• Journal of Pharmaceutical Investigation
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• v.38 no.2
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• pp.135-142
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• 2008

The present study describes the evaluation of the bioequivalence of two atorvastatin tablets, Lipitor $Tablet^{(R)}$ (Pfizer, reference drug) and Atorva $Tablet^{(R)}$ (Yuhan, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Forty-nine healthy male Korean volunteers received each medicine at the atorvastatin dose of 40 mg in a $2{\times}2$ crossover study with a two weeks washout interval. After drug administration, serial blood samples were collected at a specific time interval from 0-48 hours. The plasma atorvastatin concentrations were monitored by an high performance liquid chromatography -tandem mass spectrometer (LC-MS/MS) employing electrospray ionization technique and operating in multiple reaction monitoring (MRM) and positive ion mode. The total chromatographic run time was 4.5 min and calibration curves were linear over the concentration range of 0.1-100 ng/mL for atorvastatin. The method was validated for selectivity, sensitivity, linearity, accuracy and precision. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 48hr) was calculated by the linear log trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were complied trom the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for Atorva $Tablet^{(R)}$ / Lipitor $Tablet^{(R)}$ were ${\log}\;0.9413{\sim}{\log}\;1.0179$ and ${\log}\;0.831{\sim}{\log}\;1.0569$, respectively. These values were within the acceptable bioequivalence intervals of ${\log}\;0.8{\sim}{\log}\;1.25$. Based on these statistical considerations, it was concluded that the test drug, Atorva $Tablet^{(R)}$ was bioequivalent to the reference drug, Lipitor $Tablet^{(R)}$.

• Journal of the Korean Society of Earth Science Education
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• v.9 no.2
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• pp.123-138
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• 2016

The purpose of this study is to examine the effects of applying the Question-Answer Relationship (QAR)strategy on the attitude toward science of the elementary fifth grade students whose learning styles have beenidentified. The population of the study constitutes the total of 97 elementary fifth grade students who wereassigned into a comparison (n=48) or experimental group (n=49). To understandhow the QAR strategy potentially influencedscientific attitude, both groups were surveyedin the areas of scientific attitude before and after the experiment. TheKolb's Test was used to identifythe students' learning stylein the experimental group. According tothe learners' learning style, the results have been compared and analyzed. The results of this study are as follows:First, the findings revealed a significant difference in the experimental group students' attitude toward sciencecompared to the comparison group. Second, four learning styles were identified among the studentsin theexperimental group: a) Accommodators (46.9%), b) Convergers (24.5%), c) Divergers (20.4%), and d) Assimilator (8.2%). Following the data analysis, there was no meaningful statistical difference between four groups oflearning styles with respect to their scientific attitude.Applyingthe QAR strategy in a science class seemed toimprove the accommodators, convergers, and divergers' scientific attitude positively.

• School Mathematics
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• v.19 no.4
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• pp.751-774
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• 2017

Having mathematics for everyone in terms of students' mathematics achievement and attitudes toward mathematics is challenging in high school in South Korea. To gain such purpose, teachers are supposed to have a considerable amount of knowledge and develop mathematical and pedagogical reasoning and insight because equity can be fulfilled in mathematics classroom when any student share their ideas and have mathematical discussions. As a part of a large project aimed to develop and enact professional development for equity and examine its effects and, finally, to propose the direction of professional development to help students cognitively and affectively balanced grow in mathematics, the current study briefly introduces how such professional development was designed and implemented. This study reports its effect based on the statistical analysis of students' responses for the three different surveys, which are parts of the National Assessment of Educational Achievement study, TIMSS Advanced, and the survey about classroom interaction. The data collected in all students in school whose three mathematics teachers had participated in the professional development for two years. The findings consistently indicate the strong and impressive growths in students' attitudes toward mathematics, which are statistically significant. Furthermore, their attitudes toward mathematics are also related to interactions in a mathematics classroom. Based on such results, this study claims expansion of professional development for equity.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.20 no.6
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• pp.564-574
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• 2008

