• Archives of Pharmacal Research
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• 제18권6호
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• pp.385-390
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• 1995

The analytical methods for the analysis of cyclosporine (CsA), a fluorescence polarization immunoassay (FPIA) and HPLC method, were compared in a pharmacokinetic study of two CsA soft capsule formultaions ($Sandimmun^{\circledR}$; Sandoz, $Implanta^{\circledR}$; Hanmi). Sixteen healthy volunteers completed the study and each subjected single doses ($4{\tiems}100$ mg) of the test and the reference formulations in a two-way crossover design with a one-week drug-free interval between doses. Following each administration, whole blood concentrations of CsA were monitored over a period of 24 hour by both FPIA and HPLC methods. Blood concentrations nad pharmacokinetic parameters determined by either analytical method showed large intersubject variation, with the FPIA data showing relatively higher magnitude of intersubjecte variation than the HPLC data. The blood concentrations determined by FPIA were 1.1-1.3 times higher than those determined by HPLC. There were strong and significant correlations between the two methods (r>0.83 : p<0.0001). Intersubuject variation for the $AUC_{inf}{\;}and{\;}AUC_{24hr}$ of the test formulation was slightly reduced without statistical significance (paried -t test : p>0.05 $t_{max}$ was earlier nad $C_{max}$ was slightly lower for the test formulation, $AUC_{24h}, {\;}C_{max}, {\;}T_{max}$ and MRT determined separately from the data obtained by the two methods for the two formulations were examined by analyses of variance (ANOVA) for the bioequivalency evaluation. Results of ANOVA and confidence limits of terst/reference ratios of $AUC_{24th}$, $C_{max}$, $t_{max}$ and MRT, and statistical tests indicated the bioequivalence of the two formulations (i.e., test/reference ratio was within $100{\times}20%$) except for $C_{max}$ and $t_{max}$. The mean of tmax also showed 11.1% and 9.3% differences but the detection limit were 29.2% and 29.6% as determined by FPIA and HPLC resepctively. This experiments suggest that the data yielded for the two formulations demonstrated that they were bioequivalent.

• 약학회지
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• 제45권5호
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• pp.468-475
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• 2001

Fenofibrate is a fibric acid derivative that is a strong reducer of triglyceride. Micronozed formulation of fenofibrate has improved bioavailability compared to non-micrornized formulation. This study performed a retrospective comparison of micrornized and non-micrornized fenofibrate (28 in micronized and 51 in non-micronized group) by comparing the means of changes in total triglyceride, total cholesterol, HDL-cholesterol and TC/HDL ratio in type 2 diabetics with dyslipidemia The result skewed that after 12 weeks of treatment both drugs produced a significant reduction in total triglyceride levels (62% with micronized, 37% with non-micronized). The mean decrease observed for total triglyceride levels were significantly lower for micronized fenofibrate (p<0.001). Both drugs showed a significant reduction for total cholesterol levels (-22% with micronized, -14% with non-micronized fenofibrate). The mean decrease observed for total cholesterol was not significantly different between the two drugs (p>0.05). HDL-cholesterol levels increased by 24% and 15%) with micronized and non-micronized, respectively and the differences from the baseline were statistically significant for both drugs (p<0.05). The mean change of HDL-cholesterol was not significantly different between the two drugs. There was a statistically significant reduction in TC/HBL-cholesterol ratio from baseline for both drugs (7.1 to 4.8 with micronized and 5.1 to 4.5 with non-micronized), and the reduction of TC/HDL-cholesterol ratio tended to be significantly greater with micronized fenofibrate (p<0.05). This study shows that short-term treatment with micronized fenofibrate is more effective than non-micronized fenosbrate in type 2 diabetes patients with dyslipidemia.

