• Biomolecules & Therapeutics
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• v.11 no.1
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• pp.65-71
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• 2003

Terbinafine is a synthetic allylamine that is available in an oral formulation and is used at a dosage of 250mg/day. It is used as an active antifungal agent and inhibits the fungal enzyme squalene epoxidase, which leads to the accumulation of the sterol squalene, which is toxic to the organism. The purpose of the present study was to evaluate the bioequivalence of two terbinafine tablets, Lamisil (Novartis Korea Ltd.) and Terbinex (C-TRI Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Eighteen normal male volunteers, 26.00$\pm$2.57 year in age and 70.51$\pm$9.36 kg in body weight, were divided into two groups and a randomized 2${\times}$2 cross-over study was employed. After one tablet containing 125 mg of terbinafine was orally administered, blood was taken at predetermined time intervals and the concentrations of terbinafine in plasma were determined using HPLC with UV detector. Pharmacokinetic parameters such as AUC, $C_{max}$ and $T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC, $C_{max}$ and $T_{max}$ between two tablets were －4.191％, 5.223％ and －25.720％, respectively when calculated against the Lamisil, tablet. The powers (1-$\beta$) for AUC, $C_{max}$ and $T_{max}$ were 81％, 87％ and below 60％, respectively. Minimum detectable differences(.il) at alpha=O.1 and 1-/3=0.8 were less than 20％ (e.g., 19.72％ and 17.77％ for AUC and $C_{max}$, respectively). But minimum detectable differences($\Delta$) at alpha=0.1 and 1-$\beta$=0.8 for $T_{max}$ were more than 20％ (e.g., 26.25％). The 90％ confidence intervals were within $\pm$20％ (e.g., －17.440∼9.06 and －6.713∼17.160 for AUC and $C_{max}$ respectively). But 90％ confidence intervals for $T_{max}$ were not within $\pm$20％ (e.g., －43.346∼8.083). Another ANOVA test was conducted for logarithmically transformed AUC and $C_{max}$. These results showed that there are no significant differences in AUC and $C_{max}$ between the two formulations: The differences between the formulations in these log transformed parameters were all for less than 20％ (e.g., －4.19％ and 5.22％ for AUC and $C_{max}$, respectively). The 90％ confidence intervals for the log transformed data were not the acceptance range of log 0.8 to log 1.25 in AUC but the acceptance range of log 0.8 to log 1.25 in $C_{max}$ (e.g., log 1.13∼log 1.50 and log 0.94-log 1.22 for AUC and $C_{max}$ respectively). The major parameters, AUC and $C_{max}$ met the criteria of KFDA for bioequivalence although $T_{max}$ did not meet the criteria of KFDA (1998 year) for bioequivalence, indicating that Onfran tablet is bioequivalent to Zofran tablet. But in another ANOVA test AUC did not meet the criteria of KFDA (2002) for bioequivalence but $C_{max}$ met the criteria of KFDA (2002 year) for bioequivalence.or bioequivalence.equivalence.equivalence.equivalence.

• Journal of Korean Society of Transportation
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• v.23 no.7 s.85
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• pp.17-33
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• 2005

Highway design speed is a very important design element which determines highway design level. When determining highway design speed, one would estimate it utilizing the most likelihood of design speed and vehicle operating speed relationship. Existing operating speed prediction models only include highway geometric characteristics and their impacts on speed, which usually can not consider the impact of highway design speed on surrounding roadway environment and land use pattern. If this happens, excessive highway construction cost and huge environmental impact can occur. In this research project, a new vehicle operating speed prediction model was developed which can reflect the effect of surrounding roadway environment into vehicle speed prediction. The followings are the research findings : Firstly, highway terrain types and land use pattern on national roads were classified and integrated into drivers' visual recognition pattern. This was performed using a data management software. Secondly, the developed highway terrain types and land use pattern were related to vehicle speeds and it was found that there were significant statistical differences among vehicle speed for each different terrain and land use pattern. Thirdly. the General Linear Model analysis was employed to analyze the effects of highway geometric features, terrain types, and land use patterns. For two-lane highway and four-lane highway tested in this research project, it was found that R squares were 0.67 and 0.85, respectively. Additionally an optimal highway design speed range table, based on this research project. was proposed for practical use. This table can be reliably used on South Korean national road design, but discretion is required for applying this table to other types of highways including provincial roads and municipal roads.

