• Journal of Microbiology and Biotechnology
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• v.24 no.12
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• pp.1654-1663
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• 2014

To examine the effect of tumor suppressor protein p53 on the antitumor activity of 2-methoxyestradiol (2-MeO-$E_2$), 2-MeO-$E_2$-induced cell cycle changes and apoptotic events were compared between the human colon carcinoma cell lines HCT116 ($p53^{+/+}$) and HCT116 ($p53^{-/-}$). When both cell types were exposed to 2-MeO-$E_2$, a reduction in the cell viability and an enhancement in the proportions of $G_2/M$ cells and apoptotic sub-$G_1$ cells commonly occurred dose-dependently. These 2-MeO-$E_2$-induced cellular changes, except for $G_2/M$ arrest, appeared to be more apparent in the presence of p53. Immunofluorescence microscopic analysis using anti-${\alpha}$-tubulin and anti-lamin B2 antibodies revealed that after 2-MeO-$E_2$ treatment, impaired mitotic spindle network and prometaphase arrest occurred similarly in both cell types. Following 2-MeO-$E_2$ treatment, only HCT116 ($p53^{+/+}$) cells exhibited an enhancement in the levels of p53, p-p53 (Ser-15), $p21^{WAF1/CIP1}$, and Bax; however, the Bak level remained relatively constant in both cell types, and the Bcl-2 level decreased only in HCT116 ($p53^{+/+}$) cells. Additionally, mitochondrial apoptotic events, including the activation of Bak and Bax, loss of ${\Delta}{\psi}m$, activation of caspase-9 and -3, and cleavage of lamin A/C, were more dominantly induced in the presence of p53. The Bak-specific and Bax-specific siRNA approaches confirmed the necessity of both Bak and Bax activations for the 2-MeO-$E_2$-induced apoptosis in HCT116 cells. These results show that among 2-MeO-$E_2$-induced apoptotic events, including prometaphase arrest, up-regulation of Bax level, down-regulation of Bcl-2 level, activation of both Bak and Bax, and mitochondria-dependent caspase activation, the modulation of Bax and Bcl-2 levels is the target of the pro-apoptotic action of p53.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.36 no.5
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• pp.927-936
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• 2016

This research aims to analyze the effect of different types of urban parks and their locational characteristics on the apartment price in the entire metropolitan area of Busan, Korea. Although an urban park is an environmental good that influences the surroundings in many ways, most of the previous studies have underestimated its impact on the value of the surrounding area. This research focuses on the economic value of urban parks by understanding their relationship with the value of the apartments in the surrounding area with its significance in their physical and objective characteristics. Furthermore, the research emphasizes the different typological characteristics of urban parks in the analysis. In summary of the result, the number of levels (stories) and units of the apartment complex, ranking of the contractor, age of a park and accessibility to sub-central are positively related to the price of apartment units. On the other hand, the total area of apartment complex, the age of apartments, the distance to the nearest park and accessibility to civic-central or regional district are negatively related to the price of apartment units. Having a plan for constructing a park is also positively related to the price. For the typological characters of a park, neighborhood park, small-sized park, and sports park are positively related to the price, while children's park is negatively related to the price of apartment units. Considering that the price increases as the distance to the nearest park decreases, people prefer to live near the benefits that urban parks provide. In order to maximize the value and benefits that parks provide, it is necessary to approach them creatively.

• International Commerce and Information Review
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• v.15 no.2
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• pp.129-162
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• 2013

The purpose of this work is to explore the role of international entrepreneurship(IE) in explaining internationalization process of Korean ventures and to structure the model of IE with the logics of effectuation. The internationalization of entrepreneurial company is regarded as the realization of entrepreneurship which find out and use opportunities across borders in this point of view, and the realization process gets more realistic and applicable to the internationalization of ventures by effectuation. So we constructed the new concepts of the generating-internationalization-outcome capability(GIOC), which is the effectual capability allowing ventures to go international despite their lack of internal resources and experiences. Its sub-capabilities of GIOC are extemporaneous coping capability, perform-resource-in-hand capability and network-use capability. The empirical analyses of the relations among the capabilities and the performances of internationalization are performed in order to prove the rationale of the model, which provides finally significant evidences of the relationships. The key contribution of this study is that it highlights the important role of IE in internationalization of ventures and shows the possible role of effectuation in explaining the realization process of IE.

• Journal of the Korea Society of Computer and Information
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• v.17 no.1
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• pp.31-40
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• 2012

u-GIS DSMSs have been researched to deal with various sensor data from GeoSensors in ubiquitous environment. Also, they has been more important for high availability. The data from GeoSensors have some characteristics that increase explosively. This characteristic could lead memory overflow and data loss. To solve the problem, various load shedding methods have been researched. Traditional methods drop the overloaded tuples according to a particular criteria in a single server. Tuple deletion sensitive queries such as aggregation is hard to satisfy accuracy. In this paper a dual processing load shedding method is suggested to improve the accuracy of aggregation in clustering environment. In this method two nodes use replicated stream data for high availability. They process a stream in two nodes by using a characteristic they share stream data. Stream data are synchronized between them with a window as a unit. Then, processed results are merged. We gain improved query accuracy without data loss.

