• The Korean Journal of Nuclear Medicine
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• v.30 no.1
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• pp.95-103
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• 1996

Reverse redistribution(RRD) refers to a perfusion defect that develops or becomes more evident on rest imaging compared with the stress imaging. This phenomenon was not uncommonly noted on myocardial perfusion single photon emission computed tomography (SPECT). However, the clinical significance and pathophysiological mechanism of RRD were unclear. The aim of this study was to evaluate the incidence and clinical significance of RRD on either dipyridamole T1-201 or Tc-99m MIBI myocardial perfusion SPECT. RRD was defined as ${\geq}10%$ decrease in relative T1-201 and Tc-99m MIBI uptakes on rest images compared to the stress images or as an appearance of new perfusion defects on rest images. It was observed in both T1-201 (44/463, 9.5%) and Tc-99m MIBI (124/999, 12.4%) myocardial SPECTs similarly, with an overall incidence of 11.5%(168/1462). Many apparent)y unrelated disease groups showed the finding: post-revascularization(53.9%), coronary artery disease(24.6%), myocardial infarction(12.3%), and those with normal coro-nary arteries (9.2%). Clinical and angiographic characteristics of 65 consecutive patients who underwent coronary arteriography in 168 patients who had RRD on myocardial perfusion SPECT were reviewed. Tc-99m MIBI was used in 44 patients, and T1-201 was used in 21 patients. Of the 81 myocardial segments analyzed which showed RRD, 32 segments(39.5%) were in septum, 24(29.5%) in inferior wallL, 12(14.8%) in anterior wall, 7(8.7%) in apex and 6(7.4%) in lateral wall. There was no clear association between RRD and coronary arterial stenosis or Presence of collateral circulations. Ventriculographical wall motion was evaluated in 27 regions with RRD; it was normal in 12 regions, hypokinetic in 12 regions and dyskinetic in 3 regions. In 14 of 21 patients who showed RRD on T1-201 myocardial SPECT, T1-201 reinjection was performed immediately after the 3-4 hour redistribution studies. Ten of 14 (71.4%) showed enhanced T1-201 activity(${\geq}10%$ increased) after reinjection. We conclude that RRD is not related to mode of stress or radiopharmaceuticals. RRD might represent many inhomogeneous pathophysiological processes.

• Archives of Pharmacal Research
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• v.27 no.10
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• pp.1065-1072
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• 2004

Depression is associated with a dysfunctional serotonin (5-hydroxytryptamine; 5-HT) system. More recently, several lines of evidence suggest that an important factor in the development of depression may be a deficit in the function and expression of $5-HT_{1A}$ receptors. The present study assessed if Nelumbinis Semen (N. s.) had an anti-depression effect through reversing a decrease in $5-HT_{1A}$receptor binding in rats with depression-like symptoms induced by chronic mild stress. Using a $5-HT_{1A}$ receptor binding assay, with a specific $5-HT_{1A}$receptor agonist, 8- OH-DPAT (8-hydroxy-2-(di-n-propylamino) tetralin), the mechanism of the anti-depression effect of N. s. on rats was investigated, and the effects compared with two well-known antidepressants, Hyperium Perforatum (St. Johns Wort) and fluoxetine (Prozac). Animals were divided into five groups: the normal (N) group without chronic mild stress (CMS), the control (C) group under CMS for 8 weeks, the Nelumbinis Semen (N. s.) treatment group under CMS for 8 weeks, the Hyperium Perforatum (H. p.) treatment group under CMS for 8 weeks and finally, the fluoxetine (F) treatment group under CMS for 8 weeks. Each treatment was administered to rats during the last 4 weeks of the 8-week CMS. A sucrose intake test was performed to test the anti-depression effect of N. s. The N. s. treatment significantly reversed the decreased sucrose intake under CMS (P<0.05 compared to control group under CMS). In the CA2 and CA3 regions of the hippocampus, both N. s. and H. p. reversed the CMS-induced decrease in $5-HT_{1A}$receptor binding. In the I to II regions of the frontal cortex, N. s. and H. p. also reversed the CMS-induced decrease in$5-HT_{1A}$receptor binding, and even showed a significant increase in $5-HT_{1A}$receptor binding compared to the F treatment group (N. s. vs. P, p<0.05, H. p. vs. P, p<0.05). However, in the hypothalamus, all treatments reversed the CMSinduced decrease in $5-HT_{1A}$receptor binding. This reversal effect of N. s. on the decrease in $5-HT_{1A}$receptor binding in the frontal cortex, hippocampus and hypothalamus of rat brains was very similar to that of H. p, but different from that of F. It is concluded that N. s. presents an anti-depression effect through enhancing $5-HT_{1A}$receptor binding.

