• 약학회지
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• 제58권3호
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• pp.181-189
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• 2014

The aim of this was to evaluate the effects of Rhus Verniciflua Stoke (RVS) extract powder on the endurance capacity for the forced swimming mice. Thirty mice were divided into 3 groups including negative control, 250 (RVS-250) and 500 (RVS-500) mg/kg RVS extract powder groups for 4-times swimming exercises. The swimming times to exhaustion in RVS-250 and RVS-500 mice were prolonged 1.6- and 2.0-fold at 4 weeks compared with negative control mice, respectively. Blood biochemical parameters for AST, ALT, T-CHO and TG were not significantly different between RVS fed or negative control mice. However, blood concentration of creatinine was significantly increased in RVS-250 mice, but not in RVS-500 mice. During the longer swimming exercise in RVS group, blood glucose and lactate levels were significantly decreased, but free fatty acid not changed. And also LDH levels were significantly decreased in RVS groups compared to negative control mice. Hepatic lipid peroxidation was not affected by RVS, but SOD and catalase activity were significantly increased in RVS groups. Interestingly, the levels of testosterone and free testosterone were significantly increased in RVS groups before swimming exercise, but they were not significantly changed among groups after swimming exercise. The present results suggest that RVS extract powders may enhance swimming exercise performance by recovering the exercise-fatigue via reduction of blood LDH activity and by burning blood glucose as an energy source. These results imply that RVS-produced testosterone may act as an energy buster to enhance physical activity.

• 대한응급의학회지
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• 제29권5호
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• pp.399-407
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• 2018

Objective: Regionalization is one of the principal subjects for the advancement of rural emergency medical service systems in South Korea. This study shows the characteristics of interhospital transfer and status of the incidence of three major emergency disorders (acute myocardial infarction [AMI], acute stroke, and severe trauma) in one local province. Methods: A retrospective study was conducted for patients with three major emergency disorders who visited emergency medical facilities in one local province from January 2013 to December 2015, on the basis of the National Emergency Department Information System (NEDIS) data. Results: The incidence of three major emergency disorders had increased annually. Patients with each of these disorders tended to choose distinguishing methods of visiting emergency medical facilities. AMI patients tended to visited emergency medical facilities using private cars or on foot, while severe trauma patients usually visited by 119 ambulance, and acute stroke patients used 119 ambulance and private car in similar amounts. Overall, 65% of AMI patients were treated in intraregional medical facilities, but about 70% of acute stoke and severe trauma patients were transferred outside of the region. Conclusion: Because each of these disorders has an individual characteristic, it is difficult to expect a solution for the problems associated with emergency disorders just by assuring the availability of medical resources. Based on regionalization, a policy to provide the optimal treatment for those emergency disorders should be developed by planning public medical service systems based on the individual characteristics of emergency disorders, the standardized transfer plans of emergency patients and the assurance for mobilization and sharing of confined medical resources.

• 대한한방내과학회지
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• 제42권5호
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• pp.1045-1053
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• 2021

Objectives: This study investigated the effectiveness of acupuncture and herbal medicine (Gami-banhabakchulchunma-tang) for post-stroke visual impairment. Methods: A 79-year-old male with headache, dizziness, visual field defects, and blurred vision caused by a posterior cerebral infarction was treated with acupuncture and Gami-banhabakchulchunma-tang for three months. We used the Numerical Rating Scale (NRS) for each symptom and measured the patient's eye-movement range. Results: Following treatment, the NRS score for headache decreased from 5 to 0, and for dizziness and blurred vision, it decreased from 5 to 1. The NRS score for visual field defects decreased from 5 to 2. The range of the patient's left and right eye movements both improved, and no adverse side effects were observed during the admission period. Conclusions: Korean medical treatment with acupuncture and herbal medicine (Gami-banhabakchulchunma-tang) could effectively treat post-stoke visual impairment.

