• Journal of Biomedical Engineering Research
• /
• v.15 no.3
• /
• pp.253-258
• /
• 1994

Three-dimensional steady and pulsatile flows in an end-to-side anastomosis were investigated using a finite difference method in order to understand the flow dynamics in the preferential development of distal anastomotic intimal hyperplasia or thrombosis. Steady flow results revealed that a double helical vortex was formed in the host artery and flow recirculations near toe find heel regions were restricted due to the secondary flow. Oscillating wall shear stress with significant secondary flow might be flow dynamic reason of developing intimal hyperplasia or thrombosis near the anastomotic region.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 1999.11a
• /
• pp.457-460
• /
• 1999

The effects of electrical positive stress on n-channel LDD and offset structured poly-Si TFT\`s have been systematically investigated in order to analyze the transfer curve\`s shift mechanism. It has been found that the LDD and offset regions behave as a series resistance that reduce the electric field near drain. Hot carrier effects are reduced because of these results. After electrical stress transfer curve’s shift and variation of the off-current are dependent upon the offset length rather than offset region’s doping concentration. Variation of the subthreshold slope is dependent upon offset region’s doping concentration as well as offset length.

• Journal of Welding and Joining
• /
• v.17 no.2
• /
• pp.36-43
• /
• 1999

The effect of microstructure on the fracture toughness of multi pass weld metal has been investigated. The micromechanisms of fracture process are identified by in-situ scanning electron microscopy(SEM) fracture observation using single edge notched specimen. The notches of the in-situ fracture specimens were carefully located such that the ends of the notches were in the as-deposited top bead and the reheated weld metal respectively. The observation of in-situ fracture process for as-deposited top bead indicated that as strains are applied, microcracks are formed at the interfaces between soft proeutectoid ferrite and acicular ferrite under relatively low stress intensity factor. Then, the microcracks propagate easily along the proeutectoid ferrite phase, leading to final fracture. These findings suggest that proeutectoid ferrite plays an important role in reducing the toughness of the weld metal. On the other hand, reheated regions showed that the microcrack initiated at the notch tip grows along the localized shear bands under relatively high stress intensity factor, confirming that reheated area showing momogeneous and fine microstructure would be beneficial to the fracture resistance of weld metal.

• Computers and Concrete
• /
• v.28 no.6
• /
• pp.621-634
• /
• 2021

For the reliable strut-and-tie model (STM) design of disturbed regions of concrete members, structural designers must accurately determine the strength of concrete struts to check the strength conditions of a selected STM el and the anchorage of reinforcing bars in nodal zones. In this study, the author proposed a consistent numerical method for strut strength, applicable to all two-dimensional STMs. The proposed method includes the effects of a biaxial stress state associated with tensile strains in reinforcing bars crossing a strut, deviation angle between strut orientation and compressive principal stress flow, and degree of confinement provided by reinforcement. The author examined the method's validity through the STM prediction of the ultimate strengths of 517 reinforced concrete (RC) deep beams, 24 RC panels, and 258 RC corbels, all tested to failure.

• Biomolecules & Therapeutics
• /
• v.32 no.4
• /
• pp.451-459
• /
• 2024

Apoptosis signal-regulating kinase 1 (ASK1) is an upstream signaling molecule in oxidative stress-induced responses. Because oxidative stress is involved in asthma pathogenesis, ASK1 gene deficiency was investigated in animal models of allergic asthma. However, there is no study to investigate whether ASK1 inhibitors could be applied for asthma to date. Selonsertib, a potent and selective ASK1 inhibitor, was applied to BALB/c mice of an ovalbumin (OVA)-induced allergic asthma model. Selonsertib suppressed antigen-induced degranulation of RBL-2H3 mast cells in a concentration-dependent manner. The administration of selonsertib both before OVA sensitization and OVA challenge significantly reduced airway hyperresponsiveness, and suppressed eosinophil numbers and inflammatory cytokine levels in the bronchoalveolar lavage fluid. Histopathologic examination elucidated less inflammatory responses and reduced mucin-producing cells around the peribronchial regions of the lungs. Selonsertib also suppressed the IgE levels in serum and the protein levels of IL-13 in the bronchoalveolar lavage fluid. These results suggest that selonsertib may ameliorate allergic asthma by suppressing immune responses and be applicable to allergic asthma.

