• The Journal of Korean Physical Therapy
• /
• v.10 no.1
• /
• pp.31-44
• /
• 1998

This observation was made on 163 cases of CVA that were confirmed through survey. They were treated in the Bulgyo Oriental Hospital in Taegu from February to March 1998. The results was as follows, 1. The ration of male to female was 1:1:36 in whole groups. 2. Onset time was occurred $37.4\%$ at 06:00-12:00. $20.0\%$, 00:00-16:00. 3. Of 157 cases of cerebrovascular accidents cerebral infarction (included cerebral thrombosis & cerebral embolism) was presented in $47.4\%$, cerebral hemorrhage in $38.2\%$, subarachnoid hemorrhage in $5.1\%$, and others in $8.9\%$. 4. The most ordinary preceding disease was hypertension. 5. The family history was appeared as $12.9\%$ of the mother, $9.7\%$ of the father.(This observation was made on 155 cases) 6. The body weight of CAV patients was appeared $37.4\%$ in 51-60kg, $30.7\%$ in 61-70kg, $17.8\%$ in below 50kg, and $9.8\%$ in 71-80kg, $4.3\%$ in above 80kg. 7. Of 161 cases, $46.6\%$ did not exercise. 8. Of 163 cases, $65.6\%$ of them did not drink alcohol. 9. Of 162 cases, $63\%$ did not smoke cigarettes. 10. The food taste (food habit) of stroke patients was that they comprised a fancy as $38.0\%$ of salty food, $33.8\%$ of fresh food, and $24.7\%$ of hot food, $3.5\%$ of sweet food.(This observation was made on 143 cases) According to the above result, We must restrain salty food and control positively hypertension and in terms of CVA prevention.

• Journal of Korean Academy of Nursing
• /
• v.44 no.4
• /
• pp.351-360
• /
• 2014

Purpose: This study was done to compare demographic characteristics, comorbidity, and health habits of elders with mild cognitive impairment (MCI) and elders with cognitively normal function (CNF). Methods: Secondary data analysis was conducted using data from the Database of the Seoul Dementia Management Project for 5,773 adults age 60 and above. Results: The MCI group showed an older age distribution, but there was no significant education difference between the two groups. Elders with MCI had more diabetes and stroke than elders with CNF. In subgroups, the same findings were observed in women, but not in men. While more men with MCI had hypertension compared to men with CNF, there was no significant difference in hypertension between the two groups for women. Elders with MCI, men in particular, had a lower prevalence of obesity than men with CNF. MCI individuals did less exercise compared to individuals with CNF. While there were no significant differences in alcohol consumption and smoking between MCI and CNF groups, the over 80's subgroup with MCI reported more alcohol consumption. Conclusion: Findings from this study could be helpful in designing community-based dementia prevention programs and health policies to reduce the prevalence of dementia or related cognitive impairments.

• Korean Journal of Clinical Pharmacy
• /
• v.15 no.1
• /
• pp.1-8
• /
• 2005

Clopidogrel is used to reduce the risk of cardiovascular events in patients with atherosclerosis documented by recent ischemic stroke, recent myocardial infarction (MI), or established peripheral arterial disease (secondary prevention). Clopidogrel is metabolized by CYP3A4, and the active metabolites inhibit platelet aggregation. The purpose of this study was to assess clopidogrel only versus clopidogrel + others (aspirin, CYP3A4 inhibitor, and CYPBA4 inducer) in terms of cardiovasculalr events and bleeding complications. We reviewed the charts of patients who visited between August 1, 2002 and August 31, 2003, retrospectively. Total 72 patients were included and they consisted of 5 groups; clopidogrel group (n=36), clopidogrel + aspirin group (n=11), clopidogrel + CYP3A4 inhibitor group (n=15), clopidogrel + aspirin + CYP3A4 inhibitor group (n=6), clopidorel + CYP3A4 inducer group (n=4). The primary endpoints at 6 months, 12 months were the composite of cardiovascular (CV) events. The secondary end-point was the incidence of bleeding events at 6months, and 12months. At 12months, the primary endpoint was not significantly different among the five groups (p=0.056). In comparison of two groups as clopidogrel only versus clopidogrel + others (aspirin, CYP3A4 inhibitor and CYP3A4 inducer), the primary endpoint was significantly different (p=0.02). The CV events were increased in the clopidogrel + others group. The secondary end point was not significantly different among the five groups (p=0.52). However, time to bleeding events was 230.8 in the clopidogrel group and 74.7 in the clopidogrel + others group (p = 0.046). In conclusion, clopidogrel interaction with aspirin, CYP3A4 inhibitor, and CYP3A4 inducer affected cardiovascular events and bleeding events. Drug interaction of clopidogrel with concurrent medications should be considered cautiously.

