• Structural Engineering and Mechanics
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• v.7 no.5
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• pp.513-525
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• 1999

This paper presents exact close form solutions of plastic limit loads of a clamped circular plate under uniformly distributed load with different loading radii. A unified yield criterion, which includes a family of piecewise linear yield criteria and the commonly adopted yield criteria such as the Tresca criterion and the maximum principal deviatoric stress criterion or the twin shear stress criterion that are its special cases, and the Mises criterion can be approximated by it, is employed in the analysis. The plastic limit loads, moment fields and velocity fields of the clamped circular plate are calculated based on the unified yield criterion. The influences of the yield criteria, the edge effects and the loading radius on the plastic limits of the clamped circular plate are investigated. Analytical results are calculated and compared. The exact close form solutions presented in this paper provide efficient approaches for obtaining plastic limit loads and the corresponding moments and velocities of the clamped circular plates. The previously derived solutions based on the Tresca and the Mises criteria are its special cases.

• International Journal of Highway Engineering
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• v.19 no.6
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• pp.47-56
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• 2017

PURPOSES : The purpose of this study is to investigate the stresses of the middle slab in a double-deck tunnel owing to the slab lift to replace the underlying elastic pads during maintenance work. METHODS : The middle slab was divided into three different sections: typical section, expansion joint section, and emergency passageway section. Finite element analysis models of these three sections of middle slab were developed, and the stress distribution and maximum stresses were obtained using the models when the middle slab was lifted to replace the underlying elastic pads. Various slab lifting methods were examined in this study such as one-, two-, and multiple-point lifts, distributed lifts, and one or both slab side edge lifts. RESULTS : When the slab side edge is lifted, the longitudinal stresses of the slab are almost the same as the principal stresses. This implies that the governing stresses are the longitudinal stresses. The maximum stresses with both-edge lifts are generally smaller than those with one-edge lifts at all three sections of middle slab. CONCLUSIONS : If the middle slab in a double-deck tunnel is lifted for maintenance, the slab should be lifted at multiple points along the longitudinal direction to reduce the tensile stresses.

• Journal of Animal Science and Technology
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• v.64 no.1
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• pp.97-109
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• 2022

Species are facing strong selection pressures to adapt to inhospitable high-altitude environments. Yaks are a valuable species and an iconic symbol of the Qinghai-Tibet Plateau. Extensive studies of high-altitude adaptation have been conducted, but few have focused on metabolism. In the present study, we determined the differences in the serum metabolomics between yaks and the closely related species of low-altitude yellow cattle and dairy cows. We generated high-quality metabolite profiling data for 36 samples derived from the three species, and a clear separation trend was obtained between yaks and the other animals from principal component analysis. In addition, we identified a total of 63 differentially expressed metabolites among the three species. Functional analysis revealed that differentially expressed metabolites were related to the innate immune activation, oxidative stress-related metabolism, and energy metabolism in yaks, which indicates the important roles of metabolites in high-altitude adaptation in yaks. The results provide new insights into the mechanism of adaptation or acclimatization to high-altitude environments in yaks and hypoxia-related diseases in humans.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.10 no.5
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• pp.118-123
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• 2001

Most structures of automobile are composed of many substructures connected to one another by various types of mechanical joints. In automotive engineering, it is important to study these connected structures under various dynamic farces for the evaluations of fatigue life and stress concentration exactly. It is rarely obtained the accurate load history of specified positions because of the errors such as modeling, measurement, and etc. In the beginning of design, exact load data are actually necessary for the fatigue strength and life analysis to minimize the cost and time of designing. In this paper, the procedure of practical dynamic load determination is developed by the combination of the principal stresses of F.E. analysis and experiment. Inverse problem and least square pseudo inverse matrix are adopted to obtain an inverse matrix of analyzed stresses matrix. Pseudo-Practical dynamic load was calculated for Lab. Test of sub-structure. GUI program(PLODAS) was developed for whole of above procedure. This proposed method could be extended to any geometric shape of structure.

• Kidney Research and Clinical Practice
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• v.35 no.2
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• pp.69-77
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• 2016

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, and its pathogenesis is complex and has not yet been fully elucidated. Abnormal glucose and lipid metabolism is key to understanding the pathogenesis of DN, which can develop in both type 1 and type 2 diabetes. A hallmark of this disease is the accumulation of glucose and lipids in renal cells, resulting in oxidative and endoplasmic reticulum stress, intracellular hypoxia, and inflammation, eventually leading to glomerulosclerosis and interstitial fibrosis. There is a growing body of evidence demonstrating that dysregulation of 50 adenosine monophosphate-activated protein kinase (AMPK), an enzyme that plays a principal role in cell growth and cellular energy homeostasis, in relevant tissues is a key component of the development of metabolic syndrome and type 2 diabetes mellitus; thus, targeting this enzyme may ameliorate some pathologic features of this disease. AMPK regulates the coordination of anabolic processes, with its activation proven to improve glucose and lipid homeostasis in insulin-resistant animal models, as well as demonstrating mitochondrial biogenesis and antitumor activity. In this review, we discuss new findings regarding the role of AMPK in the pathogenesis of DN and offer suggestions for feasible clinical use and future studies of the role of AMPK activators in this disorder.