• Acta Via Serica
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• v.1 no.1
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• pp.95-104
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• 2016

The Silk Route in ancient times served as a link between the World's greatest civilizations and as a source of knowledge, art, religion and philosophy. This network of ancient caravan paths formed the first bridge between East and West, where two different civilizations came in contact with their respective cultural traditions and religious beliefs, as well as their scientific and technological achievements. One of the main routes of the Great Silk Route passed through the Karakoram, linking Kashgar with Kashmir and the Gandhara regions. The Karakoram Highway connects the Chinese province with Pakistan and follows the ancient Silk Route, which connected the Heartlands of Asia with the Western fringes and further beyond the entire continent of Europe. Evidences of the history of humankind, ranging from Pre-historic times to the spread of Buddhism from South Asia to China and the Far East, is depicted in the rocky cliffs on the waysides and on rough boulders scattered in the upper valley of the Indus River and its tributaries. The ancient trade routes also carried scholars, teachers, missionaries and monks of different beliefs and practices, who met and exchanged ideas. The Buddhists as well as Zoroastrians and other missionaries all followed the Silk Route, leaving permanent footprints of their passage. The ancient greater Gandhara is situated in the North-West of the Indian Sub-continent, with the steep mountain ranges of the Karakoram, the Pamir and the Hindu-Kush bordering it and the dry areas of Central Asia to its rear. A number of races from Central Asia migrated to Gandhara because of its mild climate and plentiful farm products and fruits. This area was an entry point of Western Culture into India and at the same times the exit point of Indian Culture, including Buddhism, to the West. In Gandhara, the diffusion of different cultures developed an art form, during the 1-7th centuries CE commonly known after its geographic name as "Gandhara Art". The Buddhism's route of introduction into China originated in Gandhara, then reached in Korea and Japan and other countries. The fame of Gandhara however, rested on its capital, "Taxila" which was a great centre of learning. From the time of the Achaemenians, down through Muslim period, Gandhara continued to establish and maintain a link between East & West, as shown by material evidences recovered from Taxila and other Buddhist centres of Gandhara during the course of archaeological excavations.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.26 no.12C
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• pp.280-291
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• 2001

LL (Leased Line service) is a facility-based service as a traditional business data service, but new competition services, such as FR (Frame Relay), VPN (Virtual Private Network), and ATM (Asynchronous Transfer Mode), are value-added services. Because of different service classifications, it is hard to gather necessary data for the service providers to plan their market strategies and regulations and policies are also applied asymmetrically to each service provider. Therefore an appropriate market classification is required for the business data services. After various methods of market classification are reviewed, the Hendry model is selected in this paper to analyze substitution-degree among brands or among services. Since the structure of virtual competitions is required for the Hendry model to be applied to data service market, the market is analyzed first by the well-known Porter's model. By the analysis of Porter's model, two virtual competition structures are set up - one is for the competitions among leased line service providers, and the other is for the competitions among business data services such as LL, FR, VPN and ATM. After the Hendry model is applied to each competition structure, it is confirmed that 7 LL service providers do not compete directly, but 2 sub-markets exist for the LL service provisions. However, it is shown that 4 business data services compete directly. Using the Switching Probability Matrix from Hendry model, future market shares of LL service providers and market shares of business data services are forecasted. These empirical results are helpful for service providers to set competitive strategies with the minimization of cannibalization effect and they can easily and efficiently predict their market demands.

• Journal of Korean Society of Forest Science
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• v.109 no.1
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• pp.81-98
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• 2020

In this study, forest-related research papers published in North Korean journals were analyzed to understand the research trends in North Korean forest science. The Korea Science and Technology Information Institute (KISTI) North Korea Science and Technology Network (NKtech) is constructing a database related to science and technology in North Korea. From this, a total of 1,389 articles published from 1962 to 2016 were collected with forest science key words based on the South Korean National Science and Technology Standard Classification System. The topics were divided into four categories: afforestation, forest protection, forest use, and forest management. In the field of afforestation, research activities on nursery and agroforestry were active, and the survival rate was emphasized. In the forest protection field, there was a significant research effort into forest pests, and efforts were being made to reduce soil erosion through agroforestry. In the field of forest use, research activities on pulp/paper and mushrooms were active. In the forest management field, activities related to "ecological information" were conspicuous, and efforts were being made to reduce carbon. These results suggest that the perspective of North Korean forest research has changed from nature reorganization to nature protection. Thus, a comparative study on forest science and technology in each sub-sector of the forest research field, along with analysis of the relationship between policy direction and research direction of North Korea over time, would be worthwhile future investigations. To overcome the problem of technical terminology, a compilation/dictionary of inter-Korean forestry terminology would be useful for effective communication between the two Koreas.

