• Journal of the Korean Society for Precision Engineering
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• v.28 no.5
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• pp.537-542
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• 2011

The thermo-mechanical interaction between brake block and wheel tread during braking has been found to cause thermal crack on the wheel tread. Due to thermal expansion of the rim material, the thermal cracks will protrude from the wheel tread and be more exposed to wear during the wheel/block contact than the rest of the tread surface. The wheel rim is in residual compression stress when is new. After service running, the region in the tread has reversed to tension. This condition can lead to the formation and growth of thermal cracks in the rim which can ultimately lead to premature failure of wheel. In the present paper, the thermal cracks of railway wheel, one of severe damages on the wheel tread, were evaluated to understand the safety of railway wheel in running condition. The residual stresses for damaged wheel which are applied to tread brake are investigated. Mainly X-ray diffusion method is used. Under the condition of concurrent loading of continuous rolling contact with rails and cyclic frictional heat from brake blocks, the reduction of residual stress is found to correlate well with the thermal crack initiation.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.35 no.1
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• pp.25-31
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• 2011

In the tensile test necking occurs at the maximum load point and non-uniform stress state is generated in this section. The equivalent stress becomes quite different from the axial stress as necking proceeds. Methods for obtaining the true stress-true strain curves, by overcoming difficulties due to the necking phenomena, have been developed by many authors. One of the methods based on the finite element analysis simulation is a very promising method. In this paper, general-purpose finite element program is used to simulate the tensile test. A round specimen and a flat specimen prepared from the same steel block are tested and simulated. The true stress-true strain curves are determined without assuming that the material follows Hollomon's law.

• Journal of Advanced Marine Engineering and Technology
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• v.23 no.4
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• pp.453-461
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• 1999

The estimation of fatigue life at the design stage is very important in order to arrive at feasible and cost effective solutions considering the total lifetime of the structure and machinery compo-nents. In this study the practical procedure of prediction of fatigue life by use of cumulative damage factors based on Miner-Palmgren hypothesis and probability density function is shown with a $135,000m^3$ LNG tank being used as an example. In particular the parameters of Weibull distribution taht determine the stress spectrum are dis-cussed. At the end some of uncertainties associated with fatigue life prediction are discussed. The main results obtained from this study are as follows: 1. The practical procedure of prediction of fatigue life by use of cumulative damage factors expressed in combination of probability density function and S-N data is proposed. 2. The calculated fatigue life is influenced by the shape parameter and stress block. The conser-vative fatigue design can be achieved when using higher value of shape parameter and the stress blocks divded into more stress blocks.

• Journal of Microbiology and Biotechnology
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• v.29 no.4
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• pp.571-576
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• 2019

Microenvironmental stress, which is naturally observed in solid tumors, has been implicated in anticancer drug resistance. This tumor-specific stress causes the degradation of topoisomerase $II{\alpha}$, rendering cells resistant to topoisomerase $II{\alpha}$-targeted anticancer agents. In addition, microenvironmental stress can induce the overexpression of 78kDa glucose regulated protein (GRP78), which can subsequently block the activation of apoptosis induced by treatment with anticancer agents. Therefore, inhibition of topoisomerase $II{\alpha}$ degradation and reduction in GRP78 expression may be effective strategies for inhibiting anticancer drug resistance. In this study, we investigated the active compound arctigenin, which inhibited microenvironmental stress-induced etoposide resistance in HT-29 cells. Arctigenin was also highly toxic to etoposide-resistant HT-29 cells, with an $IC_{50}$ value of $10{\mu}M$ for colony formation. We further showed that arctigenin inhibited the degradation of topoisomerase $II{\alpha}$ and reduced the expression of GRP78. Thus, these results suggest that arctigenin is a novel therapeutic agent that inhibits resistance to etoposide associated with microenvironmental stress conditions.

• Structural Engineering and Mechanics
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• v.34 no.3
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• pp.391-394
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• 2010

• Economic and Environmental Geology
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• v.53 no.3
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• pp.271-285
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• 2020

In this study, a numerical experiment related to the stress-strain analysis was performed on 3-D discrete fracture network(DFN) systems based on the distinct element method to evaluate the effect of joint geometry on deformability of jointed rock masses. Using one or two joint sets with deterministic orientation, a total of 12 3-D DFN blocks having 10m cube domain were generated with different joint density and size distribution. Directional deformation modulus of the DFN cube blocks were estimated along the axis directions of 3-D cartesian coordinate. In addition, deviatoric stress directions were chosen at every 30° of trend and plunge in 3-D for some DFN blocks to examine the variability of directional deformation modulus with respect to joint geometry. The directional deformation modulus of the DFN block were found to reduce with the increase of joint size distribution. The increase in joint density was less likely to have a significant effect on directional deformation modulus of the DFN block in case of the effect of rock bridges was relatively large because of short joint size distribution. It, however, was evaluated that the longer the joint size, the increase in the joint density had a more significant effect on the anisotropic deformation modulus of the DFN block. The variation of the anisotropic deformation modulus according to the variations in joint density and size distribution was highly dependent on the number of joint sets and their orientation in the DFN block. Finally, this study addressed a numerical procedure for stress-strain analysis of jointed rock masses considering joint geometry and discussed a methodology for practical application at the field scale.

