• BMB Reports
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• v.42 no.3
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• pp.142-147
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• 2009

Small-molecule inhibitors of protein kinases have contributed immensely to our understanding of biological signaling path-ways and have been exploited therapeutically for the treatment of cancers and other disease states. The pyridinyl imidazole compounds SB 203580 and SB 202190 were identified as ATP competitive antagonists of the p38 stress-activated protein kinases and have been widely used to elucidate p38-dependent cellular processes. Here, we identify SB 203580 and SB 202190 as potent inhibitors of stress-induced CREB phosphorylation on Serine 111 (Ser-111) in intact cells. Unexpectedly, we found that the inhibitory activity of SB 203580 and SB 202190 on CREB phosphorylation was independent of p38, but instead correlated with inhibition of casein kinase 1 (CK1) in vitro. The inhibition of CK1-mediated CREB phosphorylation by concentrations of pyridinyl imidazoles commonly employed to suppress p38, suggests that in some cases conclusions of p38-dependence derived solely from the use of these inhibitors may be invalid.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.9 no.3
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• pp.65-73
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• 1989

Continuum formulations for the expressions of dynamic energy release rates and computational methods for dynamic stress intensity factors are developed for the analysis of dynamic fracture problems subjected to stress wave loading. Explicit volume integral expressions for instantaneous dynamic energy release rates are derived by modeling virtual crack extensions with the dynamic Eulerian-Lagrangian kinematic description. In the finite element applications a finite region around a crack-tip is modeled by using quarter-point singular isoparametric elements, and the volume integrals are evaluated for each crack-tip element during virtual crack extensions while the singularity is maintained. It is shown that the use of the present method is more reliable and accurate for the dynamic fracture analysis than that of other path-independent integral methods when the effects of stress waves are significant.

• Computers and Concrete
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• v.1 no.2
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• pp.115-130
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• 2004

The flexural ductility of solid rectangular reinforced concrete beams has been studied quite extensively. However, many reinforced concrete beams are neither solid nor rectangular; examples include T-, ${\Gamma}$-, ${\Pi}$- and box-shaped beams. There have been few studies on the flexural ductility of non-rectangular reinforced concrete beams and as a result little is known about the possible effect of sectional shape on flexural ductility. Herein, the effect of sectional shape on the post-peak flexural behaviour of reinforced normal and high-strength concrete beams has been studied using a newly developed analysis method that employs the actual stress-strain curves of the constitutive materials and takes into account the stress-path dependence of the stress-strain curve of the steel reinforcement. It was revealed that the sectional shape could have significant effect on the flexural ductility of a concrete beam and that the flexural ductility of a T-, ${\Gamma}$-, ${\Pi}$- or box-shaped beam is generally lower than that of a solid rectangular beam with the same overall dimensions and the same amount of reinforcement provided. Based on the numerical results obtained, a simple method of ensuring the provision of a certain minimum level of flexural ductility to non-rectangular concrete beams has been developed.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1995.10a
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• pp.185-193
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• 1995

The softening behaviors of concrete have been the object of numerous experimental and numerical studies, because the load carrying capacity of cracked concrete structure is not zero. Numerical studies are devoted to the investigation of three-dimensional softening behaviors of concrete on the basis of a viscoplastic theory, which may be able to represent the effects of plasticity and also of rheology. In order to properly describe material behaviors corresponding to different stress levels, two surfaces in stress space are adopted; one is a yield surface, and the other is a failure or bounding surface. When a stress path reaches the failure surface, it is considered that the softening behaviors are initiated as micro-cracks coalesce and are simulated by assuming that the actual strain increments in the post-peak region are less than the equivalent viscoplastic strain increment. The experimental studies and the finite element analyses have been carried out under the displacement control. Numerically simulated results indicate that the model is able to predict the essential characteristics of concrete behaviors such as the non-linearity, stiffness degradation, different behaviors in tension and compression, and specially dilatation under uniaxial compression.

• Korean Journal of Human Ecology
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• v.21 no.6
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• pp.1095-1110
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• 2012

The purpose of this study was to examine pathways between job characteristics and job satisfaction among local officials in the child care sector. Participants of this study comprised of 128 local officials who worked in the child care sectors. Structural equation modeling was used to test the direct and indirect effects of job characteristics on job satisfaction through job stress and job burnout. Results confirmed the initial model that assumed there would be an indirect effect of job characteristics based on job satisfaction. The path involving three variables of job characteristics, however, were not statistically significant. The initial model was modified by removing the job characteristics variables. The modified model that confirmed the initial model showed that job stress of local officials in the child care sector was likely to increase job burnout; in turn, the job burnout tended to decrease job satisfaction.

• Journal of Magnetics
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• v.16 no.3
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• pp.294-299
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• 2011

Nd-Fe-B high performance magnets were prepared by die-upset forging. The effects of the deformation parameters on magnetic properties and flow stress were studied. Deformation temperatures in the range of $600{\sim}900^{\circ}C$ enable to achieve an effective anisotropy and temperature $800^{\circ}C$ proves to be suitable for deformation of Nd-Fe-B magnets. The amount of c-axis alignment along the press direction seems to depend on the amount of deformation and a saturation behavior is shown at deformation ratio of 75%. Magnetic properties are also related to strain rate, and maximum energy product is attained at an optimum strain rate of ${\varphi}=1{\times}10^{-2}s^{-1}$. By analyzing the relationship of stress and strain at different deformation temperature during die-upset forging process, deformation behavior of Nd-Fe-B magnets was studied and parameters for describing plastic deformation were obtained. Nd-rich boundary liquid phase, which is additionally decreasing the flow stress during deformation, is supposed to play the role of diffusion path and enhance the diffusion rate.

