• 한국재료학회:학술대회논문집
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• 한국재료학회 2012년도 춘계학술발표대회
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• pp.102.2-102.2
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• 2012

Different layers of zirconium nitride (ZrN) and hydroxyapatite (HA) coatings were prepared on cp Ti substrate for biomedical applications. The main idea is to improve the mechanical strength as well as the biocompatibility of the coating. ZrN is known for its high mechanical strength, corrosion resistance. HA is well known for its biocompatibility properties. Hence, in this study, both materials were coated on a cp Ti substrate with bottom layer with ZrN for good bonding with substrate and the top layer with HA for induce bioactivity. Middle layer was formed by a composite of HA and ZrN. Detail analyses of the layered coatings for its structural, morphological, topographical properties were carried out. Then the mechanical property of the layered coatings was analyzed by nanoindentation. Biomimetic growths of apatite on the functionally graded coatings were determined by simulated body fluid method. This study provides promising results to use this kind of coatings in biomedical field.

• 한국식품위생안전성학회:학술대회논문집
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• 한국식품위생안전성학회 2003년도 추계 국제심포지움 및 학술발표회
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• pp.46-46
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• 2003

Hypocholesterolemic peptide isolated from glycimin (11S protein) hydrolyzate by trypsin was purified and identified as LPYP and IAVPGEVA. To investigate the effects of phyiscal properties of side chains of the hypocholesterolemic activity, some of mutant peptides were designed and synthesized chemically. The structure related structures of each peptide were simulated and constructed and their conformations were observed by using spectropolarimeter. The hypocholesterolemic activities were monitored by assaying the inhibition of 3-hydroxy-3-methylglutaryl CoA reductase (HMG-CoA reductase) in vitro and by the determination of cholesterol content in mice serum. For LPYP derivatives, Hypocholesterolemic activity was lost when hydrophobic leucine residue at N-terminus was not so critical for maintaining hypocholesterolemic activity. For idealogical design of hypocholesterolemic peptides, the structure of HMG-CoA reductase are shown and inhibition mechanism of some peptides or inhibitors will be presented. For IAVPGEVA derivative inhibition of HMG-CoA reductase has been studied. For detail study of hypocholesterolemic activity, kinetic study of inhibition of peptides on HMG-CoA reductase and structural view of ligand binding should be investigated.

• 한국주거학회:학술대회논문집
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• 한국주거학회 2008년도 춘계학술발표대회 논문집
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• pp.241-244
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• 2008

This study focused on the checking of design guideline using concept of reference plane as a promoting tool in order to apply to practical affair in relation to material standardization in housing build. For this purpose, we above all defined the role of reference plane. After establishing structural type can correspond to planning module of building components and coordination condition, we did exemplicated the sub-detail of building components which be to detach according to design method using the concept of reference plane that be complexed with spacial territory and replace cycle of building component or material.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2003년도 정기총회 및 학술발표회
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• pp.64-64
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• 2003

In growing number of diseases it has been shown that the aggregation of specific proteins has an important role in the pathogenesis of the disorder. This has been demonstrated in structural detail with the liver cirrhosis of ${\alpha}$$_1$-antitrypsin deficiency, and it is now believed that similar protein aggregation underlies many neurodegenerative disorders such as autosomal dominant Parkinson disease, prion diseases, Alzheimer disease, Huntington disease.

• Journal of Ship and Ocean Technology
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• 제3권1호
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• pp.12-26
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• 1999

A new concept of collision energy absorbing system for ;he New Oil-tankers with Advanced Double Hull Structure(NOAHS and NOAHS II) are presented through the joint-research pro-gran between Inha and Hamburg-Harburg University. A comparative study on col vision resistance of these proposed side structures with standard double hull structure of 310K DWT class VLCC, is carried out. The fatigue investigation of structural detail parts is also included. It contains a comparative fatigue study based on pertinent regulations of Classification Societies.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2002년도 추계학술대회 논문집(II)
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• pp.1106-1111
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• 2002

The design of sleeper in high-speed railway turnouts is complicated and time-consuming because the length and loading position of sleepers change continuously along the turnout line. It is, therefore, necessary to develop an automated design program which can design automatically the PSC sleepers in turnout region. In this study, a computer program for automatic design of turnout sleepers was developed based on graphic user-interface(GUI) environment. The structural analysis is performed considering the varying loading position of vehicular wheels. The sleepers are treated as located on elastic supports. The user can choose the desirable shape of sleepers before starting the detail design. The present study allows more realistic and automatic design of PSC sleepers in high-speed railway turnouts.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2004년도 추계학술대회 논문집
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• pp.1144-1149
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• 2004

This study deals with the damage reinforcement of structures under the ground such as gallery pipes subjected to railway loads. Railway loads with various moving velocities make significant influences on the ground gallery pipes passing through under the railway. For real structures this study analyzes such effects in detail and establishes a method for the efficient damage reinforcement Moreover we predict the hereafter structural behaviors of gallery pipes under the ground by several numerical simulation. The results of this study are expected to offer useful guidelines for explaining the complicated damage characteristics of the ground gallery pipe structures.

• Bulletin of the Korean Chemical Society
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• 제33권11호
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• pp.3772-3776
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• 2012

Mitogen-activated protein kinase phosphatase 4 (MKP4) has proved to be a promising target for the development of therapeutics for the treatment of diabetes and the other metabolic diseases. Here, we report an example for a successful application of the structure-based virtual screening to identify three novel inhibitors of MKP4. These inhibitors have desirable physicochemical properties as a drug candidate and reveal a moderate potency with $IC_{50}$ values ranging from 4.9 to $32.3{\mu}M$. Therefore, they deserve consideration for further development by structure-activity relationship studies to optimize the inhibitory and antidiabetic activities. Structural features relevant to the stabilization of the newly identified inhibitors in the active site of MKP4 are discussed in detail.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2005년도 봄학술 발표회 논문집(I)
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• pp.31-34
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• 2005

An experimental investigation was conducted to examine the hysteric behavior of Ultra-High strength concrete columns for the requirement of ACI provision. Seven 1/3 scaled columns were fabricated to simulate an 1/2 story of actual structural members with the cross section $300\times300mm$ and the shear span ratio 4. The main variables are axial load ratio, configuration and volumetric ratio of transverse reinforcement. It has been found that the behavior of columns was affected by axial load ratio rather than the amount and the configuration of transverse reinforcement. Consequently, to secure the ductile behavior of 100MPa Ultra-High strength concrete columns, ACI provision for the requirement of transverse steel may considered axial level and the detail of transverse reinforcement.

• Structural Engineering and Mechanics
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• 제56권6호
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• pp.1041-1061
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• 2015

The influence of hygrothermal effects on the vibration frequency and buckling load of a shear deformable composite plate with arbitrary initial stresses was investigated. The governing equations of the effects of humid, thermal and initial stresses are established using the variational method. The material properties of the composite plate are affected by both temperature and moisture. The initial stress is taken to be a combination of uniaxial load and pure bending in a hygrothermal environment. The influence of various parameters, such as the fiber volume fraction, temperature, moisture concentration, length/thickness ratios, initial stresses and bending stress ratio on the vibration and stability of the response of a laminated plate are studied in detail. The behavior of vibration and stability are sensitive to temperature, moisture concentration, fiber volume fraction and initial stresses.