Background: Evaluation of Human papilloma virus (HPV) and its association with promoter methylation of candidate genes, p53 and Aurora A in esophageal cancer. Materials and Methods: One hundred forty-one esophageal tissue samples from different pathologies were evaluated for HPV infection by PCR, while the promoter methylation status of p53 and Aurora A was assessed by methylation-specific restriction based PCR assay. Statistical analyses were performed with MedCalc and MDR software. Results: Based on endoscopy and histopathology, samples were categorized: cancers (n=56), precancers (n=7), esophagitis (n=19) and normals (n=59). HPV infection was found to be less common in cancers (19.6%), whereas its prevalence was relatively high in precancers (71.4%), esophagitis (57.8%) and normals (45.7%). p53 promoter methylation did not show any significant difference between cancer and normal tissues, whereas Aurora A promoter methylation demonstrated significant association with disease (p=0.00016, OR:5.6452, 95%CI:2.18 to 14.6) when compared to normals. Aurora A methylation and HPV infection was found in a higher percentages of precancer (66.6%), esophagitis (54.5%) and normal (45.2%) when compared to cancers (14.2%). Conclusions: Aurora A promoter methylation is significantly associated with esophageal cancer, but the effect of HPV infection on this epigenetic alteration is not significant. However MDR analysis showed that the hypostatic effect of HPV was nullified when the cases had Aurora methylation and tobacco exposure. Further HPV sub-typing may give an insight into its reduced prevalence in esophageal cancer verses normal tissue. However, with the present data it is difficult to assign any significant role to HPV in the etiopathology of esophageal cancer.
Background: Despite the fact that ovarian cancer is the seventh most common cancer in women worldwide and the fifth leading cause of cancer death, It is the most common cause of death due to reproductive cancers in Thailand where epithelial ovarian cancer (EOC) is commonly found. According to a Thai statistical analysis in 2010 by the Department of Medical Services, epithelial ovarian cancer was the sixth most common cancer in Thailand from 2001to 2003.The incidence of 5.1 per 100,000 women per year. Human epididymis protein 4 (HE4) is a novo diagnostic tumor marker for EOC. The combination of HE4 and carcinoma antigen 125 (CA 125) is a tool for detecting epithelial ovarian cancer (EOC) better than using CA 125 alone. Therefore, the researcher is interested in HE4 does have a role to predict recurrent epithelial ovarian cancer. Materials and Methods: The patients who had complete response after diagnosed with epithelial ovarian cancer by pathology, FIGO stage 3 or more had been treated through surgery and chemotherapy at the Sunpasitthiprasong Hospital from June 2014 until March 2016. The patients were followed up every three months, using tumor marker (CA 125, HE4,Carcinoma antigen 19-9) together with other checkup methods, such as rectovaginal examination, CXR every year and other imaging as indication. Afterwards, the data was analyzed for the ability of HE4 to detect recurrence of epithelial ovarian cancer. Results: In 47 patients in this study follow-up for 22 months after complete response treatment from surgery and chemotherapy in epithelial ovarian cancer, 23 had recurrent disease and HE4 titer rising. The patients with recurrent epithelial ovarian cancer demonstrated high levels of both HE4 and CA125 with sensitivity of 91.3% and 52.7% respectively, specificity of 87.5% and 95.6% and positive predictive values of 87.5% and 85.7%. HE4 can predict recurrent epithelial ovarian cancer (p-value=0.02242). Comparing HE4 and CA125 in predicting recurrent epithelial ovarian cancer HE4 had more potential than CA125 (p-value =0.8314). Conclusions: The present study showed HE4 to have a role in predicting recurrent epithelial ovarian cancer and HE4 is potentially better than CA125 as a marker for this purpose.
This study aims at investigating and comparing the diphthongs, words, and sentences between two Korean highschool students groups using the Praat program. To do this English words and sentences were uttered and recorded by twenty Korean subjects; each group has ten subjects. All the subjects are female and their grades range from freshman to sophomore. Acoustic features were measured from a sound spectrogram with the help of the Praat software program and analyzed through statistical analysis. Results showed that the lengths of diphthongs and words were different between two groups, but the difference was not significant. However, in the lengths of sentence utterance, the group of 5 to 6 grade students in the current grading system pronounced longer than that of 1 to 2 grade students. Especially in the pronunciation of the first two sentences with more than five words, the difference was significant. From the data of the overall sum of words between the two subject groups, we were able to find out that the differences of the lengths of the words with the diphthongs were not significant, but those of the sentences with more than five words were significant. In the pronunciation of the words between coat and code, the length of the diphthong in coat was smaller than that of in code.
