• Ocean and Polar Research
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• v.37 no.2
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• pp.119-125
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• 2015

This paper focuses on the efficient arrangement plan of buoyancy modules, which plan is used to secure the safe operation and structural stability of a marine riser. The marine riser is connected between a vessel and seabed devices. The movement of the vessel and the seabed devices are affected by the motion of the riser. The riser of a deep-seabed integrated mining system exerts a strong influence on the healthy transfer of minerals. So, buoyancy modules must be equipped to compensate for the problem which is the structure stability and the dynamic motion. Installation locations and quantities of the buoyancy modules are determined by real sea experiments. But this is not easy to do because in real sea experimental conditions the cost is expensive as well as being, time-consuming and dangerous. Therefore, the locations and quantities should be determined by numerical simulation. This method is called simulation-based design. The dynamic analysis models of the riser and the buoyancy modules are built into the commercial software of DAFUL.

• BMB Reports
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• v.54 no.12
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• pp.592-600
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• 2021

Parkinson's disease (PD) is one of the most common neurodegenerative diseases in the elderly population and is caused by the loss of dopaminergic neurons. PD has been predominantly attributed to mitochondrial dysfunction. The structural alteration of α-synuclein triggers toxic oligomer formation in the neurons, which greatly contributes to PD. In this article, we discuss the role of several familial PD-related proteins, such as α-synuclein, DJ-1, LRRK2, PINK1, and parkin in mitophagy, which entails a selective degradation of mitochondria via autophagy. Defective changes in mitochondrial dynamics and their biochemical and functional interaction induce the formation of toxic α-synuclein-containing protein aggregates in PD. In addition, these gene products play an essential role in ubiquitin proteasome system (UPS)-mediated proteolysis as well as mitophagy. Interestingly, a few deubiquitinating enzymes (DUBs) additionally modulate these two pathways negatively or positively. Based on these findings, we summarize the close relationship between several DUBs and the precise modulation of mitophagy. For example, the USP8, USP10, and USP15, among many DUBs are reported to specifically regulate the K48- or K63-linked de-ubiquitination reactions of several target proteins associated with the mitophagic process, in turn upregulating the mitophagy and protecting neuronal cells from α-synuclein-derived toxicity. In contrast, USP30 inhibits mitophagy by opposing parkin-mediated ubiquitination of target proteins. Furthermore, the association between these changes and PD pathogenesis will be discussed. Taken together, although the functional roles of several PD-related genes have yet to be fully understood, they are substantially associated with mitochondrial quality control as well as UPS. Therefore, a better understanding of their relationship provides valuable therapeutic clues for appropriate management strategies.

• Advances in concrete construction
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• v.13 no.5
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• pp.385-394
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• 2022

Recently, an increasing number of cutting-edged studies have shown that designing a smart active control for real-time implementation requires piles of hard-work criteria in the design process, including performance controllers to reduce the tracking errors and tolerance to external interference and measure system disturbed perturbations. This article proposes an effective artificial-intelligence method using these rigorous criteria, which can be translated into general control plants for the management of civil engineering installations. To facilitate the calculation, an efficient solution process based on linear matrix (LMI) inequality has been introduced to verify the relevance of the proposed method, and extensive simulators have been carried out for the numerical constructive model in the seismic stimulation of the active rigidity. Additionally, a fuzzy model of the neural network based system (NN) is developed using an interconnected method for LDI (linear differential) representation determined for arbitrary dynamics. This expression is constructed with a nonlinear sector which converts the nonlinear model into a multiple linear deformation of the linear model and a new state sufficient to guarantee the asymptomatic stability of the Lyapunov function of the linear matrix inequality. In the control design, we incorporated H Infinity optimized development algorithm and performance analysis stability. Finally, there is a numerical practical example with simulations to show the results. The implication results in the RMS response with as well as without tuned mass damper (TMD) of the benchmark building under the external excitation, the El-Centro Earthquake, in which it also showed the simulation using evolved bat algorithmic LMI fuzzy controllers in term of RMS in acceleration and displacement of the building.

• Journal of Veterinary Clinics
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• v.33 no.5
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• pp.278-285
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• 2016

Epidemiological studies have shown the association between transportation of live animals and the potential transmission of infectious disease between premises. This finding was also observed in the 2014-2015 foot-and-mouth disease (FMD) outbreak in Korea. Furthermore, slaughterhouses played a key role in the global spread of the FMD virus during the epidemic. In this context, in-depth knowledge of the structure of direct and indirect contact between slaughterhouses is paramount for understanding the dynamics of FMD transmission. But the social network structure of vehicle movements to slaughterhouses in Korea remains unclear. Hence, the aim of this study was to configure a social network topology of vehicle movements between slaughterhouses for a better understanding of how they are potentially connected, and to explore whether FMD outbreaks can be explained by the network properties constructed in the study. We created five monthly directed networks based on the frequency and chronology of on- and off-slaughterhouse vehicle movements. For the monthly network, a node represented a slaughterhouse, and an edge (or link) denoted vehicle movement between two slaughterhouses. Movement data were retrieved from the national Korean Animal Health Integrated System (KAHIS) database, which tracks the routes of individual vehicle movements using a global positioning system (GPS). Electronic registration of livestock movements has been a mandatory requirement since 2013 to ensure traceability of such movements. For each of the five studied networks, the network structures were characterized by small-world properties, with a short mean distance, a high clustering coefficient, and a short diameter. In addition, a strongly connected component was observed in each of the created networks, and this giant component included 94.4% to 100% of all network nodes. The characteristic hub-and-spoke type of structure was not identified. Such a structural vulnerability in the network suggests that once an infectious disease (such as FMD) is introduced in a random slaughterhouse within the cohesive component, it can spread to every other slaughterhouse in the component. From an epidemiological perspective, for disease management, empirically derived small-world networks could inform decision-makers on the higher potential for a large FMD epidemic within the livestock industry, and could provide insights into the rapid-transmission dynamics of the disease across long distances, despite a standstill of animal movements during the epidemic, given a single incursion of infection in any slaughterhouse in the country.

