• Molecules and Cells
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• 제39권6호
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• pp.439-446
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• 2016

Clearing and labeling techniques for large-scale biological tissues enable simultaneous extraction of molecular and structural information with minimal disassembly of the sample, facilitating the integration of molecular, cellular and systems biology across different scales. Recent years have witnessed an explosive increase in the number of such methods and their applications, reflecting heightened interest in organ-wide clearing and labeling across many fields of biology and medicine. In this review, we provide an overview and comparison of existing clearing and labeling techniques and discuss challenges and opportunities in the investigations of large-scale biological systems.

• Industrial Engineering and Management Systems
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• 제12권2호
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• pp.85-94
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• 2013

This research investigates the supply chain contract between a distributor and a supplier in which the selling period is relatively short in comparison with long production lead time. At the first stage, supplier who is a Stackelberg leader offers the distributor a contract with a set of parameters, and subjected to those parameters, the distributor places the number of initial orders as well as options. In order to purchase the option, the distributor pays non-linear option premium price with respect to the number of purchased options. At the second stage, based on realized demand, the distributor has the right to exercise option as either put or call which is limited up to the number of purchased options. The wholesale price contract is used as a benchmarking contract. This research has confirmed that the supply chain contract with a non-linear option premium price can help to coordinate the supply chain.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 2003년도 춘계 학술발표회논문집
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• pp.61-68
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• 2003

The H/V ratio (Horizontal to Vertical spectral ratio) has been used to infer site amplification without previous knowledge of near-surface geology and in fact may provide useful general site condition information. This method is used to classify the site characteristics of seismic stations in Korea by comparison with known H/V ratios representative of various sites all over the world. In addition, differences between horizontal and vertical kappa values were evaluated for each seismic stations by comparing WV ratio and Weak Motion amplification derived from inversion of stochastic ground motion parameters and were used as index to quantitatively classify the site characteristics.

• International Journal of Naval Architecture and Ocean Engineering
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• 제10권2호
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• pp.119-128
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• 2018

A numerical method is proposed to simulate level ice interaction with ship in transverse and longitudinal directions in time domain. A novel method is proposed to simulate non-symmetric transverse force in a stochastic way. On the basis of observations from the model tests, the simulation of longitudinal force combines the ice bending force acting on the waterline, submersion force below the waterline and ice friction forces caused by transverse force and ice floes rotation amidships. In the simulations the ship was fixed and towed through an intact ice sheet at a certain speed. The setup of the numerical simulation is similar to the ice tank setup as much as possible. The simulated results are compared with model tests data and the results show good agreement with the measurement.

• Wind and Structures
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• 제31권6호
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• pp.549-560
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• 2020

Methods for stochastic simulation of non-Gaussian wind pressure have increasingly addressed the efficiency and accuracy contents to offer an accurate description of the extreme value estimation of the long-span and high-rise structures. This paper presents a linear prediction and z-transform (LPZ) based Cumulative distribution function (CDF) mapping algorithm for the simulation of multivariate non-Gaussian fluctuating wind pressure. The new algorithm generates realizations of non-Gaussian with prescribed marginal probability distribution function (PDF) and prescribed spectral density function (PSD). The inverse linear prediction and z-transform function (ILPZ) is deduced. LPZ is improved and applied to non-Gaussian wind pressure simulation for the first time. The new algorithm is demonstrated to be efficient, flexible, and more accurate in comparison with the FFT-based method and Hermite polynomial model method in two examples for transverse softening and longitudinal hardening non-Gaussian wind pressures.

• Advances in Computational Design
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• 제7권1호
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• pp.37-56
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• 2022

Phase-type distributions are the distributions of the time to absorption in finite and absorbing Markov chains. They generalize, while at the same time, retain the tractability of the exponential distributions and their family. They are widely used as stochastic models from queuing theory, reliability, dependability, and forecasting, to computer networks, security, and computational design. The ability to fit phase-type distributions to intractable or empirical distributions is, therefore, highly desirable for many practical purposes. Many methods and tools currently exist for this fitting problem. In this paper, we present the results of our investigation on using orthogonal-distance fitting as a method for fitting phase-type distributions, together with a comparison to the currently existing fitting methods and tools.

• Communications for Statistical Applications and Methods
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• 제29권6호
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• pp.679-694
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• 2022

Mortality risk is a significant threat to individual life, and quantifying the risk is necessary for making a national population plan and is a traditionally fundamental task in the insurance and annuity businesses. Like other advanced countries, the sustainability of life pensions and the management of longevity risks are becoming important in Asian countries entering the era of aging society. In this study, mortality and pension value sustainability trends are compared and analyzed based on national population and mortality data, focusing on four Asian countries from 1990 to 2017. The result of analyzing the robustness and accuracy of generalized linear/nonlinear models reveals that the Cairns-Blake-Dowd model, the nonparametric Renshaw-Haberman model, and the Plat model show low stability. The Currie, CBD M5, M7, and M8 models have high stability against data periods. The M7 and M8 models demonstrate high accuracy. The longevity risk is found to be high in the order of Taiwan, Hong Kong, Korea, and Japan, which is in general inversely related to the population size.