• 한국해양공학회지
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• 제36권3호
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• pp.143-152
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• 2022

To reach a port, a ship must pass through a shallow water zone where seabed effects alter the hydrodynamics acting on the ship. This study examined the maneuvering characteristics of an autonomous surface ship at 3-DOF (Degree of freedom) motion in deep water and shallow water based on the in-port speed of 1.54 m/s. The CFD (Computational fluid dynamics) method was used as a specialized tool in naval hydrodynamics based on the RANS (Reynolds-averaged Navier-Stoke) solver for maneuvering prediction. A virtual captive model test in CFD with various constrained motions, such as static drift, circular motion, and combined circular motion with drift, was performed to determine the hydrodynamic forces and moments of the ship. In addition, a model test was performed in a square tank for a static drift test in deep water to verify the accuracy of the CFD method by comparing the hydrodynamic forces and moments. The results showed changes in hydrodynamic forces and moments in deep and shallow water, with the latter increasing dramatically in very shallow water. The velocity fields demonstrated an increasing change in velocity as water became shallower. The least-squares method was applied to obtain the hydrodynamic coefficients by distinguishing a linear and non-linear model of the hydrodynamic force models. The course stability, maneuverability, and collision avoidance ability were evaluated from the estimated hydrodynamic coefficients. The hydrodynamic characteristics showed that the course stability improved in extremely shallow water. The maneuverability was satisfied with IMO (2002) except for extremely shallow water, and collision avoidance ability was a good performance in deep and shallow water.

• Journal of Dental Anesthesia and Pain Medicine
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• 제22권1호
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• pp.11-18
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• 2022

Background: The vasoconstrictive effect of epinephrine in local anesthetics affects the heart, which leads to hesitation among dentists in injecting local anesthetics into patients with cardiovascular disease. Due to its vasoconstrictive effects, the present study investigated the effects of vasopressin administration on cardiac function in rats. Methods: Experiment 1 aimed to determine the vasopressin concentration that could affect cardiac function. An arterial catheter was inserted into the male Wistar rats. Next, 0.03, 0.3, and 3.0 U/mL arginine vasopressin (AVP) (0.03V, 0.3V, and 3.0V) was injected into the tongue, and the blood pressure was measured. The control group received normal saline only. In Experiment 2, following anesthesia infiltration, a pressure-volume catheter was placed in the left ventricle. Baseline values of end-systolic elastance, end-diastolic volume, end-systolic pressure, stroke work, stroke volume, and end-systolic elastance were recorded. Next, normal saline and 3.0V AVP were injected into the tongue to measure their effect on hemodynamic and cardiac function. Results: After 3.0V administration, systolic blood pressures at 10 and 15 min were higher than those of the control group; they increased at 10 min compared with those at baseline. The diastolic blood pressures at 5-15 min were higher than those of the control group; they increased at 5 and 10 min compared with those at baseline. The preload decreased at 5 and 10 min compared to that at baseline. However, the afterload increased from 5 to 15 min compared with that of the control group; it increased at 10 min compared with that at baseline. Stroke volume decreased at 10 and 15 min compared with that of the control group; it decreased from 5 to 15 min compared with that at baseline. Stroke work decreased from 5 to 15 min compared with that of the control group; it decreased from 5 to 15 min compared with that at baseline. Conclusion: Our results showed that 3.0 U/mL concentration of vasopressin resulted in increased blood pressure, decreased stroke volume and stoke work, decreased preload and increased afterload, without any effect on myocardial contractility.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2022년도 학술발표회
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• pp.91-91
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• 2022