• Korean Journal of Health Education and Promotion
• /
• v.21 no.3
• /
• pp.195-211
• /
• 2004

Stress is a primary health promotion issue in worksite research because psychological distress is closely related not only to workers' health status but also to their job performance. This study identified the significant health behaviors affecting workers' job-related stress in Korean manufacturing industry with the national survey data conducted by the Korean Occupational Safety and Health Agency in 2003. A total of 7,818 factory workers in 1,562 manufacturing companies participated in the Korean nation-wide occupational health survey and 3,390 workers answered that they had any stressors in their workplace among the 7,818 workers finally participated in the analysis. Participants were selected by the stratified proportional sampling process by manufacturing industry classification, company size, and company locations (8 metropolitan and 8 non-metropolitan regions) in Korea. Trained interviewers visited the target companies and interviewed the factory workers randomly selected in each company. Smoking, drinking, weight control, exercise, sleeping, break time at work, and perceived fatigue were included in the health behavior construct. Stress symptoms was consisted of physical and psychological stress with 8 items. All survey responses were anonymously coded into the SPSS statistical program and testified using stepwise multiple regression analysis. Male workers were 73.5% and the 30s were 40.0% among the age groups. The married and the high school graduate were majority with 52.1% and 61.8% each. Current smokers were 44.7% and More than 50% of the participants drank alcohol sometimes. No exercise group was 59.3% and the participants who dissatisfied with their daily sleeping hours were 43.5%. In t-test and analysis of variance, the significant general characteristics associated with physical and psychological job stress were young age (p<0.001), single marital status (p<0.001), and short working period at the present company (p<0.001). The health behaviors related to physical job stress were current smoking, weight change during the past one year (p<0.001), weight control effort (p<0.001), exercise (p<0.001), daily sleeping dissatisfaction (p<0.001), break time, and perceived fatigue (p<0.001). All 10 health behavior factors were significantly associated with psychological job stress (p<0.05). Weight change, weight control effort, exercise, daily sleeping dissatisfaction, little break at work, and high perceived fatigue were significant factors affecting job stress. Daily sleeping dissatisfaction, little break at work, little exercise, weight change for the past one year and young age were selected as the significant health behavior and general factors affecting physical job stress symptoms in stepwise multiple regression analysis. The five factors explained 18.9% of the physical stress score variance. Six factors were selected as the significant health behaviors affecting psychological job stress: daily sleeping dissatisfaction, little exercise, frequent drinking alcohol, high perceived fatigue, little break at work, and little weight control effort. The six factors explained 10.6% of the psychological stress score variance.

• Journal of the Korean Society for Nondestructive Testing
• /
• v.28 no.2
• /
• pp.125-130
• /
• 2008

A spherical indentation has been proposed as a nondestructive method of measuring local residual stress field in laser-voided joints. The apparent yield strengths interpreted from the spherical indentation data of as-welded cutting wheel were compared with the intrinsic yield strengths measured at nearly equivalent locations in annealed wheel. Their difference along the distance from the welding line is welding stress distribution because the intrinsic yield strength is invariant regardless of the elastic residual stress. The spherical indentations show that the laser-welded diamond cutting wheel displays a 10 min-wide distribution of the welding residual stress and has peak compressive and tensile stresses in the shank and tip regions, respectively.

