• Anatomy and Cell Biology
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• v.56 no.1
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• pp.16-24
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• 2023

Endothelial cells (EC) are the anatomical boundaries between the intravascular and extravascular space. Damage to ECs is catastrophic and induces endothelial cell dysfunction. The pathogenesis is multifactorial and involves dysregulation in the signaling pathways, membrane lipids ratio disturbance, cell-cell adhesion disturbance, unfolded protein response, lysosomal and mitochondrial stress, autophagy dysregulation, and oxidative stress. Autophagy is a lysosomal-dependent turnover of intracellular components. Autophagy was recognized early in the pathogenesis of endothelial dysfunction. Autophagy is a remarkable patho (physiological) process in the cell homeostasis regulation including EC. Regulation of autophagy rate is disease-dependent and impaired with aging. Up-regulation of autophagy induces endothelial cell regeneration/differentiation and improves the function of impaired ones. The paper scrutinizes the molecular mechanisms and triggers of EC dysregulation and current perspectives for future therapeutic strategies by autophagy targeting.

• International Journal of Highway Engineering
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• v.10 no.1
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• pp.63-74
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• 2008

Resilient deformation characteristics on unbound pavement materials have been adopted for design and nonlinear analysis of pavement structure under traffic loadings. However, relatively few studies have been done on the nonlinear resilient behavior of unbound pavement materials in Korea. In addition, only the limited information is available for estimating the resilient modulus values on unbound materials. In this study, a laboratory resilient-deformation test under repeated loadings is performed in order to fud a proper constitutive model that correlates the resilient modulus with stress state from field condition. Finally, a finite element analysis is conducted for evaluating the nonlinear characteristics of unbound materials. and the pavement performance respectively.

• Structural Engineering and Mechanics
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• v.49 no.2
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• pp.203-223
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• 2014

The extensive use of prestressed reinforced concrete (PSC) highway bridges in marine environment drastically increases the sensitivity to both fatigue-and corrosion-induced damage of their critical structural components during their service lives. Within this scenario, an integrated method that is capable of evaluating the fatigue reliability, identifying a condition-based maintenance, and predicting the remaining service life of its critical components is therefore needed. To accomplish this goal, a procedure for fatigue reliability prediction of PSC highway bridges is proposed in the present study. Vehicle-bridge coupling vibration analysis is performed for obtaining the equivalent moment ranges of critical section of bridges under typical fatigue truck models. Three-dimensional nonlinear mathematical models of fatigue trucks are simplified as an eleven-degree-of-freedom system. Road surface roughness is simulated as zero-mean stationary Gaussian random processes using the trigonometric series method. The time-dependent stress-concentration factors of reinforcing bars and prestressing tendons are accounted for more accurate stress ranges determination. The limit state functions are constructed according to the Miner's linear damage rule, the time-dependent S-N curves of prestressing tendons and the site-specific stress cycle prediction. The effectiveness of the methodology framework is demonstrated to a T-type simple supported multi-girder bridge for fatigue reliability evaluation.

• Journal of Ocean Engineering and Technology
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• v.6 no.1
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• pp.78-86
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• 1992

The creep behaviors of 1%Cr-Mo-V and 12%Cr steam turbine rotor steels under static or cyclic load were examined at 600 and $700^{\circ}C$. The relationship between these two kinds of phenomena was studied and the experimental results were summarized as follows: 1) It is confirmed that the cyclic creep strain dependent on time is more available for creep, behavior analysis according to frequency change than that dependent on number of cycles, and the static creep, the special case of cyclic creep with stress ratio of 1 can be also more effectively analyzed by time-dependence. 2) The steady cyclic creep rate vs. the steady static creep rate, increases according to the increase of stress ratio, and this phenomena may occur on occasion of the decrease of the internal stress. 3) The initial strain affects on all the creep properties of the transient region, the steady state region and the rupture time in cyclic creep as well as static creep, and the quantitative relationships among them exist.

• Geomechanics and Engineering
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• v.8 no.6
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• pp.829-844
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• 2015

In the current paper the results of a numerical simulation that were verified by a well instrumented experimental procedure for studying the arching effect over a trapdoor in sand is presented. To simulate this phenomenon with continuum mechanics, the experimental procedure is modeled in ABAQUS code using stress dependent hardening in elastic state and plastic strain dependent frictional hardening-softening with Mohr Coulomb failure criterion applying user sub-routine. The apparatus comprises rectangular trapdoors with different width that can yield downward while stresses and deformations are recorded simultaneously. As the trapdoor starts to yield, the whole soil mass deforms elastically. However, after an immediate specified displacement, depending on the width of the trapdoor, the soil mass behaves plastically. This behavior of sand occurs due to the flow phenomenon and continues until the stress on trapdoor is minimized. Then the failure process develops in sand and the measured stress on the trapdoor shows an ascending trend. This indicates gradual separation of the yielding mass from the whole soil body. Finally, the flow process leads to establish a stable vault of sand called arching mechanism or progressive collapse of the soil body.