• 대한교통학회지
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• 제23권5호
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• pp.15-25
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• 2005

본 연구는 성과를 측정하는 방법론에 따른 결과를 비교하고 도시철도 운영기관의 효율성과 생산성을 높일 수 있는 방안을 제시하기 위해 자료포락분석기법을 이용하여 효율성 및 생산성을 분석한 연구에서 사용된 동일한 자료를 바탕으로 확률적 비용변경접근법을 이용해 서울시지하철공사와 철도청의 수도권 전철부문 및 부산교통공단의 효율성과 생산성을 추정하였다. 추정결과 자료포락분석기법은 확률적 오차와 측정오차를 인정하지 않고 비효율성으로 간주하므로 효율성 값이 낮고 생산성 증가율의 값은 크게 도출된 반면, 확률적 비용변경접근법은 통계적 오차를 인정하기 때문에 효율성 값은 높고 생산성 증가율의 값은 작은 것으로 나타났다. 이처럼 변경접근법에 따라 추정된 결과는 다르게 나타난 반면, 이러한 결과로부터 도출되는 정책적 시사점은 다음과 같이 비슷한 것으로 나타났다. 첫째, 도시철도 운영기관들의 생산성을 높이기 위해서는 신기술 도입보다는 먼저 현재의 기술을 효율적으로 활용함으로써 효율성을 향상시켜야 하며, 둘째, 효율성을 높이기 위해서는 요소 투입량을 감축하여 기술적 효율성을 높여야 하고, 마지막으로 생산성 측정의 편의를 방지하기 위해서는 생산적 효율성 증가율. 기술 진보율, 규모의 경제 효과 요인을 모두 고려해야 하는 것으로 나타났다.

• 대한교통학회지
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• 제27권4호
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• pp.63-76
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• 2009

본 연구는 확률적 변경 접근법으로 비용 효율성을 분석한 선행연구에서 사용된 동일한 철도자료로 비용함수모형 대신에 수입함수모형을 설정하여 한국과 일본 철도산업의 수입 효율성을 분석하고 난 다음 이를 비용 효율성의 추정결과와 비교분석하고, 민영화가 수입과 비용 측면에서 더 효율적인지를 검증하였다. 확률적 변경 접근법을 이용한 일반초월대수 수입함수모형 추정 결과 한국과 일본 철도업체의 수입 비효율성은 표본평균에서 반정규분포의 경우 7.02%, 지수분포의 경우 6.98%로 추정되었으며, 비효율성항을 반정규분포로 가정했을 때 표준화된 수입 비효율성은 표본평균에서 7.5%로 표준화된 비용 비효율성 2.1%보다 더 큰 것으로 분석되었다. 또한 평균적으로 가장 수입 효율적인 업체는 JR 동일본이고 가장 비용 효율적인 업체는 JR 서일본이며, 가장 비효율적인 업체는 수입 측면과 비용 측면 모두 JNR과 JR 구주로 나타났다. 마지막으로 수입과 비용 효율성 및 민영화 변수를 이용하여 상관분석을 시행한 결과 수입 효율성과 비용 효율성간에 그리고 이들 효율성과 민영화 변수 간에 양의 상관관계가 존재하는 것으로 나타나 비용 측면에서 효율적인 업체가 수입 측면에서도 효율적이고, 경영 자율성이 높을수록 수입과 비용 측면에서 더 효율적인 것으로 분석되었다.

• 한국안전학회지
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• 제35권3호
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• pp.49-57
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• 2020

In comparison with the existing static reliability analysis methods, the dynamic reliability analysis(DyRA) method is more suitable for estimating the failure probability of a structure subjected to earthquake excitations because it can take into account the frequency characteristics and damping capacity of the structure. However, the DyRA is known to have an issue of numerical stability due to the uncertainty in random sampling of the earthquake excitations. In order to solve this numerical stability issue in the DyRA approach, this study proposed two earthquake-scale factors. The first factor is defined as the ratio of the first earthquake excitation over the maximum value of the remaining excitations, and the second factor is defined as the condition number of the matrix consisting of the earthquake excitations. Then, we have performed parametric studies of two factors on numerical stability of the DyRA method. In illustrative example, it was clearly confirmed that the two factors can be used to verify the numerical stability of the proposed DyRA method. However, there exists a difference between the two factors. The first factor showed some overlapping region between the stable results and the unstable results so that it requires some additional reliability analysis to guarantee the stability of the DyRA method. On the contrary, the second factor clearly distinguished the stable and unstable results of the DyRA method without any overlapping region. Therefore, the second factor can be said to be better than the first factor as the criterion to determine whether or not the proposed DyRA method guarantees its numerical stability. In addition, the accuracy of the numerical analysis results of the proposed DyRA has been verified in comparison with those of the existing first-order reliability method(FORM), Monte Carlo simulation(MCS) method and subset simulation method(SSM). The comparative results confirmed that the proposed DyRA method can provide accurate and reliable estimation of the structural failure probability while maintaining the superior numerical efficiency over the existing methods.