• Journal of the Korean Society of Safety
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• v.29 no.6
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• pp.15-21
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• 2014

Many kinds of falling prevention systems with a safety block have been supplied in order to prevent falling accidents and acquire the long life and cost down for the maintenance. However, there are not the reliable and domestic the falling prevention system until now. Almost systems were imported from U.S.A, Japan, U.K and Germany. The structural safety of the imported safety block is satisfied sufficiently, but it has heavy weight due to the cover with the aluminum and thickness. Especially, the falling prevention system as the safety block is very expensive. It brings about flow the enormous money out of country. Furthermore it has a heavy weight when workers climbed the ladder with a falling prevention system and moved, many workers are not feeling themselves. Thus, the aim of this work is to develop a commercial self-escape SRL(Self Retracting Lifeline) with the safety block function that has a light weight and an advanced strength. The cost efficiency and convenience of the system and safety for workers also will be improved remarkably even though this system has a light weight. The results show that the maximum stress is obtained in each part by the lower more than yield strength and has sufficient safety in the developed new safety block.

• The Korean Journal of Pain
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• v.9 no.1
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• pp.94-97
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• 1996

Two hundred and eighty eight patients suffering from excessive sweating of palms, soles and axillae etc., visited our Neuro-Pain clinic from November 1991 to March 1996. The sex ratio was 1:1.2. the third decade of age was the major age group. the onset time of hyperhidrosis was prepubertal period (in 95.1% of them). the provocative factors fo excessive sweating were tension and stress from interpersonal relationship. they had the family history (30.9%) and the past history treated with herb medication (56.9%), medicine (30.6%), operation (1.4%), and no treatment (39.6%). We treated 113 patients by sympathetic ganglion block with pure alcohol. the average times of thoracic sympathetic ganglion block were 2.1 (left), 2.4 (right) and those of lumbar sympathetic ganglion block were 1.2 (left), 1.6 (right). Average admission period was 14.7 days. Recurrence rare was 7.1%. Most longstanding effective period was 45 months. We conclude from our results that sympathetic ganglion block is one of the most effective treatments for hyperhidrosis owing to its simple technique and low recurrence rate.

• Proceedings of the KSR Conference
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• 2011.10a
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• pp.966-970
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• 2011

The thermo-mechanical interaction between brake block and wheel tread during braking has been found to cause thermal crack on the wheel tread. Due to thermal expansion of the rim material, the thermal cracks will protrude from the wheel tread and be more exposed to wear during the wheel/block contact than the rest of the tread surface. The wheel rim is in residual compression stress when is new. After service running, the region in the tread has reversed to tension. This condition can lead to the formation and growth of thermal cracks in the rim which can ultimately lead to premature failure of wheel. In the present paper, the thermal cracks of railway wheel, one of severe damages on the wheel tread, were evaluated to understand the safety of railway wheel in running condition. The residual stresses for damaged wheel which are applied to tread brake are investigated. Mainly X-ray diffusion method is used. Under the condition of concurrent loading of continuous rolling contact with rails and cyclic frictional heat from brake blocks, the reduction of residual stress is found to correlate well with the thermal crack initiation.

• Journal of Advanced Research in Ocean Engineering
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• v.1 no.3
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• pp.148-156
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• 2015

Deck plates of ships or offshore structures would make out-of-plane distortion for their thin thickness. These distortions are usually straightened by thermal straightening such as flame heating method. After thermal straightening, the blocks are lifted and moved by cranes to assemble it at dry-dock stage. After this lifting process, out-of-plane deformation again happens frequently. And then, they continuously cause quality and accuracy problems in the final dry-dock process. So, it takes more time for repair and correction working. According to preceding research, the lifting process by cranes would offset the effect on thermal straightening. The target of this study is to develop a methodology analyzing the remaining efficiency of thermal straightening after block lifting. The development was based on the assumption of yield state at straightening region. Therefore the remaining efficiency was obtained by different stiffness slope while lifting & relieving. The efficiency formula was designed using inherent strain, and we made a table of zero-efficiency by cooling speed and class rule's steels. As a result, if the stress orthogonal to straightened line is calculated during lifting analysis by FEA, the efficiency can be obtained linearly to the values in the table. Finally, even optimized carling position can be designed by considering the regional data from series project and welding region on deck.