• Proceedings of the International Microelectronics And Packaging Society Conference
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• 2002.11a
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• pp.39-47
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• 2002

Heat is always the root of stress acting upon the electronic package, regardless of the heat due to the device itself during operation or working under the adverse environment. Due to the significant mismatch in coefficient of thermal expansion (CTE) and the thermal conductivity (K) of the packaging components, on one hand intensive research has been conducted in order to enhance the device reliability by minimizing the mechanical stressing and deformation within the package. On the other hand the effectiveness of different thermal enhancements are pursued to dissipate the heat to avoid the overheating of the device. However, the interactions between the thermal-mechanical loading has not yet been address fully. in articular when the temperature gradient is considered within the package. To address the interactions between the thermal loading upon the mechanical stressing condition. coupled-field analysis is performed to account the interaction between the thermal and mechanical stress distribution. Furthermore, process induced defects are also incorporated into the analysis to determine the effects on thermal conducting path as well as the mechanical stress distribution. It is concluded that it feasible to consider the thermal gradient within the package accompanied with the mechanical analysis, and the subsequent effects of the inherent defects on the overall structural integrity of the package are discussed.

• Journal of the Korean Ceramic Society
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• v.37 no.7
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• pp.686-692
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• 2000

Tin-doped In2O3 (ITO) films were fabricated using a d.c. magnetron reactive sputteirng of a In-10 wt% Sn alloy target in an Ar and O2 gas mixture. To understand the behavior of the carrier mobility in ITO films with O2 partial pressure, the resistivity, carrier concentration and mobility, film density, and intrinsic stress in the films were measured with O2 partial pressure. It was found experimentally that the carrier mobility increased rapidly as the film density increased. In the ITO film with the density close to theoretical one, the mean free path was the same as the columnar diameter. This indicated that the mobility in ITO films was strongly influenced by the crystall size. However, in the case where the film density was smaller than a theoretical density, the mean free paths were also smaller the columnar diameter. It was analyzed that the electron scattering at pores and holes within the crystalline was the major obstacle for electron conduction in ITO films. The measurement of intrinsic stress in ITO films also made it clear that the density of ITO films was controlled by the bombardment of oxygen neutrals on the growing film.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.30 no.1
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• pp.26-33
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• 2019

Objectives: Suicide is the most frequent cause of death among Korean adolescents, and adolescents who have experienced trauma have an increased risk of post-traumatic stress disorder (PTSD) symptoms, depression, and suicide attempts. However, resilience and self-esteem are protective factors. We examined the effects of resilience and self-esteem on the relationship among traumatic experiences, PTSD symptoms, depression, and suicidal ideation. Methods: Middle-school students (n=403) completed questionnaires assessing traumatic experiences, PTSD symptoms, depression, suicidal ideation, resilience, and self-esteem. Path analysis was performed to investigate the mediating effects of PTSD symptoms, resilience, self-esteem, and depression on the relationship between trauma exposure and suicidal ideation. Results: Traumatic experience was positively correlated with PTSD symptoms, depression, and suicidal ideation. PTSD symptoms and depression were positively correlated with suicidal ideation. The relationship between traumatic experiences and suicidal ideation was mediated by PTSD symptoms, which had both direct and indirect effects on suicidal ideation; the indirect effect was mediated by resilience, self-esteem, and depression. Conclusion: Korean adolescents who had experienced trauma were more likely to develop PTSD symptoms, increasing their risk of depression and suicidal ideation. However, self-esteem and resilience may help protect against depression and suicidal ideation. Our findings could inform suicide prevention initiatives.

• Nuclear Engineering and Technology
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• v.54 no.1
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• pp.357-373
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• 2022

The high-temperature gas-cooled reactor pebble-bed module project is the first commercial Generation-IV NPP(Nuclear Power Plant) in China. A new joint is used for the vertical support of RPV(Reactor Pressure Vessel). The steel corbel is integrally embedded into the reactor-cabin wall through eight asymmetrically arranged pre-stressed high-strength bolts, achieving the different path transmission of shear force and moment. The vertical monotonic loading test of two specimens is conducted. The results show that the failure mode of the joint is bolt fracture. There is no prominent yield stage in the whole loading process. The stress of bolts is linearly distributed along the height of corbel at initial loading. As the load increases, the height of neutral axis of bolts gradually decreases. The upper and lower edges of the wall opening contact the corbel plate to restrict the rotation of the corbel. During the loading, the pre-stress of some bolts decreases. The increase of the pre-stress strength ratio of bolts has no noticeable effect on the structure stiffness, but it reduces the ultimate bearing capacity of the joint. A simplified calculation model for the elastic stage of the joint is established, and the estimation results are in good agreement with the experimental results.