• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2000년도 제15차 학술회의논문집
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• pp.481-481
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• 2000

We investigated the structure-activity relationships on use of multi-layer neural networks. The relationships are techniques required in developments of medicines. Since many kinds of observations might be adopted on the techniques, we discussed some points between the observations and the properties of multi-layer neural networks. In the structure-activity relationships, an important property is not that standard deviations are nearly equal to zero for observed physiological activity, but prediction ability for unknown medicines. Since we adopted non-linear approximation, the function to represent the activity can be defined by observations; therefore, we believe that the standard deviations have not significance. The function was examined by "leave-one-out" method, which was originally introduced for the multi-regression analysis. In the linear approximation, the examination is significance, however, we believe that the method is inappropriate in case of nonlinear fitting as neural networks; therefore, we derived a new index fer the relationships from the differential of information propagation in the neural network. By using the index, we discussed physiological activity of an anti-cancer medicine, Mitomycine derivatives. The neuro-computing suggests that there is no direction to extend the anti-cancer activity of Mitomycine, which is close to the trend of anticancer developing.

• 전기전자학회논문지
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• 제27권1호
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• pp.93-102
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• 2023

악성코드 분석을 위한 기술 중 하나로 실행 프로그램의 함수 호출 관계를 시퀀스 또는 그래프 작성한 후, 그 결과를 분석하는 기술이 제안되었다. 이러한 기술들은 일반적으로 실행 프로그램 파일의 정적 분석을 통해 함수 호출 코드를 분석하고, 함수 호출 관계를 시퀀스 또는 그래프로 정리한다. 그러나 난독화 된 실행 프로그램의 경우, 실행 프로그램 파일의 구성이 표준구성과 다르기 때문에 정적분석 만으로는 함수 호출관계를 명확히 분석하기 어렵다. 본 논문에서는 난독화 된 실행 프로그램의 함수 호출관계를 분석하기 위한 동적 분석 방법을 제안하고, 제안된 기술을 이용하여 함수 호출관계를 그래프로 구성하는 방법을 제안한다.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2000년도 제15차 학술회의논문집
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• pp.518-518
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• 2000

We have researched quantitative structure activity relationships between molecular structure of medicines and physiological activity. Since they are non-linear, neural networks are useful tool to research them. There are many ranks for the non-linearity; therefore, the neuron function must be selected carefully. As the results of some trial calculations, Ire find the sigmoid-linear functions pair. We call the neural network constructed of the pair as ANN. The inter- or extrapolation abilities of the ANN are excellent; therefere, ANN is a superior predictor for the relationships. We evaluated the anticarcinogenic medicines, Carboquinone derivatives, by the developed ANN and leave-one-out method.

• 대한인간공학회지
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• 제20권2호
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• pp.29-46
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• 2001

This study is about the modeling of comfort feeling structure in indoor environments. To represent the degree of practical comfort feeling level in an environment, we measured elements of human sense and resultant elements of comfort feeling such as coziness, refreshment, and freshness with physical values(temperature, illumination, noise. etc.). The relationships of elements of human sense and elements of comfort feeling were formulated as a fuzzy model. And a hybrid-neural network with three layers were designed where obtained from fuzzy membership function values of the elements of human sense were used as inputs, and given as fuzzy membership function values of resultant elements of comfort feeling were used as outputs. Both kinds of fuzzy membership function values were obtained from physical values. The network was trained by measured data set. The proposed hybrid-neural network were tested and proposed a more realistic model of comfort feeling structure in indoor environments.

• 미생물과산업
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• 제16권3호
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• pp.6-14
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• 1990

PRDI DNA polymerase is the smallest member of the family B DNA polymerase (Jung et al., 1987). This DNA polyerase is specified by bacteriophage PRDI which infects a wide variety of gram-negative bacteria(Mindich and Bamford, 1988). Because PRDI is highly amenable to genetic and biochemical manipulation, it is a convenient model system with which to study structure-function relationships of DNA polymerase molecules. To determine the functional roles of the highly conserved regions of the family B DNA polymerases, we have initiated site-directed mutagenesis with PRD1 DNA polymerase, and our results show that mutations at the conserved regions within PRD1 DNA polymerase inactivate polymerase complementing activity and catalytic activity.