• The Journal of Internal Korean Medicine
• /
• v.39 no.4
• /
• pp.480-494
• /
• 2018

Objectives: To investigate the effect of fermented extract of Artemisiae Iwayomogii Herba, Curcumae Longae, Crataegi Fructus and Salviae Miltiorrhizae Radix (FMH) on anti-inflammation associated with dyslipidemia and anti-oxidation in RAW264.7 and HUVEC cells. Methods: The total polyphenols, total flavonoids, DPPH radical scavenging activity, ABTS radical scavenging activity, and cytotoxicity of FMH were measured. RAW264.7 cells treated with FMH were tested for production of NO, and for cytokine and LTB4 levels and HUVEC cells treated with FMH were examined for production of cDNA of genes related to inflammation. Results: 1. FMH contained polyphenols and flavonoids. The DPPH and ABTS radical scavenging activity of FMH increased in a concentration-dependent manner. 2. FMH treatment inhibited the production of nitric oxide (NO), cytokines, and LTB4 in RAW264.7 cell when compared to the untreated control group. 3. FMH decreased the transcription of pro-inflammatory genes, whereas it increased transcription of anti-inflammatory genes, in HUVEC cells. Conclusion: FMH is effective as an antioxidant and for treatment and prevention of dyslipidemia, atherosclerosis, ischemic heart disease, stroke, and other cardiocerebrovascular diseases.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.18 no.6
• /
• pp.1860-1868
• /
• 2004

Geijibokryunghwan has a wide range of therapeutic applications, and some reports have indicated that it has protective activity against atherosclerosis, and more specifically stroke and myocardial infarction. A recent report showed that atherosclerotic plaque volume can be reduced by supplying Geijibokryunghwan extracts for several years. In this study, we used a component of Geijibokryunghwan, which has been used for the prevention of atherosclerosis in Korea for several years, and has proven to be useful in lowering the occurrence of cerebral infarction. In a preliminary study, we found that Geijibokryunghwan potently suppressed platelet aggregation induced by various agonists. In this study, we sought to explore the mechanism by which Geijibokryunghwan inhibits platelet aggregations.

• Journal of the Korean Society of Physical Medicine
• /
• v.15 no.1
• /
• pp.85-94
• /
• 2020

PURPOSE: This study examined the effects of the meridian muscle release technique on the pain and functional movement of patients with myofascial pain syndrome (MPS) of the shoulder joint. METHODS: The subjects of this study included 45 patients with MPS of the shoulder joint. The subjects were divided randomly into the following groups; the meridian muscle release technique group (n=15), the Graston technique group (n=15), and the control group (n=15). Both the meridian muscle release group and the Graston technique group received conventional therapy for 35 minutes initially and were then treated using the meridian muscle releases technique and Graston technique for 10 minutes, respectively. The control group received only conventional therapy for 35 minutes. All three groups underwent treatments three times a week for four weeks. Each subject was evaluated randomly using the VAS, PPT, SPADI and ROM both before and after treatment. RESULTS: The Graston technique group showed a significantly more substantial increase in functional movement (p<.05) than the meridian muscle release technique and control groups. The meridian muscle release technique group had significantly less pain (p<.05) compared to the Graston technique and control groups. CONCLUSION: These findings suggest that the meridian muscle release technique can be useful for decreasing pain and increasing the functional movement of patients with MPS of the shoulder joint.