하천 합류부에서 수체의 흐름은 매우 역동적으로 변화하며 합류부의 복잡한 3차원 흐름과 난류 구조는 2차류(secondary currents)의 강도변화, 전단층(shear layer)의 뒤틀림 그리고 재순환구역(recirculation zone)의 발생 등 합류부에서의 독특한 특징을 형성한다. 이러한 특징들의 변화는 수체의 흐름구조 뿐만 아니라 하천으로 유입된 오염물의 거동에도 영향을 준다. 기존의 합류부 연구들은 주로 본류와 지류의 합류각이나 유량비에 차이를 두어 합류부의 특징 변화를 모의하였다. 하지만 실제 자연하천에서 홍수방지를 위한 수심확보, 건축자재의 골재수집 등 다양한 목적으로 수행되는 본류의 준설작업으로 인해 발생하는 본류와 지류의 하상면 단차 또한 합류부의 특성에 영향을 미치는 주요한 인자 중 하나이다. 단차가 커짐에 따라 증가하는 지류수체의 낙차는 이차류의 강화를 야기하며 이는 합류부에서의 유속구조를 변화시켜 흐름을 가속시키거나 지체시키며 오염물의 혼합에 영향을 미친다. 본 연구에서는 3차원 수치모의를 통해 90도로 합류되는 수로에서의 흐름구조와 오염물의 혼합에 단차비와 유량비가 미치는 영향을 모의하였다. 유동장 해석을 위해 3차원 RANS (Reynolds-averaged Navier-Stoke) 방정식을 사용하였으며 난류해석은 k-𝜔 SST 모델을 이용하였다. 본류의 경우 11.4m의 수로 연장을 갖고, 하폭은 0.3m이며 수심은 단차의 크기에 따라 변화한다. 지류의 경우는 수로연장 1m, 하폭 및 수로깊이는 0.1m이다. 수치결과의 검증을 위해 이주하(2013)이 수행한 실내 합류수로의 실험결과를 이용하였다. 모의결과를 통해 파악한 합류부의 흐름특성을 이용하여 적절한 2차원 분산계수를 산정한다. 자연하천에서 오염물의 혼합거동을 효과적으로 모의하기 위해 수심 평균된 2차원 이송-분산모형을 이용하는데 이때 적절한 분산계수의 산정이 필수적이다. 본 연구에서는 합류 후 흐름방향에 따라 분산특성이 상이한 구간을 구분하여 분산계수를 산정하였으며 이를 통해 오염물의 거동을 정확하게 모의하였다.

• Korean Journal of Radiology
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• 제22권10호
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• pp.1671-1679
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• 2021

Objective: We quantitatively measured the fat fraction (FF) in the vertebrae of patients with ankylosing spondylitis (AS) using magnetic resonance imaging (MRI) and investigated the role of FF as an indicator of both active inflammation and chronicity. Materials and Methods: A total of 52 patients with AS who underwent spinal MRI were retrospectively evaluated. The FF values of the anterosuperior and anteroinferior corners of the bone marrow in the L1-S1 spine were assessed using the modified Dixon technique. AS activity was measured using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), AS Disease Activity Score (ASDAS), and serum inflammatory marker levels. AS disease chronicity was assessed by AS disease duration and the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS). Univariable and multivariable regression analyses were conducted to investigate the correlation between FF and other clinical characteristics. Results: The mean FF ± standard deviation of the total lumbar spine was 43.0% ± 11.3%. At univariable analysis, spinal FF showed significant negative correlation with BASDAI (β = -0.474, p = 0.002) and ASDAS with C-reactive protein (ASDAS-CRP; β = -0.478, p = 0.002) and a significant positive correlation with AS disease duration (β = 0.440, p = 0.001). After adjusting for patient age, sex, and total mSASSS score, spinal FF remained significantly negatively correlated with BASDAI (β = -0.543, p < 0.001), ASDAS-CRP (β = -0.568, p < 0.001), and ASDAS with erythrocyte sedimentation rate (β = -0.533, p = 0.001). Spinal FF was significantly lower in patients with very high disease activity (ASDAS-CRP > 3.5) than in those with only high disease activity (2.1 ≤ ASDAS-CRP ≤ 3.5) (p = 0.010). Conclusion: Spinal FF may help assess both AS disease activity and chronicity.

• 한국산학기술학회논문지
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• 제15권1호
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• pp.299-305
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• 2014

본 연구는 순환식 과제 지향 훈련이 편마비 환자의 하지 기능과 삶의 질에 미치는 영향을 알아보기 위하여 실시하였다. 연구에는 총 25명의 만성 뇌졸중 환자들이 참여하였고, 무작위로 순환식 과제 지향 훈련군 13명, 트레드밀 훈련군 12명으로 나누어 시행하였다. 두 군 모두 8주 동안 주 5회, 30분 트레드밀 훈련을 실시하였으며, 순환식 과제 지향 훈련군은 30분 동안 순환식 과제 지향 훈련을 추가로 실시하여 슬관절 근력, 균형 능력, 10m 보행 능력, 그리고 뇌졸중 영향 척도를 평가하였다. 연구 결과 순환식 과제 지향 훈련군이 트레드밀 훈련군에 비해 슬관절 신전근과 굴곡근, 그리고 균형 능력, 뇌졸중 영향 척도에서 유의한 차이를 보였다(p<.05). 이것은 순환식 과제 지향 훈련이 편마비 환자의 하지 기능과 삶의 질을 향상시킬 수 있다는 것을 의미한다. 향후 좀 더 많은 환자에게 다양한 과제를 적용하여 일반화하는 연구가 필요할 것이다.