• 한국전문물리치료학회지
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• 제30권2호
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• pp.136-143
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• 2023

Background: The International Classification of Functioning, Disability and Health (ICF) model, created by the World Health Organization, provides a theoretical framework that can be applied in the diagnosis and treatment of various disorders. Objects: Our research purposed to ascertain the relationship between structure/function, activity, and participation domain variables of the ICF and pain, pain-associated disability, activities of daily living (ADL), and quality of life in patients with chronic low back pain (LBP). Methods: Two-hundred patients with chronic LBP (mean age: 35.5 ± 8.8 years, females, n = 40) were recruited from hospital and community settings. We evaluated the body structure/function domain variable using the Numeric Pain Rating Scale (NPRS) and Roland-Morris disability (RMD) questionnaire. To evaluate the activity domain variable, we used the Oswestry Disability Index (ODI) and Quebec Back Pain Disability Scale (QBDS). For clinical outcome measures, we used Short-form 12 (SF-12). Pearson's correlation coefficient was used to ascertain the relationships among the variables (p < 0.05). All the participants with LBP received 30 minutes of conventional physical therapy 3 days/week for 4 weeks. Results: There were significant correlations between the body structure/function domain (NPRS and RMD questionnaire), activity domain (ODI and QBDS), and participation domain variables (SF-12), rending from pre-intervention (r = -0.723 to 0.783) and postintervention (r = -0.742 to 0.757, p < 0.05). Conclusion: The identification of a significant difference between these domain variables point to important relationships between pain, disability, performance of ADL, and quality in participants with LBP.

• 시스템엔지니어링학술지
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• 제10권2호
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• pp.1-13
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• 2014

Put Abstract text here. Recently, the Korea industry need systems engineering technology more than yesterday. The systems engineering management function is needed to use the systems engineering engine process effectively. The systems engineering management function is overlapped a lot with project management function and has vague interface. The project management and systems engineering are two independent disciplines. So there are few references which address the scope and relationships clearly between systems engineering management and project management. This paper suggest the scope and relationships between systems engineering management and project management and revise the PMP and SEMP structure of Blanchard and Fabrycky. Followings are the key concept of this paper presenting. The project management(PM) composed of technical management and non-technical management. The technical management scope is same with systems engineering management. The non-technical management scope is composed of parts of enterprise support processes.

• Journal of Plant Biotechnology
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• 제1권1호
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• pp.13-19
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• 1999

The visco-elastic properties of gluten are major determinants of the processing properties of doughs. These visco-elastic properties are strongly influenced by the ratio of monomeric and polymeric proteins and the size distribution of the polymeric proteins, which make up the gluten fraction of the dough. Recent studies have revealed that other features, such as the number of the cysteine residues of the HMW-GS, also play an important role in determining the functional characteristics. To modify the processing properties at molecular level, the relationship between the structure of molecules and dough properties has to be understood. In order to explore the relationships between individual proteins and dough properties, we have developed procedures for incorporating bacterially expressed proteins into doughs, and measuring their functional properties in small-scale equipment. A major problem in investigating the structure/function relationships of individual seed storage proteins is to obtain sufficient amounts of pure polypeptides from the complex families of proteins expressed in the endosperm. Therefore, we have established a simplified model system in which we produce specific protein genes through bacterial expression and test their functional properties in smallscale apparatus after incorporation into base flour. An S poor protein gene has been chosen as a template gene. This template gene has been modified using standard recombinant DNA techniques in order to test the effects of varying the number and position of cysteine residues, and the size of the protein. Doughs have been mixed in small scale apparatus and characterized with respect to their polymeric composition and their functional properties, including dough mixing, extensibility and small scale bating. We conclude that dough characteristics can be manipulated in a predictable manner by altering the cysteine residues and the size of high molecular weight glutenins.

• 대한수학회지
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• 제44권3호
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• pp.647-659
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• 2007

Relationships between the Ricci curvature and the squared mean curvature and between the shape operator associated with the mean curvature vector and the sectional curvature function for slant submanifolds of an S-space-form are proved, particularizing them to invariant and anti-invariant submanifolds tangent to the structure vector fields.

• Journal of Ginseng Research
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• 제31권2호
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• pp.69-73
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• 2007

Since chemical structures of ginsenoside as active ingredient of Panax ginseng are known, accumulating evidence have shown that ginsenoside is one of bio-active ligands through the diverse physiological and pharmacological evaluations. Chemical structures of ginsenoside could be divided into three parts depending on diol or triol ginsenoside: Steroid- or cholesterol-like backbone structure, carbohydrate portions, which are attached at the carbon-3, -6 or -20, and aliphatic side chain coupled to the backbone structure at the carbon-20. Ginsenosides also exist as stereoisomer at the carbon-20. Bioactive ligands usually exhibit the their structure-function relationships. In ginsenosides, there is little known about the relationship of chemical structure and biological activity. Recent reports have shown that ginsenoside $Rg_3$, one of active ginsenosides, exhibits its differential physiological or pharmacological actions depending on its chemical structure. This review will show how ginsenoside $Rg_3$, as a model compound, is functionally coupled to voltage-gated ion channel or ligand-gated ion channel regulations in related with its chemical structure.