The purpose of this study was to examine the possibility of the existence of high-risk groups of dental caries and influential factors for the high-risk groups, as there was a possibility that certain people might especially be at risk of suffering from dental caries when decayed, missing, and filled teeth index were analyzed, which were the typical indicators of dental caries. The data of the 4th National Health & Nutrition Survey for 2007, 2008 and 2009 were analyzed. Significant caries index (SiC index) were calculated, which were one of the representative devices to indicate high-risk groups of dental caries, and the SiC index and related factors were analyzed by using $x^2$ (chi-square) test. Besides, logistic regression analysis was utilized to find out influential factors, and a statistical package STATA 11.0 was employed. As a result of analyzing what factors would be linked to high-risk groups of dental caries, it's found that women were more likely to belong to high-risk groups than men (p<0.01). How the related factors affected the high-risk groups was analyzed, and it's found that those who didn't find themselves to be in good oral health were more likely to be classified into a high-risk group, and that those who brushed their teeth three times a more a day on a regular basis were more likely to belong to a high-risk group than the others who didn't (p<0.01). Thus, SiC index were calculated in this study to confirm the existence of dental caries high-risk groups, and what factors impacted on the high-risk groups was ascertained. It's required to implement efficient national policies to step up the promotion of national oral health based on the findings of the study.
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
/
v.23
no.3
/
pp.122-137
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2010
Objective : Atopic dermatitis (AD) in children may profoundly affect the quality of life (QOL), and also cause financial burden, to the families of those suffering from this ailment. The aim of our study was to examine the quality of life and the financial burden of atopic dermatitis in children and their families to evaluate this relationship with the degree of AD. Methods : 37 infant and child atopic dermatitis patients were included and evaluated using the SCORing of Atopic Dermatitis (SCORAD) Index and Eczema Area and Severity Index (EASI). Patients and carers were asked to fill in the questionnaires about their quality of life and financial costs during the past year. Data about sleep disturbance and pruritus were also obtained. Pearson's correlation was used for statistical analysis. Results : 1. The mean score of Children's Dermatology Life Quality Index (CDLQI) was $10.52{\pm}4.82$, Infants' Dermatologic Quality of Life (IDQOL) was $8.21{\pm}3.95$. 2. The mean score of Family Dermatology Life Quality Index (FDLQI) was $13.30{\pm}5.72$, Dermatitis Family Impact (DFI) was $12.5{\pm}4.98$. 3. By analyzing the questionnaire, the monthly average cost was determined to be 730,800 won for each patient : the direct cost was 283,500 won, and the indirect cost was 447,300 won. 4. By analyzing the correlation between the severity of AD and QOL, subjective SCORAD were significantly and positively correlated with QOL(IDQOL, FDLQI, DFI, CDLQI). 5. By analyzing the correlation between the severity of AD and any economic impact, EASI were significantly and positively correlated with the direct cost. Conclusion : The above results show that the QOL of the patients and carers is significantly related to their disease severity. Atopic dermatitis patients pay an average of 730,800 won a month, and the economic impact on the patients is significantly related to their disease severity. The CDLQI, IDQOL, FDLQI and DFImay potentially be of value to help in the appropriate management of AD and can be used as an added measurement in clinical trials involving AD management.
The present study investigates the effects of lopsided regional policy and social prejudice on homeownership disparities by household's place of birth of household head in Seoul. The present study utilizes individual household-level census data (2% sample) to evaluate households' residential well-being denoted by homeownership status during the period of 1980-2000. Decomposition techniques based on tenure choice models were used to provide evidences of the home-ownership disparities caused by regional policy and prejudice. We found that households from Gangwon and Honam provinces represent a disproportionately small percentage of homeownership compared with those originated from other provinces. In the statistical analysis, the present study found that having controlled for the factors traditionally thought to influence households' choice of housing tenure, as well as other housing market characteristics in Seoul, place of birth has played a primary role in determining whether or not households become a homeowner. Most strikingly, while most of the disparity in homeownership ratios between households from Youngnam and households from Gangwon in the housing market is due to the endowment differences in human capitals they bring to the market, those between households from Youngnam and households from Honam is largely due to residual differences explained mainly by social discrimination and prejudice against people from Honam. The present study summarized that place of birth has played a primary role in determining whether or not households become a homeowner in Korea. The present study concluded with some policy issues relevant to this study and suggested some future studies.