• Journal of Korean Society of Transportation
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• v.20 no.3
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• pp.17-30
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• 2002

Incident duration prediction is one of the most important steps of the overall incident management process. An accurate and reliable estimate of the incident duration can be the main difference between an effective incident management operation and an unacceptable one since, without the knowledge of such time durations, traffic impact can not be estimated or calculated. This research presents several multiple linear regression models for incident duration prediction using data consisting of 384 incident cases. The main source of various incident cases was the Traffic Incident Reports filled out by the Motorist Assistant Units of the Korea Highway Corporation. The models were proposed separately according to the time of day(daytime vs. nighttime) and the fatality/injury incurred (fatality/injury vs. property damage only). Two models using an integrated dataset, one with an intercept and the other without it, were also calibrated and proposed for the generality of model application. Some findings are as follows ; ?Variables such as vehicle turnover, load spills, the number of heavy vehicles involved and the number of blocked lanes were found to significantly affect incident duration times. ?Models, however, tend to overestimate the duration times when a dummy variable, load spill, is used. It was simply because several of load spill incidents had excessively long clearance times. The precision was improved when load spills were further categorized into "small spills" and "large spills" based on the size of vehicles involved. ?Variables such as the number of vehicles involved and the number of blocked lanes found not significant when a regression model was calibrated with an intercept. whereas excluding the intercept from the model structure signifies those variables in a statistical sense.

• Archives of Plastic Surgery
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• v.32 no.2
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• pp.155-160
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• 2005

The aim of this study is to establish anatomical dimension of the lip in young population in Korean, using specially designed soft ware with photographic image. We measure 13 anatomical dimensions of lips in 2,229 young people. (917 male, 1312 female, Aged from 18-33 years. Average age 19.7). Statistical analysis of these measurements of large population could offer useful information in facial plastic surgery. The mean measurements are as follows 1. Lengths (male/female) Widths of philtrum: $1.11{\pm}0.19cm/1.02{\pm}0.21cm$ Heights of philtrum: $1.6{\pm}0.24cm/1.47{\pm}0.21cm$ Heights of cupid bow: $0.88{\pm}0.16cm/0.83{\pm}0.16cm$ Height of upper vermilion: $0.74{\pm}0.16cm/0.70{\pm}0.15cm$ Height of lower vermilion: $1.08{\pm}0.17cm/1.02{\pm}0.15cm$ Height of upper lip(Rt.): $1.24{\pm}0.2cm/1.23{\pm}0.2cm$ Height of upper lip(Lt.): $1.24{\pm}0.2cm/1.17{\pm}0.19cm$ Half horizontal length of lip: $2.2{\pm}0.26cm/2.11{\pm}0.2cm$ Horizontal length of lip: $4.41{\pm}0.4cm/4.25{\pm}0.36cm$ Height of lower face: $7.1{\pm}0.58cm/6.52{\pm}0.6cm$ 2. Angles Nasolabial angle: $97.77{\pm}11.97^{\circ}/95.5{\pm}11.34^{\circ}$ Mentolabial angle: $133.88{\pm}14.65^{\circ}/129.27{\pm}13.67^{\circ}$ Angle of Cupid's bow: $111.65{\pm}13.99^{\circ}/116.75{\pm}16.2^{\circ}$ Previous reported photogrammetric measurements was difficult to implement to surgical practice. Because these were printed photographies of the same size. Therefore, in this study, we can measure a lot of objects and items more conveniently and correctly by using proportional program on computer after taking a digital photograph. Consequently, proportional measurements with photogrammetry of lip could be useful and corrective substitute for anthropometrical measuring. These data could be useful reference for preoperative consultation, surgical planning and learning anatomical measurement of lips and adjacent structures.

• Korean Journal of Community Nutrition
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• v.15 no.3
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• pp.379-392
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• 2010

The purposes of this study were to investigate recipients' handling and consumption of home-delivered meals at home and to assess their perceptions on home-delivered meal services for older adults. A total of 312 elderly people who received home-delivered foodservice were surveyed using an individual interview technique. A statistical data analysis was completed using SPSS (ver. 14.0). It was found that 90.2% (n = 166) of the lunch box recipients received services for six days per week, and 76.6% (n = 95) of the side-dish recipients got services once per week. More than half of the clients reported that they cooked meals by themselves on days when meals were not delivered. The two hundred thirty-two (75.3%) ate their meals as soon as they were delivered. It was found that 66.8% of the lunch box recipients and 7.3% of the side-dish recipients left delivered meals on the counter (at room temperatures) before eating. Only 11.4% of the lunch box recipients and 48.4% of the side-dish recipients kept delivered meals in the refrigerator before eating. Less than half of the lunch box recipients consumed all foods they were served at once. The reasons the recipients did not eat their all meals delivered at once were "saving for next meals" and "big portion size" Of those clients who left delivered meals, 19% of the lunch box recipients and 9.7% of the side-dish recipients ate leftovers without reheating. An average score of quality of delivered meal services was 3.5 out of 5 points. The results suggest that the clients of the home-delivered meal service should be provided information on proper handling and consumption practices with delivered meals at home. The findings of the study will be used to develop nutrition and food safety management guidelines for senior foodservice.

