• 대한조선학회지
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• 제23권4호
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• pp.1-10
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• 1986

A container ship, due to wide hatch openings, has characteristics of poor torsional rigidity, strong coupling of horizontal-torsional modes and significant discontinuity in the longitudinal variation of hull sections. In the mathematical formulation of the problem the hull is modeled as a beam and the transfer matrix method is utilized. The cross decks between cargo hatch opening are separated from the main hull and regarded as equivalent springs restraining torsion of hull. The effect of shear deformation of ship-side plating on torsion is taken into account in addition to St. Venant's and bending torsional rigidities. Compatibility requirements at cross section discontinuity are approximately considered. Developing the practical calculation procedure and the computer programs for application to an actual ship, some parametric studies on modeling methods of the cross deck, the compatibility condition, added-mass center etc. are out for the purpose of comparison.

• 한국항해학회지
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• 제14권1호
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• pp.39-55
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• 1990

Numerical model simulations are conducted for the evaluation of the water level variation in and out of the harbor due to the development and improvement of a harbor. The method used for the numerical analysis is the hybrid element method which includes energy dissipation due to imperfect reflection at the shore boundary and friction at the bottom. The model also includes the radiation condition on the open boundary by the analytic formulation and is applied to a real harbor, Guryongpo Harbor at the east coast of Korea. The result of experiment within the selected wave frequency band shows that the amplification factor out of the harbor is more than 2.0 at 32 sec period and strong responses near 20 sec, 25 sec, 54 sec periods in the harbor. Moreover, simulation results indicate that other longer wave periods affect to the variation of water level and horizontal water particle velocity exist. Thus, it seems to be necessary to modify the planform and the design of the harbor structures for the coming development.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2005년도 춘계학술대회 논문집
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• pp.155-158
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• 2005

Precipitates, present in most commercial alloys, can have a strong influence on strength and hardening behavior of a single crystal. The effect of thin precipitates on the anisotropy of initial slip resistance and hardening behavior of crystals is modeled in this article. For the convenience of the computational derivation and implementation, the material formulation is given in the unrelated intermediate configuration mapped by the plastic part of the deformation gradient. Material descriptions for the considered two phased aggregates consisting in lattice hardening as well as isotropic hardening and kinematic hardening are suggested. Numerical simulations of various loading cases are presented to discuss and assess the performance of the suggested model.

• Structural Engineering and Mechanics
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• 제35권4호
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• pp.511-533
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• 2010

As a truly meshfree method, meshless equilibrium on line method (MELM), for 2D elasticity problems is presented. In MELM, the problem domain is represented by a set of distributed nodes, and equilibrium is satisfied on lines for any node within this domain. In contrary to conventional meshfree methods, test domains are lines in this method, and all integrals can be easily evaluated over straight lines along x and y directions. Proposed weak formulation has the same concept as the equilibrium on line method which was previously used by the authors for enforcement of the Neumann boundary conditions in the strong-form meshless methods. In this paper, the idea of the equilibrium on line method is developed to use as the weak forms of the governing equations at inner nodes of the problem domain. The moving least squares (MLS) approximation is used to interpolate solution variables in this paper. Numerical studies have shown that this method is simple to implement, while leading to accurate results.

• Steel and Composite Structures
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• 제47권3호
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• pp.365-374
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• 2023

This paper presents a new scheme for constructing locking-free finite elements in thick and thin plates, called Discrete Shear Gap element (DSG), using multiphase material topology optimization for triangular elements of Reissner-Mindlin plates. Besides, common methods are also presented in this article, such as quadrilateral element (Q4) and reduced integration method. Moreover, when the plate gets too thin, the transverse shear-locking problem arises. To avoid that phenomenon, the stabilized discrete shear gap technique is utilized in the DSG3 system stiffness matrix formulation. The accuracy and efficiency of DSG are demonstrated by the numerical examples, and many superior properties are presented, such as being a strong competitor to the common kind of Q4 elements in the static topology optimization and its computed results are confirmed against those derived from the three-node triangular element, and other existing solutions.

