• BMB Reports
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• 제34권6호
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• pp.489-495
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• 2001

DNA damage by UV and environmental agents are the major cause of genomic instability that needs to be repaired, otherwise it give rise to cancer. Accordingly, mammalian cells operate several DNA repair pathways that are not only responsible for identifying various types of DNA damage but also involved in removing DNA damage. In mammals, nucleotide excision repair (NER) machinery is responsible for most, if not all, of the bulky adducts caused by UV and chemical agents. Although most of the proteins involved in NER pathway have been identified, only recently have we begun to gain some insight into the mechanism by which proteins recognize damaged DNA. Binding of Xeroderma pigmentosum group C protein (XPC)-hHR23B complex to damaged DNA is the initial damage recognition step in NER, which leads to the recruitment of XPA and RPA to form a damage recognition complex. Formation of damage recognition complex not only stabilizes low affinity binding of XPA to the damaged DNA, but also induces structural distortion, both of which are likely necessary for the recruitment of TFIIH and two structure-specific endonucleases for dual incision.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2011년 춘계학술대회논문집
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• pp.218-224
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• 2011

A supersonic inlet at angle of attack has anti-symmetric pressure distribution, and it can make flow instability and structural problem. In this study, numerical analysis of three-dimensional inviscid flow was conducted under various throttle ratio and angle of attack conditions. Throttle ratio was defined as the ratio of the exit area to the smallest cross section area at inlet, and the ratio is controlled from 0 to 2.42. At various angle of attack, the characteristics of steady and unsteady flow around supersonic inlet is observed under different throttling ratios. From these results, pressure recovery curves and pressure history curves were plotted by post processing. Using pressure history data, FFT analysis is also carried out. Through these processes, it shows the tendency of pressure distribution anti-symmetricity and changing dominant frequency as increasing angle of attack.

• 한국공간구조학회:학술대회논문집
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• 한국공간구조학회 2005년도 춘계학술발표회 및 정기총회 2권1호(통권2호)
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• pp.161-166
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• 2005

In spatial structures with large spaces, one important issue in structures with large spaces is how to carry the weight of the roof. A tensegrity cable dome structure is a kind of soft structural system using the tension cable and compression column as a main element. The tensegrity cable dome is built into a variety of shape around the world but then a collapse accident is increasing. Owing to a collapse accident we must grip of the collapse mechanism to prevent an accident and construct the structure with safety and economy. In this study, I investigated the unstable characteristics of the Geiger-type and Flower-type tcnsegrity cable dome structures, which is the lightweight hybrid structures using compression and tension elements continuously, according to the difference of loading conditions.

• 한국초전도학회:학술대회논문집
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• 한국초전도학회 2001년도 High Temperature Superconductivity Vol.XI
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• pp.29-29
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• 2001

• International Journal of Control, Automation, and Systems
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• 제6권4호
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• pp.551-558
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• 2008

This paper deals with the real-time stable walking for a humanoid robot, ISHURO-II, on uneven terrain. A humanoid robot necessitates achieving posture stabilization since it has basic problems such as structural instability. In this paper, a stabilization algorithm is proposed using the ground reaction forces, which are measured using FSR (Force Sensing Resistor) sensors during walking, and the ground conditions are estimated from these data. From this information the robot selects the proper motion pattern and overcomes ground irregularities effectively. In order to generate the proper reaction under the various ground situations, a fuzzy algorithm is applied in finding the proper angle of the joint. The performance of the proposed algorithm is verified by simulation and walking experiments on a 24-DOFs humanoid robot, ISHURO-II.

• Steel and Composite Structures
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• 제1권1호
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• pp.75-96
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• 2001

Actual buckling curves are always characterised by the erosion of ideal buckling curves. In case of compact sections this erosion is due to the imperfections, while for thin-walled members, a supplementary erosion is induced by the phenomenon of coupled instabilities. The ECBL approach- Erosion of Critical Bifurcation Load - represents a practical and convenient tool to characterise the instability behaviour of thin-walled members. The present state-of-art paper describes the theoretical background of this method and the applications to cold-formed steel sections in compression and bending. Special attention is paid to the evaluation methods of erosion coefficient and to their validation. The ECBL approach can be also used to the plastic-elastic interactive buckling of thin-walled members, and the paper provides significant results on this line.

• Structural Engineering and Mechanics
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• 제4권5호
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• pp.529-540
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• 1996

The dynamic buckling mechanism of a single-degree-of-freedom dissipative/nondissipative gradient system is thoroughly studied, employing energy criteria. The model is chosen in such a manner, that its corresponding static response is associated with all types of distinct critical points. Under a suddenly applied load of infinite duration, it is found that dynamic buckling, occurring always through a saddle, leads to an escaped motion, which is finally attracted by remote stable equilibrium positions, belonging sometimes also to complementary paths. Moreover, although the existence of initial imperfection changes the static behaviour of the system from limit point instability to bifurcation, it is established that the proposed model is dynamically stable in the large, regardless of the values of all other parameters involved.

• Earthquakes and Structures
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• 제9권6호
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• pp.1181-1192
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• 2015

In this paper, an analytical method is proposed to study the effect of crack and axial load on vibration behavior and stability of the cracked columns. Using the local flexibility model, the crack has been simulated by a torsional spring with connecting two segments of column in crack location. By solving governing eigenvalue equation, the effects of crack parameters and axial load on the natural frequencies and buckling load as well as buckling load are investigated. The results show that the presents of crack cause to reduction in natural frequencies and buckling load whereas this reduction is affected by the location and depth of the crack. Furthermore, the tensile and compressive axial load increase and decrease the natural frequencies, respectively. In addition, as the compression load approaches to certain value, the fundamental natural frequency reaches zero and instability occurs. The accuracy of the model is validated through the experimental data reported in the literature.

• 한국광학회:학술대회논문집
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• 한국광학회 2003년도 제14회 정기총회 및 03년 동계학술발표회
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• pp.208-209
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• 2003

We have developed a practical Brillouin active fiber ring sensor of length less than 20m, by employing an optical amplifier to compensate for most of the connection losses in the ring. The loss reduction brings the standard Brillouin threshold from 21 down to 0-0.1 through the enhancement of the finesse of the ring. However, in the course of our experiments, some level of temporal instability and chaotic behavior in the backscattered Stokes intensity and also in its spectral line shift were consistently observed. (omitted)

• International Journal of Concrete Structures and Materials
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• 제11권2호
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• pp.285-300
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• 2017

This study investigates the seismic performance of a staggered wall structure designed with conventional strength based design, and compares it with the performance of the structure designed by capacity design procedure which ensures strong column-weak beam concept. Then the seismic reinforcement schemes such as addition of interior columns or insertion of rotational friction dampers at the ends of connecting beams are validated by comparing their seismic performances with those of the standard model structure. Fragility analysis shows that the probability to reach the dynamic instability is highest in the strength designed structure and is lowest in the structure with friction dampers. It is also observed that, at least for the specific model structures considered in this study, R factor of 5.0 can be used in the seismic design of staggered wall structures with proposed retrofit schemes, while R factor of 3.0 may be reasonable for standard staggered wall structures.