This study investigates a long-term variation of annual maximum surge heights(AMSH) and main characteristics of high surge events, which is influenced by the global warming and intensifying typhoons, using sea level data at Sokcho and Mukho tidal stations over 34 years ($1974{\sim}2007$). It is found that the there is a longterm uptrend of the AMSH at Sokcho (8.3 cm/34yrs) and at Mukho (8.7 cm/34yrs), which is significant within 95% confidence level based on the linear regression. The statistical analysis reveals that 53% of the AMSH occurs during typhoon's event in both tidal stations and the highest surge records are mostly produced by the typhoon. It is concluded that the uptrend in the AMSH is attributed by the increasing typhoon activities globally as well as locally in Korea due to the increased sea surface temperature in tropical oceans. The continuous efforts monitering and predicting the extreme surge events in the future warm environments are required to prevent the growing storm surge damage by the intensified typhoon.

• Restorative Dentistry and Endodontics
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• v.24 no.2
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• pp.381-391
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• 1999

A new 5th generation adhesive system(ONE-STEP) has been supplied which operators can apply to conditioned tooth surfaces by one simplified step. The purpose of this study was to determine whether different methods of adhesive application and various air drying duration after applying adhesive affect the shear bond strength of composite resin to dentin, and to evaluate the adhesive pattern of composite resin and dentin under SEM. Seventy-seven extracted human molar teeth were cleaned and mounted in palstic test tubes. The occlusal dentin surfaces were exposed with Diamond Wheel Saw and smoothed with Lapping and Polishing Machine (South Bay Technology Co., U.S.A.). Teeth were randomly divided into 7 groups (n=11), In experimental A group, adhesive was applied to dentin with agitation for 20 sec. In experimental N-A group, adhesive were continuously applied to dentin for 20 sec. Also control and experimental 1, 2, 3, 4 groups were dried for 10, 0, 5, 20, 30 seconds after applying adhesive, respectively, Adhesives were light cured for 10 sec. A gelatin capsule 5mm in diameter was filled with Aelitefil$^{TM}$ composite resin, placed on the treated dentin surface and light cured for 40 see, from three sides, All specimens were stored in distilled water at room temperature for 24 hours. The shear bond strengths were measured using a universal testing machine(AGS-1000 4D, Japan) at a crosshead speed of 5mm/min. An one-way ANOVA and LSD test were used for statistical analysis of the data. For SEM evaluation, seven specimens were made and sectioned. Representive postfracture and seven specimens were mounted on brass stubs, sputter-coated with gold and observed under SEM. The results were as follows : 1. The shear bond strength of experimental A group which adhesive were applied to dentin with agitation was higher than that of experimental N-A group (continuous application), and there was significant difference between two groups (p<0.01). 2. The interface between composite and dentin according to different application methods showed close adaptation in experimental A group and showed tinny gap in experimental N-A group. 3. The shear bond strength accoding to various air drying duration was the lowest value(7.57${\pm}$2.60 MPa) in experimental 1 group, so there was significant difference between experimental 1 group and other four groups (p<0.05). But there was no significant difference of shear bond strength between four groups (p>0.05). 4. The interface between composite and dentin according to various air drying duration showed close adaptation in control group and tinny gap in experimental 3 and 4 groups. But experimental 1 and 2 groups showed $30{\mu}$ and 6 - $10{\mu}m$ thick gaps, respectively.

• Journal of the Korean Institute of Landscape Architecture
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• v.39 no.1
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• pp.75-83
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• 2011

This research aims to grasp the use status and satisfaction level based on citizen consciousness to improve future design. This study employs a combination literature review and field survey. In the literature review, the related materials were collected to obtain the most useful information for references, and the POE study of the Xi'an Ming City Wall Park was conducted. The survey instrument is a questionnaire that includes questions regarding Xi'an Ming City Wall Park. Data were analyzed using the Statistical Package for the Social Sciences(SPSS17.0 for Windows). Through the POE analysis of the usage status and variables which significantly affect the users' degree of satisfaction with the spaces and facilities were investigated and the following problems have been found.Xi'an Ming City Wall Park requires extensive modification to meet the demands of citizens. Several shortcomings are hampering the development of the park. The rest space and the nightscape seem to be the two most problematic aspects in the park. The nightscape design should be particularly emphasized in the overall park design in the future. The results also show that the major population visiting the park is the elderly, so the characteristics of this age should be taken into consideration when improvement decisions are made, and the facilities and activities suitable to elderly people should also be increased.

