• Journal of Service Research and Studies
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• v.13 no.1
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• pp.144-158
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• 2023

R&D (Research and Development) investment by companies and the government continues to increase, and the total R&D expenditure of public and private sectors in 2021 reached KRW 102 trillion, and the ratio of R&D investment to GDP was 4.96%. It ranks second in the world after Israel. This study analyzes the current status of the domestic R&D service industry and the research and development (R&D) innovation ecosystem based on the business activity survey data of the National Statistical Office in terms of improving R&D productivity of domestic R&D investment that has exceeded 100 trillion won, and analyzes the global R&D service industry and analyzes the global research service industry and R&D service Industry support government policy As a result of the analysis, in the domestic R&D ecosystem, the R&D outsourcing demand of service companies is rapidly increasing, compared to the stagnant R&D outsourcing demand of traditional manufacturing companies. In order to respond to these changing demands for technological innovation, this study suggests balanced support for R&D outsourcing for manufacturing and service companies, expansion of domestic R&D outsourcing, establishment of R&D outsourcing strategies specialized for the service industry, establishment of an open R&D ecosystem, and innovation in connection with materials/parts/equipment strategies.

• Korean Journal of Animal Reproduction
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• v.9 no.2
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• pp.133-139
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• 1985

An immunoassay may be defined as an analytical procedure involving the competitive reaction between a limiting concentration of specific antibody and two populations of antigen, one of which is labelled or immobillized. The advent of immunoassay has revolutionised our knowledge of reproductive physiology and the practice of veterinary and clinical medicine. Radioimmunoassay (RIA) was the first of these methods to be developed, which meausred the analyte with good sensitivity, accuracy and precision (1,2). The essential components of RIA are:-(i) a limited concentration of antibodies, (ii) a reference preparation, and (iii) an antigen labelled with a radioisotope (usually tritium or iodine-125). Most procedures invelove isolating the antibody-bound fraction and measuring the amount of labelled antigen. Good facilities are available for scintilltion counting, data reduction nd statistical analysis. RIA is undergoing refinement through:-(i) the introduction of new techniques to separate the antibody-bound and free fractions which minimize the misclassification of labelled antigen into these compartments, and the amount of non-specfic binding. (3), (ii) the development of non-extration for the measurement of haptens (4), (iii) the determination of a, pp.rent free (i.e. non-protein bound) analytes (5), and (iv) the use of monoclonal antibodies(6). In 1968, Miles and Hales introduced in important new type of immunoassay which they termed immunora-diometric assay (IRMA) based on t도 use of isotopically labelled specific antibodies(7) in a move from limited to excess reagent systems. The concept of two-site IRMAs (with a capture antibody on a solid-phase, and a second labelled antibody to a different antigenic determinant of the analyte) has enabled the development of more sensitive and less-time consuming methods for the measurement of protein hormones ovar wide concentration of analyte (8). The increasing use of isotopic methos for diverse a, pp.ications has exposed several problems. For example, the radioactive half-life and radiolysis of the labelled reagent limits assay sensitivity and imposes a time limit on the usefulness of a kit. In addition, the potential health hazards associated with the use and disposal of radioactive cmpounds and the solvents and photofluors necessary for liquid scientillation counting are incompatable with the development of extra-laboratory tests. To date, the most practical alternative labels to radioisotopes, for the measurement of analytes in a concentration > 1 ng/ml, are erythrocytes, polystyrene particiles, gold sols, dyes and enzymes or cofactors with a visual or colorimetric end-point(9). Increased sensitivity to<1 pg/ml may be obtained with fluorescent and chemiluminescent labels, or enzymes with a fluorometric, chemiluminometric or bioluminometric end-point. The sensitivity of any immunoassay or immunometric assay depends on the affinity of the antibody-antigen reaction, the specific activity of the label, the precision with which the reagents are manipulated and the nonspecific background signal (10). The sensitivity of a limited reagent system for the measurement of haptens or proteins is mainly dependent upon the affinity of the antibodies and the smalleest amount of reagent that may be manipulated. Consequently, it is difficult in practice to improve on the sensitivity obtained with iodine-125 as the label. Conversely, with excess reagent systems for the measurement of proteins it is theoretically possible to increase assay sensitivity at least 1000 fold with alternative luminescent labels. To date, a 10-fold improvement has been achieved, and attempts are being made to reduce the influence of other variables on the specific signal from the immunoreaction.

• The Journal of Korean Medicine
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• v.44 no.2
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• pp.149-169
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• 2023

Objectives: This study was designed to statistically analyze patients hospitalized for thoracolumbar compression fractures at Daejeon University Daejeon Korean Medicine Hospital from January 1, 2017 to December 31, 2021. Methods: A total of 62 patients were analyzed through electronic medical records in this study. The extracted data was analyzed using IBM SPSS ver.27.0. Results: 1. Traffic accident patients were more likely to reduce pain by more than half compared to falls and other patients. Patients without spinal disease were more likely to reduce pain by more than half compared to those without. The shorter the absolute bed rest and the longer the hospital stay, the higher the probability of pain reduction by more than half. 2. The duration of pain half-reduction was longer in patients with diabetes than in patients without diabetes. 3. The longer the hospitalization period and the shorter the absolute bed rest period, the less pain was reported upon discharge. Males complained of less pain at discharge than females, and patients without spinal disease complained less than those without. Patients who did not receive absolute bed rest complained of less pain upon discharge than those who did not. Conclusions: This study included patients hospitalized for thoracolumbar compression fractures and showed that etiology, absolute bed rest period, hospitalization period, gender, spinal disease, diabetes statistically affected the degree of pain reduction.

