• BMB Reports
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• v.47 no.2
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• pp.98-103
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• 2014

Orostachys japonicus shows various biological activities. However, the molecular mechanisms remain unknown in LPS-stimulated macrophages. Here, we investigated the anti-oxidizing effect of the dichloromethane (DCM) and hexane fractions from O. japonicus (OJD and OJH) against oxidative stress in RAW 264.7 cells stimulated by LPS. OJD and OJH significantly increased the expression of heme oxygenase-1 (HO-1) in a dose- and time-dependent manner. Additionally, it was found that the expression of HO-1 was stimulated by Nrf2 activated via degradation of Keap1. ERK and p38 inhibitors repressed HO-1 induced by OJD and OJH in LPS-stimulated cells, respectively. In conclusion, these results suggest that OJD and OJH may block oxidative damage stimulated by LPS, via increasing the expression of HO-1 and Nrf2, and MAPK signaling pathway.

• Journal of Power Electronics
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• v.12 no.3
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• pp.410-417
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• 2012

In this paper, a direct current control method based on a one-cycle controller (DCOCC) for double frequency buck converters (DF buck) is proposed. This control method can make the average current through the high frequency and low frequency inductors of a DF buck converter equal. This is similar to the average current control method. However, the design of the loop compensator is much easier when compared with the average current control. Since the average current though the high frequency and low frequency inductors is equivalent, the current stress of the high frequency switches and the switch losses are minimized. Therefore, the efficiency of the DF buck converter is improved. Firstly, the operation principle of DCOCC is described, then the small signal models of a one cycle controller and a DF buck converter are presented based on the state space average method. Eventually, a system block diagram of the DCOCC controlled DF buck is established and the compensator is designed. Finally, simulation and experiment results are given to verify the correction of the theory analysis.

• Magazine of the Korean Society of Agricultural Engineers
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• v.36 no.2
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• pp.123-131
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• 1994

Experimental studies were conducted to make clear the soil moisture environment under the condition of paddy-upland rotational fields by investigating water-table depths and soil moisture contents during growing season of crops in two kinds of soil. The following results were obtained. 1.Although water-table depths fluctuated with the amount of rainfall in the experimental field, it seemed that the variation of vater4able depths in the paddy-upland rotational, field was strongly affected by the condition of locations on paddy fields. 2.It is recognized that the concept of sum of excess water depth(SEWxx) and sum of excess water day(SEDxx) can be used to represent the soil moisture stress index due to the fluctuation of water-table depths. 3.The results of this study clearly indicate that drainage in paddy-upland rotational field to maintain an optimum soil moisture content must be made by introducing the concept of block drainage which needs both subsurface drainage and intercept drainage around a field. 4.Soil moisture contents were affected by both the amount of rainfall and water-table depths, however, the moisture content for top soil showed higher correlation with the amount of rainfall while that for subsoil with water-table depths.

• International Journal of Aeronautical and Space Sciences
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• v.16 no.1
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• pp.8-18
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• 2015

A numerical simulation for a nonslender BWB UCAV configuration with a rounded leading edge and span of 1.0 m was performed to analyze its aerodynamic characteristics. Numerical results were compared with experimental data obtained at a free stream velocity of 50 m/s and at angles of attack from -4 to $26^{\circ}$. The Reynolds number, based on the mean chord length, is $1.25{\times}106$. 3D multi-block hexahedral grids are used to guarantee good grid quality and to efficiently resolve the boundary layer. Menter's shear stress transport model and two transition models (${\gamma}-Re_{\theta}$ model and ${\gamma}$ model) were used to assess the effect of the laminar/turbulent transition on the flow characteristics. Aerodynamic coefficients, such as drag, lift, and the pitching moment, were compared with experimental data. Drag and lift coefficients of the UCAV were predicted well while the pitching moment coefficient was underpredicted at high angles of attack and influenced strongly by the selected turbulent models. After assessing the pressure distribution, skin friction lines and velocity field around UCAV configuration, it was found that the transition effect should be considered in the prediction of aerodynamic characteristics of vortical flow fields.

• Journal of the Society of Naval Architects of Korea
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• v.41 no.2
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• pp.106-113
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• 2004

The block assembly of ship consists of a certain type of heat processes such as cutting, bending, welding, residual stress relaxation and fairing. The residual deformation due to welding is inevitable at each assembly stage. The geometric inaccuracy caused by the welding deformation tends to preclude the introduction of automation and mechanization and needs the additional man-hours for the adjusting work at the following assembly stage. To overcome this problem, a distortion control method should be applied. For this purpose, it is necessary to develop an accurate prediction method which can explicitly account for the influence of various factors on the welding deformation. Systematic and quantitative theoretical works to clarify the effects of various factors on the welding deformation have rarely been found. Therefore, in this paper, the effects of various factors, such as welding process and gravity on the butt welding deformation have been investigated through a number of numerical analyses. In addition, this paper proposes a simplified analysis method to predict the butt welding deformation in actual plate structure. For this purpose, a simple prediction model for butt welding deformations has been derived based on numerical and experimental results through the regression analysis. Based on these results, the simplified analysis method has been applied to some examples to show its validity.