• Journal of Korean Society of Rural Planning
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• v.26 no.4
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• pp.67-79
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• 2020

As globalization, international cooperation has grown in importance. In accordance with this trend, Korea has been receiving high demands from international organizations about expanding the scale of Official Development Assistance(ODA) in line with its improved national status. In addition, in the economic aspect of Korea, the ODA project is expected to provide new growth opportunities in the mid- to long-term by promoting cooperation with developing countries. Uganda is an area with high strategic value due to good agricultural conditions and favorable geographical conditions. The poultry industry is a business that is generally carried out to the Ugandan, but due to economic problems such as initial investment cost, most of them have raised poultry on a small scale which is not enough for main income. This paper proposes the construction and operation plan of adapting to small poultry farms in the village-intensive type to sustainable income for residents in Uganda through ODA project in Korea's agricultural technology. The economic feasibility was analyzed from the long-term perspective when the initial construction cost was supported or not and the poultry species ratio was adjusted in terms of initial and operating costs. Economic analysis was performed using Net Present Value(NPV) method. As of after 10 years, when operating in the form of shifting kuroiler to layers, it was estimated to earn about 700,000 ugx more than when only kuroiler is raised, and it is able to reduce about 14 million ugx from the initial cost than when only raising layers. As of 20 years, the most profitables scenario was the breeding of 100 kuroilers and 400 layers methods. however, this case was anlayzed to be unsuitable for Uganda farmers, with initial costs more than three times higher than the shifting method of the kuroiler to layers. If the initial construction cost is supported by ODA project, the initial investment cost can be recovered in the first year with the shifting method, whereas raising only layers take two years to recoup the cost. In the meantime, when studying livestock industry in Uganda, it was examined by relying on statistical data, but this paper is meaningful in that it predicted how much it is economically effective based on field experience.

• Archives of Plastic Surgery
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• v.37 no.6
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• pp.721-725
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• 2010

Purpose: The survival of composite graft is dependent on three steps, (1) plasmatic imbibitions, (2) inosculation, and (3) neovascularization. Among the many trials to increase the survival rate of composite graft, prostaglandin E1 (PGE1) has beneficial effects on the microcirculatory level with vasodilating, antithrombotic, anti-inflammatory and neoangiogenic properties. Lipo-PGE1 which is lipid microspheres containing PGE1 had developed to compensate the systemic and local side effects of PGE1. This study was proposed to determine whether Lipo-PGE1 administration enhanced the survival of composite graft through neovascularization quantitatively in a rabbit ear model. Methods: Fourteen New Zealand White Rabbits each weighing 3~4 kg were divided in two groups: (1) intravenous Lipo-PGE1 injection group and (2) control group. A $2{\times}1\;cm$ sized, full-thickness rectangular composite graft was harvested in each auricle. Then, the graft was reaaproximated in situ using a 5-0 nylon suture. For the experimental group, $3{\mu}g$/kg/day of Lipo-PGE1 ($5{\mu}g$/mL) was administered intravenously through the marginal vein of the ear for 14 days. The control group was received no pharmacologic treatment. On the 14th postoperative day, composite graft of the ear was harvested and immunochemistry staining used Monoclonal mouse anti-CD 31 antibody was performed. Neoangiogenesis was quantified by counting the vessels that showed luminal structures surrounded by the brown color-stained epithelium and counted from 10 random high-power fields (400x) by independent blinded observer. Statistical analysis (Wilcoxon Signed Ranks test for nonparametric data) was performed using SPSS v12.0, with values of p<0.05 considered significant. Results: The mean number of the microvessels was $15.48{\pm}8.65$ in the experimental group and $9.82{\pm}7.25$ in the control group (p=0.028). Conclusion: The use of Lipo-PGE1 facilitated the neoangiogenesis, resulted in the improvement of the survival rate of graft. On the basis of this results, we could support wider application of Lipo-PGE1 for more effective therapeutic angiogenesis and successful survival in various cases of composite graft in the human.