• 한국해양공학회지
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• 제32권6호
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• pp.466-473
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• 2018

This paper presents an estimation method for the static configuration of a steel lazy wave riser (SLWR) using the dynamic relaxation method applied to estimate the configuration of structures with strong geometric non-linearity. The lumped mass model is introduced to reflect the flexible structural characteristics of the riser. In the lumped mass model, the tensions, shear forces, buoyancy, self-weights, and seabed reaction forces at nodal points are considered in order to find the static configuration of the SLWR. The dynamic relaxation method using a viscous damping formulation is applied to the static configuration analysis. Fictitious masses are defined at nodal points using the sum of the largest direct stiffness values of nodal points to ensure the numerical stability. Various case studies were performed according to the bending stiffness and size of the buoyancy module using the dynamic relaxation method. OrcaFlex was employed to validate the accuracy of the developed numerical method.

• Structural Engineering and Mechanics
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• 제85권4호
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• pp.433-443
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• 2023

The current paper discusses the dynamic and stability responses of cross-ply composite laminated plates by employing a refined quasi-3D trigonometric shear deformation theory. The proposed theory takes into consideration shear deformation and thickness stretching by a trigonometric variation of in-plane and transverse displacements through the plate thickness and assures the vanished shear stresses conditions on the upper and lower surfaces of the plate. The strong point of the new formulation is that the displacements field contains only 4 unknowns, which is less than the other shear deformation theories. In addition, the present model considers the thickness extension effects (ε_z≠0). The presence of the Winkler-Pasternak elastic base is included in the mathematical formulation. The Hamilton's principle is utilized in order to derive the four differentials' equations of motion, which are solved via Navier's technique of simply supported structures. The accuracy of the present 3-D theory is demonstrated by comparing fundamental frequencies and critical buckling loads numerical results with those provided using other models available in the open literature.

• Geomechanics and Engineering
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• 제36권2호
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• pp.183-204
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• 2024

In current investigation, a novel beam finite element model is formulated to analyze the buckling and free vibration responses of functionally graded porous beams resting on Winkler-Pasternak elastic foundations. The novelty lies in the formulation of a simplified finite element model with only three degrees of freedom per node, integrating both C⁰ and C¹ continuity requirements according to Lagrange and Hermite interpolations, respectively, in isoparametric coordinate while emphasizing the impact of z-coordinate-dependent porosity on vibration and buckling responses. The proposed model has been validated and demonstrating high accuracy when compared to previously published solutions. A detailed parametric examination is performed, highlighting the influence of porosity distribution, foundation parameters, slenderness ratio, and boundary conditions. Unlike existing numerical techniques, the proposed element achieves a high rate of convergence with reduced computational complexity. Additionally, the model's adaptability to various mechanical problems and structural geometries is showcased through the numerical evaluation of elastic foundations, with results in strong agreement with the theoretical formulation. In light of the findings, porosity significantly affects the mechanical integrity of FGP beams on elastic foundations, with the advanced beam element offering a stable, efficient model for future research and this in-depth investigation enriches porous structure simulations in a field with limited current research, necessitating additional exploration and investigation.

• 대한전자공학회논문지SD
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• 제41권2호
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• pp.9-15
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• 2004

본 논문에서는 부분공핍(partially-depleted : PD) 영역과 완전공핍(fully-depleted : FD) 영역을 나누는 임계 전면 게이트 전압 V/sub c/의 해석적 표현을 이용해서 PD 영역과 FD 영역의 천이를 정확히 설명하는 해석적 표면전위 모델(analytical surface potential model)을 소개한다. 이 모델은 모든 동작영역(subthreshold에서 strong inversion까지)에서 유효하고 반복 계산 절차 (iteration procedure)인 수치 해석적 방법보다 훨씬 짧은 계산시간이 걸린다. 이 모델에 기초한 charge sheet 모델이 모는 동작영역에 유효한 드레인 전류의 단일 공식을 유도하는데 사용된다. 대부분의 secondary 효과들이 charge sheet 모델에 쉽게 포함되고 그 모델의 결과들은 수치해석 결과와 실험 결과를 비교적 정확히 일치한다. 세 가지의 smoothing 함수가 사용될지 라도 표면전위 미분 값은 연속이다 더욱 중요한 점은 smoothing 함수에 사용된 파라미터들은 공정 파라미터들에 크게 의존하지 않는다.

