• Journal of the Korean earth science society
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• v.30 no.1
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• pp.49-57
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• 2009

We studied a structure of the Kunsan basin in the Yellow Sea using ship-borne magnetic data and altimetry satellite-derived gravity data provided from the Scripps institution of oceanography in 2006. The gravity data was analyzed via power spectrum analysis and gravity inversion, and the magnetic data via analytic signal technique, pseudo-gravity transformation, and its inversion. The results showed that the depth of bedrock tended to increase as we approached the center of the South Central Sag in Kunsan basin and that the maximum and minimum of its depth were estimated to be about 6-8 km and 2 km, respectively. Inaddition, the observed high anomaly of gravity and magnetism was attributed to the intrusion of igneous rock of higher density than the surrounding basement rock in the center of South Central Sag, which was consistent with the interpretation of seismic data obtained in the same region.

• The Journal of the Acoustical Society of Korea
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• v.28 no.1E
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• pp.9-15
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• 2009

In this paper, FSTL (Field Sound Transmission Loss) measured in a mock-up simulating ship cabins is studied. A mock-up is built by using 6 mm steel plate, and two identical cabins are made where 25 mm or 50 mm sandwich panel is used to construct wall and ceiling inside the steel structure. Various wall panels and ceilings are tested, where effects of wall and ceiling panel thickness, and presence of a unit toilet on FSTL are investigated. It is found that the effect of unit toilet on FSTL is at most 1 dB. From the comparison of FSTL for panels of the same thickness of 50 mm, it is observed that panel having inside air cavity of 10 mm shows higher STL than that of the panel without air cavity. Comparison of FSTL for panels of 50 mm and 25 mm thickness shows that dependency on surface density predicted by mass law is not observed. The sandwich panels act as a mass-spring system, which shows a resonant mode that cannot be explained by the mass law. It is also found that STL from laboratory test is higher than FSTL by 5- 10 dB, which can be explained by flanking structure-borne noise transmission path such as ceiling, floor and corridor-facing wall.

• Journal of the Korean earth science society
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• v.30 no.2
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• pp.165-175
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• 2009

The East Sea including the area of this study is identified as a typical back-arc sea located in the backside of the Circum-Pacific volcanic and earthquake belt. Previous studies reported that the East Sea has begun to open by tensile force and formed its current shape. In this study, we investigate the regional tectonic structure of the East Sea using ship-borne gravity, magnetic, and satellite gravity data. The result of three-dimensional depth inversion shows that Moho depth of the study area is approximately 13-25km and inversely proportional to the thickness of the crust. In addition, as approaching to the center of the Ulleung Basin (UB), the thickness of the crust of the UB becomes thinner due to the extension caused by tensile force which had opened the East Sea.

• Journal of Microbiology and Biotechnology
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• v.32 no.4
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• pp.504-513
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• 2022

Chitin deacetylase (CDA) inhibitors were developed as novel antifungal agents because CDA participates in critical fungal physiological and metabolic processes and increases virulence in soil-borne fungal pathogens. However, few CDA inhibitors have been reported. In this study, 150 candidate CDA inhibitors were selected from the commercial Chemdiv compound library through structure-based virtual screening. The top-ranked 25 compounds were further evaluated for biological activity. The compound J075-4187 had an IC50 of 4.24 ± 0.16 µM for AnCDA. Molecular docking calculations predicted that compound J075-4187 binds to the amino acid residues, including active sites (H101, D48). Furthermore, compound J075-4187 inhibited food spoilage fungi and plant pathogenic fungi, with minimum inhibitory concentration (MIC) at 260 ㎍/ml and minimum fungicidal concentration (MFC) at 520 ㎍/ml. Therefore, compound J075-4187 is a good candidate for use in developing antifungal agents for fungi control.

