• 한국결정학회:학술대회논문집
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• 한국결정학회 2002년도 정기총회 및 추계학술연구발표회
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• pp.4-4
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• 2002

PDZ domains bind to short segments within target proteins in a sequence-specific fashion. GRIP/ABP family proteins contain six to seven PDZ domains and interact via its sixth PDZ domain (class Ⅱ) with the C-termini of various proteins, including liprin-α. In addition the PDZ456 domain mediates the formation of homo- and heteromultimers of GRIP proteins. To better understand the structural basis of peptide recognition by a class Ⅱ PDZ domain and DZ-mediated multimerization, we determined the crystal structures of the GRIPI PDZ6 domain, alone and in complex with a synthetic C-terminal octapeptide of human liprin-α, at resolutions of 1.5 Å and 1.8 Å, respectively. Remarkably, unlike other class Ⅱ PDZ domains, Ile736 at αB5 rather than conserved Leu732 at αB1 makes a direct hydrophobic contact with the side chain of the Tyr at the -2 position of the ligand. Moreover, the peptide-bound structure of PDZ6 shows a slight reorientation of helix αB, indicating that the second hydrophobic pocket undergoes a conformational adaptation to accommodate the bulkiness of the Tyr's side chain, and forms an antiparallel dimer through an interface located at a site distal to the peptide-binding groove. This configuration may enable formation of GRIP multimers and efficient clustering of GRIP-binding proteins.

• 한국지진공학회논문집
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• 제25권5호
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• pp.223-232
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• 2021

The spatial variation characteristics of seismic motions at the nuclear power plant's site and structures were analyzed using earthquake records obtained at the Fukushima nuclear power plant during the Great East Japan Earthquake. The ground responses amplified as they approached the soil surface from the lower rock surface, and the amplification occurred intensively at about 50 m near the ground. Due to the soil layer's nonlinear characteristics caused by the strong seismic motion, the ground's natural frequency derived from the response spectrum ratio appeared to be smaller than that calculated from the shear wave velocity profile. The spatial variation of the peak ground acceleration at the ground surface of the power plant site showed a significant difference of about 0.6 g at the maximum. As a result of comparing the response spectrums at the basement of the structure with the design response spectrum, there was a large variability by each power plant unit. The difference was more significant in the Fukushima Daiichi site record, which showed larger peak ground acceleration at the surface. The earthquake motions input to the basement of the structure amplified according to the structure's height. The natural frequency obtained from the recorded results was lower than that indicated in the previous research. Also, the floor response spectrum change according to the location at the same height was investigated. The vertical response on the foundation surface showed a significant difference in spectral acceleration depending on the location. The amplified response in the structure showed a different variability depending on the type of structure and the target frequency.

• Smart Structures and Systems
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• 제31권4호
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• pp.421-436
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• 2023

This paper presents a vibration displacement measurement and damage identification method for a space truss structure from its vibration videos. Features from Accelerated Segment Test (FAST) algorithm is combined with adaptive threshold strategy to detect the feature points of high quality within the Region of Interest (ROI), around each node of the truss structure. Then these points are tracked by Kanade-Lucas-Tomasi (KLT) algorithm along the video frame sequences to obtain the vibration displacement time histories. For some cases with the image plane not parallel to the truss structural plane, the scale factors cannot be applied directly. Therefore, these videos are processed with homography transformation. After scale factor adaptation, tracking results are expressed in physical units and compared with ground truth data. The main operational frequencies and the corresponding mode shapes are identified by using Subspace Stochastic Identification (SSI) from the obtained vibration displacement responses and compared with ground truth data. Structural damages are quantified by elemental stiffness reductions. A Bayesian inference-based objective function is constructed based on natural frequencies to identify the damage by model updating. The Success-History based Adaptive Differential Evolution with Linear Population Size Reduction (L-SHADE) is applied to minimise the objective function by tuning the damage parameter of each element. The locations and severities of damage in each case are then identified. The accuracy and effectiveness are verified by comparison of the identified results with the ground truth data.