• Journal of Trauma and Injury
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• v.21 no.2
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• pp.115-119
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• 2008

Purpose: Abrupt abstinence from alcohol in cause of chronic alcohol addiction can trigger alcohol withdrawal syndrome. The authors studied the effect of post-operative alcohol withdrawal syndrome in patients who require intensive care due to trauma. Methods: For the study group, we selected 70 patients who had undergone emergency surgery from May 2003 to March 2007 due to trauma and who had been treated with prophylactic thiamine. Data was collected retrospectively. We excluded those who extended their hospital stay for other than traumatic causes, those who died within 3 days of surgery after trauma, those who transferred to other institutions, and those who received a psychiatric diagnosis. Patient groups were determined by the existence or the non-existence of withdrawal syndrome. Age, sex, injury mechanism, mortality, complications, durations of hospital stay and intensive care, use of mechanical ventilator, and sedative use were investigated. A Chi-square test and The Mann-Whitney method were used for statistical analysis in this study. Results: Twenty-four (24) patients from the 58 who had an ISS of 16 or more showed alcohol withdrawal syndrome, and men were shown to be affected with the syndrome significantly more than women. Although ISS was higher in the group with alcohol withdrawal syndrome, statistically, the difference was not significant (P<0.08). The total hospital stay in the patient group with alcohol withdrawal syndrome was on average 10 days longer. However, the difference was not significant (P<0.054). The duration of intensive care in the patient group with alcohol withdrawal syndrome was significantly longer (P<0.029). The patients with alcohol withdrawal syndrome showed no significant difference in the duration of mechanical ventilator use (P<0.783), or in the duration of sedative use (P<0.284). Respiratory distress, pneumonia, upper airway infection, sepsis, acute renal failure, and mortality in the alcohol withdrawal syndrome group were investigated, but no statistically significant difference were noted. Conclusion: We found that the duration of intensive care in chronic alcohol abusers was longer due to the development of alcohol withdrawal syndrome. We also discovered that, when the patients overcame the symptoms of alcohol withdrawal syndrome after intensive care, no difference was found in the frequency of developing complications, the morbidity, and the mortality. Therefore, we conclude that intensive care in trauma patients who are chronic alcohol abusers decreases the incidence of complications found in patients with post-operative alcohol withdrawal syndrome and does not adversely impact the prognoses for those patients.

• Journal of Korean Society of Transportation
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• v.31 no.5
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• pp.71-78
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• 2013

This paper investigated the influences of ramp traffic flow on the lane utilization for signalized intersection approaches which are adjacent to an off-ramp-street junction. The statistical test showed a correlation between lane utilization and the ramp traffic flow. As the ramp traffic flow increases, the left lanes are less utilized and the right lanes are more utilized. The lane utilization factors are calculated by applying traffic data collected from the Seoul Metropolitan area. The utilization factors are 1.113 for 2 lanes, 1.124 for 3 lanes, and 1.131 for 4 lanes. The lane utilization factors proposed in the paper show higher values than those in current Korea Highway Capacity Manual (KHCM) under the conditions that the number of lanes is 2 or 3. However, the lane utilization factor for 4 lanes in the paper shows lower value than in KHCM. The ramp traffic flow causes more utilization of the right lanes than at normal signalized intersections and the extent gets larger as the number of lanes decreases. Based on the results of the paper, the lane utilization factors at signalized intersection approaches should be revised and reasonable capacity should be recalculated if the signalized intersection is adjacent to an off-ramp-street junction.