• Proceedings of the KSRS Conference
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• 1999.11a
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• pp.148-153
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• 1999

Baikdu-san was a very active volcano during the Cenozoic era and is believed to be formed in late Cenozoic era. Recently it was also reported that there was a major eruption in or around 1002 A.D. and there are evidences which indicate that it is still an active volcano and a potential volcanic hazard. Remote sensing techniques have been widely used to monitor various natural hazards, including volcanic hazards. However, during an active volcanic eruption, volcanic ash can basically cover the sky and often blocks the solar radiation preventing any use of optical sensors. Synthetic aperture radar(SAR) is an ideal tool to monitor the volcanic activities and lava flows, because the wavelength of the microwave signal is considerably longer that the average volcanic ash particle size. In this study we have utilized several sets of SAR data to evaluate the utility of the space-borne SAR system. The data sets include JERS-1(L-band) SAR, and RADARSAT(C-band) data which included both standard mode and the ScanSAR mode data sets. We also utilized several sets of auxiliary data such as local geological maps and JERS-1 OPS data. The routine preprocessing and image processing steps were applied to these data sets before any attempts of classifying and mapping surface geological features. Although we computed sigma nought ($\sigma$$^{0}$) values far the standard mode RADARSAT data, the utility of sigma nought image was minimal in this study. Application of various types of classification algorithms to identify and map several stages of volcanic flows was not very successful. Although this research is still in progress, the following preliminary conclusions could be made: (1) sigma nought (RADARSAT standard mode data) and DN (JERS-1 SAR and RADARSAT ScanSAR data) have limited usefulness for distinguishing early basalt lava flows from late trachyte flows or later trachyte flows from the old basement granitic rocks around Baikdu-san volcano, (2) surface geological structure features such as several faults and volcanic lava flow channels can easily be identified and mapped, and (3) routine application of unsupervised classification methods cannot be used for mapping any types of surface lava flow patterns.

• The Journal of the Korea Contents Association
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• v.18 no.4
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• pp.99-113
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• 2018

Recently, global warming has widened the habitat of mosquitoes and infection chances for mosquito-borne diseases are increasing. Flavivirus is a typical mosquito-borne virus. Flaviviruses with a relatively high frequency of infection in Asian countries include Zika, Dengue, and Japanese encephalitis viruses. Although distinctive diagnosis of flaviviruses is required because the symptoms and therapeutic method differ, there is no diagnostic method that can distinguish them accurately yet. In this study, we propose distinctive diagnosis method of flaviviruses using informations and analysis tools constructed in bioinformatic databases. The envelope protein and non-structural protein 1 which are useful protein for the immuno-diagnostics of three flaviviruses were selected. Their homology was analyzed by multiple sequence alignments and epitope candidates consisting of 10-15 amino acids were selected. Finally two epitopes were suggested to be most useful by immunogenicity analysis and 3D structure prediction. These approaches and results are expected to be great value in the distinctive diagnosis of three flaviviruses with a high frequency of infection in Asian countries.

• Molecules and Cells
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• v.40 no.4
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• pp.299-306
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• 2017

The transcriptional activator AphB has been implicated in acid resistance and pathogenesis in the food borne pathogens Vibrio vulnificus and Vibrio cholerae. To date, the full-length AphB crystal structure of V. cholerae has been determined and characterized by a tetrameric assembly of AphB consisting of a DNA binding domain and a regulatory domain (RD). Although acidic pH and low oxygen tension might be involved in the activation of AphB, it remains unknown which ligand or stimulus activates AphB at the molecular level. In this study, we determine the crystal structure of the AphB RD from V. vulnificus under aerobic conditions without modification at the conserved cysteine residue of the RD, even in the presence of the oxidizing agent cumene hydroperoxide. A cysteine to serine amino acid residue mutant RD protein further confirmed that the cysteine residue is not involved in sensing oxidative stress in vitro. Interestingly, an unidentified small molecule was observed in the inter-subdomain cavity in the RD when the crystal was incubated with cumene hydroperoxide molecules, suggesting a new ligand-binding site. In addition, we confirmed the role of AphB in acid tolerance by observing an aphB-dependent increase in cadC transcript level when V. vulnificus was exposed to acidic pH. Our study contributes to the understanding of the AphB molecular mechanism in the process of recognizing the host environment.

