• Biomolecules & Therapeutics
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• v.15 no.1
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• pp.58-64
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• 2007

The previous study reported the biological effect of magnetic field exerted by acting on endocrine and anti-oxidant system. The present study aims to study whether ELF-MF (extremely low frequency magnetic field) affects the physiological endocrine systems such as thyroid and whether ELF-MF affects the defense system against oxidative stress when it alters the function of thyroid. Finally, we correlate the effects of MF on oxidative stress, and adrenal and thyroid with an environmental stress factor. We exposed sham or MF to rats for 5 or 25 days. After the exposure, we determined pain sensitivity, level of TSH, $T_3$ and free $T_4$ in plasma. We also assayed in whole brain, lipid peroxidation, the activity of enzymatic anti-oxidant defense including superoxide dismutase(SOD) and glutathione peroxidase (GPx), and non enzymatic defense such as reduced or oxidized glutathione contents. MF induced the hypersensitivity to thermal stimuli with the reduction of latency. $T_3$ and $T_4$ levels were also increased by the exposure of MF. In addition, we observed the rise of MDA level in rat brain by MF although the MF did not change superoxide dismutase and glutathione peroxidase activity. The effect of MF on both reduced and oxidized glutathione results in decrease in reduced or oxidized glutathione in whole brain. In every experiment, there was no significant difference in MF influence between short term (5 days) and long term (25 days) exposure. Taken together, MF exposure affects the thyroid hormonal control in brain. The elevated thyroid hormone acts on brain, leading to hyper-utilization of oxygen. This phenomenon may be correlated with oxidative stress resulting from MF exposure. In conclusion, we suggest that MF exposure may be an environmental stress by exerting oxidative stress.

• Transactions of the Korean Society of Mechanical Engineers
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• v.17 no.9
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• pp.2172-2180
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• 1993

Under general loadings, including body forces, crack-face tractions and thermal loading, the energy release rate equation for a two-dimensional cracked body is presented. Defining the virtual crack extension as the variation of the geometry, the equation is directly derived by a shape design sensitivity of the potential energy. Although the form of the derived energy release rate equation is different from other researchers's results, the three example show that the former is exactly the same as the latter. However, the final integral equation do not involve the derivative of the displacement on the crack surface and crack tip region, thereby improving the numerical accuracy in the computation of the energy relase rate. Moreover, as it was derived from the governing equation including non-linear elasticity without special assumptions, the energy release rate of a elasto-plastic fracture can be obtained and any numerical stress analysis method can be applied.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.33 no.6
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• pp.584-589
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• 2009

As the automobile energy efficiency stands out an important matter of interest, the magnetic engine valve system receives attention. It has an advantage of no engine power leakage in opening and closing the valve. Moreover, it generates much bigger force than the piezo actuator system, so it can be a good alternative system of the cam and camshaft system. However, since the valve system is not light enough, it is necessary to make its weight reduce. In this study, topology optimization is applied to find the optimal shape of the armature in a magnetic valve system combined with the finite element analysis for the magnetic field analysis. The result is used to obtain a concept design. The adjoint variable method is employed in order to calculate the design sensitivity of the magnetic driving force in the armature component mostly to reduce the computational time during the repeated sensitivity calculation. The sequential linear programming is employed for the optimization algorithm.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.21 no.4
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• pp.532-540
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• 2012

In this study, some considerations have been suggested in developing on-site techniques to evaluate the sensitization of stainless steels. Electrochemical potentiokinetic reactivation (EPR) technique is known to be a candidate tool for field applications since it enables quantitative assessment in reasonable test time, compared to oxalic etching (ditch) technique. The on-site application of the test method imposes additional restrictions on the selection of the test method (for example, minimum surface preparation requirement, insensitivity to testing temperature, etc.). The EPR and etching techniques have been compared in order to sensitization of stainless steel structures. It has been widely reported that the maximum sensitivity in the welded structure of stainless steel is shown at heat-affected zone (HAZ) than weldments with cast structure. In this work, sectioned weldments and external surfaces were investigated to reveal the degree of sensitization by the etching and the results were compared with those of EPR test. The EPR test showed little sensitivity to surface roughness and test temperature.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.20 no.2
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• pp.575-584
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• 1996

The objective of this paper is to develop an expert system for nuclear piping integrity. This paper describes the selection methodology of integrity evalution method and the inference of material properties. To select the integrity evaluation method, the weight factor for respective material properties was obtained by the sensitivity analysis of the effect of material properties on integrity evaluation method. Subsequently the possession ratio for respective integrity evaluation method was computed, and the most appropriate integrity evaluation method for given input information is selected. In the material properties inference, stress-strain curves and J-R curves were predicted from tensile properties such as yield strength and tensile strength.

