• The Korea Journal of Herbology
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• 제33권1호
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• pp.37-46
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• 2018

Objectives : Liver disease is an inflammatory reaction caused by oxidative stress, viral, alcohol, and drug properties. Inflammatory reaction causes hepatitis and chronic hepatitis is persistent, it progresses to liver fibrogenesis and liver cancer. The aim of this study was to confirm the hepatoprotective effect of Tongyuhwalhyeol-tang(Tongqiaohuoxue Decoction) (TH) and Gamtongyuhawlhyeol-tang(GTH) in TAA-induced liver injury animal model. Methods : The antioxidant activities were evaluated through in vitro experiments, such as 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and 2, 2'-azinobis-3-ethyl-benzothiazoline-6-sulfonic acid (ABTS) radical scavenging assays, total polyphenol and total flavonoid content measurement. To confirm the liver protective effect, induced by Thioacetamide (TAA) for 3 days injection at 200 mg/kg rats. TH and GTH were treated 3 days at 200 mg/kg/day. The changes of reactive oxygen species (ROS), peroxynitrite ($ONOO^-$), alanine aminotransferanse (ALT) and aspartate aminotransferase (AST) in serum were analyzed after experiment. Also, expression of anti-inflammation, anti-oxidant related proteins were investigated by western blot analysis. Results : TH was inhibited the antioxidant activities. In the TAA-induced rat, TH decreased ROS, $ONOO^-$, ALT, AST level in serum. Inflammation related protein expressions increased in TAA-induced rat compared to normal rat. However, TH group inhibited the down expression of these proteins. Also, anti-oxidant related protein expressions increased in TH group compared TAA-induced rat. Conclusion : Therefor, these results suggested that TH provided hepatoprotective effects on the hepatic injury leading to the reduction of inflammatory response. In addition, the effect of TH was superior to that of GTH.

• Journal of the Computational Structural Engineering Institute of Korea
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• 제35권4호
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• pp.243-248
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• 2022

Weight optimization was performed for a rotorcraft shaft system using one-dimensional Euler-Bernoulli beam elements. Torsion, shaft support stiffness such as bearings, flange mass are all considered. To guarantee structural dynamic stability, eigenvalue analysis was performed to avoid critical speed and tooth mesh excitation form the gearbox. The weight optimization was performed by adjusting the thickness and radius while the length of the shaft was fixed, and the optimization process was divided into two stages. In the first, the weight is optimized with the torsional strength constraint. In the second, the difference between the primary mode of shaft and the critical speed is maximized so that the primary mode of the shaft can avoid the critical speed while the constraint on the torsional strength of the shaft is satisfied according to the standard for shaft system stability (AMC P 706-201, 1974). The proposed method was verified by comparing the results of the optimal design using the given one-dimensional beam elements with the stress results of the 3D finite element and the actual manufactured shaft.

• Journal of Life Science
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• 제32권2호
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• pp.125-134
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• 2022

This study investigated whether or not the major bioactive compounds of Noni (Morinda citrifolia) are involved in anti-inflammatory activity through the JAK/STAT upper signaling pathway in RAW 264.7 cells. The experimental results show that the M. citrifolia ethyl acetate fraction (Mc-EtOAc) obtained by sequential fractionation with organic solvents from the plant's dried fruits exhibits the highest antioxidant activity. In addition, the cytoprotective effects of Mc-EtOAc against H₂O₂-induced oxidative stress in the RAW 264.7 cells suppressed cytotoxicity in a dose-dependent manner. The group pretreated with Mc-EtOAc at a concentration of 240 ㎍/ml showed higher cell viability of 84.5%, compared to 71.6% in the LPS-treated group, and LPS-induced NO production decreased to half the amount in the positive control group. Mc-EtOAc treatment also led to a significant dose-dependent reduction in iNOS expression. Although COX-2 expression was increased by 300% following LPS induction, it was significantly decreased in a dose-dependent manner by pretreatment with Mc-EtOAc at concentrations of 120 and 240 ㎍/ml. An inhibition of the mRNA expression of pro-inflammatory cytokines IL-1β and TNF-α was observed. The investigation also revealed that the phosphorylation levels of pJAK1 and pSTAT3 in LPS-induced RAW 264.7 cells were significantly reduced by Mc-EtOAc treatment.

