 2008, Jun 30. The subjects was received a dietary supplement of 12 pieces hard capsules per day (4 pieces in one, 3 times in a day) during the clinical study. At the end of clinical study, body weight of subjects was significantly decreased from $72.21{\pm}11.44\;kg$ to $70.53{\pm}11.67\;kg$ (p<0.05). Waist circumferences of subjects were reduced $91.58{\pm}6.43\;cm$ to $85.25{\pm}7.70\;cm$ (p<0.05). Also, a BMI of subjects was significantly decreased $26.07{\pm}2.35\;kg/m^2$ to $25.63{\pm}2.63\;kg/m^2$ (p<0.05). Particularly, a decrease in body weight, waist circumferences, and BMI was more significant in woman than man. But, other biochemical levels including lipid and glucose in plasma had no changes at the end of clinical study. In conclusion, administration of Bangpoongtongsungsan in subjects with high body weight fat could inhibit obesity associated with a decrease in body weight, waist circumferences, and BMI.