• The Mathematical Education
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• v.50 no.4
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• pp.489-505
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• 2011

This study is an analysis on the focus of textbooks regarding the statistical chapters of "measures of representative(central tendency) and of the spread". Applying the summary-concept criteria of Juhyeon Nam(2007), 4 kinds of aspect of the chapter; (1) definition and its teleological validity of the measures of representative, (2) definition and practical value of the measures of spread (3) distributional form on the measures of representative and of spread (4) location and scale preservation or invariance of the measures of representative and of spread were observed. On the measures of representative, some definitions were insufficient to check the teleological validity of the measure. Most definitions of the measure of spread were based on the practical view points but no preparation for the future statistical inferences were found even by implication. Some books mention about the measures of representative and of spread for distributions, but we could not find any comments on the correspondence between the sample mean and the expectation of a distribution or population mean. However it is stimulant that some books check the validity of corresponding measures with the location and scale preservation or invariant property, that were not found in the previous curriculum.

• Journal of Life Science
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• v.10 no.4
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• pp.362-364
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• 2000

Opuntia ficus-indca(Op) extract has been claimed to have several therapeutic properties in oriental medicine including anti-inflammatory and anti-rheumatoid arthritis effects. Little is known of its effect on the activation of immune cells such as T cells and macrophages. To evaluate the functional effect of Op extract on immune cells, we examined whether Op extract stimulates the proliferation of T cells and the secretion of cytokines including IL-1 beta, IL-6 and tumor necrosis factor-alpha in THP-1 cell lines by RT-PCR. Op extract significantly enhanced the proliferation of T cell clone(D10S). Transcription of cytokines including IL-1 beta, IL-6, and TNF-alpha peaked 6 hrs after exposure to Op extract(100g/ml) in the THP-1 cell line and declined and declined thereafter. In an experiment to test the dose dependency of transcription of cytokines, transcription increased at a dose of 10 g/ml and the maximum expression was obtained at 100 g/ml, 6 hrs after exposure to Op extract. These findings suggest that Op extract is a potent stimulant of immune cells including T cells and macrophages, which acts by stimulating T cell proliferation and upregulating cytokines. These phenomena imply that some edible plants may be beneficial to living animals through the activation of immune functions.

• Journal of Ginseng Research
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• v.13 no.1
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• pp.66-70
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• 1989

The specific growth rate was investigated to find the of(emits of major ginseng components in fractions extracted by several solvents on the growth of Candida parapsilosis. The cell proliferation of C. purapsilosis was inhibited by fraction A(hexane soluble components), while enhanced by fraction B(Et2O soluble components), C(AcOEt soluble components), E and F(dialysis outer and inner extract). The additive stimulant effect of cell proliferation was exerted by fraction D(crude saponinE) and B, C or E.

• The Research Journal of the Costume Culture
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• v.13 no.2 s.55
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• pp.289-299
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• 2005

Through the formative analysis of the traditional jokakbo, we have composed surface composition that was made by a perfect square, triangle, a weather vane type, vertical type, cintamani type, and a mixed rectangular. And we have composed 18 kinds of motif stimulants that was made by vivid tone, pale tone, and so on, and finally analyzed sensibility image, preference rate of them. The cause of composition for the sensibility image of stimulant was composed by the cause of simplicity characteristics, interesting characteristics, rigid-flexibility characteristics, and modern characteristics. And from these things, the cause of simplicity characteristics and the cause of interesting characteristics were revealed as important dimensional factors of sensibility image. The sensibility image of motif was revealed as a simple image of perfect square, a feminine image of cintamani type, a modern image of mixed rectangular. And black-white colored mixed rectangular and chromatic colored cintamani type were also revealed as an interesting image. The preference rate of motif is related with the cause of interesting characteristics and simplicity characteristics, it also has been revealed to prefer the pale tone than others. And it also has been revealed that achromatic colored mixed rectangular, cintamani type of vivid tone, perfect square and rectangular of pale tone were mostly preferred.

• Archives of Pharmacal Research
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• v.11 no.1
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• pp.65-73
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• 1988

The effects of clonidine on the negative chronotropic response induced by stimulation of vagus nerve were studied in the presence of propranolol in reserpinized and anesthetized rats. When the heart rate was decreased by stimulation of the vagus nerve, clonidine significantly inhibited vagally induced heart rate decrease (negative chronotropic response) in dose dependent manner. This inhibitory effect of clonidine was virtually abolished by phentolamine, ${\alpha}_1-\;and\;{\alpha}_2-adrenoceptor$ antagonist, and partially antagonized by prazosin, ${\alpha}_1-adrenoceptor$ antagonist. On the other hand, when the heart rate was decreased by the infusion of bethanechol, a muscarinic parasympathetic stimulant, clonidine had no effect on the bethanechol-induced heart rate decrease. These results suggest that clonidine inhibits vagally induced negative chronotropic response by activation of presynaptic ${\alpha}-adrenoceptors$ located on the parasympathetic cholinergic nerve terminal in the heart and this effect of clonidine is more related to ${\alpha}_2-adrenoceptors$ than ${\alpha}_1-adrenoceptors$.