• Journal of Korean Public Health Nursing
• /
• v.21 no.2
• /
• pp.193-205
• /
• 2007

Purpose: To evaluate the current status of utilization and implementation of health promotion programs for Korean middle-aged women in public health centers. Methods: Three-phase stratified sampling was done to select 1304 middle-aged women (aged 40-64 years) from all regions of Korea. The data were collected by face-to-face interviews using a structured questionnaire for individual responses and mailed surveys to 126 public health centers. Descriptive statistics and $x^2$-test were done for data analysis. Results: Only 12 of the 126 public health centers (9.9%) implemented health promotion programs for middle-aged women, with the lack of manpower being cited as the main reason for the absence of programs. From individual responses, 11.3% had participated in health promotion programs offered by public health centers. The main reasons for not participating were inconvenient times and lack of information. Significant differences were found in the frequency of participation in programs, exercise programs and diabetes management according to the size of region. The majority of the respondents cited the need for medical services, followed by programs focused on stroke prevention and leisure time management. The responses on the willingness to participate followed a similar pattern. Conclusion: There are gaps between the utilization of health promotion programs by middle-aged women and what is offered by public health centers. The results of this study support the need to develop more health promotion programs focusing specifically on the needs of middle-aged women.

• Journal of Oriental Neuropsychiatry
• /
• v.24 no.1
• /
• pp.123-130
• /
• 2013

Objectives : During several thousand years, Peucedanum Japonicum Thunberg has been considered as a vegetable side dish in Korea. There is folk knowledge that Peucedanum Japonicum Thunberg prevents vascular disease such as stroke. To identify the effects Peucedanum Japonicum Thunberg, we made up its extract and named it as KH020. Then, we employed common carotid artery ligation (CCAl) surgery for vascular dementia model (VDM), and two types doses of per os (per oral: p.o) treatment. Methods : To confirm prevention and recovery effects for vascular dementia, we treated two doses (100, 400 mg/kg) KH020 in male C57BL/6 mouse during 7 days. After treatment, animals were CCAl operated, and given time to recover. Then, animal were tested in a Y-maze and passive avoidance test. Results : Y-maze results demonstrated that cognition and memory performance were decreased in the VDM group, compared to the sham group. KH020 treatment abolished these effects significantly. The results from the passive avoidance test showed the same phenomenon, but it was not statically significant. Conclusions : Therefore, KH020 prevents the onset of vascular dementia. In future studies, we will evaluate KH020 in regard to alzheimer dementia.

• Journal of the Korean Society of Marine Environment & Safety
• /
• v.14 no.1
• /
• pp.83-87
• /
• 2008

We have a lot of interest in alternative fuels to provide energy independence from oil producing country and to reduce exhaust emissions for air pollution prevention. Biodiesel, which can be generated from natural renewable sources such as new or used vegetable oils or animal fats, may be used as fuel without change of engine structure in diesel engine of compression ignition engine. In this paper, the test results on specific fuel consumption and exhaust emissions of neat diesel oil and biodiesel blends(10 vol.% biodiesel and 20 vol.% biodiesel) were presented using four stroke, direct injection diesel engine. Especially this biodisel was produced from rape oil at our laboratory by ourselves. This study showed that specific fuel consumption and NOx emission were slightly increased, on the other hand CO emission and Soot were tolerably decreased more in the case of biodiesel blends than neat diesel oil.

• The Journal of Internal Korean Medicine
• /
• v.41 no.1
• /
• pp.44-58
• /
• 2020

Objectives: This study was conducted to identify the protective effects of Chongmyunggongjin-dan (CMGJD) on Hydrogen peroxide (H₂O₂)-induced apoptosis mechanisms in C6 glial cells. Method: We used CMGJD after distilled water extraction, filtration, and lyophilization. The ROS scavenging effect was examined by fluorescence microscopy. Expression levels of proteins related to ROS generation were investigated by western blotting. Functional changes in organelles related to Reactive oxygen species (ROS) generation were investigated by immunoblotting and by verifying expression level of relevant enzymes. Results: The CMGJD extract protected the cells against H₂O₂-induced morphological changes and DNA fragmentation, inhibited the increase of Heme_oxygenase-1(HO^-1) and the decrease in catalase, protected against the loss of mitochondrial membrane potential, inhibited disturbances of lysosomal function, and induced an increase in peroxisomes. Conclusion: CMGJD was confirmed to have a protective effect on H₂O₂-induced C6 glial cell death possibly by blocking the pathways causing damage to subcellular organelles, such as mitochondria, lysosomes, and peroxisomes. We assume that CMGJD will be effective for the prevention and treatment of ischemic stroke in a clinical environment.