• Korean Journal of Microbiology
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• v.38 no.4
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• pp.230-230
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• 2002

Class Ⅲ chitin synthases in filamentous fungi are important for hyphal growth and differentiation of several filamentous fungi. A genomic clone containing the full gene encoding Chs4, a class Ⅲ chitin synthase in Penicillium chrysogenum, was cloned by PCR screening and colony hybridization from the genomic library. Nucleotide sequence analysis and transcript mapping of chs4 revealed an open reading frame (ORF) that consisted of 5 exons and 4 introns and encoded a putative protein of 915 amino acids. Nucleotide sequence analysis of the 5′flanking region of the ORF revealed a potential TATA box and several binding sites for transcription activators. The putative transcription initiation site at -716 position was identified by primer extension and the expression of the chs4 during the vegetative growth was confirmed by Northern blot analysis. Amino acid sequence analysis of the Chs4 revealed at least 5 transmembrane helices and several sites for past-transnational modifications. Comparison of the amino acid sequence of Chs4 with those of other fungi showed a close relationship between P chrysogenum and genus Aspergillus.

• The KIPS Transactions:PartD
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• v.16D no.2
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• pp.169-176
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• 2009

Rule discovery is an operation that discovers patterns frequently occurring in a given database. Rule discovery makes it possible to find useful rules from a stock database, thereby recommending buying or selling times to stock investors. In this paper, we discuss storage structures for efficient processing of queries in a system that recommends stock investments. First, we propose five storage structures for efficient recommending of stock investments. Next, we discuss their characteristics, advantages, and disadvantages. Then, we verify their performances by extensive experiments with real-life stock data. The results show that the histogram-based structure improves the query performance of the previous one up to about 170 times.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.18 no.8
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• pp.2316-2332
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• 2024

In this paper, we introduce a web-based system that leverages the capabilities of the ρ(rho)-algorithm, which is a Structure Information Control Net (SICN)-oriented process mining algorithm, with open-source platforms, including Django, Graphviz, and Cytoscape, to facilitate the rediscovery and visualization of business process models. Our approach involves discovering SICN-oriented process models from process instances from the IEEE XESformatted process enactment event logs dataset. This discovering process is facilitated by the ρ-algorithm, and visualization output is transformed into either a JSON or DOT formatted file, catering to the compatibility requirements of Cytoscape or Graphviz, respectively. The proposed system utilizes the robust Django platform, which enables the creation of a userfriendly web interface. This interface offers a clear, concise, modern, and interactive visualization of the rediscovered business processes, fostering an intuitive exploration experience. The experiment conducted on our proposed web-based process discovery system demonstrates its ability and efficiency showing that the system is a valuable tool for discovering business process models from process event logs. Its development not only contributes to the advancement of process mining but also serves as an educational resource. Readers, students, and practitioners interested in process mining can leverage this system as a completely free process miner to gain hands-on experience in rediscovering and visualizing process models from event logs.

• Bulletin of the Korean Chemical Society
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• v.31 no.5
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• pp.1397-1399
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• 2010

• Bulletin of the Korean Chemical Society
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• v.35 no.11
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• pp.3156-3157
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• 2014

• Transactions on Electrical and Electronic Materials
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• v.13 no.2
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• pp.51-59
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• 2012

Piezoelectric langasite crystals have superior properties such as high temperature performance and high quality Q and can be applied in combustion pressure sensors and surface acoustic wave (SAW) filters. Crystal growth, crystal structure and properties of langasite group are reviewed, and the mechanism of piezoelectricity of langasite is presented based on the crystal structure and deformation under high pressure. Finally, for the discovery of new piezoelectric materials, this paper presents the role of the framework, and recommends the search of framework crystal structure, because the characteristic of the mechanism exists on the framework of the crystal structure.

• Journal of information and communication convergence engineering
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• v.6 no.3
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• pp.255-260
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• 2008

In the recently years, there has been a big interest in ad hoc wireless network as they have tremendous military and commercial potential. An Ad hoc wireless network is composed of mobile computing devices that use having no fixed infrastructure of a multi-hop wireless network formed. So, the fact that limited resource could support the network of robust, simple framework and energy conserving etc. In this paper, we propose a new ad hoc multicast routing protocol for based on the ontology scheme called inference network. Ontology knowledge-based is one of the structure of context-aware. And the ontology clustering adopts a tree structure to enhance resilient against mobility and routing complexity. This proposed multicast routing protocol utilizes node locality to be improve the flexible connectivity and stable mobility on local discovery routing and flooding discovery routing. Also attempts to improve route recovery efficiency and reduce data transmissions of context-awareness. We also provide simulation results to validate the model complexity. We have developed that proposed an algorithm have design multi-hierarchy layered networks to simulate a desired system.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.797-802
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• 2014

We screened a small molecular library that was designed and independently synthesized in vitro and found a new drug (MY-03-01) that is active against ovarian cancer. We established that MY-03-01 effectively inhibited SKOV-3 cell survival in a dose-dependent manner, based on cell viability rates, and that it not only induced SKOV-3 apoptosis by itself, but also did so synergistically with paclitaxel. Secondly, when MY-03-01 was applied at $40{\mu}M$, its hemolytic activity was less than 10%, compared with the control, and there was almost no damage to nor mal cells at this concentration. In addition, we used DAPI staining and flow cytometry to show that MY-03-01 could significantly induce apoptosis of SKOV-3 cells. Finally, we found that MY-03-01 likely induced SKOV-3 apoptosis by activating caspase3 and caspase9 through the mitochondrial pathway.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2020.12a
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• pp.16-44
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• 2020

Cancer is the second leading cause of death in the world. According to the 2018 reports, one in six people worldwide is reported to die as a result of cancer. The discovery of anticancer drugs has been utilized extensively, but there has been no report on excellent selective activity in cancer cells. The discovery of bioactive substances from marine sponges has been the limelight in the pharmaceutical field over the past decade owing to the production of many bioactive compounds from the sponges to protect themselves against the environment. On top of that, marine sponges also produced cytotoxic compounds such as terpenoids, alkaloids, steroids, and peptides which suggests that marine sponges have high potential in the development of anticancer drugs. Thus, this study aimed to obtain new cytotoxic compounds from S. siphonella in Egypt and Arenoscelra sp. and Gelliodes sp. in Vietnam, and further investigation of the extract from these marine sponges led to isolation of ten new compounds and 21 known compounds. Chapter 1 will discuss about the isolation and structure elucidation of eight new polyacetylene derivatives from S. siphonella and their cytotoxic activities. The isolation and structural elucidation of one new polybrominated iododiphenyl ether from Arenosoclea sp. as well as cytotoxic activities of the isolated compounds will be reported in chapter 2. Finally, isolation and structure elucidation of new compounds from the marine sponge Gelliodes sp. and their cytotoxic activities will be discussed in chapter 3.

• Journal of Pharmaceutical Investigation
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• v.38 no.2
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• pp.105-110
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• 2008

Indapamide (4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoyl-benz-amide) is an oral antihypertensive diuretic agent indicated for the treatment of hypertensive. The diuretic and natriuretic effects are mainly due to the structure of o-chlorobenzenesulfonamide. The objective of this study was to formulate sustained release indapamide granules and assess their formulation variables. Granules were prepared by fluid bed coating method and consist of drug layer and membrane layer. The granules were coated with HPC and ethyl cellulose along with plasticizer dibuthyl sebacate. The release of indapamide depended on the type of Eudragit such as RS and NE 30 D used in the formulation controlled release layer. These results obtained clearly suggest that the sustained release oral delivery system for indapamide could be designed with satisfying drug release profile approved.