• Title/Summary/Keyword: stimulating effect

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Anticomplementary Activity and Immune-Stimulating Effect of the Extracts from Barley (Hordeum Vulgare) (보리(Hordeum vulgare)추출물의 항보체 및 면역증강 효과)

  • 김유영;구성자
    • Korean journal of food and cookery science
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    • v.13 no.5
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    • pp.661-668
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    • 1997
  • By using several solvents, barley extracts containing the anticomplementary activities in classical pathway were prepared (250 $\mu\textrm{g}$/ml): methanol (83.1%), ethanol (71.9%), water extract (25.4%), M-1 (250 $\mu\textrm{g}$/ml), and the soluble part of methanol extract which showed the highest activity (83.4%) and the yield. Anticomplementary activity of methanol extract as well as protease digestion in classical pathway showed 82.4% and 78.4% in the concentration of 250 $\mu\textrm{g}$/ml, respectively. It was found that protein was not involved in anticomplementary activity in the classical pathway and the methanol extract made an impact on classical pathway, but not on alternative pathway. For the immune-stimulating effect, the T cell proliferation effect of the protease digestion displayed little effect irrespective of the dose. In addition, the T cell proliferation effect of methanol extract showed 13-fold higher proliferation effect compared with positive control. It was revealed that the substance containing protein serves as an important factor for the immune proliferation. Therefore, the anticomplementary activity ${\beta}$-glucan in classical pathway and alternative pathway displayed the lowest activity, showing 2.2%, 22.3% respectively. However, the immune-stimulating effect of ${\beta}$-glucan showed the T cell stimulating effect 13 times higher than positive control.

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Effect of Calcium on Estrogen and Follicle Stimulating Hormone Secretion in Rabbits

  • Rabia, Ahmad M.;El-Shishtawy, Mamdouh M.;Ibrahim, Tarek M.;El-Gayar, Amal M.
    • Archives of Pharmacal Research
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    • v.13 no.4
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    • pp.379-381
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    • 1990
  • The effect of calcium gluconate on estrogen (estradiol) serum level as well as follicle stimulating hormone level was studied. Our results revealed that oral administration of calcium gluconate (100 mg/kg body wight) to adult non-pregnant female rabbits caused a significant increase of serum levels of estradiol and follicle stimulating hormone. On the other hand, oral contraceptive (Norminest tablets) decreased significantly follicle stimulating hormone serum level, while combined administration of calcium gluconate and oral contraceptive caused significant increase of serum level of follicle stimulating hormone compared with control values. Also, concurrent administration of calcium gluconate and Norminest tablet increased significantly the rate of conception compared with group recieved Norminest tablets only. These results indicated that combined administration of calcium and oral contraceptives must be cautiously.

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A Study on the Structural Causal Relationship of Marketing Stimulating Factors on Online Impulse Purchase through Consumer Value: Focusing on the Mediating Effect of Consumer Value

  • KWON, Lee-Seung;LEE, Jae-Min
    • Journal of Wellbeing Management and Applied Psychology
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    • v.5 no.3
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    • pp.7-17
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    • 2022
  • Purpose: With the introduction of Web 2.0, the advent of smartphones, and the recent outbreak of COVID-19 worldwide, interest in online shopping has soared. In an online shopping environment, the desire for impulse buying increases compared to offline shopping. Research design, data and methodology: In this study, three marketing stimulating factors such as product factor, price factor, and facilitating factor were selected which affect impulse buying for clothing and accessory products in the Korean online shopping environment. The mechanism of causal relationship among them, and the role customer value between marketing stimulating factor and impulse buying was analyzed. Results: The analysis results are as follows. First, the product factor had a significant positive effect on consumer value and impulse buying. Second, the price factor also had a significant positive effect on consumer value and impulse buying. Conclusions: Although the facilitating factor had no significant influence on consumer value and impulse buying, the indirect effect through consumer value was positively significant. Consumer value had a positive mediating effect on impulse purchase in the order of price factor, product factor, and promotion factor.

