• Molecules and Cells
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• v.37 no.2
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• pp.89-94
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• 2014

Fission and fusion of mitochondrial tubules are the main processes determining mitochondrial shape and size in cells. As more evidence is found for the involvement of mitochondrial morphology in human pathology, it is important to elucidate the mechanisms of mitochondrial fission and fusion. Mitochondrial morphology is highly sensitive to changing environmental conditions, indicating the involvement of cellular signaling pathways. In addition, the well-established structural connection between the endoplasmic reticulum (ER) and mitochondria has recently been found to play a role in mitochondrial fission. This minireview describes the latest advancements in understanding the regulatory mechanisms controlling mitochondrial morphology, as well as the ER-mediated structural maintenance of mitochondria, with a specific emphasis on mitochondrial fission.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.33 no.4
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• pp.396-400
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• 2009

The demand of JIB crane to handle a container or a bulk in a vessel is increasingly because of the growth of the scale of trade through the sea. This deck crane such as JIB crane is required the weight reduction design because it is installed in the deck of a vessel due to the environment regulation. In this study first we carry out the structural analysis of JIB with respect to the luffing angle of it to calculate the maximum equivalent stress of JIB, and next the optimum design for the weight reduction design of JIB. The thickness in a cross section of JIB is adopted as the design variable, the weight of JIB as the objective function, and the von mises stress as the constraint condition for the optimum design of JIB using the ANSYS 10.0.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.20 no.5
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• pp.598-604
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• 2011

In guard rail crashes, the development of guard rail structure to ensure the maintenance of safety for passengers is very important. So, this paper focuses on understanding the possibility of efficient structural development considering crash strength of guard rail through computer simulation using the commercial code, LS-DYNA3D at the initial stage of guard rail development. For this study, guard rail structure was modeled using shell elements to represent major structural members and passenger car was modeled using plate elements of simple shape to do not have the drawing, and impact boundary conditions required by regulation was applied. In order to confirm the validity of the computational results, they were compared with the test results.

• Proceedings of the KSR Conference
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• 2008.06a
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• pp.101-108
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• 2008

The dynamic behavior of railway bridges originates from dynamic properties of various spans and structural types. As a result, the exact estimation of dynamic properties of the railway bridge can produce the exact estimations of dynamic performances of the railway bridge. The damping ratio affects the dynamic reponses of the railway bridge in the vicinity of the critical speed seriously. Eurocode, National Annex of each European country and Japan have their own specification for the damping ratio for the estimation of dynamic performance of railway bridges. In our case, the specification for Honam high speed railways follows the Eurocode. In the present study, for the verification and regulation of the damping ratio and investigation of various dynamic properties, modal tests of various structural types are performed. In addition, for the investigation of effects of track structures on the dynamic property of the bridge, ballast track and concrete track are installed and tested.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2011.04a
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• pp.429-432
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• 2011

과적차량은 도로 및 교량 구조물과 도로 횡단 시설물 등에 손상요인으로 작용하며 기존의 단속 시스템은 축조작 및 인력부족등 많은 문제점을 내포하고 있어서 이에 대한 대처방안이 요구되고 있다. 이에 본 논문에서는 주행중인 과적차량의 지능형 임베디드 단속 시스템 개발을 위하여 유전자 알고리즘 기법을 적용, 도로자체를 저울로 하여 주행중인 차량의 하중 및 주행정보를 분석을 연구하였으며 이를 통하여 효율적인 과적 단속이 이루어 질 수 있다고 판단된다. 또한 USN구성을 위한 임베디드 센서와 함께 Internal/External Network의 무선화 시스템을 통한 사용자 중심의 시스템을 구축하는 것이 최종 목적이므로 향후 WCDMA/HSDPA를 이용한 External Network의 구성과 실제 과적 단속 적용을 위하여 Test Bed를 통한 실험이 실시되어야 할 것이다.

• Journal of the Korean Professional Engineers Association
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• v.28 no.2
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• pp.13-20
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• 1995

This paper Is to help the structural engineers for a better understanding of "Earthquake" with regard to the nature o( earthquake and the effect of earthquake on building structures. This reveals that the damage Inflicted upon by earthquake varies with many factors such as : magnitude of earthquake, distance from epicenter, site conditions, building structural characteristics and etc.. It is emphasized that in order to resist very strong earthquake, the ductility demand in the building structure Is important, and the proper duc-tility enables the structure to demonstrate inelastic rotation capacity of the joints and thus the structure may absorb and dissipate the seismic energy. This also presents a comparison between the current Americal UBC Code and the Korean Code, and the author expresses some points of concern on each code. Since earthquake almost invariably strikes at times and places, it is suggested that the current Korean Build-ing Code should be revised to enforce more stringent regulation against possible strong earthquake in the Korean peninsula.

