• Journal of The Korean Association For Science Education
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• v.22 no.4
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• pp.796-805
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• 2002

This study examined the knowledge structure constructed by children before formal instruction, and successive changes in the structural complexity of knowledge during and after the learning of 'Structure and Function of Plant' unit. It also investigated how those changes were affected by children's learning modes. The researchers made the 5th graders draw the first draft of their concept map to see the pre-existing knowledge structure concerned with the unit and four more concept maps after completing every fourth lesson. And to see how long their knowledge structures were preserved, the researchers made children draw additional concept maps in 3 days, 3 months, and 7 months after completing the unit. Children drew their current concept maps on the basis of the previous one while learning the unit and without the previous one after completing the unit. Each concept map drawn by children showed the degree of their current understanding on the structures and functions of plants. The results revealed that only two levels of hierarchy and five relationships among the components of the first concept map(relationship, hierarchy, cross link and example) were proven to be valid in terms of conceptual relevance. Growth in the structural complexity of knowledge took place progressively throughout the unit and the effects of learning mode on the growth were favorably reflected in concept map scores of meaningful learners over time(relationship, cross link, example: p<.01, hierarchy: p<.05). Although there were some differences on the concept map scores between two types of learners, they commonly showed that knowledge restructuring had occurred apparently in the early periods from the 1st to the 6th lesson and had not occurred at all in the last period of the unit. The frequency of tuning was higher in rote learners than in meaningful learners throughout the unit, but the frequency of accretion was reverse. Concept map scores of rote learners constructed in the course of learning of the unit decreased little by little gradually in all the categories after completing the unit. However, the average total map score of meaningful learners increased a little more in 7 months than in 3 months after completing the unit. Therefore it can be inferred that meaningful learners construct more stable and well-differentiated knowledge structures than the rote learners.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.5
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• pp.881-887
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• 2002

This treatise is written in order to solve the important contradiction between the two theories; in oriental medicine psychological function is responsible for heart, but in western one it is responsible for brain. So we take the methods of studying in the aspects of morphological characteristics(MC) and visceral manifestation theory(VMT, 藏象論) and others about two organs-heart and brain. Brain(頭腦) is preferred to understand as a structure which is manifesting mental activity of heart. So the brain can be named with external heart(外心) corresponding to the relation of kidney(外 and external kidney. Saying conversely, the nutritional foundation of the mental function is the blood of heart, but the enlightening and insightful features of mentality make it's own residence move to the organ in the uppermost and positive site, that is head. And the close relationships on mental functions between heart and brain were discussed in various aspects, like investigation on east and west etymological literature, or Jiu gong and Taoist theory as well as Me and VMT, These understandings can make us know about the pathology of brain by itself. It has deep relations with heart fire and heart blood and kidney essence, and gastrointestinal function and liver with lung additionally. In another point, it makes the highly complicated psychological functions to be explained free from body relatively, and so can do a role in the complement of the strict 5 viscera theory.

• Toxicological Research
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• v.26 no.3
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• pp.171-175
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• 2010

The human genome contains approximately 13 orphan cytochrome P450 (P450, CYP) genes, of which the apparent function or substrate has not been identified. However, they seem to possess their own biological relevance in some tissues or developmental stages. Here, we characterized the heterologously expressed CYP2W1, an orphan P450 enzyme. The recombinant CYP2W1 protein containing a $6{\times}$(His)-tag at Nterminus has been expressed in Escherichia coli and purified. Expression level of CYP2W1 holoenzyme was around 500 nmol P450 holoenzyme per liter culture medium. The reduced CO difference spectrum of CYP2W1 showed a maximum absorption at 449 nm. CYP2W1 indicated the significant induction to bioactivate Trp-P-1, MeIQ, and IQ in E. coli DJ701 tester strain. However, the bioactivation of B[$\alpha$]P, and NNK by CYP2W1 was relatively low. The model structure of CYP2W1 suggested the characteristic P450 folds with the lengths and orientations of the individual secondary elements. The F-G loop is situated on the distal side of heme to accommodate the flexibility of active site of CYP2W1. These studies can provide useful information for the finding of its biological roles and structure-function relationships of an orphan CYP2W1 enzyme.