• Composites Research
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• v.28 no.4
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• pp.182-190
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• 2015

The phenomenological evolution laws of damage can be defined either based on residual life or residual strength. The failure of a specimen can be defined immediately after or before fracture. The former is called in this paper by "failure defined by approach I" and the latter "failure defined by approach II." Usually at failure there is a discontinuity of loading variables and, because of this, damage at failure is discontinuous. Therefore the values of damage at failure by two different approaches are not the same. Based on this idea the sequence effects of the phenomenological evolution law of damage given by $dD/dN=g(D)f({\Phi})$ were studied. Thin-walled graphite/epoxy tubes consisting of four of $[{\pm}45]_s$ laminates were used for the experimental study of sequence effects and the effects of mean stress on fatigue life. It was found that the sequence effects in two step uniaxial fatigue for $[{\pm}45]_s$ graphite/epoxy tubular specimen showed that a high-low block loading sequence was less damaging than a low-high one.

• Geomechanics and Engineering
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• v.9 no.5
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• pp.547-567
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• 2015

This study investigates the behavior of group of tapered and cylindrical piles. The bearing capacities of groups of tapered and cylindrical piles are computed and compared. Modeling of group of piles in this study is conducted in sand using three-dimensional finite element software. For this purpose, total bearing capacity of each group is firstly calculated using the load-displacement curve under specific load and common techniques. Then, the model of group of piles is reloaded under this calculated capacity to find group settlements, stress states on the lateral surfaces of group block, efficiency of group and etc. In order to calculate the efficiency of each group, single tapered and cylindrical piles are modeled separately. Comparison for both tapered and cylindrical group of piles with same volume is conducted and a relation to predict tapered pile group efficiency is developed. A parametric study is also performed by changing parameters such as tapered angle, angle of internal friction of sand, dilatancy angle of soil and coefficient of lateral earth pressure to find their influences on single pile and pile group behavior.

• International Journal of Automotive Technology
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• v.7 no.1
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• pp.109-114
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• 2006

Half-beads of multi-layer-steel cylinder head gaskets take charge of sealing of lubrication oil and coolant between the cylinder head and the block. Since the head lifts off periodically due to the combustion gas pressure, both the dynamic sealing performance and the fatigue durability are essential for the gasket. A finite element model of the halfbead has been developed and verified with experimental data. The half-bead forming process was included in the model to consider the residual stress effects. The model is employed to assess the dependence of the sealing performance and the fatigue durability on the design parameters of half-bead such as the width and height of bead and the flat region length. The assessment results show that the sealing performance can be enhanced without significant deterioration of the fatigue durability in a certain range of the half-bead width. In the other cases the improvement of sealing performance is accompanied by the loss of the fatigue durability. Among three parameters, the bead width has the strongest influence.

• Journal of Welding and Joining
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• v.7 no.1
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• pp.51-58
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• 1989

The purpose of this study is to investigate the corrosion fatigue crack growth of PWTHT specimens(SS41, SM53B) which are the compact tension ones extracted from the muti-passed weldment and weld block. The corrosion fatigue test was done at the cyclic stress frequency of 3Hz in 3.5% NaCl solution. The results are as follows. 1. Corrosion fatigue crack growth of as-weld was slower than that of base metal. 2. In the low .DELTA.K region, the effect of corrosion environment on crack growth was obvious. However, the corrosion effect decreased with the .DELTA.K slowly. 3. The behaviour of fatigue and corrosion fatigue crack growth depended on the material, heat treatment as well as experimental conditions. 4. Corrosion fatigue crack growth of PWHT specimens(SS41, SM53B) subjected to 1/4hr, was increased compared with that of as-weld. 5. There was a tendency that the exponent value(m) obtained in 3.5% NaCl solution was decreased in comparison with that in air, and the material constant(C)was increased for Paris equation, da/dN=C((.DELTA.K))$^{m}$ , compared with that in air considerably.

• Journal of the Korean Society of Visualization
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• v.17 no.2
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• pp.10-16
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• 2019

Considering the role of viscosity in the hemorheology, the characteristics of non-Newtonian fluid are important in the pulsatile blood flows. Stenosis, with an abnormal narrowing of the vessel, contributes to block blood flows to downstream tissue and lead to plaque rupture. Therefore, systematic analysis of blood flow around stenosed vessels is crucial. In this study, non-Newtonian behaviors of blood analog fluids around the micro-stenosis with 60 % severity in diameter of $500{\mu}m$ was examined by using CFX under the pulsatile flow conditions with the period of 10 s. Viscosity information of two non-Newtonian fluids were obtained by fitting the value of normal blood and highly viscous blood. As the Newtonian fluid, the water at room temperature was used. During the pulsatile phase, wall shear stress (WSS) is highly oscillated. In addition, high viscous solution gives rise to increases the variation in the WSS around the micro-stenosis. Highly oscillating WSS enhance increasing tendency of plaque instability or rupture and damage of the tissue layer. These results, related to the influence on the damage to the endothelium or stenotic lesion, may help clinicians understand relevant mechanisms.