• Journal of the Korean Society of Clothing and Textiles
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• v.26 no.1
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• pp.133-143
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• 2002

The textile industry is petting increased effort to manufacture the value-added products that gives the differentiated characters at every level of fiber and fabric production. The color is an important element to be used strategically in order to push up the value-added design. The colors of apparel products have a close relationship with the skin colors of consumers and their preference colors. This study was carried out to cluster the skin colors of the Korean women into several similar skin colors and to analyze their preference colors by the classified groups. We measured the skin colors of 354 Korean women. With color spectrometer, JX-777, we measured 4 points of the body; cheek with removing cosmetics off, forehead, rear neck and arm on the interior part near elbow. All subjects had been shown with 40 color chips and answered the preference colors and preference colors of apparel. Data were analysed to classify skin colors using K-means Cluster Analysis and Duncan test, Frequency and Chi square test on the preference colors about the clustered 3 groups. In doing so, we used in SPSS Win 10 statistical package. Findings were as fellows: 1) The skin colors of the Korean women were clustered into YR, R, and Y skin colors. The majority of the subjects, 324 observations had YR skin colors and the subjects were classified into 3 kinds of skin color groups who had YR skin colors. 2) The average skin colors of total 324 subjects was 5.23YR 6.49/4.09 in Munsell Color System(MCS), 66.56 in L value, 10.53 in a value, and 20.67 in b value. 3) The average skin color of Type 1 was 7.98YR 6.24/4.14 in MCS, 64.10 in L value, 15.05 in a value, and 24.0 in b value. For Type 2 was 7.30 YR 6.56/3.28 in MCS, 67.24 in L value, 6.89 in a value, and 18.4 in b value, and Type 3 was 7.01 YR 7.20/4.38 in MCS, 73.53 in L value, L 16.04 in a value, and 24.87 in b value. 4) The average face color of total 324 subjects was 7.31YR 6.65/3.56 in MCS, 68.13 in L value, 9.53 in a value, and 20.18 in b value. 5) The average face color of Type 1 was 4.19 YR 6.92/5.05 in MCS, 70.78 in L value, 13.2 in a value, and 25.32 in b value. For Type 2 was 5.24YR 6.33/3.79 in MCS, 64.94 in L value, 9.84 in a value, and 19.08 in b value. Type 3 was 5.4YR 6.85/4.68 in MCS, 70.1 in L value, 11.73 in a value, and 23.92 in b value. 6) The difference of mean values between the clustered 3 skin color groups showed significantly different except the a value of neck and H value of cheeks and H value of foreheads. 7) All 3 groups showed that the most preference colors and the most preference colors of apparel was 5R 4/14. and their preference colors were much more than the preference colors of apparel.

• Journal of the Korean Society of Clothing and Textiles
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• v.33 no.12
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• pp.1862-1872
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• 2009

This study identifies the apparel shopping value segments of Korean and Chinese college students to examine the differences in the importance of apparel store attributes. Data from 504 questionnaires filled out by college students from Seoul and Beijing were used for statistical analysis. The four segments of apparel shopping values are, hedonic shopping segment, low involvement shopping segment, high involvement shopping segment, and utilitarian shopping segment. In the high involvement shopping segment, Korean respondents considered store atmosphere, convenience, and the services of salespersons to be more important than the other segments. Chinese respondents in both the hedonic shopping segment and high involvement shopping segment considered store atmosphere more important than the other segments. Korean respondents considered store service more important than the Chinese respondents in the hedonic shopping segment, but Chinese respondents were more likely to consider store convenience to be more important than Korean respondents. In the low involvement shopping segment, Korean respondents considered store atmosphere, store services, and the selection of goods more important than Chinese respondents did. In the high involvement shopping segment, Korean respondents considered the services of salespersons to be more important than the Chinese respondents but the Chinese respondents evaluated store convenience as more important than Korean respondents. In the utilitarian shopping segment, Korean respondents were more likely to consider store service, the selection of goods, and services of salespersons more important than Chinese respondents did.

• Journal of Korean Physical Therapy Science
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• v.8 no.2
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• pp.977-987
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• 2001

