• BMB Reports
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• v.48 no.8
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• pp.429-430
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• 2015

Angiogenesis is a complex process involving dynamic interaction of various cell to cell interactions. Endothelial cell interactions regulated by growth factors, inflammatory cytokines, or hemodynamic stress are critical for balancing vascular quiescence and activation. Yes-associated protein (YAP), an effector of Hippo signaling, is known to play significant roles in maintaining cellular homeostasis. However, its role in endothelial cells for angiogenic regulation remains relatively unexplored. We demonstrated the critical role of YAP in vascular endothelial cells and elucidated the underlying molecular mechanisms involved in angiogenic regulation of YAP. YAP was expressed in active angiogenic regions where endothelial cell junctions were relatively loosened. Consistently, YAP subcellular localization and activity were regulated by VE-cadherin-mediated PI3K/Akt pathway. YAP thereby regulated endothelial sprouting via angiopoietin-2 expression. These results provide an insight into a model of coordinating endothelial junctional stability and angiogenic activation through YAP. [BMB Reports 2015; 48(8): 429-430]

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.19 no.8
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• pp.1-7
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• 2020

In this study, three models on the installation of automotive additional front bumper guard were designed and the structural analysis was carried out. The additional front bumper models B and C appears to be safer on stability instead of the basic front bumper model A. Model A with a simple structure is shown to have the safe region overall except in the area where the load is applied directly. Models B and C are shown to have the shortest lives at the regions where the bumpers are connected with each other. By comparing with the least fatigue lives at models A, B and C, Model B has the longest life with the best durability.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.24 no.4
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• pp.495-503
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• 2000

The present numerical study investigates flow characteristics and heat transfer enhancement of the viscoelastic non-Newtonian fluid in a 2:1 rectangular duct. The combined effect of temperature-dependent viscosity, buoyancy and secondary flow caused by second normal stress difference are all considered. The Reiner-Rivlin model is used as a viscoelastic fluid model to simulate the secondary flow and temperature-dependent viscosity model is adopted. Three types of thermal boundary conditions involving different combinations of heated walls and adiabatic walls are considered in this study. Calculated Nusselt numbers are in good agreement with experimental results in both the thermal developing and thermally developed regions. The heat transfer enhancement can be explained by the combined viscoelasticity-driven secondary flow, buoyancy-induced secondary flow and temperature-dependent viscosity.

• 한국공간정보시스템학회:학술대회논문집
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• 2004.05a
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• pp.206-211
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• 2004

This paper deals with the flexural strengthening of reinforced concrete beams by means of thin fiber reinforced plastic(FRP) laminas. This study focuses on modeling of structural of concrete bonded FRP laminate in flexural bending members. Used computational equation is derived by relation of stress and strain. The section analysis is based on experimental observations of a linear strain distribution in the cross section until failure, and a multi-linear moment-deflection curve that is divided into four regions, each terminated by a similarly numbered point. The load-deflection relationship in each region is assumed to be linear. The present model is validated to compare wit the experiment of 4-point bending tests of R/C rectangular beams strengthened with CFRP laminates, and has well predicted the moment-displacement relationships of members.

• Structural Engineering and Mechanics
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• v.9 no.1
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• pp.51-68
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• 2000

The paper presents theoretical and experimental investigations on three varying thickness circular cylinders, which were tested to destruction under external hydrostatic pressure. The five buckling theories that were presented were based on inelastic shell instability. Three of these inelastic buckling theories adopted the finite element method and the other two theories were based on a modified version of the much simpler von Mises theory. Comparison between experiment and theory showed that one of the inelastic buckling theories that was based on the von Mises buckling pressure gave very good results while the two finite element solutions, obtained by dividing the theoretical elastic instability pressures by experimentally determined plastic knockdown factors gave poor results. The third finite element solution which was based on material and geometrical non-linearity gave excellent results. Electrical resistance strain gauges were used to monitor the collapse mechanisms and these revealed that collapse occurred in the regions of the highest values of hoop stress, where considerable deformation took place.