• Journal of The Korean Society of Grassland and Forage Science
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• v.42 no.1
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• pp.1-9
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• 2022

This study was carried out to compare the DMY (dry matter yield) of IRG (Italian ryegrass) in the southern coastal regions of Korea due to seasonal climate scenarios such as the Kaul-Changma (late monsoon) in autumn, extreme winter cold, and drought in the next spring. The IRG data (n = 203) were collected from various Reports for Collaborative Research Program to Develop New Cultivars of Summer Crops in Jeju, 203 Namwon, and Yeungam from the Rural Development Administration - (en DASH). In order to define the seasonal climate scenarios, climate variables including temperature, humidity, wind, sunshine were used by collected from the Korean Meteorological Administration. The discriminant analysis based on 5% significance level was performed to distinguish normal and abnormal climate scenarios. Furthermore, the DMY comparison was simulated based on the information of sample distribution of IRG. As a result, in the southern coastal regions, only the impact of next spring drought on DMY of IRG was critical. Although the severe winter cold was clearly classified from the normal, there was no difference in DMY. Thus, the DMY comparison was simulated only for the next spring drought. Under the yield comparison simulation, DMY (kg/ha) in the normal and drought was 14,743.83 and 12,707.97 respectively. It implies that the expected damage caused by the spring drought was about 2,000 kg/ha. Furthermore, the predicted DMY of spring drought was wider and slower than that of normal, indicating on high variability. This study is meaningful in confirming the predictive DMY damage and its possibility by spring drought for IRG via statistical simulation considering seasonal climate scenarios.

• Journal of Dental Anesthesia and Pain Medicine
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• v.22 no.2
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• pp.107-116
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• 2022

Background: Pain during fixed orthodontic treatment can have a detrimental effect on patient treatment compliance. To overcome this, there is a definite need to establish the best pain-relieving methods suitable for orthodontic patients in terms of efficacy and use. The objective of this study was to compare the effect of chewing gum and pre-emptive tenoxicam on pain after initial archwire placement and to evaluate the pain perceptions of orthodontic patients in the two groups while performing various functions at specific time intervals. Methods: Forty-two patients were selected and randomly divided into two groups: group A (chewing gum) and group B (pre-emptive tenoxicam). Pain perception was documented by patients immediately; at 4 h; at bedtime on the day of archwire placement; the next morning; at 24 h; and at bedtime on the 2nd, 3rd, and 7th day after the initial archwire placement. Pain scores were noted during fitting of the posterior teeth, biting, and chewing using a visual analog scale. The data obtained were subjected to statistical analysis. Results: Group A showed a significant increase in pain until the next morning while fitting the posterior teeth, biting, and chewing [36.2, 52.0, 33.4, respectively]], followed by a gradual decrease by the 7th day. Group B showed a significant increase in pain at bedtime on biting, with a peak value of 47.5. Pain on chewing, fitting posterior teeth, peaked the morning of the next day (100.0, 45.0). The Freidman test showed a statistically significant difference with a p-value of < 0.01. Higher pain scores were observed while chewing and biting compared with that while fitting the posterior teeth in both groups. The overall comparison of pain control between the two groups was not statistically significant [P > 0.05] between the two groups. Conclusions: Chewing gum was not inferior to pre-emptive tenoxicam. Thus, chewing gum is a non-pharmacological alternative to analgesics for orthodontic pain control that eliminates the chance of adverse reactions and can be used in the absence of adult observation.

• Journal of the Korean Society of Marine Environment & Safety
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• v.29 no.1
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• pp.24-35
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• 2023

Rapid industrialization and urbanization have led to severe marine pollution. A Water Quality Index (WQI) has been developed to allow the effective management of marine pollution. However, the WQI suffers from problems with loss of information due to the complex calculations involved, changes in standards, calculation errors by practitioners, and statistical errors. Consequently, research on the use of artificial intelligence techniques to predict the marine and coastal WQI is being conducted both locally and internationally. In this study, six techniques (RF, XGBoost, KNN, Ext, SVM, and LR) were studied using marine environmental measurement data (2000-2020) to determine the most appropriate artificial intelligence technique to estimate the WOI of five ecoregions in the Korean seas. Our results show that the random forest method offers the best performance as compared to the other methods studied. The residual analysis of the WQI predicted score and actual score using the random forest method shows that the temporal and spatial prediction performance was exceptional for all ecoregions. In conclusion, the RF model of WQI prediction developed in this study is considered to be applicable to Korean seas with high accuracy.