A VAR Model of Stimulating Economic Growth in the Guangdong Province, P.R. China

  • Ortiz, Jaime;Xia, Jingwen;Wang, Haibo
    • The Journal of Asian Finance, Economics and Business
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    • v.2 no.2
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    • pp.5-12
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    • 2015
  • The authors calculate the long-term predictability of GDP, domestic demand, investment, and net exports for Guangdong province, P.R. China from 2000 to 2013. A vector autoregressive (VAR) model with quarterly data for this period is first co-integrated then the Granger causality test is applied to empirically assess the relationships among gross domestic product (GDP), consumption, investment, and net exports. There is a strong causality effect between investment and net exports in Guangdong province. However, the variance decomposition results indicate that exports respond to foreign shocks rather than domestic ones, making their impact on the Guangdong economy to predict. Results show the stimulating effect of domestic demand on GDP is larger than the stimulating effect of net exports and much larger than even the stimulating effect of investment. The analysis suggests that there are dynamic influences with various levels of persistence between GDP, consumption, investment, and net exports. Macroeconomic policy adjustments are urgently required to expand domestic demand and thereby stimulate economic growth in Guangdong province.

Purification of Embryogenesis Stimulating Activity from Bovine Oviduct Epithelial Cell Conditioned Medium and Its Effect on the Development of Bovine Embryos (소 난관상피세포 배양액 유래 배발육촉진인자의 정제와 소 수정란 체외배양시 발육에 미치는 영향)

  • 김현일;노상호;박종임;신태영;이병천;황우석
    • Journal of Embryo Transfer
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    • v.13 no.1
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    • pp.43-52
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    • 1998
  • The embryogenesis stimulating activity(ESA) had been shown in co-culture of embryos with bovine oviduct epithelial cell(BOEC) and culture in BOEG-conditioned medium. The present study was undertaken to purify and quantify the embryotropic proteins and to determine the optimum concentration of the embryotropic protein for the proper development of embryos. In BOEC-conditioned medium, five major bands of proteins were detected(66, 53, 40, 32 and 24 kDa) by SDS-PAGE. From these proteins, 288pg of protein that had a 32kDa molecular weight was purified by gel filtration column and perfusion chromatography ion-exchange column. When purified protein was supplemented to the in vitro culture media at various concentrations in protein-free media, 2.5$\mu$g /ml supplement group showed significantly higher rates of embryo development into morula /blastocyst stages than other groups(p<0.05). In conclusion, we purified 32kDa protein from BOEC-conditioned medium and this protein showed optimum embryogenesis stimulating effect at 2.5$\mu$g /ml.

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Macrophage Stimulating Activity of Exo-Biopolymer from Submerged Culture of Lentinus edodes with Rice Bran

  • Yu, Kwang-Won;Shin, Kwang-Soon;Choi, Yang-Mun;Suh, Hyung-Joo
    • Journal of Microbiology and Biotechnology
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    • v.14 no.4
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    • pp.658-664
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    • 2004
  • To find a new utilization of rice bran, nine higher fungi were examined for the production of exo-biopolymer with macrophage stimulating activity from rice bran. Among the exo-biopolymers produced from submerged cultures, Lentinus edodes showed the highest activity, followed by Grifola frondosa, Schizophyllum commune, and Coriolus versicolor. L. edodes also had the most potent macrophage stimulating activity in a liquid culture rather than in a solid culture. In order to improve rice bran utilization and the yield of exo-biopolymer with macrophage stimulating activity, the treatment of Rapidase effectively increased the macrophage stimulating activity (about 30% increase), whereas the other enzymes (Econase, Viscozyme, Ultraflo, Celluclast, and Thermylase) treatments did not increase the macrophage stimulating activity. Exo-biopolymer with macrophage stimulating activity from L. edodes contained mainly neutral sugars (58.7%) with considerable amounts of uronic acid (32.2%) and a small amount of proteins (9.1%). Component sugars of exo-biopolymer consisted of mainly arabinose, galactose, glucose, mannose, and xylose (0.95:0.81:0.96:1.00:0.39, respectively). When the exo-biopolymer was treated with $NaIO_4, NaClO_2$, and pronase, the $NaClO_2$ treatment and pronase digestion had little effect, whereas $NaIO_4$ oxidation significantly decreased the macrophage stimulating activity (47.6% reduction at $100\mug/ml$). Therefore, the carbohydrate moiety in exo-biopolymer from L. edodes plays an important role in the expression of the macrophage stimulating activity.