• Tribology and Lubricants
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• v.30 no.4
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• pp.199-204
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• 2014

Various heat-treated and surface coating methods are used to mitigate abrasion in sliding machine parts. The most cost effective of these methods involves hard coatings such as diamond-like carbon (DLC). DLC has various advantages, including a high level of hardness, low coefficient of friction, and low wear rate. In practice, a supporting layer is generally inserted between the DLC layer and the steel substrate to improve the load carrying capacity. In this study, an indentation and sliding contact problem involving a small, hard, spherical particle and a DLC-coated steel surface is modeled and analyzed using a nonlinear finite element code, MARC, to investigate the influence of the supporting layer thickness on the coating characteristics and the related coating failure mechanisms. The results show that the amount of plastic deformation and the maximum principal stress decrease with an increase in the supporting layer thickness. However, the probability of the high tensile stress within the coating layer causing a crack is greatly increased. Therefore, in the case of DLC coating with a supporting layer, fatigue wear can be another important cause of coating layer failure, together with the generally well-known abrasive wear.

• Steel and Composite Structures
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• v.28 no.1
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• pp.1-11
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• 2018

In this paper, local ratcheting behavior of 1045 steel plates with circular cutout was investigated. Experimental tests were carried out by a Zwick/Roell HB 100 servo hydraulic machine. In order to measure the local strain at notch root, a data acquisition system with strain gauge was used. Various notch diameters and distances of strain gauges mounted from the notch root were found influential in the magnitude of local ratcheting strain. It was found that the local maximum principal stress plays a crucial role in increasing the local plastic deformation. Numerical simulation was done by ABAQUS software using nonlinear isotropic/kinematic hardening model. Material parameters of hardening model were attained from several stabilized cycles of flat specimens subjected to symmetric strain cycles. The nonlinear kinematic hardening model along with the Neuber's rule was employed to assess local ratcheting at the notch root of steel plates. The results of the numerical simulations agreed closely with those measured values in this study. Both ratcheting progress and mean stress relaxation occurred simultaneously at the notch root.

• The Plant Pathology Journal
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• v.39 no.3
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• pp.245-254
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• 2023

The plant microbiota plays a crucial role in promoting plant health by facilitating the nutrient acquisition, abiotic stress tolerance, biotic stress resilience, and host immune regulation. Despite decades of research efforts, the precise relationship and function between plants and microorganisms remain unclear. Kiwifruit (Actinidia spp.) is a widely cultivated horticultural crop known for its high vitamin C, potassium, and phytochemical content. In this study, we investigated the microbial communities of kiwifruit across different cultivars (cvs. Deliwoong and Sweetgold) and tissues at various developmental stages. Our results showed that the microbiota community similarity was confirmed between the cultivars using principal coordinates analysis. Network analysis using both degree and eigenvector centrality indicated similar network forms between the cultivars. Furthermore, Streptomycetaceae was identified in the endosphere of cv. Deliwoong by analyzing amplicon sequence variants corresponding to tissues with an eigenvector centrality value of 0.6 or higher. Our findings provide a foundation for maintaining kiwifruit health through the analysis of its microbial community.

• Structural Engineering and Mechanics
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• v.91 no.1
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• pp.63-73
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• 2024

Improving the blast resistance of structural establishments has become an imperative engineering commitment to prevent property damage and fatalities in terrorist incidents. This study investigates the effects of blast mass and stand-off distance on CFRP skin concrete core sandwich bunkers of varying thicknesses using ABAQUS/Explicit software with CONWEP functionality. The considered parameters include TNT masses of 1, 10, and 25 kg and stand-off distances of 0.1, 1, 2, and 2.5 meters on structures with 200, 250, and 500 mm core thicknesses. The study finds that there exists a declining response corresponding to the blasting mass reduction coupled with increases in the stand-off distance and core thickness. The 500 mm thick bunker sustains less damage compared to those with 200 mm and 250 mm core thicknesses. The sandwich configuration remains structurally advantageous vs. those without skins. The sandwich bunker with a 500 mm thick concrete core gives the best performance against the 10 kg TNT blast load with a 1 m standoff distance exhibiting a 22.8% reduction in damage vs. that without skins. Mathematical expressions are then formulated for predicting maximum von Mises stress, principal stress, and displacement of sandwich bunkers as functions of TNT masses, stand-off distances, and core thicknesses.

• Molecules and Cells
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• v.25 no.1
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• pp.1-6
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• 2008

Osteoarthritis (OA), one of the most common skeletal disorders characterized by cartilage degradation and osteophyte formation in joints, is induced by accumulated mechanical stress; however, little is known about the underlying molecular mechanism. Several experimental OA models in mice by producing instability in the knee joints have been developed to apply approaches from mouse genetics. Although proteinases like matrix metalloproteinases and aggrecanases have now been proven to be the principal initiators of OA progression, clinical trials of proteinase inhibitors have not been successful for the treatment, turning the interest of researchers to the upstream signals of proteinase induction. These signals include undegraded and fragmented matrix proteins like type II collagen or fibronection that affects chondrocytes through distinct receptors. Another signal is proinflammatory factors that are produced by chondrocytes and synovial cells; however, recent studies that used mouse OA models in knockout mice did not support that these factors have a role in the central contribution to OA development. Our mouse genetic approaches found that the induction of a transcriptional activator Runx2 in chondrocytes under mechanical stress contributes to the pathogenesis of OA through chondrocyte hypertrophy. In addition, chondrocyte apoptosis has recently been identified as being involved in OA progression. We hereby propose that these endochondral ossification signals may be important for the OA progression, suggesting that the related molecules can clinically be therapeutic targets of this disease.