• 한국전산구조공학회논문집
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• 제32권5호
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• pp.323-331
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• 2019

강한 지진의 영향에 있는 레디얼 게이트에 작용하는 동수압 산정을 위한 계산 모형이 제시되었다. 지진동으로 움직이는 구조물의 영향을 호소부와의 이동경계면으로 처리함과 아울러 강한 지진동 효과를 고려하여 동적 레이어링법이 적용된 ALE 알고리즘과 호소부 자유수면 거동을 위한 SIMPLE법을 사용하는 것이 제안된다. 제안된 방법은 단순한 수직 또는 경사 댐체 벽면에 대하여 널리 알려진 실험 결과 및 그로부터 유도된 제안식과 비교하여 타당성과 유효성이 증명되었다. 계산모형에서 사용할 호소부 상류부 측의 무한경계까지의 거리를 산정하기 위한 파라미터 분석을 수행하여 호소부 수위의 2배가 최적의 길이임을 관찰하였다. 마지막으로 제안된 계산 모형을 사용하여 여러 곡률의 대형 레디얼 게이트에 작용하는 지진동수압을 성공적으로 산출하였다.

• 대한조선학회논문집
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• 제49권1호
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• pp.26-32
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• 2012

The 3-D unsteady viscous flow around an impulsively started rotating marine propeller is simulated using VIC(Vortex-In-Cell) method which is adequate to analyze the strong vortical flow around complicatedly-shaped body. The computational procedure is governed by the vorticity transport equation in Lagrangian form. In order to solve the equation, a regular grid which is independent to the shape of a body is introduced and each term of the equation is evaluated numerically on the grid by applying immersed boundary concept. In this paper, the overall algorithm including the formulation of governing equations and boundary conditions is described and some computational results are presented with discussing their physical validity.

• IMMUNE NETWORK
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• 제15권2호
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• pp.51-57
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• 2015

Vaccines are the most effective and cost-efficient method for preventing diseases caused by infectious pathogens. Despite the great success of vaccines, development of safe and strong vaccines is still required for emerging new pathogens, re-emerging old pathogens, and in order to improve the inadequate protection conferred by existing vaccines. One of the most important strategies for the development of effective new vaccines is the selection and usage of a suitable adjuvant. Immunologic adjuvants are essential for enhancing vaccine potency by improvement of the humoral and/or cell-mediated immune response to vaccine antigens. Thus, formulation of vaccines with appropriate adjuvants is an attractive approach towards eliciting protective and long-lasting immunity in humans. However, only a limited number of adjuvants is licensed for human vaccines due to concerns about safety and toxicity. We summarize current knowledge about the potential benefits of adjuvants, the characteristics of adjuvants and the mechanisms of adjuvants in human vaccines. Adjuvants have diverse modes of action and should be selected for use on the basis of the type of immune response that is desired for a particular vaccine. Better understanding of current adjuvants will help exploring new adjuvant formulations and facilitate rational design of vaccines against infectious diseases.

• 한국응용과학기술학회지
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• 제22권3호
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• pp.212-218
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• 2005

Most of cosmetics are emulsion products that contain the source of nutrition vegetable oil, mineral oil, natural extract and carbohydrate etc. There are many possibilities to be contaminated by microbials. We investigated the effect of antimicrobial and minimum inhibitory concentration(MIC) with thiamine dilauryl sulfate(TDS), which was prepared to use cosmetic lotion formulation. Staphylococcus aureus(S. aureus) and Escherichia col(E. coli) were used as test organism. MIC value of TDS was determined aganist microorganism for the growth inhibition by concentration of TDS. From the MIC results, antimicrobial effect of TDS was generally more effective to gram positive than gram negative. Antimicrobial effect with pH value against some microorganism appeared in the following order : pH 5 > pH 6 > pH 7. It showed strong antimicrobial activities against S. aureus, and weak antimicrobial activities against E. coli. If it was possible to determine the formulations with TDS, it would be effective to reduce the artificial preservatives.