Central nervous system stimulating activity of the ethanolic extract of Fleurya interrupta Guad. (Urticaceae)

  • Shilpi, Jamil Ahmad;Rouf, Razina;Ferdous, MM;Uddin, Shaikh Jamal
    • Advances in Traditional Medicine
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    • v.6 no.1
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    • pp.21-26
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    • 2006
  • The ethanolic extract of Fleurya interrupta Gaud, (Urticaceae) was tested for its possible neuropharmacological effects on experimental animals, For the primary neuropharmacological screening of this plant, the ethanolic extract of its aerial parts was subjected to preliminary evaluation for acute toxicity, antinociceptive activity and central nervous system (CNS) activities. At the doses of 125 and 250 mg/kg, the extract significantly (P < 0.01 and P < 0. 001) and dose-dependently increased the frequency of acetic acid induced writhing in mice. In the pentobarbitone induced sleeping time test, the extract at the above dose levels, significantly and dose-dependently decreased the pentobarbitone induced sleeping time (P < 0.001) and increased the time for onset of sleep (P < 0.001) in mice. In the open field and hole cross tests, test animals showed an increase in their movement in the both tests from the 2nd observation period (30 min) and persisted throughout the entire experimental period (240 min). These results of the extract may attribute a stimulating action on the CNS. On the basis of these findings, it can be assumed that the extract exerts its stimulating effect on the CNS in mice by interfering with the cortical function or increasing the effect of some CNS stimulating neurotransmitters.

Effect of Follicle Stimulating Hormone Dosage on the Production and Pregnancy of Embryos Derived from Korean Brindle Cows (난포자극호르몬(Follicle Stimulating Hormone) 투여 농도가 칡소 수정란의 생산과 이식에 미치는 영향)

  • Choi, Soo-Ho;Park, Yong-Soo
    • Journal of Practical Agriculture & Fisheries Research
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    • v.16 no.1
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    • pp.115-122
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    • 2014
  • Korean native cattles (Han woo) are divided yellow, tiger(blinder), and black by coat color. Chikso has tiger coat color, which cultured about 1,700 heads within Korea. However there were a few researches reported about preservation and production. This study was conducted to investigated that the effect of follicle stimulating hormone (FSH) dosage(240 mg and 280 mg) on the embryo production, pregnancy and calf birth weights. There were no difference total embryo and transferable embryo between FSH 240 mg or 280 mg treatment, but pregnancy rate was increased 46% in embryos derived from 280 mg group than 240 mg group's 29.6%. The birth weight of Chikso calves was similar between artificial insemination(25.6 kg) and embryo transfer(24.8 kg) groups.

Study on Components of Bovine Follicular Fluid Affecting on Sperm Movement (소 정자의 운동성에 영향을 미치는 난포액 성분에 관한 연구)

  • 박영식
    • Journal of Embryo Transfer
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    • v.12 no.2
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    • pp.219-226
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    • 1997
  • Follicular fluid influxed into the oviduct during ovulation may affect movement of sperm for fertilization Thus, in this study, the effect of follicular fluid, obtained from follicles of l0mm in diameter, on number and quality of sperm recovered by swim-up separation was investigated and sperm-movement stimulating components extracted from follicular fluid with methanol and isooctane were separated by gel filtration with Sepadex G-1O, G-25 and G-1OO gels, and were isolated by electrophoresis with SDS-PAGE mini gel. The results obtained were as follows; 1. Diluted follicular fluid stimulated sperm movement. 2. Sperm-movement stimulating factors were in methanol extract. 3. Sperm-movement stimulating effect of methanol extract appeared in fraction I among fractions recovered after gel filtration. And the fraction I contained proteins indicating 4 major bands as about 47, 43, 25 and 14 kilodaldons and 5 minor bands as about 67, 58, 23, 22 and 21 kilodaldons. 4. The fraction I recovered from G-100 gel showed significantly low percentage of motile sperm and had no protein indicating the band of 67 kilodaldons among the minor bands.

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The Effect of Stimulating Twelve Meridional Dermomeres though Moving Cupping Therapy on Obesity (부항의 주관법을 이용하여 12피부 자극을 통한 비만 개선 효과)

  • Ji, Joong-Gu;Kim, Mi-Kyung
    • Journal of Korean Medicine for Obesity Research
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    • v.11 no.2
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    • pp.33-40
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    • 2011
  • Objectives: The purpose of this study was to evaluate the effect of stimulating Twelve Meridional Dermomeres though moving cupping therapy on obesity Methods: We stimulated abdomen and upper arms in equational strength by using cups for 30minutes a week. It was totally ten times from April 2011 to June 2011. We checked body composition, body measuring and serum lipid test before procedure and after 1st, 4th, 7th and 10th procedure. Results: Body composition and abdomen and upper arms measuring were significantly decreased compared before procedure with after. TG in serum lipid test was significantly decreased but TC, LDL-c and HDL-c in serum lipid test were not significantly decreased. Conclusions: Body composition and body measuring weren't decreased a wide variation, but it was a significant decrease. So it is effective on obesity stimulating Twelve Meridional Dermomeres though moving cupping therapy.