Objectives: The present study is aimed at comprehending the organizational setup of clinical dental hygienists and to establish an organizational setup that fits their roles. Methods: The survey data of 776 clinical dental hygienists who understood the purpose of the study and agreed to write the questionnaire was utilized. Statistical analysis was performed using SPSS Ver. 20.0 program and the significance level was 0.05. Results: The presence of an organizational setup in dental hygienists was surveyed as being higher, with university dental hospital (89.86%) showing the highest. However, the presence of position terms was highest in dental hospitals with 76 subjects (38.78%). Standards for positions most commonly followed hospital regulations in the case of general hospitals (48.42%), whereas they were often based on service period in the case of dental hospitals (48.90%). Salary standards were most commonly determined by service period in all institutions. The job satisfaction of dental hygienists was significantly different according to social status and financial satisfaction depended on having organizational hierarchy for those who work in university dental hospitals. Conclusions: The results of the present study show that dental hygienists who work in organizational setups mostly enjoy high satisfaction in terms of job satisfaction. In other words, the study shows that systemizing the organizational setup of dental hygienists within dental institutions is required, and additional research to achieve efficient human resource management within the organization is necessary as well as institutional utilization of the results of the present study.
Kim Young-Ho;Choi Eun-Chang;Hong Won-Pyo;Kim Moon-Suk;Lee Sei-Young;Hong Jung-Pyoe;Chung Hyung-Jin
Korean Journal of Head & Neck Oncology
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v.14
no.1
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pp.46-53
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1998
Background: Hypopharyngeal cancer represents about one-third the incidence of laryngeal cancer which is the most common cancer in head and neck area. Although there have been numerous reports regarding its clinical and statistical characteristics, more precise and ample data should be collected and analyzed in this country. Objectives: This study was designed to evaluate the pattern and patient's profile of the hypopharyngeal cancer, and we reviewed the treatment outcomes to search for an index of treatment modalities. Materials and Methods: The authors retrospectively analyzed 73 cases of hypopharyngeal cancer treated at Yonsei Medical Center during the 10-year period from 1985 to 1994. Five-year survival rate was calculated according to the primary site, clinical stage and treatment modality. Results: The incidence was predominated in male by 9 to 1 and peak incidence was 6th and 7th decades. Pyriform sinus was the main primary site(80.8%) followed by posterior hypopharyngeal wall(13.7%) and postcricoid area(5.5%). Advanced stage cancers(87.7%) were more common than early stage cancers. Radiotherapy(60.3%) was the most commonly used as primary treatment modality. Neck node metastasis was early occurred even in early stage cancers(61.5%), and overall rate of neck node metastasis was 69.9%. All surgical cases received procedures more than total laryngectomy and partial pharyngectomy. The most common cause of death was primary failure(81.5%) and it was highest in radiotherapy group. Five-year survival rate was significantly high in surgery group(90.9%). The overall 5-year survival rate of hypopharyngeal cancer was 30.3%. Conclusion: High index of suspicion should be required for early diagnosis. Also, surgery may be recommended for the primary treatment modality in advanced stage cancers.
Social Network Service (SNS) such as Twitter and Facebook has explosively grown nationwide since iPhone was introduced to Korea in 2009. In addition, KakaoStory has recently opened and joined to the SNS market, and it has grown to one of the most popular SNS in the domestic market in a short period of time. Social Network Service supports not only the formation of relationship between SNS users in common interests but also various activities such as management of personal connections and the sharing of information or contents. These three types of SNS have several common functions of sharing and distributing various contents rooted on the personal relationship formed through SNS. As each SNS user has specific reasons for the use of each service, a survey was conducted targeting those who use all of Twitter, Facebook, and KakaoStory was drawn by the statistical analyses of survey answers on users' reasons for each service. This result of study suggests factors to consider in order to exploit a new SNS or to enhance an existing service and can be used as a standard of which SNS for users to select for their own different purposes. It will also provide the basic data for the trust formation, one of the ethics in the upcoming Social Era.
Journal of the Korean Society for Library and Information Science
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v.30
no.2
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pp.107-125
/
1996
The exhibit programs of library are considered an effective and imporant mechanism to satisfy the demand for information of library users and to innovate a library image. Accordingly, the purpose of this paper is to investigate their recognitions as to how librarians and library users think of the effectiveness of the exhibition programs and as to how the programs exert an influence upon libraries. For research methodology, this research is randomly questionnaired to 360 library users and 90 librarians in July 1995. The collected data is analyzed by such statistical methods as frequency, crosstabs, T test and annova. The analysis shows that there are interesting research findings as follw; 1. The exhibition programs are appeared to be effective for education of library users. 2. The programs are appeared to be effective for increased use of library materials. 3. The programs are appeared to be effective for public relations. 4. The programs are appeared to be effective for collection development. 5. They are revealed to have academic values like academic articles. In sum, among the opinions of librarians, they indicate that the programs are very important in activating the functions of library. Therefore, university libraries should lavishly support the exhibition programs with enough budget and exhibition planners to manage.
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