• Journal of the Korean Society of Food Science and Nutrition
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• v.4 no.1
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• pp.45-48
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• 1975

Coffee is a popular beverage with many people at home and in the tea-room. Caffeine is a major chemical compound of coffee. A little caffeine is a stimulant to the movement and spiritual nerve, but much caffeine influences sleep, nervousness, non-concentration, headache and giddiness depending upon each person. The writer expresses the result of the caffeine content in the coffee which is collected from the coffee- shops of Seoul. The contents are as follows : 1) Caffeine content of the coffee of the tea-room was researched dividing into the central Seoul city and the outskirts of Seoul. 2) Caffeine content of the coffee in the outskirts tea-rooms is $0.32{\sim}1.23mg/ml$ and the average is 0.546mg/ml (SD 0.19). 3) Caffeine content of the coffee of the central city is $0.34{\sim}0.73mg/ml$ and the average is 0.513mg/ml(SD 0.12). 4) There was no difference between the outskirts and the central city. 5) Caffeine content of the coffee of the tea-rooms according to each season is going to be researched.

• Archives of Pharmacal Research
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• v.28 no.7
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• pp.770-774
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• 2005

This study investigated the stimulative or sedative effects of inhaling fragrant essential oils (EOs) by using a forced swimming test (FST) with mice. This behavioral test is commonly used to measure the effects of antidepressant drugs. The inhalation by mice of EOs, such as ginger oil (p<0.05), thyme oil (p<0.05), peppermint oil (p<0.05), and cypress oil (p<0.01) resulted in 5% to 22% reduction of immobility. The same results were achieved when over-agitation was artificially induced in the mice by an intraperitoneal injection of caffeine (a psycho-stimulant). In contrast, inhalation of some EOs by the mice resulted in increased immobility. To evaluate more correctly the sedative effects of EOs, the immobility of over-agitated mice induced with caffeine was ascertained after the inhalation of various EOs. Inhalation of lavender oil (p<0.01) and hyssop oil (p<0.01) increased the immobile state in mice that were treated with caffeine. The results of this study indicate that the inhalation of essential oils may induce stimulative or sedative effects in mice.

• KIEAE Journal
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• v.12 no.3
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• pp.115-122
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• 2012

Based on previous research and existing literature, this study examines the development of admixture, which increases the early concrete strength (1 and 3 day) by mixing blast furnace slag cement and concrete stimulant. The research on early strength development of concrete is necessary in dealing with the drawbacks of slow early strength concrete on site and to shorten the construction time. The study confirmed that when a high alkaline mortar mixture is mixed with blast furnace slag, the early strength of admixture exceeds that of ordinary portland cement (OPC). The use of calcium chloride ($CaCl_2$) promotes hydration of cement at low temperature and show similar strength as the blast furnace slag admixture. Although calcium chloride seems economically advantageous, it causes steel corrosion and its use in concrete should be further studied in-depth.

• Toxicological Research
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• v.30 no.4
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• pp.297-304
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• 2014

Peppermint (Mentha piperita) is a plant native to Europe and has been widely used as a carminative and gastric stimulant worldwide. This plant also has been used in cosmetic formulations as a fragrance component and skin conditioning agent. This study investigated the effect of peppermint oil on hair growth in C57BL/6 mice. The animals were randomized into 4 groups based on different topical applications: saline (SA), jojoba oil (JO), 3% minoxidil (MXD), and 3% peppermint oil (PEO). The hair growth effects of the 4-week topical applications were evaluated in terms of hair growth, histological analysis, enzymatic activity of alkaline phosphatase (ALP), and gene expression of insulin-like growth factor-1 (IGF-1), known bio-markers for the enhanced hair growth. Of the 4 experimental groups, PEO group showed the most prominent hair growth effects; a significant increase in dermal thickness, follicle number, and follicle depth. ALP activity and IGF-1 expression also significantly increased in PEO group. Body weight gain and food efficiency were not significantly different between groups. These results suggest that PEO induces a rapid anagen stage and could be used for a practical agent for hair growth without change of body weight gain and food efficiency.

• YAKHAK HOEJI
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• v.48 no.5
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• pp.266-271
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• 2004

Ginger (Zingiber officinale Roscoe) is widely used as a common condiment for a variety of foods and beverages. In addition to its extensive utilization as a spice, the fresh or the processed rhizome is a useful crude drug in traditional Chinese medicine. It is considered to possess stomachic, carminative, stimulant, diuretic and antiemetic properties. Chemical studies on the pungent principles of ginger have been carried out by a number of investigators, and 6-gingerol and 6-shogaol as a major pungent substance have been isolated. In this study, the constituents inhibiting a drug metabolizing enzyme CYP3A4 from ginger were investigated. CYP3A4 is responsible for drug metabolism as heme-containing monooxygenases. As a result of experiment, 10-gingerol (lC$_{50}$ 5.75$\mu$M) isolated from EtOAc extract of ginger showed remarkable inhibitory activity compared to 6-gingerol ($IC_{50}$/ 14.56 $\mu$M) and zingerone ($IC_{50}$/ 379.63 $\mu$M). This paper describes the isolation, structure elucidation, and CYP3A4 inhibitory activity of these compounds. The structure of the compounds were identified by instrumental analysis such as LC-mass spectrometer and NMR.R.