• Bulletin of the Korean Chemical Society
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• v.34 no.2
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• pp.565-568
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• 2013

Acetyl-CoA carboxylases (ACCs) play critical roles in fatty acid synthesis and oxidation by the catalytic activity of the carboxylation of acetyl-CoA to malonyl-CoA. It is known that ACCs are inactivated through reversible phosphorylation by AMP-activated protein kinase (AMPK) and allosterically activated by citrate. Here, we determined the crystal structures of biotin carboxylase (BC) domain of human ACC2 phosphorylated by AMPK in the presence of citrate in order to elucidate the activation mechanism by citrate. This structure shows that phosphorylated Ser222 is released from the dimer interface, and thereby facilitating the dimerization or oligomerization of the BC domain allosterically. This structural explanation is coincident with the experimental result that the phosphorylated Ser222 was dephosphorylated more easily by protein phosphatase 2A (PP2A) as the citrate concentration increases.

• Journal of the Korean Magnetic Resonance Society
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• v.23 no.3
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• pp.67-72
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• 2019

Caveolae are small plasma membrane invaginations that play many roles in signal transduction, endocytosis, mechanoprotection, lipid metabolism. The most important protein in caveolae is the integral membrane protein, caveolin, which is divided into three families such as caveolin 1, caveolin 2, and caveolin 3. Caveolin 1 and 3 are known to incorporate palmitate through linkage to three cysteine residues. Regulation of the protein palmitoylation cycle is important for the cellular processes such as intracellular localization of the target protein, membrane association, conformation, protein-protein interaction, and activity. However, the detailed aspect of individual palmitoylation has not been studied. In the present work, the role of each lipid modification at three cysteines was studied by NMR. Our results suggest that each lipid modification at the natively palmitoylation site has its own roles. For example, lipidations to C106 and C129 are play a role in structural stabilization, however, interestingly, lipid modification to C116 interrupts the structural stabilization.

• Journal of the Korean Society of Industry Convergence
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• v.26 no.6_3
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• pp.1279-1288
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• 2023

Recently, domestic leisure boats have been actively researching eco-friendly product development to enter the global market. Since the hulls of existing leisure boats are mainly made of fiber reinforced plastic (FRP) or aluminum, design techniques for securing structural safety by applying related materials have been mainly studied. In this study, an initial structural design safety assessment of a trimaran pontoon leisure boat with a modular hull structure and eco-friendly high-density polyethylene (HDPE) material was conducted, and sensitivity evaluation and optimization analysis for lightweight design were performed. The initial structural design safety assessment was carried out by creating a finite element analysis model and applying the loading conditions specified in the ship classification regulation to check whether the specified allowable stresses are satisfied. For the sensitivity evaluation, the influence of stress and weight of each hull structural member was evaluated using the orthogonal array design of experiments method, and an approximate model based on the response surface method was generated using the results of the design of experiments. The optimization analysis set the thickness of the hull structural members as the design variable and considered the optimal design formulation to minimize the weight while satisfying the allowable stress. The algorithm of the optimization analysis applied the Gradient-population Based Optimizer (GBO) to improve the accuracy of the optimal solution convergence while reducing the numerical cost. Through this study, the optimal design of a newly developed eco-friendly trimaran pontoon leisure boat with a weight reduction of 10% was presented.

• International Commerce and Information Review
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• v.16 no.2
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• pp.47-67
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• 2014

Since the global financial crisis, criticism against the integrity of financial institutions proposed new financial regulations such as Basel III. These systems are expected to have impacts multilaterally on management and structure of mid- and long-term financial industry. It is also believed that financial institutions will inevitably review business model to respond to these enhanced regulations. The ongoing global financial regulation pursues regulation scope extension, introduction of global regulatory capital system, introduction of global liquidity, etc. As for quantitative index, Basel Committee on Banking Supervision is promoting QIS which is discussed mainly on implementation time from the juridical point of view. This study aims to present domestic banking industry's structural changes depending on regulation enhancement of foreign countries after global financial crisis, and suggest strategy that improves competitiveness of products. Looking at the research result, global financial regulation requires compliance with the regulations through treaties but it shows negative time center around banks. Furthermore, it is also pointed out financially advanced countries' passive attitude on regulation enhancement is problem. Therefore, regulations differentiated between developing and developed countries, dualistic regulations on financial industry, participation of advanced nations, etc are the postulation to change the structure of financial industry.