• Journal of Ocean Engineering and Technology
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• v.28 no.5
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• pp.387-395
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• 2014

In this paper, a numerical analysis for an internal turret moored vessel located at a 400-m water depth is conducted. The target vessel has an internal turret that is located at the 0.2 Lpp position from the fore-side, with $3{\times}4$ complex mooring lines installed around the turret circumference. To investigate the motion response of the vessel and the structural reliability of the lines, model tests were conducted. The KRISO ocean basin has a water depth of 3.2 m, which represents 192m using a scaling of 1:60. In order to precisely represent the real-scale condition, equivalent mooring lines needed to be designed. Truncated mooring lines were designed to supplement the restriction of the flume's water depth and increase the reliability of the model testing. These truncated mooring lines were composed of two different chains in order to match the pre-tension, simultaneously restoring the curve and variation in the effective line tension. The static similarities were compared using a static pull-out test and free decaying test, and the dynamic similarities were matched via a regular wave test and combined environments test. Consequently, the designed truncated mooring system could represent the prototype mooring system relatively well in the aspects of kinematics and dynamics.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.36 no.5
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• pp.472-482
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• 2008

A modulation transfer function(MTF) tree is established to estimate the overall MTF of an observation satellite and to analyze the image performance. Basic MTF models relevant to each MTF tree component are represented as mathematical relationship between optics-structural dynamics, thermal deformation, attitude and dynamic characteristics of a satellite and the effects due to the space environment. The Basic MTF models consist of diffraction limited MTF with central obscuration, aberration, defocus, line-of-sight(LOS) jitter, linear motion, detector integration, and so forth. Performance estimation is demonstrated for a virtual earth-observation satellite in order to validate the constructed modeling method. The proposed models enable the system engineers to calculate the overall system MTF and to determine the crucial design parameters that affect the image performance in the conceptual design phase of an observation satellite.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.41 no.11
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• pp.855-864
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• 2013

Active tab is one of the promising technology for the BVI (blade-vortex interaction) noise reduction, and analysis of noise reduction performance is very important phase of the technology development. For the purpose of analysing the performance of noise reduction using active tab, CAMRAD II model for a model-scale rotor system was constructed utilizing structural design result and airfoil aerodynamic data generated by CFD (computational fluid dynamics) calculation. HHC strategy was applied to descent flight condition and air-load was calculated by CAMRAD II then variations of BVI noise was calculated by in-house program. Calculation result with respect to tab length and control phase changes showed BVI noise could be reduced by -3.3dB.

• Korean Journal of Construction Engineering and Management
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• v.12 no.6
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• pp.22-30
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• 2011

In the construction operation, foundation work should be done in advance for the building structure to be installed. This foundation work include a number of activities such as excavation, ground water prevention, piling, wale installation, etc. Caution should be taken in the operation because the dynamics of earth movement can cause a significant failure in the temporary structure. The temporary structure, therefore, should be constantly monitored to understand its behavior. This paper introduces the USN-based monitoring system to automatically identify the behavior of the temporary structure in addition to visual inspection. The autonomous capability of the monitoring system can increase the safety in the construction operation by providing the detailed structural changes of temporary structures.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.30 no.6
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• pp.92-100
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• 2002

In this study, transonic/supersonic nonlinear flutter analysis system of a complete aircraft including forced harmonic motion pf control surfaces has been effectively developed using the modified transonic small disturbance (TSD) equation. To consider the nonlinear effects, the coupled time marching method (CTM) combining computational structural dynamics (CFD) has been directly applied for aeroelastic computations. The grid system for a complex full aircraft configuration is effectively generated by the developed inhouse code. Intransonic and supersonic flight regimes, the characteristics of static and dynamic aeroelastic effect has been investigated for a complete aircraft model. Also, nonlinear flutter flight simulations for the forced harmonic motion of control surfaces are practically presented in detail.

• Proceedings of the Korea Association of Crystal Growth Conference
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• 1996.06b
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• pp.285-309
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• 1996

Non oxide ceramics such as nitrides of transition metals have shown significant potential for future economic impact, in diverse applications in ceramic, aerospace and electronic industries, as refractory products, abrasives and cutting tools, aircraft components, and semi-conductor substrates amid others. Combustion synthesis has become an attractive alternative to the conventional furnace technology to produce these materials cheaply, faster and at a higher level of purity. However he process os highly exothermic and manifests complex dynamics due to its strongly non-linear nature. In order to develop an understanding of this process and to study the effect of operational parameters on the final outcome, numerical modeling is necessary, which would generated essential knowledge to help scale-up the process. the model is based on a system of parabolic-hyperbolic partial differential equations representing the heat, mass and momentum conservation relations. The model also takes into account structural change due to sintering and volumetric expansion, and their effect on the transport properties of the system. The solutions of these equations exhibit steep moving spatial gradients in the form of reaction fronts, propagating in space with variable velocity, which gives rise to varying time scales. To cope with the possibility of extremely abrupt changes in the values of the solution over very short distances, adaptive mesh techniques can be applied to resolve the high activity regions by ordering grid points in appropriate places. To avoid a control volume formulation of the solution of partial differential equations, a simple orthogonal, adaptive-mesh technique is employed. This involves separate adaptation in the x and y directions. Through simple analysis and numerical examples, the adaptive mesh is shown to give significant increase in accuracy in the computations.