• Geophysics and Geophysical Exploration
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• v.9 no.1
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• pp.129-138
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• 2006

Helicopter-borne aeromagnetic surveys at two different times separated by three years were conducted to better understand the shallow subsurface structure of the Vulcano and Lipari volcanic complex, Aeolian Islands, southern Italy, and also to monitor the volcanic activity of the area. As there was no meaningful difference between the two magnetic datasets to imply an apparent change of the volcanic activity, the datasets were merged to produce an aeromagnetic map with wider coverage than was given by a single dataset. Apparent magnetisation intensity mapping was applied to terrain-corrected magnetic anomalies, and showed local magnetisation highs in and around Fossa Cone, suggesting heterogeneity of the cone. Magnetic modelling was conducted for three of those magnetisation highs. Each model implied the presence of concealed volcanic products overlain by pyroclastic rocks from the Fossa crater. The model for the Fossa crater area suggests a buried trachytic lava flow on the southern edge of the present crater. The magnetic model at Forgia Vecchia suggests that phreatic cones can be interpreted as resulting from a concealed eruptive centre, with thick latitic lavas that fill up Fossa Caldera. However, the distribution of lavas seems to be limited to a smaller area than was expected from drilling results. This can be explained partly by alteration of the lavas by intense hydrothermal activity, as seen at geothermal areas close to Porto Levante. The magnetic model at the north-eastern Fossa Cone implies that thick lavas accumulated as another eruption centre in the early stage of the activity of Fossa. Recent geoelectric surveys showed high-resistivity zones in the areas of the last two magnetic models.

• Journal of KSNVE
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• v.8 no.6
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• pp.1158-1165
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• 1998

Low frequency interior noise in cars is mainly due to structure-borne excitations which are related with road excitation and component vibrations such as suspension and engine mounts. In order to analyze the annoying interior noise. a technique (Transfer Path Analysis) is introduced to find a noise source and the path of that noise. In this study, TPA is reviewed theoretically and applied to investigate the case when the low frequency interior noise at front seat due to road excitations needs to be optimized. The subjective and objective appraisal was performed under the conditions that a testing vehicle traveled on asphalt at 30 km/h. so that the low frequency to be eliminated was detected. The related vibration and noise data for TPA were measured on running and static vehicle. The results reveal that the noise contribution along the z-direction of trailing arm is prominent to low frequency interior noise.

• Journal of the Korean Society for Precision Engineering
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• v.22 no.8 s.173
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• pp.143-150
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• 2005

To verify applicability of multi-dimensional spectral analysis (MDSA) fur noise source identification two different approaches which are frequency response and coherent function have been investigated. The coherence function approach appears able to separate the correlated system when the noise sources were coherent. In this study, we identify contribution of structure-borne-noise of vehicle HVAC system using MDSA method. Firstly, to identify the applicability of MDSA method, 4-inputs of vehicle HVAC system were the signals measured by accelerometers attached on the selected noise sources which were composed of blower, evaporator, heater and duct. While 1-output which was driver's position sound was the SPL signals measured by a remote microphone, when the blower motor was operating. We identify efficiency of systems modeled with four Inputs/single output through ordinary coherence function (OCF) and partial coherence function (PCF). As a result of experiment, the blower accounted for $62-88\%$ of the overall level of sound energy density. Also, according to the analysis of acoustic signal and vibration signals measurement, an investigation of the noise source identification in the vehicle HVAC is presented. With the sound intensity method, the major sources of the vehicle HVAC radiation are verified. Also the method of improving the noise reduction is proposed by attaching damping patch access to blower motor and noise reduction is verified.