• Journal of Korea Spatial Information System Society
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• v.11 no.3
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• pp.9-18
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• 2009

Recently, due to the advanced technologies of mobile devices and wireless communication, there are many studies on telematics and LBS(location-based service) applications. because moving objects usually move on spatial networks, their locations are updated frequently, leading to the degradation of retrieval performance. To manage the frequent updates of moving objects' locations in an efficient way, a new distributed grid scheme, called DS-GRID (distributed S-GRID), and k-NN(k-nearest neighbor) query processing algorithm was proposed[1]. However, the result of k-NN query processing technique may be invalidated as the location of query and moving objects are changed. Therefore, it is necessary to study on continuous k-NN query processing algorithm. In this paper, we propose both MCE-CKNN and MBP(Monitoring in Border Point)-CKNN algorithmss are S-GRID. The MCE-CKNN algorithm splits a query route into sub-routes based on cell and seproves retrieval performance by processing query in parallel way by. In addition, the MBP-CKNN algorithm stores POIs from the border points of each grid cells and seproves retrieval performance by decreasing the number of accesses to the adjacent cells. Finally, it is shown from the performance analysis that our CKNN algorithms achieves 15-53% better retrieval performance than the Kolahdouzan's algorithm.

• Journal of The Korean Astronomical Society
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• v.50 no.6
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• pp.167-178
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• 2017

We present a study of the inexplicit connection between radio jet activity and ${\gamma}$-ray emission of BL Lacertae (BL Lac; 2200+420). We analyze the long-term millimeter activity of BL Lac via interferometric observations with the Korean VLBI Network (KVN) obtained at 22, 43, 86, and 129 GHz simultaneously over three years (from January 2013 to March 2016); during this time, two ${\gamma}$-ray outbursts (in November 2013 and March 2015) can be seen in ${\gamma}$-ray light curves obtained from Fermi observations. The KVN radio core is optically thick at least up to 86 GHz; there is indication that it might be optically thin at higher frequencies. To first order, the radio light curves decay exponentially over the time span covered by our observations, with decay timescales of $411{\pm}85$ days, $352{\pm}79$ days, $310{\pm}57$ days, and $283{\pm}55$ days at 22, 43, 86, and 129 GHz, respectively. Assuming synchrotron cooling, a cooling time of around one year is consistent with magnetic field strengths $B{\sim}2{\mu}T$ and electron Lorentz factors ${\gamma}$ ~ 10 000. Taking into account that our formal measurement errors include intrinsic variability and thus over-estimate the statistical uncertainties, we find that the decay timescale ${\tau}$ scales with frequency ${\nu}$ like ${\tau}{\propto}{\nu}^{-0.2}$. This relation is much shallower than the one expected from opacity effects (core shift), but in agreement with the (sub-)mm radio core being a standing recollimation shock. We do not find convincing radio flux counterparts to the ${\gamma}$-ray outbursts. The spectral evolution is consistent with the 'generalized shock model' of Valtaoja et al. (1992). A temporary increase in the core opacity and the emergence of a knot around the time of the second ${\gamma}$-ray event indicate that this ${\gamma}$-ray outburst might be an 'orphan' flare powered by the 'ring of fire' mechanism.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.10 no.6
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• pp.27-36
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• 2015

The purpose of this study was to investigate the influence relationships among individual career orientation, preparation of old age, social networks, and the entrepreneurial intention of the potential entrepreneurs. 408 numbers of structured questionnaire were collected from the potential entrepreneurs who live in Seoul through the online Google survey method and offline face to face method. And the collected data was analyzed on frequency analysis, validity analysis, t-test, ANOVA, and regression analysis etc. using the SPSS WIN 21.0 program. The results are as follows. Firstly, innovation, entrepreneurial creativity, and autonomy orientation affect on entrepreneurial intention positively(+), but security orientation has a negative(-) effect on entrepreneurial intention in the influence relationships between individual career orientation and entrepreneurial intention. Secondly, economical and emotional preparation have positive(+) influences on entrepreneurial intention in the influence relationships between individual career orientation and entrepreneurial intention. Thirdly, the sub-variables of social networks, that is, assist and role models exert a positive(+) influence on entrepreneurial intention in the influence relationships between social networks and entrepreneurial intention. Fourthly, social networks plays a moderating role only on the relationship between security orientation and entrepreneurial intention in the analysis about the moderating effects of social networks on the influence relationships among individual career orientation, preparation of old age, and entrepreneurial intention. Fifth, a social network of relationships to help prepare the old establishment has been found to help regulate effective analysis of whether or not the results of adjustment.