• Proceedings of the KSR Conference
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• 2007.05a
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• pp.1626-1630
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• 2007

This dissertation finds out trouble types and occurrence regions using the faulty statistics of nondestructive test items in rolling stock parts of the Seoul Metro and using mechanical test about defective and broken parts with broken surface observation, cutting examination about trouble region, hardness experiment and tensile test. Also this dissertation finds out cause of trouble and damage through observation of microscopic formation using metallurgical microscope and scanning electron microscope, residual stress measurement about welding parts and damage diagnosis about defective and broken parts. Moreover it will present the improved plan of nondestructive method about trouble and the removal method of defect and repair welding and find solutions of reliability in parts and preventive maintenance.

• Proceedings of the Korea Concrete Institute Conference
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• 2003.05a
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• pp.865-871
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• 2003

This paper presents the test results of 24 beam-end specimens to investigate the effect of concrete strength and cover thickness on the development resistance capacity in tensile lap splice length regions. The results showed that as higher strength concrete was employed, nor only development resistance capacity was influenced by cover thickness, but also more sufficient safety factor reserved shorter than the lap splice length provision in current design code. From experimental research results, high-strength concrete development length was not inverse ratio of ($\sqrt{f_{ck}}$) but directly inverse of $f_{ck}$, and it is also said that there is a certain limit length of the embedded steel over which the assumption of uniform bond stress distribution is valid specially for high-strength concrete not having a same embed length such as normal-strength concrete in current design criteria hypothesis.

• Proceedings of the KIEE Conference
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• 2015.07a
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• pp.742-743
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• 2015

Magnetic couplings are do not require any mechanical contact with the power transmitted to the secondary side according to the primary side. For this reason, well-suited for isolated systems such as vacuums or high pressure. So, this paper presents the force characteristic analysis of the permanent magnet (PM) linear coupling with vertical magnetized using an analytical magnetic field calculations. Based on the definition of governing equations and magnetic vector potential, we obtained the analytical solutions according to the boundary condition for each of the regions. Also, we derived from the force generated in the permanent magnet surface using the Maxwell stress tensor. The analytical results are proved the validity by comparing to the finite element method (FEM).

• Structural Engineering and Mechanics
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• v.75 no.1
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• pp.101-108
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• 2020

The present study intends to analyze damage in thin-walled steel cylinders undergoing constant internal pressure and thermal cycles through use of anisotropic continuum damage mechanics (CDM) model coupled with nonlinear kinematic hardening rule of Chaboche. Materials damage in each direction was defined based on plastic strain and its direction. Stress and strain distribution over wall-thickness was described based on the CDM model and the return mapping algorithm was employed based on the consistency condition. Plastic zone expansion across the wall thickness of cylinders was noticeably affected with change in internal pressure and temperature gradients. Expansion of plastic zone over wall-thickness at inner and outer surfaces and their boundaries demarking elastic and plastic regions was attributed to the magnitude of damage induced over thermomechanical cycles on the thin-walled samples tested at various pressure stresses.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.1
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• pp.31-34
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• 2015

While mammography has been used for diagnosis of breast cancer in Kazakhstan for a long period, published data are very limited. Recently stress has been placed on increasing the accuracy by double reading of mammograms. Here we provide an overview of breast cancer screening in the different regions of Kazakhstan with data on the stages of cancers detected. A total 459,816 women aged 50, 52, 54, 56, 58 and 60 years were screened in 2012 and 379,903 in the first 9 months of 2013. Clear differences in levels of detection were noted between urban and rural residents, the latter demonstrating lower rates for both screening and cancer detection. Women aged 50 were more likely to undergo screening than their counterparts aged 60. While there were no clear relationships evident between screening rates and stage or numbers of breast cancers observed, this might be due to a number of complicating factors like geographical variation in risk factors as well as ethnicity. Future analyses should focus on the efficacy of mammography in Kazakhstan to reduce mortality.