• Journal of Yeungnam Medical Science
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• 제39권4호
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• pp.269-277
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• 2022

The amyloid hypothesis has been considered a major explanation of the pathogenesis of Alzheimer disease. However, failure of phase III clinical trials with anti-amyloid-beta monoclonal antibodies reveals the need for other therapeutic approaches to treat Alzheimer disease. Compared to its relatively short history, optogenetics has developed considerably. The expression of microbial opsins in cells using genetic engineering allows specific control of cell signals or molecules. The application of optogenetics to Alzheimer disease research or clinical approaches is increasing. When applied with gamma entrainment, optogenetic neuromodulation can improve Alzheimer disease symptoms. Although safety problems exist with optogenetics such as the use of viral vectors, this technique has great potential for use in Alzheimer disease. In this paper, we review the historical applications of optogenetic neuromodulation with gamma entrainment to investigate the mechanisms involved in Alzheimer disease and potential therapeutic strategies.

• Journal of Information Technology Applications and Management
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• 제22권3호
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• pp.129-141
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• 2015

The purpose of this study is to provide an explanation for the association between the characteristics of a network and the type of innovation by considering the effect of absorptive capacity. To do so, this study examined the moderating effects of absorptive capacity on the characteristics of network-innovation relationship in a technical-driven venture company. In order to obtain a better understanding about consequences caused by interfirm network, information was obtained from 169 Korean IT venture companies. Results confirmed that the network diversity is positively associated with exploration. Our results also suggested that the network strength is positively associated with exploitation. Finally, we found a positive two-way interaction between absorptive capacity and the network diversity-exploration relationship. Then, we discussed implications and directions for future research.

• Journal of Information Technology Applications and Management
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• 제11권2호
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• pp.1-14
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• 2004

The level of sunk cost and risk-taking theory have been offered as one explanation for the escalation of commitment behavior. This Study attempted to replicate Keil's study in Korea. Keil examined the level of sunk cost associated with the risk propensity and risk perception of decision-makers, and these factors are assessed for cross-cultural robustness using matching laboratory experiments carried out in three countries. The level of sunk cost and the risk perception of decision-makers contributed significantly to their continuous willingness to their project. Moreover, the risk propensity of decision-makers was inversely related to risk perception, and this inverse relationship was significantly more weak in Korea than in Singapore. These results show that the sunk-cost effect exists across cultures, and that the risk-taking behaviors are partially mediated by cultural factors.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2011년도 제42회 하계학술대회
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• pp.1404-1404
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• 2011

Shortage of fossil fuel energy makes current industry to find a new energy sources. One of the solutions is using the renewable energy sources like wind, sun, water, and so on. If we think with flex idea, the existing PV system's role can be greatly changed. So in this paper, I want to suggest some ideas for PV systems as one of outstanding energy source. The specific and technical explanation will be shown in the following paper in detail.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2001년도 ICCAS
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• pp.25.2-25
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• 2001

This paper describes a mobile robot intended for being employed in a multi-agent system. We have already proposed a multi-agent system which realizes patient-aid by helping a lying patient take a distant object on the table. In this paper, a mobile robot agent is developed and is included in the system. An effective man-machine communication strategy is proposed by use of a vision agent settled on the ceiling. If a human (assumed to be a patient) wishes to take an object distant on the floor, he points to the object. The vision agent detects the direction of his arm by image processing and guesses which object he intends to take. The vision agent asks him if it is what he wants and, if yes, the mobile robot runs to take and bring it to him. The system is overviewed with the explanation of a mobile robot. Some experimental results are shown with discussion.

• Nonlinear Functional Analysis and Applications
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• 제27권2호
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• pp.381-403
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• 2022

The main goal of this research is to solve variational inequalities involving quasimonotone operators in infinite-dimensional real Hilbert spaces numerically. The main advantage of these iterative schemes is the ease with which step size rules can be designed based on an operator explanation rather than the Lipschitz constant or another line search method. The proposed iterative schemes use a monotone and non-monotone step size strategy based on mapping (operator) knowledge as a replacement for the Lipschitz constant or another line search method. The strong convergences have been demonstrated to correspond well to the proposed methods and to settle certain control specification conditions. Finally, we propose some numerical experiments to assess the effectiveness and influence of iterative methods.