• Journal of the Korean Society of Marine Environment & Safety
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• 제28권7호
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• pp.1244-1251
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• 2022

Marine accidents due to a loss of stability, have been gradually increasing over the last decade. Measures must be taken on the roll reduction of a ship. Amongst the measures, building an anti-roll tank in a ship is recognized as the most simple and effective way to reduce the roll motion. Therefore, this study aims to develop a computational model for a U-tube type anti-roll tank and to validate it by experiment. In particular, to validate the developed computational model, the height of the free surface in the tank was measured in the experiment. To develop a computational model, the mesh dependency test was carried out. Further, the effects of a turbulence model, time step size, and the number of iterations on the numerical solution were analyzed. In summary, a U-tube type anti-roll tank simulation had to be performed accurately with conditions of a realizable k-𝜖 turbulence model, 10^-2s time step size, and 15 iterations. In validation, the two cases of measured data from the experiment were compared with the numerical results. In the present study, STAR-CCM+ (ver. 17.02), a RANS-based commercial solver was used.

• Composites Research
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• 제20권4호
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• pp.31-41
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• 2007

Dome shape design methods of Filament Winding (FW) composite pressure vessel, which can suggest various dome contour according to the external loading conditions, were investigated analytically and numerically. The performance indices(PV/W) of the pressure vessels with same cylinder radius and boss opening but different dome shape were evaluated by finite element analysis under the internal pressure loading condition. The analysis results showed that as the dome shape becomes flat, the performance index decreases significantly due to the reduced burst pressure. Especially, for the case of the high value of the parameter ro, the ratio between the radii of the cylinder part and the boss opening, the flat dome is disadvantageous in the aspect of the weight reduction, and additional reinforcing dome design technique should be required to increase the burst pressure. For example, above ro=0.54 condition, the dome shape change according to the loading condition could cause the low burst pressure and increase of composite weight in dome region and is not recommendable except for the special case that maximum inner volume or sufficient space between skirt and dome is the primary design objective. However, at ro=0.35, the dome shape change brings not so significant differences in the performance of FW vessel.

• Journal of the Korean Institute of Gas
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• 제27권2호
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• pp.39-48
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• 2023

This study presents the experimental results to measure the adsorption amount of methane gas by coal according to the conditions of a coalbed methane (CBM) reservoir. Adsorbed gas to coal seam particles was measured under reservoir conditions (normal pressure ~ 1,200 psi pressure range, temperature range15 ~ 45℃) using coal samples obtained from random mines in Kalimantan Island, North Indonesia. The obtained amount of absolute adsorbed gas was applied to triangular with linear interpolation to calculate the maximum amount of adsorbed gas according to temperature and pressure change, at which no experiment was performed. As a result, it was revealed that the amount of adsorbed gas to coal particles increased as the pressure increased and temperature decreased, but the increase of the amount of adsorbed gas decreased at more than an appropriate depth(1,000 ft). In the cleat permeability and cleat porosity for each depth of the coal bed considering the effective stress, the cleat permeability was 28.86 ~ 46.81 md, and the cleat porosity was 0.83 ~ 0.98%. This means that the gas productivity varies significantly with the depth because the reduction of the permeability according to the depth in the coal seam is significant. Therefore, a coalbed depth should be considered essential when designing the spacing of production wells in a coalbed methane reservoir in further study.

• KSCE Journal of Civil and Environmental Engineering Research
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• 제28권6C호
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• pp.321-329
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• 2008

In this study, a series of column test as a way in order to make up for the weakness point of the conventional acceleration method were conducted to both propose the suction board drain method and grapes the specific improvement character of this method as a result of a sort of plastic drain board and a phase of vacuum pressure conditions. On this occasion, the study focused on computing the effective factors of the fittest Suction board drain method affected by each condition through confirming the settlement generated during the test, the water content reduction and stress increase effect occurred arising from the test, and the ratio of consolidation related to the improvement period. In accordance with the shape of core and that whether the core is attached to the filter(pocket or adhesion), the castle type of adhesion and the column type of pocket are more efficient than the others as a consequence of the test to find out the improvement effect depending on each drainage such as a castle type, coil type, harmonica type, column type of pocket and a castle of the adhesion. In case of the step suction pressure, the shorter the period of $-0.8\;kg/cm^2$ as a final step of the suction pressure is, the better the improvement is. In addition, the correlation between degree of consolidation per each suction pressure level and duration of application was drawn as a curve and the point of inflection on this curve was provided to determine the duration period to maximize the consolidation.