• 대한간호학회지
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• 제45권2호
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• pp.240-250
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• 2015

Purpose: The purpose of this study was to validate the Korean version of the Ethical Leadership at Work questionnaire (K-ELW) that measures RNs' perceived ethical leadership of their nurse managers. Methods: The strong validation process suggested by Benson (1998), including translation and cultural adaptation stage, structural stage, and external stage, was used. Participants were 241 RNs who reported their perceived ethical leadership using both the pre-version of K-ELW and a previously known Ethical Leadership Scale, and interactional justice of their managers, as well as their own demographics, organizational commitment and organizational citizenship behavior. Data analyses included descriptive statistics, Pearson correlation coefficients, reliability coefficients, exploratory factor analysis, and confirmatory factor analysis. SPSS 19.0 and Amos 18.0 versions were used. Results: A modified K-ELW was developed from construct validity evidence and included 31 items in 7 domains: People orientation, task responsibility fairness, relationship fairness, power sharing, concern for sustainability, ethical guidance, and integrity. Convergent validity, discriminant validity, and concurrent validity were supported according to the correlation coefficients of the 7 domains with other measures. Conclusion: The results of this study provide preliminary evidence that the modified K-ELW can be adopted in Korean nursing organizations, and reliable and valid ethical leadership scores can be expected.

• The Journal of Asian Finance, Economics and Business
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• 제6권3호
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• pp.283-293
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• 2019

The purposes of the study are threefold: (1) develop key successful factors of blockchain platform for micro-enterprises based on Balanced Scorecard (BSC), (2) find out the correlation between the key successful factors of blockchain platform for micro-enterprises, and (3) understand the perception of micro-enterprise blockchain and the difference between theoretical guidance and practical application. This study combines Interpretative Structural Modeling Method, (ISM) and Decision-Making Trial and Evaluation Laboratory (DEMATEL) to analyze the causal relationships and hierarchical structures of the 12 key successful factors of blockchain platform for micro-enterprises and understand the correlation between factors. The 12 key successful factors developed based on the four perspectives of the Balanced Scorecard, and the questionnaire designs based on the concept of DEMATEL, and then analyzed data by DEMATEL and ISM methods to understand the correlation between key factors. The research results show that the key successful factors of blockchain platform for micro-enterprises include "brand equity", "security and anti-counterfeiting", "sales growth", "transparency and clear", "trust", "consensus mechanism", "traceability", "consistency", "tracking", "innovation management", "international", "organizational adaptation", in which consumer "trust" plays an important role. Micro-enterprises can use blockchain to expand the market, provide customers with better service quality, and bring sales growth to micro-enterprises.

• 한국주거학회논문집
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• 제21권6호
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• pp.91-98
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• 2010

The purpose of this study is to develop the feasibility of movable partition wall components that are able to correspond changes of structure system and spatial configuration by the needs of residents for the activation of long-life housing. The key element of various movable partition wall components, a movable partition wall, was analyzed for problems through both as-is analysis and field installation in Korea and Japan, and then its feasibility was verified. The movable partition wall can break the uniformity of a fixed one, can integrate and separate limited space by changes in the demands of residents, can be easy to separate, and can be independent. The development of the movable partition wall is important for the realization of diverse residential space, ease of remodeling, environment adaptation, promotion of modularization, etc. It is comprised of surfacing materials, core materials, structural materials, and movable parts. The domestic movable partition wall was verified regarding the feasibility of an apartment house through on-site inspections and sound insulation tests by KOHP21, KICT. In conclusion, the construction of long-life housing that has sustainable values in the use of housing is nationally an important assignment, so as to secure good housing stock.