• 한국방재학회:학술대회논문집
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• 한국방재학회 2007년도 정기총회 및 학술발표대회
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• pp.75-78
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• 2007

The structural methodology in designing a transmission tower have been performed to assume a simple truss behavior. But there're quite differences between a simple truss behavior and a real one. A suitable explanation for a structural stability can be expressed as a semi-rigid connection instead of the assumed hinged connection. This study proposes an alternative structural analysis modelling strategy for the transmission tower design. Proposed element models are truss element model, beam element model, and combined beam-truss element model. The static finite element analysis shows that there's a moment distribution between a mainpost member and the other bracing member.

• Bulletin of the Korean Chemical Society
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• 제22권11호
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• pp.1236-1242
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• 2001

(3S,1'S)-3-(1'-Carboxy-2'-phenyl)ethylamino-2-oxetanone (1a) and (3R,1'S)-3-(1'-carboxy-2'-phenyl)ethylamino-2-oxetanone (1b) were designed, synthesized, and evaluated as inhibitors for carboxypeptidase A, a prototypical zinc protease that removes the C-terminal amino acid having an aromatic side chain from oligopeptide substrate. It was concluded from the analysis of inhibition kinetics that while 1a inactivates CPA irreversibly, its diastereoisomer, 1b is a weak competitive inhibitor for CPA. A possible explanation for the observed difference in inhibition mode that is dependent on the inhibitor stereochemistry is offered.

• 한국실내디자인학회논문집
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• 제21권2호
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• pp.174-185
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• 2012

The purpose of this study is to suggest planning strategy of tenant mix for UEC based on the final result of tenant mix analysis of five different research cases. The following is the comprehensive explanation about the result of tenant mix planning strategy for UEC currently in operation and when planning a new facility. First, overall research cases in this study show the tendency of following an old tradition, which stresses direct sales focusing on retail and dining adaptation. In order to compensate the defect, it is suggested to adopt new type of tenants with the functional mix of retail and dining with entertainment rather than decreasing the proportion of retail and dining tenant and increasing it of entertainment tenant. Second, the floorplan of UEC should adopt racetrack or circuit form that can stimulate shoppers' circular movement so to expose them to as much tenants as possible. Service consumption mode related tenants are required to place on the side or the edge of UEC, while retail consumption mode related tenants should be planned in the center. Among dining consumption mode related tenants, impulse dining tenants like a coffee shop should be placed at the turning point or at the end of the pathway, destination tenants like a restaurant and a food court, on the other hand, is needed to be placed in the center of the space. In case of Entertainment related tenants, destination tenants like bookstore or multiplex should also be placed at the end of the pathway, and on the way to those tenants, it is required to place general tenants that can share target customers with them. On the contrary, game center or record shop like tenants that can stimulate impulse sales should be placed on the visitor's main move or near the other destination tenants. Third, anchor tenants play an important role in gathering people to the UEC, and then induce them to visit the other tenants that are located near the anchors. Thus it is suggested to plan to place general tenants on the same floor as anchor tenants are placed so they can share the characteristics of target customers which create synergy effect.

• 한국어교육
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• 제29권4호
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• pp.225-254
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• 2018

The purpose of this study is to contrast the patterns of realization and understanding of refusal speech acts between Korean and Thai learners. This study intends to answer the following questions: (1) Do Koreans and Thai learners perform refusal speech acts differently? (2) Do Koreans and Thai learners understand refusal speech acts differently? A DCT and a follow-up interview were conducted to collect data of two groups of 30 native Korean speakers and 30 native Thai speakers. For research question 1, we analyzed the refusal strategy and provided reasons given by Koreans and Thai learners depending on the context. For research question 2, we ran a chi-squared test on the elements of the follow-up interviews, such as the weight of burden of refusing, and whether the participant would actually refuse or not. The differences between the refusal strategies of the two groups could be categorized by the preceding inducing speech act. In refusing a request, the difference was prominent in the apologizing strategy, whereas in refusing a suggestion, the difference was mainly in the direct refusal strategy. When refusing an invitation, the most evident difference was the number of refusal strategies employed. When providing an explanation of refusal to people with high social status, Koreans gave more specific reasons for refusals, whereas Thai learners tended to use more vague reasons. Moreover, when refusing an invitation, Koreans primarily mentioned the relationship, and Thai learners showed the spirit of Greng Jai. When asked the weight of burden of refusing, Koreans felt pressured to refuse a request from people with high social status, and a suggestion or invitation from people with high level of intimacy while Thai learners found it highly difficult to make a refusal in all cases. In answering whether they would actually refuse or not, Koreans tried not to make a refusal to people with high level of intimacy, and such a trend was not evident among the Thai. This study can help us better understand the learner's pragmatic failure, and serve as a basis in establishing a curriculum for teaching speech acts.