• Transactions of the Korean Society of Automotive Engineers
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• v.22 no.1
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• pp.142-147
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• 2014

Finite element analysis along with DOE scheme has been performed to obtain robust design of connecting rod assembly. An analysis was conducted with five loading steps. Fatigue analysis was done using commercial software FEMFAT and fatigue safety factors at the interested regions such as shank area of small end and big end were calculated. 27 design cases using 3 factors with 3 levels are constructed by design of experiment. Each case is simulated to find the most influential factors. Response for this study, maximum Von-Mises stress, has been used to determine main factors of connecting rod assembly. Among the 3 factors, compression load affected the response greatly. However, bolt assembly load and width of shank flat area showed a little influence to the response. Interaction effects among factors considered did not occur. Connecting rod assembly considered in this study showed its sensitivity to the noise factor such as compression load rather than design factor such as width of flat shank area.

• Structural Engineering and Mechanics
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• v.52 no.6
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• pp.1193-1208
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• 2014

A simulation of failures on responsible elements is only one form of the extreme structural behavior analysis. By understanding the dynamic behavior in incidental situations, it is possible to make a special structural design from the point of the largest axial force, stress and redundancy. The numerical realization of one such simulation analysis was performed using FEM in this paper. The boundary parameters of transient analysis, such as overall structural damping coefficient, load accelerations, time of load fall and internal forces in the responsible structural elements, were determined on the basis of the dynamic experimental parameters. The structure eigenfrequencies were determined in modal analysis. In the study, the basic incidental models were set. The models were identified by many years of monitoring incidental situations and the most frequent human errors in work with heavy structures. The combined load models of structure are defined in the paper since the incidents simply arise as consequences of cumulative errors and failures. A feature of a combined model is that the single incident causes the next incident (consecutive timing) as well as that other simple dynamic actions are simultaneous. The structure was observed in three typical load positions taken from the crane passport (range-load). The obtained dynamic responses indicate the degree of structural sensitivity depending on the character of incident. The dynamic coefficient KD was adopted as a parameter for the evaluation of structural sensitivity.

• Journal of Positioning, Navigation, and Timing
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• v.4 no.1
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• pp.9-16
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• 2015

The applications of Global Navigation Satellite System (GNSS) receivers are becoming wider in various commercial and military systems including even small weapon systems such as artillery shells. The precision-guided munitions such as Small Diameter Bomb (SDB) of United States can be used for pinpoint strike by acquiring and tracking GNSS signals in high mobility situation. In this paper, a small GNSS receiver with embedded interference suppression capability working under high dynamic stress is developed which is applicable to the various weapon systems and can be used in other several harsh environments. It applies a kind of matched filter and multiple correlator schemes for fast signal acquisition and tracking of even weak signals and frequency domain signal processing method to eliminate the narrowband interference. To evaluate the performance of the developed GNSS receiver, the test scenario of high mobility and interference environment with the GNSS simulator and signal generator is devised. Then, the signal acquisition time, navigation accuracy, sensitivity, and interference suppression performances under high dynamic operation are evaluated. And the comparison test with the commercial GNSS receiver which has high sensitivity is made under the same test condition.

• Toxicological Research
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• v.20 no.1
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• pp.21-29
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• 2004

We used cDNA microarray to assess gene expression profiles in hematopoetic cell line, U-937, exposed to low doses of ionizing irradiation. The 1,000 DNA elements on this array were PCR-amplified cDNAs selected from named human cancer related genes. According to the strength of irradiation, the levels of some gene expression were increased or decreased as dose-dependent manner. The gene expressions of Tubulin alpha, protein kinase, interferon-alpha, -beta, -omega receptor and ras homolog gene family H were significantly increased. Especially, Tubulin gene was shown 2.5 fold up-regulated manner under stress of 500 rad irradiation than 200 rad. On the other hand, fibroblast growth factor 12 and four and a half LIM domains, etc. were significantly down-regu-lated. Also, tumor protein 53(TP53) related genes that p53 inducible protein, tumor protein 53-binding protein looks of little significance as radiation sensitive manner. The radio-sensitivity of tubulin gene etc. that we proposed could be useful to rapid and correct survey for the bio-damage by exposure to low dose irradiation.

• Steel and Composite Structures
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• v.26 no.3
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• pp.347-360
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• 2018

The aim of this paper is to evaluate the accuracy and reliability of the available bond-slip laws which are being used for the numerical modeling of Fiber Reinforced Polymer (FRP)/concrete interfaces. For this purpose, a set of Reinforced Concrete (RC) beams retrofitted with external FRP were modeled using the 3D nonlinear Finite Element (FE) approach. All considered RC beams have been previously tested and the corresponding experimental data are available in the literature. The failure modes of these beams are concrete crushing, steel yielding and FRP debonding. Through comparison of the numerical and experimental results, the effectiveness of each FRP/concrete bond-slip model for the prediction of the structural behavior of externally retrofitted RC beams is assessed. The sensitivity of the numerical results against different modeling considerations of the concrete constitutive behavior and bond-slip laws has also been evaluated. The results show that the maximum allowable stress of FRP/concrete interface has an important role in the accurate prediction of the FRP debonding failure.