• Therapeutic Science for Rehabilitation
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• v.11 no.1
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• pp.35-47
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• 2022

Objective : In this study, we conducted a questionnaire survey of occupational therapists to examine their perceptions on and willingness to provide telerehabilitation dementia prevention education. Methods : From March 13 to 19, 2021, a questionnaire survey targeting occupational therapists in Busan, Ulsan, and Gyeongnam was conducted. 100 questionnaires were distributed but only 70 were collected. The collected data were subjected to frequency analysis and descriptive statistics using the statistical program SPSS version 23.0. Results : The average scores by region were as follows. The average compatibility score was highest at 3.92 score, intention to providing education, doctors 3.89 score, community-centric rehabilitation awareness 3.81 score, cost saving 3.78 score, perceiver usefulness 3.75 score, accessibility 3.62 score, the quality of telerehabilitation service was in order of 3.49 score. Conclusion : All items asking whether occupational therapists participate in community-centered rehabilitation and non-face-to-face dementia prevention education programs showed high scores, indicating the willingness to participate actively. In the future, in addition to follow-up research on the implementation of telerehabilitation dementia prevention education, measures for improving accessibility within the local and national government should be discussed.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.2B
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• pp.163-171
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• 2009

Classical linear models have been generally used to analyze and forecast hydrologic time series. However, there is growing evidence of nonlinear structure in natural phenomena and hydrologic time series associated with their patterns and fluctuations. Therefore, the classical linear techniques for time series analysis and forecasting may not be appropriate for nonlinear processes. In recent, the BDS (Brock-Dechert-Scheinkman) statistic instead of conventional techniques has been used for detecting nonlinearity of time series. The BDS statistic was derived from the statistical properties of the correlation integral which is used to analyze chaotic system and has been effectively used for distinguishing nonlinear structure in dynamic system from random structures. DVS (Deterministic Versus Stochastic) algorithm has been used for detecting chaos and stochastic systems and for forecasting of chaotic system. This study showed the DVS algorithm can be also used for detecting nonlinearity of the time series. In this study, the stochastic and hydrologic time series are analyzed to detect their nonlinearity. The linear and nonlinear stochastic time series generated from ARMA and TAR (Threshold Auto Regressive) models, a daily streamflow at St. Johns river near Cocoa, Florida, USA and Great Salt Lake Volume (GSL) data, Utah, USA are analyzed, daily inflow series of Soyang dam and the results are compared. The results showed the BDS statistic is a powerful tool for distinguishing between linearity and nonlinearity of the time series and DVS plot can be also effectively used for distinguishing the nonlinearity of the time series.

• Smart Media Journal
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• v.12 no.5
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• pp.111-121
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• 2023

The purpose of this study is to find methods for logo renewal design according to the brand life cycle, considering the logo as an important visual tool that represents the brand identity in terms of brand management. This study was conducted through literature study on brand life cycle and brand renewal strategy, an expert survey on logo renewal design, and logo analysis of 35 food and beverage brands with statistical data to determine brand life cycle. The results of the study are three. First, the four stages(introduction, growth, maturity, and decline) of brand life cycle characteristics and renewal strategies were derived. Second, four brand renewal strategies(partial change, total change, repositioning, new image creation) and methods for logo renewal design were proposed based on the life cycle of the brand. Based on this, renewal characteristics for each life cycle were proposed. Third, visual elements of identity that are important depending on the brand life cycle and brand renewal strategy were found. It was found that the addition and subtraction of graphic elements and change of color tone are important in the partial change strategy of the growth period and maturity period, and that the change of signature color is important in the repositioning strategy and the creation of the new image.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.4D
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• pp.351-360
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• 2010

In 2010, the number of registered vehicles reached almost at 17.48 millions in Korea. This dramatic increase of vehicles influenced to increase the number of traffic accidents which is one of the serious social problems and also to soar the personal and economic losses in Korea. Through this research, an enhanced intersection hazard prediction model by combining Genetic Algorithm and Artificial Neural Network will be developed in order to obtain the important data for developing the countermeasures of traffic accidents and eventually to reduce the traffic accidents in Korea. Firstly, this research has investigated the influencing factors of road geometric features on the traffic volume of each approaching for the intersections where traffic accidents and congestions frequently take place and, a linear regression model of traffic accidents and traffic conflicts were developed by examining the relationship between traffic accidents and traffic conflicts through the statistical significance tests. Secondly, this research also developed an intersection hazard prediction model by combining Genetic Algorithm and Artificial Neural Network through applying the intersection traffic volume, the road geometric features and the specific variables of traffic conflicts. Lastly, this research found out that the developed model is better than the existed forecasting models in terms of the reliability and accuracy by comparing the actual number of traffic accidents and the predicted number of accidents from the developed model. In conclusion, it is expect that the cost/effectiveness of any traffic safety improvement projects can be maximized if this developed intersection hazard prediction model by combining Genetic Algorithm and Artificial Neural Network use practically at field in the future.