• 재활치료과학
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• 제7권2호
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• pp.17-27
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• 2018

목적 : 본 연구는 만성 뇌졸중 환자를 대상으로 완전 몰입형 가상현실 기기를 이용한 작업치료 중재가 환자의 상지기능 향상에 미치는 효과를 알아보고자 하였다. 연구방법 : 본 연구의 연구 대상은 좌측 편마비를 가지고 있는 만성 뇌졸중 환자 1명이며, 개별사례 실험연구 중 ABA 설계를 사용하였다. 기초선 기간 4회, 중재 기간 12회, 기초선 회귀기간 4회로 총 20회의 실험을 휴지기간을 포함하여 총 10주간 진행하였다. 독립변수인 완전 몰입형 가상현실 기기를 이용한 작업치료 중재는 매 회기 30분씩 시행되었으며 종속변수 중 Fugl-Meyer Assessment(FMA) 평가는 각 기간 마다 1회씩 측정하였다. Box and Block Test(BBT) 평가와 Wolf Motor Function Test(WMFT) 평가는 매 회기 마다 시행하여 그 측정 결과를 꺾은선 그래프를 통해 제시하였다. 결과 : 완전 몰입형 가상현실 기기를 이용한 작업치료 중재 후 대상자의 환측 상지기능이 향상되었다. 기초선 회귀 기간에는 중재를 제거한 뒤 치료유지 효과를 확인하였지만 큰 변화는 나타나지 않았다. 결론 : 본 연구의 결과, 완전 몰입형 가상현실 기기를 이용한 작업치료 중재가 만성 뇌졸중 환자의 상지기능에 효과적인 중재라는 것을 알 수 있었다. 다만 치료유지 효과는 크지 않았기 때문에 보다 사용이 간편한 가정용 중재 프로그램 등의 개발이 필요하다.

• 대한지역사회작업치료학회지
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• 제2권1호
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• pp.49-63
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• 2012

목적 : 본 연구는 한국형 전산화 인지재활 프로그램인 코드라스(CoTras)가 뇌졸중 환자의 시지각 기능 및 일상생활동작 수행능력에 미치는 효과를 알아보고자 실시되었다. 연구방법 : 재활전문 C 요양병원에 거주하고 있는 뇌졸중 환자 14명을 대상으로 실험 전과 후를 측정하였다. 처치 전 후 시지각 기능의 변화를 알아보기 위하여 사용한 시지각 평가도구는 비운동성 시지각 평가를 사용하였고 일상생활동작 수행능력을 알아보기 위하여 Fisher(1999)에 의해 개발된 운동 및 처리기술 평가도구를 이용하여 일상생활수행능력을 평가하였다. 전산화 인지재활 프로그램 전과 후를 측정하였으며, 수집된 자료는 SPSS 15.0 통계프로그램을 사용하여 분석하였다. 연구대상자의 치료 전과 후의 시지각 기능 및 일상생활동작 수행능력의 효과를 알아보기 위하여 짝비교(Paired t-test)를 이용하여 분석하였다. 연구결과 : 첫째, 코트라스(CoTras)치료 전과 후의 시지각 기능의 차이를 짝비교(Paired t-test)를 이용해 분석한 결과, 통계학적으로 유의한 차이가 있었다(0.000, p <.05). 둘째, AMPS 운동기술 평균점수는 0.90에서 1.11으로 증가되었으나 통계학적으로 유의한 차이는 없었다. 처리기술 평균점수는 0.08에서 0.46점으로 증가되었으나 통계학적으로 유의한 차이가 없었고, 임상적으로 유의하게 일상생활동작 수행능력이 향상되었다(logit >0.3). 결론 : 한국형 전산화 인지재활 프로그램인 코트라스는 뇌졸중 환자의 시지각 기능을 향상시키는 효과가 있었고, 일상생활 동작 수행능력에 임상적으로 긍정적인 영향을 주었다. 시지각에 장애를 가지고 있는 뇌졸중 환자에게 코트라스(CoTras)가 시지각 기능 증진에 기여할 수 있는 기초자료로 제시할 수 있다.