• BMB Reports
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• 제48권3호
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• pp.131-138
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• 2015

Cardiac hypertrophy is a form of global remodeling, although the initial step seems to be an adaptation to increased hemodynamic demands. The characteristics of cardiac hypertrophy include the functional reactivation of the arrested fetal gene program, where histone deacetylases (HDACs) are closely linked in the development of the process. To date, mammalian HDACs are divided into four classes: I, II, III, and IV. By structural similarities, class II HDACs are then subdivided into IIa and IIb. Among class I and II HDACs, HDAC2, 4, 5, and 9 have been reported to be involved in hypertrophic responses; HDAC4, 5, and 9 are negative regulators, whereas HDAC2 is a pro-hypertrophic mediator. The molecular function and regulation of class IIa HDACs depend largely on the phosphorylation-mediated cytosolic redistribution, whereas those of HDAC2 take place primarily in the nucleus. In response to stresses, posttranslational modification (PTM) processes, dynamic modifications after the translation of proteins, are involved in the regulation of the activities of those hypertrophy-related HDACs. In this article, we briefly review 1) the activation of HDAC2 in the development of cardiac hypertrophy and 2) the PTM of HDAC2 and its implications in the regulation of HDAC2 activity.

• Structural Engineering and Mechanics
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• 제43권3호
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• pp.349-370
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• 2012

Variable-node finite element families, termed (4 + k + l + m + n)-node elements with an arbitrary number of nodes (k, l, m, and n) on each of their edges, are developed based on the generic point interpolation with special bases having slope discontinuities in two-dimensional domains. They retain the linear interpolation between any two neighboring nodes, and passes the standard patch test when subdomain-wise $2{\times}2$ Gauss integration is employed. Their shape functions are automatically generated on the master domain of elements although a certain number of nodes are inserted on their edges. The elements can provide a flexibility to resolve nonmatching mesh problems like mesh connection and adaptive mesh refinement. In the case of adaptive mesh refinement problem, so-called "1-irregular node rule" working as a constraint in performing mesh adaptation is relaxed by adopting the variable-node elements. Through several examples, we show the performance of the variable-node finite elements in terms of accuracy and efficiency.

• Human Ecology Research
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• 제52권6호
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• pp.573-586
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• 2014

The purpose of this study was to review the conceptual framework of social constructionism and critical social constructionism in the research area of multi-cultural family homes, using a literature review. Fopp argued that social constructionism had an objectivation problem that only considered the actor side as a policy object; therefore he suggested a weaker social constructionist perspective with moderate relativism and the application of feminist epistemology to marginal life for maximizing objectivity. This article explores a conceptual framework for studying the reality of housing of multi-cultural families in Korea in the light of constructionist ideas and presents a review of empirical positivist data to support the framework. Based on results, using the social constructionist framework, five contexts (structural, institutional, organizational, operational, and intersubjective) were reviewed and ideas were suggested to develop an appropriate future situation for multi-cultural family homes. For a weaker social constructionist framework, three National Survey of Multi-Cultural Family Homes data sets were reviewed to determine the real condition of multi-cultural family homes. Further, from a feminist perspective, the empirical data of marginalized multi-cultural family homes were reviewed from the perspectives of gender inequality of decision making, cultural adaptation, and differentiation in housing related areas. In conclusion, two perspectives were useful for understanding multi-cultural family housing in Korea but must be compensated with substantial empirical data for a holistic approach.

• 농촌지도와개발
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• 제24권3호
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• pp.211-222
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• 2017

The purpose of this study is to examine the effects of agriculture on the career adaptation and career decision by measuring the job value and the subjective norm of agriculture. Conclusions based on the study results can be suggested as follows. First, career decision self-efficacy and subjective norm were significant variables in career adaptability of agriculture major college students. Therefore, the belief that one can plan and practice career goals and the affirmation of career plans and decisions in the vicinity are important factors in career adaptability. Second, Self-Realization and social recognition were significant variables in career decision self-efficacy of college students majoring in agriculture. In other words, it can be judged that social recognition such as honor and honor of others in a career choice has a positive effect on the career decision self-efficacy which is self-esteem in career selection. Lastly, An important variable for the subjective norms of agricultural college students was social recognition. This can be said that the positive perception of the surrounding people is very important as the value of social recognition is more important.