• Journal of Periodontal and Implant Science
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• v.43 no.5
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• pp.209-214
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• 2013

Purpose: To assess bony trabecular changes potentially caused by loading stress around dental implants using fractal dimension analysis. Methods: Fractal dimensions were measured in 48 subjects by comparing radiographs taken immediately after prosthesis delivery with those taken 1 year after functional loading. Regions of interest were isolated, and fractal analysis was performed using the box-counting method with Image J 1.42 software. Wilcoxon signed-rank test was used to analyze the difference in fractal dimension before and after implant loading. Results: The mean fractal dimension before loading ($1.4213{\pm}0.0525$) increased significantly to $1.4329{\pm}0.0479$ at 12 months after loading (P<0.05). Conclusions: Fractal dimension analysis might be helpful in detecting changes in peri-implant alveolar trabecular bone patterns in clinical situations.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.9 no.1
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• pp.64-69
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• 1999

Polyacrylonitrile(PAN)-based carbon fiber tows were heat-treated by the internal resistance heating method under the certain load. To consider the strain behavior of the fiber tows during heat-treatments, 1200~$2200^{\circ}C$, strain changes of those were measured. It was observed that the larger longitudinal strain was induced under the larger stretching stress. The changes in the strain are different from the temperature regions below and above $1700^{\circ}C$. Obtained apparent activation energies under the stretching stresses of 70 and 322 MPa from time-strain curves were 67.46 and 52.27kJ$mol^{-1}$, respectively. Therefore, it was known that the larger stretching stresses effectively reduce the apparent activation energy of the fiber structure development of the fiber tows.

• Structural Engineering and Mechanics
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• v.73 no.6
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• pp.685-698
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• 2020

The dynamic stability of a functionally graded polymer microbeam reinforced by graphene oxides subjected to a periodic axial force is investigated. The microbeam is assumed to rest on an elastic substrate and is subjected to various immovable boundary restraints. The weight fraction of graphene oxides nanofillers is graded across the beam thickness. The effective Young's modulus of the functionally graded graphene oxides reinforced composite (FG-GORC) was determined using modified Halpin-Tsai model, with the mixture rule used to evaluate the effective Poisson's ratio and the mass density. An improved third order shear deformation theory (TSDT) is used in conjunction with the Chebyshev polynomial-based Ritz method to derive the Mathieu-Hill equations for dynamic stability of the FG-GORC microbeam, in which the scale effect is taken into account based on modified couple stress theory. Then, the Mathieu-Hill equation was solved using Bolotin's method to predict the principle unstable regions of the FG-GORC microbeams. The numerical results show the effects of the small scale, the graphene oxides nanofillers as well as the elastic substrate on the dynamic stability behaviors of the FG-GORC microbeams.

• Transactions of Materials Processing
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• v.3 no.1
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• pp.97-109
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• 1994

Closed-die forging of the spur gears with circular are fillet has been analyses by using the upper-bound method. A kinematically admissible velocity field has been developed, wherein, the tooth profile consists of the involute curve and the circular arc fillet. In the analysis, the deformation regions have been divided into eight zones. A constant frictional stress has been assumed on the contacting surfaces Utilizing the formulated velocity field, numerical calculations have been carried out to investigate the effects of various parameters, such as module, number of teeth, addendum modification coefficient and friction factor, on the relative forging pressure of spur gears. As the result of numerical calculations, the relative forging pressure does not change so much against the variation of module. On the other hand, the relative forging pressure increases at the final filling stage as the addendum modification coefficient increases.