• Proceedings of the Korean Society of Crop Science Conference
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• 한국작물학회 2022년도 추계학술대회
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• pp.95-95
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• 2022

Maize is one of the world's three largest crops and has a long cultivation history, and is an important crop used for various purposes such as food, feed, and industrial raw materials. Recently, the agricultural environment is changing, in which the limit of cultivation of crops is shifted to the north due to the rise in temperature due to climate change. This study was conducted in experimental field of Suwon in 2022 by setting a seeding period earlier than the sowing time to establish the North Korean agricultural climatic zone and meteorological conditions. The test cultivars were silage cultivars, Kwangpyeongok and Dacheongok. As a priming test method, it was used to directly plant seeds in the field through immersion using 4mM zinc (Zn) and 2.5mM manganese (Mn), which are trace elements for seeds. The planting season was early on March 15th, April 1st, and April 15th. The number of days from sowing to silk stage of the two cultivars sown on March 15, April 1, and April 15 was 107, 93, and 85 days for Kwangpyeongok and 109, 95, and 87 days for Dacheongok, respectively. The seed priming test did not show any difference from the control group in the growth survey up to the middle stage of growth. In another test, low-temperature recovery was confirmed through nitrogen (2-5%) foliar fertilization after 3 days, 5 days, and 7 days in refrigeration (0 degrees), a selective low temperature treatment for com in the third leaf stage. As a result of this study, it was confirmed that the low-temperature damaged com treated at 0℃ showed the same growth as that of the untreated com through nitrogen foliar fertilization. These results suggest that urea foliar fertilization for low-temperature damage reduction of corn for silage in high-latitude climates will be helpful. In addition, through the results of the study, additional studies are needed on the recovery mechanism and field application through urea foliar fertilization.

• Journal of the Korean Society of Marine Environment & Safety
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• 제29권7호
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• pp.992-1001
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• 2023

OWEC (Overtopping Wave Energy Converter) is a wave power generation system using the wave overtopping. The performance and safety of the OWEC are affected by wave characteristics, such as wave height, period. To mitigate this issue, optimal OWEC designs based on wave characteristics must be investigated. In this study, the environmental conditions along the Ulleungdo coast were used. The hydraulic efficiency of the OWEC was calculated using SPH (Smoothed Particle Hydrodynamics) by comparing 4 models that changed the substructure. As a result, it was possible to change the substructure. Through design optimization, a new truss-type structure, which is a substructure capable of carrying the design load, was proposed. Through a case study using member diameter and thickness as design variables, structural safety was secured under allowable stress conditions. Considering wave load, the natural frequency of the proposed structure was compared with the wave period of the relevant sea area. Harmonic response analysis was performed using wave with a 1-year return period as the load. The proposed substructure had a reduced response magnitude at the same exciting force, and achieved weight reduction of more than 32%.

• Korean Journal of Radiology
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• 제24권7호
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• pp.647-659
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• 2023

Objective: The study was conducted to investigate the effect of correct occlusion of the left atrial appendage (LAA) on intracardiac blood flow and thrombus formation in patients with atrial fibrillation (AF) using four-dimensional (4D) flow magnetic resonance imaging (MRI) and three-dimensional (3D)-printed phantoms. Materials and Methods: Three life-sized 3D-printed left atrium (LA) phantoms, including a pre-occlusion (i.e., before the occlusion procedure) model and correctly and incorrectly occluded post-procedural models, were constructed based on cardiac computed tomography images from an 86-year-old male with long-standing persistent AF. A custom-made closed-loop flow circuit was set up, and pulsatile simulated pulmonary venous flow was delivered by a pump. 4D flow MRI was performed using a 3T scanner, and the images were analyzed using MATLAB-based software (R2020b; Mathworks). Flow metrics associated with blood stasis and thrombogenicity, such as the volume of stasis defined by the velocity threshold ($\left|\vec{V}\right|$ < 3 cm/s), surface-and-time-averaged wall shear stress (WSS), and endothelial cell activation potential (ECAP), were analyzed and compared among the three LA phantom models. Results: Different spatial distributions, orientations, and magnitudes of LA flow were directly visualized within the three LA phantoms using 4D flow MRI. The time-averaged volume and its ratio to the corresponding entire volume of LA flow stasis were consistently reduced in the correctly occluded model (70.82 mL and 39.0%, respectively), followed by the incorrectly occluded (73.17 mL and 39.0%, respectively) and pre-occlusion (79.11 mL and 39.7%, respectively) models. The surfaceand-time-averaged WSS and ECAP were also lowest in the correctly occluded model (0.048 Pa and 4.004 Pa^-1, respectively), followed by the incorrectly occluded (0.059 Pa and 4.792 Pa^-1, respectively) and pre-occlusion (0.072 Pa and 5.861 Pa^-1, respectively) models. Conclusion: These findings suggest that a correctly occluded LAA leads to the greatest reduction in LA flow stasis and thrombogenicity, presenting a tentative procedural goal to maximize clinical benefits in patients with AF.