• Bulletin of the Korean Chemical Society
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• v.32 no.12
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• pp.4397-4402
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• 2011

The NF-${\kappa}B$ system of transcription factors plays a crucial role in inflammatory diseases, making it an important drug target. We combined quantitative structure activity relationships for predicting the activity of new compounds and quantitative dynamic models for the NF-${\kappa}B$ network with intracellular concentration models. GFA-MLR QSAR analysis was employed to determine the optimal QSAR equation. To validate the predictability of the $IKK{\beta}$ QSAR model for an external set of inhibitors, a set of ordinary differential equations and mass action kinetics were used for modeling the NF-${\kappa}B$ dynamic system. The reaction parameters were obtained from previously reported research. In the IKKb QSAR model, good cross-validated $q^2$ (0.782) and conventional $r^2$ (0.808) values demonstrated the correlation between the descriptors and each of their activities and reliably predicted the $IKK{\beta}$ activities. Using a developed simulation model of the NF-${\kappa}B$ signaling pathway, we demonstrated differences in $I{\kappa}B$ mRNA expression between normal and different inhibitory states. When the inhibition efficiency increased, inhibitor 1 (PS-1145) led to long-term oscillations. The combined computational modeling and NF-${\kappa}B$ dynamic simulations can be used to understand the inhibition mechanisms and thereby result in the design of mechanism-based inhibitors.

• Journal of The Korean Association For Science Education
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• v.10 no.1
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• pp.17-31
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• 1990

The purpose of this study is to make a comparative analysis of the educational bojective, organization, contents, teaching and evaluation of the biological curriculum in high school of Korea and the United States. The results are summarized as follows: 1. In case of the educational objectives, both Korea and the United States emphasize the importance of the process of inquiry, experimentation and observation. Particularily, great emphasis is placed upon the human centered curriculum by reinforcing the relationships between the nature and human being. 2. In regard to the educational organization, eleven credit units(Science I: 5 credits, Biology: 6 credits) is allocated in Korea, and ten credit unit, in the United States. Both of Korea and United Stats designate the biology as elective course. But the science I course is designated as required in Korea 3. This study have been analyzed the educational contents of the two countries within the framwork of the basic concepts and essential informations contained in the curriculum. Results of the analysis as follow: The educational contents have less quantity and lower level in Korea than in the United States. And interrelations among the other curricula are not well considered in the curriculum of Korea/ On the other hands, interrelations among the oter curricula are fully considered and the purpose for emphasizing the importance of the process of inquiry course is well considered in the United States. The themes are stressed on "Structure and Function" (34.5%), "Genetic continuty" (21.3%), "Diversity and Unit" (14.2%) and "Regulation and Homeostasis" (10.3%) in Korea, and in the United States "Structure and Function" (27.3%), "Diversity and Unity" (25.6%), "Genetic continuty" (17.9%) and "Organism and Environment" (9.3%). 4. Regarding the educational guidance, both of Korea and the United States emphasis the interrelation of the basic concepts and principles within the total framwork. Also observation and experimentation, safety education, interest of students, life dignity, pretection of nature, social biology are reguired being paid special attentions. 5. In case of evaluation, both of Korea and the United States are the same in all of methods of evaluation. But the United States is grest stressed on reading and writing.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.34 no.5
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• pp.1-17
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• 2002

The immobilization and consolidation of the model coatings based on the plastic pigment and latex binder of known particle sizes were theoretically Studied in terms of the dense random packing of binary spheres and varying extent of latex film shrinkage. The porosity of the model coatings was calculated based on three proposed latex shrinkage models: Maximum, Minimum, and Linearly Decreasing Latex Shrinkage. The increasing extent of latex shrinkage was calculated up to the critical pigment volume concentration(CPVC) as a function of plastic pigment volume fractions, and the maximum latex shrinkage was estimated from the CPVC. Also, the number of pores and the average equivalent spherical pore diameters were calculated based on those proposed models. The opacity and gloss of the model coatings on polyester films were measured and their porosity was also determined by a simple coat weight-thickness method. As expected, various coating structure-property-composition relationships, such as opacity, gloss, porosity, etc., were shown to exhibit sharp transitions near the CPVC. The CPVC values determined by the opacity, gloss, and porosity vs. PVC relationships, respectively, agreed very well with each other. Especially, the CPVC's determined by the opacity and porosity vs. PVC curves were identical. The comparison between the theoretically calculated and experimental porosity values showed that the intermediate value between the maximum and minimum latex shrinkage would best fit the experimental porosity data. The effect of plastic pigment particle size on the optical properties and porosity of model coatings was also studied and it was observed that the coating opacity and porosity increased with increasing plastic pigment particle size, but the gloss decreased. The ink gloss of the uncalendered model coatings applied onto commercial sheet offset coated papers was shown to be affected by both the coating gloss and porosity: the higher the coating gloss, the higher the ink gloss, but the higher the coating porosity, the lower the ink gloss. Their printability was also studied in terms of the number of passes-to-fail and the rate of ink setting as a function of both plastic pigment volume fractions and plastic pigment particle sizes. A minimum crack-free temperature(MCR) of latex-bound coatings was proposed to better predict the behaviors of latexes as coating binders. The wet state of model coating dispersions, the surfaces of consolidated model coatings, and their internal structure were examined by both electron and atomic force microscopy, and their micrographs were found to be consistent with our immobilization and consolidation models.