• 한국해양학회지
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• 제29권1호
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• pp.50-63
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• 1994

두 가지의 서로 다른 난류 변수화를 삼차원적이고 시간의존적인 연안해역의 모델 실험으로 수행하였다. 난류 변수화 중의 하나는 일정한 와동복합화 한 것, C1이고 다 른 하나는 층화 의존적인 와동혼합화, C2이다. C2를 이용한 유체흐름은 강한 경압적 흐름이며 담수와 염수의 수직적인 혼합을 제한하고 있다. 하구언으로부터 방출되는 유 출류는 C2의 경우가 C1의 경우보다 훨씬 더 관성적이며 강한 플륨(plume) 전선을 형성 한다. C에서는 강한 유출류로 인하여 초림계적인 유체흐름의 상태, 즉 표층류의 유출 소도가 경압적 위상속도를 능가하는 상황이 하구언의 외해쪽에 존재할 수 있다. 담수 영역에서 의 유체의 조율과정은 C1의 경우와 C2의 경우가 상당이 바른 바, C에서 의 유체의 흐름은 강한 경압적인 특성을 보여준다.

• Journal of Pharmaceutical Investigation
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• 제34권1호
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• pp.57-71
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• 2004

The objective of this study was to provide a better understanding of SUPAC-IR and its application in handling postapproval changes to immediate release solid oral dosage forms. Originally, SUPAC-IR was aimed at reducing the regulator burdern of the industry when they were making postapproval changes, but still at maintaining the formulation quality and performance of a drug product. The postapproval changes that were covered under SUPAC-IR included variations in the components ad composition of formulation, the site of manufacturing, batch size, manufacturing equipment, and manufacturing process. The guidance defined levels of changes, based on the likelihood of risk ocurrence and potential impact of postapproval changes upon the safety and efficacy of a drug product I suggested what a type of fing report should be submitted to the FDA for each level of change. Chemist, manufacturing, and control tests to be executed were also recommended for each change level The important tests specified in the guidance included batch release, stability, in vitro dissolution, and in vivo bioequivalence tests. However, there have been strong demands on revising the current SUPAC-IR in order to resolve some issues and to improve its usefulness in evaluating postapproval changes to immediate release solid oral dosage forms. In particular, the rigorous requirement of case C dissolution test and the definition of batch size were challenged by both academia and the industry. A revision work was in progress to reflect these inputs and to expand the utility of SUPAC-IR. As a result of these concerted efforts, an updated 2nd version of SPAC-IR would be likely to be issued ver soon to the public.

• 한국자원식물학회지
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• 제30권5호
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• pp.535-541
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• 2017

본 연구에서는 카카오 추출물의 알칼로이드계 성분의 함량을 관찰하고 항산화, 항균, 항염증 활성을 확인하였다. CAEt, CAMe추출물 함유 Gel을 제조하여 물리적 안정성을 관찰하였다. 카카오 추출물의 생리활성을 관찰하기 위해 DPPH, SOD 측정을 진행하였으며 세포독성 및 LPS로 유발시킨 일산화질소의 소거능에 대한 연구를 진행하였다. 또한 알칼로이드계 퓨린 구조를 가진 카카오 추출물을 첨가시킨 Gel을 제조하여 60일 동안 상온에서의 안정성을 평가하였다. 카카오 추출물의 항산화 활성 검증에서는 CAEt 추출물에서 $IC_{50}$ 값은 $43.14{\mu}g/m{\ell}$, CAMe 추출물의 $IC_{50}$ 값은 $35.42{\mu}g/m{\ell}$로 관찰되었다. SOD 측정에서도 CAEt 추출물에서 $IC_{50}$ 값은 $90.9{\mu}g/m{\ell}$, CAMe 추출물의 $IC_{50}$ 값은 $52.6{\mu}g/m{\ell}$로 관찰되었다. MeOH 조건에서 추출한 CAMe 추출물의 항산화능이 높은 것을 알 수 있었다. 추출물 3%가 함유된 gel (CAEt-Gel, CAMe-Gel)을 제조하였다. 항균활성 측정 결과 CAMe 추출물이 함유된 gel 제형이 더 높은 항균성을 나타내는 것을 확인하였다. MTT assay로 관찰한 세포독성은 80%이상의 세포 생존율을 보였으며, LPS로 활성화된 Raw 264.7 세포에서 NO 발생을 관찰한 결과 CAMe-Gel을 처리한 군에서 NO 생성량이 유의하게 억제되는 것을 확인할 수 있었다. 본 연구에서는 위와 같은 결과를 근거로 카카오 추출물의 알칼로이드계 성분을 인체내에 적용하기 위해 제조한 Gel은 화장품 및 의료용 소재로 다양한 활용이 가능할 것으로 사료된다.