• Proceedings of the KSME Conference
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• 2004.11a
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• pp.419-424
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• 2004

we performed the underwater explosion analysis for the liquefied oxygen tank - a kind of fuel tank of a mid-size submarine, and tried to verify the structural safety for this structure. First, we reviewed the theory and application of underwater explosion analysis using Structure-Fluid Interaction technique and its finite element modeling scheme. Next, we modeled the explosive and sea water as fluid elements, the LOX tank as structural elements and the interface between two regions as ALE scheme. The effect on shock pressure and impulse of fluid mesh size and shape are also investigated. As the analysis result, the shock pressure due explosion propagated into the water region and hit the structure region. The plastic deformation and the equivalent stress highly appeared at the web frame and the shock mount of LOX structure, but these values were acceptable for design criteria.

• Molecular & Cellular Toxicology
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• v.4 no.3
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• pp.199-204
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• 2008

The bio-molecules involved in defense mechanisms can be used as efficient biomarkers for physiological changes in organisms caused by both of internal and external stress. Thus, the expression level of genes which encoding such molecules serve as critical 'early warning system' for environmental assessment as well as health diagnosis of biological organisms. In this study, Cytochrome P450, Heat shock protein 90, Ubiquitin and ${\beta}$-actin gene were isolated for the first time from a red alga Gracilaria textorii. The quantitative differential gene expression analyses of three genes, GteCYP1A, GteHsp90 and Gte-UB, were carried out in G. textorii sporophytes collected from two different localities, polluted Sujeong (Masan, Korea) and potentially unpolluted Danggeum (Daemaemuldo Is., Korea). The transcripts of all three tested genes were highly expressed in the Sujeong population. The results suggest: 1) the Sujeong site was more polluted than the Danggeum site; 2) G. textorii could be applicable to marine environment monitoring in coastal regions.

• Journal of Environmental Health Sciences
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• v.35 no.5
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• pp.343-354
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• 2009

Since Barker found associations between low birth weight and several chronic diseases later in life, the hypothesis of fetal origins of adult disease (aka, Barker Hypothesis) and epigenetics have been emerging as a new paradigm for geneenvironment interaction of chronic disease. Epigenetics is the study of heritable changes in gene silencing that occur without any change in DNA sequence. Gene expression can be regulated by several epigenetic mechanisms, including DNA methylation and histone modifications, which may be associated with chronic conditions, such as cancers, cardiovascular disease, and type-2 diabetes. One carbon metabolism which involves the transfer of a methyl group catalyzed by DNA methyltransferase is an important mechanism by which DNA methylation occurs in promoter regions and/or repetitive elements of the genome. Environmental factors may induce epigenetic modification through production of reactive oxygen species, alteration of methyltransferase activity, and/or interference with methyl donors. In this review, we introduce recent studies of epigenetic modification and environmental factors, such as heavy metals, environmental hormones, air pollution, diet and psychosocial stress. We also discuss epigenetic perspectives of early life environmental exposure and late life disease occurrence.

• Journal of Powder Materials
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• v.22 no.2
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• pp.105-110
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• 2015

In this study, effect of core-shell structure on compaction behavior of harmonic powder is investigated. Harmonic powders are made by electroless plating method on Fe powders. Softer Cu shell encloses harder Fe core, and the average size of Fe core and thickness of Cu shell are $34.3{\mu}m$ and $3.2{\mu}m$, respectively. The powder compaction procedure is processed with pressure of 600 MPa in a cylindrical die. Due to the low strength of Cu shell regions, the harmonic powders show better densification behavior compared with pure Fe powders. Finite element method (FEM) is performed to understand the roll of core-shell structure. Based on stress and strain distributions of FEM results, it is concluded that the early stage of powder compaction of harmonic powders mainly occurs at the shell region. FEM results also well predict porosity of compacted materials.