• The Journal of the Korea Contents Association
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• v.8 no.10
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• pp.317-327
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• 2008

Go-Yang city, rural region by the 1980s, had rapidly grown to the big city for only 15 years because of Il-San new town development which was developed during $1990{\sim}1995$. So the population and industrial function were greatly increased too. The change of urban spatial structure was grasped by tracing the distribution of population, household and industries of Go-Yang city during $1990{\sim}2005$. The new urban center had grown to the center of the whole city, while the industries of existing centers were extended to the neighbor areas. The existing centers had been changed into 3 types - (1) changed into a part of new urban center, (2) declined to sub-center with small merchant facilities. (3) continuously grown with the development of whole city. As a result, a new town development had changed the urban structure by creating new functional relationships among the existing and new centers rather the existing centers had declined.

• Journal of KIISE:Software and Applications
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• v.29 no.8
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• pp.543-554
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• 2002

System developers create a lot of design documents by various case tools. It is necessary to have the tools for facilitating the analysis of the documents. These tools can be used to understand and verify the whole process of a system, by defining relationships among the documents and providing free navigation methods. In this paper, we develop a navigation tool that enables the developers to systematically analyze the system by capturing duplication, instance, and transition relationships between the documents. Different from the navigation facilities of the other UML design tools, this tool makes it possible to navigate design elements in design documents such as sequence diagrams, state diagrams and class diagrams. In other words, it can be used to systematically capture and verify both the static structure and the dynamic behavior of the system by keeping track of such elements. To provide such a facility, 1) we define three relationships: duplication, instance, and transition, 2) assign relation to the related design elements according to the predefined way. and then 3) present a set of functions for navigating related design elements.

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.53 no.6
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• pp.415-424
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• 2004

In this paper, we introduce and investigate a new category of rule-based fuzzy inference system based on Information Granulation(IG). The proposed rule-based fuzzy modeling implements system structure and parameter identification in the efficient form of “If..., then...” statements, and exploits the theory of system optimization and fuzzy implication rules. The form of the fuzzy rules comes with three types of fuzzy inferences: a simplified one that involves conclusions that are fixed numeric values, a linear one where the conclusion part is viewed as a linear function of inputs, and a regression polynomial one as the extended type of the linear one. By the nature of the rule-based fuzzy systems, these fuzzy models are geared toward capturing relationships between information granules. The form of the information granules themselves becomes an important design features of the fuzzy model. Information granulation with the aid of HCM(Hard C-Means) clustering algorithm hell)s determine the initial parameters of rule-based fuzzy model such as the initial apexes of the membership functions and the initial values of polynomial function being used in the Premise and consequence Part of the fuzzy rules. And then the initial Parameters are tuned (adjusted) effectively with the aid of the improved complex method(ICM) and the standard least square method(LSM). In the sequel, the ICM and LSM lead to fine-tuning of the parameters of premise membership functions and consequent polynomial functions in the rules of fuzzy model. An aggregate objective function with a weighting factor is proposed in order to achieve a balance between performance of the fuzzy model. Numerical examples are included to evaluate the performance of the proposed model. They are also contrasted with the performance of the fuzzy models existing in the literature.

• Education of Primary School Mathematics
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• v.25 no.1
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• pp.57-79
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• 2022

Current mathematics It is necessary to ensure that ratio and proportion concept is not distorted or broken while being treated as if they were easy to teach and learn in school. Therefore, the purpose of this study is to analyze the activities presented in the textbook. Based on prior work, this study reinterpreted the proportional reasoning task from the proportional perspective of Beckmann and Izsak(2015) to the multiplicative structure of Vergnaud(1996) in four ways. This compared how they interpreted the multiplicative structure and relationships between two measurement spaces of ratio and rate units and proportional expression and proportional distribution units presented in the revised textbooks of 2007, 2009, and 2015 curriculum. First, the study found that the proportional reasoning task presented in the ratio and rate section varied by increasing both the ratio structure type and the proportional reasoning activity during the 2009 curriculum, but simplified the content by decreasing both the percentage structure type and the proportional reasoning activity. In addition, during the 2015 curriculum, the content was simplified by decreasing both the type of multiplicative structure of ratio and rate and the type of proportional reasoning, but both the type of multiplicative structure of percentage and the content varied. Second, the study found that, the proportional reasoning task presented in the proportional expression and proportional distribute sections was similar to the previous one, as both the type of multiplicative structure and the type of proportional reasoning strategy increased during the 2009 curriculum. In addition, during the 2015 curriculum, both the type of multiplicative structure and the activity of proportional reasoning increased, but the proportional distribution were similar to the previous one as there was no significant change in the type of multiplicative structure and proportional reasoning. Therefore, teachers need to make efforts to analyze the multiplicative structure and proportional reasoning strategies of the activities presented in the textbook and reconstruct them according to the concepts to teach them so that students can experience proportional reasoning in various situations.