The purpose of this study was to examine the effects of sensory integration therapy (SIT) on sensory' motor development and adaptive behavior of cerebral palsy children. The design of this study was quasi experiments with a non-equivalent pre- and post-test control design. Subjects of the study were arbitrarily chosen based on predetermined selection criteria among the cerebral palsy children who were treated as out-patients at two rehabilitation hospitals one in Seoul, and the other in Kyunggi-do. The study was conducted between early April and late July in 2000. Fifteen children were in the experimental group and eleven in the control group. The allocation was done based on ease of experimental treatment. A five-step SIT program was devised from a combination of SIT programs suggested by Ayres(1985) and Finks(1989), and an author-designed SIT program for cerebral palsy children. The experimental group was subjected to 20 to 30 minutes of SIT per session. two sessions a week for ten -week period. The effects of SIT were measured with respect to 9 sub-areas that can be administered to cerebral palsy children out of a total of 17 sub-areas in the Southern California Sensory Integration Test (SCSIT) developed by Ayres (1980). In addition. the scale developed by Russell (1993) for Gross Motor Function Measure (GMFM). and Perception Motor Development Test developed by 中司利一 et al.(1987) were also applied. Adaptive behavior was analyzed using guidelines in two unpublished documents - School-Age Checklist for Occupational Therapy by the Wakefield Occupational Therapy Associates, and the OTA-Watertown Clinical Assessment by the Watertown Occupational Therapy Associates-, and an author-developed Adaptive Behavior Checklist. Collected data were statistically analyzed by SPSS PC for chi square test, Mann-Whitney test, Wilcoxon signed rank test, and paired t-test. The results were as follows: 1. In sensory development, the experimental group exhibited a score increase compared to the control group, but the difference was not statistically significant, Although the experimental group showed improvements in all. 9 sub-areas compared to the control group, only right-left discrimination exhibited statistically significant change. 2. In gross motor development, the experimental group showed improvements in score compared to the control group, but it was not statistically significant. In fine motor development, the experimental group exhibited statistically significant improvements compared to the control group. In sub-area analysis, figure synthesis showed positive change. 3. In adaptive behavior development, post-experimental adaptive behavior scores were higher compared to pre-experimental scores with statistical significance. Furthermore, sub-areas emotional behavior, perception behavior, gross-fine motor function, oral-respiration function, motor behavior, motor planning, and adaptive response exhibited higher scores after SIT. In conclusion SIT was found to be partially effective in sensory and fine motor development, effective in all adaptive behavior areas, and not effective in gross motor development. Thus, this study has shown that SIT is an effective intervention for sensory development, fine motor development, and adaptive behavior for cerebral palsy children. But, for the effectiveness of SIT on gross motor development, further studies employing longer-time experiments are recommended.

• The Journal of Engineering Geology
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• v.13 no.3
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• pp.321-334
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• 2003

This study is aimed at the effective measurement plan of discontinuity orientation on rock mass. The discontinuity orientation is expressed as three methods. strike/dip. dipdirection/dip (a three digit number / a two digit number) and right hand rule. Generally, strike/dip is measured with clinometer. and dipdirection/dip with silva compass(type15). A sign of strike/dip. discontinuity orientation is used to geological survey. and dipdirection/dip to engineering. Dipdirection/dip converted by strike/dip measured with clinometer is useful on the statistical analysis of a lot of data. To measure the azimuth of the dip with clinometer and to change strike/dip to dipdirection/dip may have potential errors in each person. The newly designed apparatus, clinometer equipped by a rotational azimuth plate and an arrow to measuring strike and dipdirection, has been developed to measure effectively the discontinuity orientation with two method (strike/dip and dipdirection/dip). The measuring method of discontinuity orientation with clinometer having newly designed apparatus is effective one for accurate measurement of strike as well as dipdirection which is degrees counted clockwise from true north. Used by clinometer with newly designed apparatus, concurrent measuring strike/dip and dipdirecton/dip of discontinuity is possible. In application to measuring discontinuity orientation on rock slope, it has been recognized that the newly designed method, unambiguously, led to drop measuring errors comparing with existing measuring apparatuses. Therefore, it is considered that measuring method of discontinuity orientation (strike/dip and dipdirecton/dip) by the newly designed apparatus is useful to one in geological engineering investigation of road design, and to unskilled investigator.

• Journal of the Korean Society for information Management
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• v.33 no.1
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• pp.111-137
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• 2016

The roles of public libraries have been diverse not only provision of information but also provision of cultural programs. According to this trend, the spatial composition of public libraries have been also changed to reflect the diverse roles. This study is conducted to explore the spatial characteristics in public libraries with two objectives: 1) to suggest spatial types in public libraries based on their physical characteristics, and 2) to explore the relationships between the spatial types and users' perception. To accomplish these objectives, we adopted observation and questionnaire survey as research methods. Consequently, three spatial types of public libraries are identified based on an investigation of several public libraries: divided, partially integrated, and integrated. Then, several statistical analyses, including one-way analysis of variance (ANOVA), are conducted with the questionnaire survey data. The results from the statical analyses show that there are significant differences in users' perceptions and behaviors between the spatial types. That is, the spatial type influences user's perceptions. This study is meaningful in terms of its first attempt to explore the relationships between spatial factors in libraries and users' perceptions. Based on this, it is suggested that libraries should consider their spatial structures for developing user's positive perception on the libraries.