• 공업화학
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• 제7권4호
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• pp.787-793
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• 1996

본 논문은 옵셋 잉크가 국내 신문고지의 탈묵에 미치는 영향을 조사하기 위해 국내신문 옵셋잉크의 조성분과, 그들 잉크로 옵셋 인쇄된 시료를 10, 30, 90, 180일 동안 열화시킨 후, 이들의 탈묵성을 비교하였다. 인쇄잉크의 조성분을 다르게 하여 인쇄한 시료는 열화기간이 증가될 수록 수율과 백색도가 감소되었다. 특히 아마인유의 첨가량이 많은 시료의 경우, 열화기간에 따라 많은 수율의 감소와 백색도의 저하를가져왔다. 따라서 아마인유의 첨가량은 탈묵에 결정적인 역할을 한다는 결론을 얻었다. 또한 로진변성페놀수지와 길소나이트가 포함된 시료는 열화과정을 통해 상대적으로 백색도의 감소가 있었다. 강도 측면에서 볼 경우, 열화기간에 따라 대체로 인장지수와 파열지수는 감소하였고, 인열지수는 증가했다. 그러나 아마인유만을 비이클 성분으로 사용한 시료의 경우 다른 시료에 비해 모든 강도가 낮았는데, 이것은 잉크와 섬유간의 강한 가교결합이 형성되어 초지 시 해리가 어렵기 때문이다.

• Archives of Pharmacal Research
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• 제18권6호
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• pp.385-390
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• 1995

The analytical methods for the analysis of cyclosporine (CsA), a fluorescence polarization immunoassay (FPIA) and HPLC method, were compared in a pharmacokinetic study of two CsA soft capsule formultaions ($Sandimmun^{\circledR}$; Sandoz, $Implanta^{\circledR}$; Hanmi). Sixteen healthy volunteers completed the study and each subjected single doses ($4{\tiems}100$ mg) of the test and the reference formulations in a two-way crossover design with a one-week drug-free interval between doses. Following each administration, whole blood concentrations of CsA were monitored over a period of 24 hour by both FPIA and HPLC methods. Blood concentrations nad pharmacokinetic parameters determined by either analytical method showed large intersubject variation, with the FPIA data showing relatively higher magnitude of intersubjecte variation than the HPLC data. The blood concentrations determined by FPIA were 1.1-1.3 times higher than those determined by HPLC. There were strong and significant correlations between the two methods (r>0.83 : p<0.0001). Intersubuject variation for the $AUC_{inf}{\;}and{\;}AUC_{24hr}$ of the test formulation was slightly reduced without statistical significance (paried -t test : p>0.05 $t_{max}$ was earlier nad $C_{max}$ was slightly lower for the test formulation, $AUC_{24h}, {\;}C_{max}, {\;}T_{max}$ and MRT determined separately from the data obtained by the two methods for the two formulations were examined by analyses of variance (ANOVA) for the bioequivalency evaluation. Results of ANOVA and confidence limits of terst/reference ratios of $AUC_{24th}$, $C_{max}$, $t_{max}$ and MRT, and statistical tests indicated the bioequivalence of the two formulations (i.e., test/reference ratio was within $100{\times}20%$) except for $C_{max}$ and $t_{max}$. The mean of tmax also showed 11.1% and 9.3% differences but the detection limit were 29.2% and 29.6% as determined by FPIA and HPLC resepctively. This experiments suggest that the data yielded for the two formulations demonstrated that they were bioequivalent.