• Structural Engineering and Mechanics
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• v.67 no.6
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• pp.565-578
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• 2018

This research article reported the nonlinear finite solutions of the nonlinear flexural strength and stress behaviour of nano sandwich graded structural shell panel under the combined thermomechanical loading. The nanotube sandwich structural model is derived mathematically using the higher-order displacement polynomial including the full geometrical nonlinear strain-displacement equations via Green-Lagrange relations. The face sheets of the sandwich panel are assumed to be carbon nanotube-reinforced polymer composite with temperature dependent material properties. Additionally, the numerical model included different types of nanotube distribution patterns for the sandwich face sheets for the sake of variable strength. The required equilibrium equation of the graded carbon nanotube sandwich structural panel is derived by minimizing the total potential energy expression. The energy expression is further solved to obtain the deflection values (linear and nonlinear) via the direct iterative method in conjunction with finite element steps. A computer code is prepared (MATLAB environment) based on the current higher-order nonlinear model for the numerical analysis purpose. The stability of the numerical solution and the validity are verified by comparing the published deflection and stress values. Finally, the nonlinear model is utilized to explore the deflection and the stresses of the nanotube-reinforced (volume fraction and distribution patterns of carbon nanotube) sandwich structure (different core to face thickness ratios) for the variable type of structural parameter (thickness ratio, aspect ratio, geometrical configurations, constraints at the edges and curvature ratio) and unlike temperature loading.

• Journal of The Korean Society of Agricultural Engineers
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• v.51 no.6
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• pp.69-76
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• 2009

Soils exhibit creep behavior in which deformation and movement proceed under a state of constant stress or load. In Korea, weathered soil is abundant and occupies around one-third of the country. Weathered soil is visually described as a sandy or gravelley soil, but the behavior is quite different from the behavior of usual sand and gravel. In particular, the permeability of weathered soil is similar to sand, but the durability of settlement is similar to clay. Therefore analysis of time-dependent behavior of weathered soil is very important. In this study, Creep tests with weathered soils were carried out under constant principal stress differences of various stress levels which were experimentally obtained by triaxial compression test. The results of these tests showed the creep behavior for which the deformation increased with time, and the results are consistent with phenomenological model by creep equation of Singh-Mitchell.

• Research in Community and Public Health Nursing
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• v.17 no.4
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• pp.552-562
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• 2006

Purpose: This study was conducted to describe the state of middle school students' addicted use of a cellular phone and their psychosocial characteristics and to examine differences in psychosocial factors as impulsivity, stress, anxiety and classroom attitudes according to the level of addiction. Method: As the subjects of this study, 747 middle school students who use a cellular phone in B Metropolitan City were selected through stratified random sampling, and they were asked to answer a self-administered study questionnaire. Data were analyzed using frequency, descriptive statistics, $x^2-test$, t-test, and one-way ANOVA. Results Among the respondents, 15.7% fell into the addicted user group while 56.0% fell into the dependent user group and 28.3% turned out to be non-addicted users. The levels of impulsivity, stress and anxiety were higher in the addicted user group than in the dependent user group and the non-addicted user group. The addicted user group also showed a very bad learning attitude. Conclusion: Addiction to the use of a cellular phone, which may have negative influences on the users' psychosocial characteristics, needs to be detected earlier, and preventive education should be offered in order to prevent such addiction.

• Structural Engineering and Mechanics
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• v.44 no.3
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• pp.289-303
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• 2012

Existing plane stress solutions for thin plates and disks have shown several qualitative features which are difficult to handle with the use of commercial numerical codes (non-existence of solutions, singular solutions, rapid growth of the plastic zone with a loading parameter). In order to understand the effect of temperature and pressure-dependency of the yield criterion on some of such features as well as on the distribution of residual stresses and strains, a semi-analytic solution for a thin hollow disk fixed to a rigid container and subject to thermal loading and subsequent unloading is derived. The material model is elastic-perfectly/plastic. The Drucker-Prager pressure-dependent yield criterion and the equation of incompressibity for plastic strains are adopted. The distribution of residual stresses and strains is illustrated for a wide range of the parameter which controls pressure-dependency of the yield criterion.

• Nuclear Engineering and Technology
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• v.46 no.5
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• pp.681-688
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• 2014

Hydride reorientation behaviors of PWR cladding tubes under typical interim dry storage conditions were investigated with the use of as-received 250 and 485ppm hydrogen-charged Zr-Nb alloy cladding tubes. In order to evaluate the effect of typical cool-down processes on the radial hydride precipitation, two terminal heat-up temperatures of 300 and $400^{\circ}C$, as well as two terminal cool-down temperatures of 200 and $300^{\circ}C$, were considered. In addition, two cooling rates of 2.5 and $8.0^{\circ}C/min$ during the cool-down processes were taken into account along with zero stress or a tensile hoop stress of 150MPa. It was found that the 250ppm hydrogen-charged specimen experiencing the higher terminal heat-up temperature and the lower terminal cool-down temperature generated the highest number of radial hydrides during the cool-down process under 150MPa hoop tensile stress, which may be explained by terminal solid hydrogen solubilities for precipitation, and dissolution and remaining circumferential hydrides at the terminal heat-up temperatures. In addition, the slower cool-down rate generates the larger number of radial hydrides due to a cooling rate-dependent, longer residence time at a relatively high temperature that can accelerate the radial hydride nucleation and growth.