• BMB Reports
• /
• v.39 no.6
• /
• pp.749-758
• /
• 2006

The cytosolic members of the HSP70 family of proteins play key roles in the molecular chaperone machinery of the cell. In the study we cloned and sequenced the full-length cDNA of Delia antiqua HSP70 gene, which is 2461 bp long and encodes 643 a.a. with a calculated molecular mass of 70,787 Da. We investigated gene copies of cytosolic HSP70 members of 4 insect species with complete genome available, and found that they are quite variable with species. In order to characterize this protein we carried out an alignment and a phylogenetic analysis with 41 complete protein sequences from insects. The analysis divided the cytosolic members of the family into two classes, HSP70 and HSC70, distinguishable on the basis of 15 residues. HSP70 class members were slightly shorter in length and smaller in molecular mass relative to the HSC70 class members, and the conservative and functional regions in these sequences were documented. Mainly, we investigated the expression of Delia antiqua HSP70 gene, in response to diapauses and thermal stresses. Both summer and winter diapauses elevated HSP70 transcript levels. Cold-stress led to increased HSP70 expression levels in summer- and winter-diapausing pupae, but heat-stress elevated the levels only in the winter-diapausing pupae. In all cases, the expression levels, after being elevated, gradually decreased with time. HSP70 expression was low in non-diapausing pupae but was up-regulated following cold- and heat-stresses. Heat-stress gradually increased the mRNA level with time whereas cold-stress gradually decreased levels after an initial increase.

• Proceedings of the Korean Vacuum Society Conference
• /
• 2010.08a
• /
• pp.157-157
• /
• 2010

Vertical-structure light-emitting diodes (V-LEDs) by laser lift-off (LLO) have been exploited for high-efficiency GaN-based LEDs of solid-state lightings. In V-LEDs, emitted light from active regions is reflected-up from reflective ohmic contacts on p-GaN. Therefore, silver (Ag) is very suitable for reflective contacts due to its high reflectance (>95%) and surface plasmon coupling to visible light emissions. In addition, low contact resistivity has been obtained from Ag-based ohmic contacts annealed in oxygen ambient. However, annealing in oxygen ambient causes Ag to be oxidized and/or agglomerated, leading to degradation in both electrical and optical properties. Therefore, preventing Ag from oxidation and/or agglomeration is a key aspect for high-performance V-LEDs. In this work, we demonstrate the enhanced thermal stability of Ag-based Ohmic contact to p-GaN by reducing the thermal compressive stress. The thermal compressive stress due to the large difference in CTE between GaN ($5.6{\times}10^{-6}/^{\circ}C$) and Ag ($18.9{\times}10^{-6}/^{\circ}C$) accelerate the diffusion of Ag atoms, leading to Ag agglomeration. Therefore, by increasing the additional residual tensile stress in Ag film, the thermal compressive stress could be reduced, resulting in the enhancement of Ag agglomeration resistance. We employ the thin Ni layer in Ag film to form Ni/Ag mutli-layer structure, because the lattice constant of NiO ($4.176\;{\AA}$ is larger than that of Ag ($4.086\;{\AA}$). High-resolution symmetric and asymmetric X-ray diffraction was used to measure the in-plane strain of Ag films. Due to the expansion of lattice constant by oxidation of Ni into NiO layer, Ag layer in Ni/Ag multi-layer structure was tensilely strained after annealing. Based on experimental results, it could be concluded that the reduction of thermal compressive stress by additional tensile stress in Ag film plays a critical role to enhance the thermal stability of Ag-based Ohmic contact to p-GaN.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.39 no.1
• /
• pp.219-225
• /
• 2019

Computing low temperature performance of asphalt mixture is one of the important tasks especially for cold regions. It is well known that experimental creep testing work is needed for computation of thermal stress and critical cracking temperature of given asphalt mixture. Thermal stress is conventionally computed through two steps of computation. First, the relaxation modulus is generated thorough the inter-conversion of the experimental creep stiffness data through the application of Hopkins and Hamming's algorithm. Secondly, thermal stress is numerically estimated solving the convolution integral. In this paper, one-step thermal stress computation methodology based on the Laplace transformation is introduced. After the extensive experimental works and comparisons of two different computation approaches, it is found that Laplace transformation application provides reliable computation results compared to the conventional approach: using two step computation with Hopkins and Hamming's algorithm.