• Genomics & Informatics
• /
• v.19 no.4
• /
• pp.37.1-37.7
• /
• 2021

Genome-wide association studies (GWASs) facilitated the discovery of countless disease-associated variants. However, GWASs have mostly been conducted in European ancestry samples. Recent studies have reported that these European-based association results may reduce disease prediction accuracy when applied in non-Europeans. Therefore, previously reported variants should be validated in non-European populations to establish reliable scientific evidence for precision medicine. In this study, we validated known associations with type 2 diabetes (T2D) and related metabolic traits in 125,850 samples from a Korean population genotyped by the Korea Biobank Array (KBA). At the end of December 2020, there were 8,823 variants associated with glycemic traits, lipids, liver enzymes, and T2D in the GWAS catalog. Considering the availability of imputed datasets in the KBA genome data, publicly available East Asian T2D summary statistics, and the linkage disequilibrium among the variants (r² < 0.2), 2,900 independent variants were selected for further analysis. Among these, 1,837 variants (63.3%) were statistically significant (p ≤ 0.05). Most of the non-replicated variants (n = 1,063) showed insufficient statistical power and decreased minor allele frequencies compared with the replicated variants. Moreover, most of known variants showed <10% genetic heritability. These results could provide valuable scientific evidence for future study designs, the current power of GWASs, and future applications in precision medicine in the Korean population.

• Korean Journal of Environmental Agriculture
• /
• v.41 no.3
• /
• pp.153-157
• /
• 2022

BACKGROUND: The residue dissipation pattern of pesticides for agricultural products during the pre-harvest period after the final application is important to prevent the maximum residue limit (MRL) violations in domestic and export markets. The MRL violations of carbendazim are observed more often in chamnamul by pesticide residue management surveys by the Ministry of Food and Drug Safety. The residue level at the pre-harvest interval (PHI) and the residue dissipation constant from the critical good agricultural practice (cGAP) trials could be estimated to meet the MRL and pose a health risk to consumers. METHODS AND RESULTS: Chamnamuls were harvested at 0, 1, 3, 5, 7, 10, and 14 days after application of carbendazim in accordance with critical GAP. The residue analysis in chamnanul was performed by HPLC-DAD with the C₁₈ column. The limit of quantitation of carbendazim was 0.04 mg/kg, and the recoveries were 74.4 - 95.8% at the two spiked levels (LOQ and 10LOQ) of carbendazim. The dissipation rates in chamnamul were calculated from the residues at the sampling days by statistical method at a 95% confidence level. The biological half-lives of residual carbendazim in the field trials 1 and 2 were 4.9 and 4.4 days, respectively. CONCLUSION(S): In this dissipation study, the residue concentrations at the recommended PHI were higher than the established MRL in Korea. Therefore, the MRL is proposed based on the residue data sets from the trials conducted at the same cGAP and the dietary exposure assessment.

• Geomechanics and Engineering
• /
• v.28 no.4
• /
• pp.397-404
• /
• 2022

Accurate prediction of the undrained shaft resistance is essential for robust design of bored piles in undrained condition. The undrained shaft resistance is calculated using the undrained adhesion factor multiplied by the undrained cohesion of the soil. However, the available correlations to predict the undrained adhesion factor have been developed using simple regression techniques and the accuracy of these correlations has not been thoroughly assessed in previous studies. The lack of the assessment of these correlations made it difficult for geotechnical engineers to select the most accurate correlation in routine designs. Furthermore, limited attempts have been made in previous studies to use advanced data mining techniques to develop simple and accurate correlation to predict the undrained adhesion factor. This research, therefore, has been conducted to fill these gaps in knowledge by developing novel and robust correlation to predict the undrained adhesion factor. The development of the new correlation has been conducted using the multi-objective evolutionary polynomial regression analysis. The new correlation outperformed the available empirical correlations, where the new correlation scored lower mean absolute error, mean square error, root mean square error and standard deviation of measured to predicted adhesion factor, and higher mean, a20-index and coefficient of correlation. The correlation also successfully showed the influence of the undrained cohesion and the effective stress on the adhesion factor. Hence, the new correlation enhances the design accuracy and can be used by practitioner geotechnical engineers to ensure optimized designs of bored piles in undrained conditions.

• The Journal of Korean Medicine
• /
• v.42 no.2
• /
• pp.50-61
• /
• 2021

Objectives: The object of this study was to examine whether there was a significant difference between morning and afternoon in heart rate variability(HRV) in healthy Korean adults. In addition, the correlation between the characteristics of the subjects and the test results was analyzed. Methods: From January 8, 2021 to January 29, 2021, twenty healthy subjects received short-term HRV test once in the morning(6:00~12:00) and twice in the afternoon(12:00~18:00). We used IBM SPSS Statistics 27 to test for statistical significance. Results: The mean heart rate and PSI decreased significantly and SDNN increased significantly in the morning compared to the afternoon. There was no significant difference except RMSSD in HRV conducted at 2 hours intervals in the afternoon. Age had a significant difference in SDNN and TP, and exercise in average heart rate. Age, weekly exercise frequency, and monthly drinking frequency showed significant correlations with HRV indicators. As a result of multiple regression analysis, monthly drinking frequency was a variable that had a significant influence on TP. Conclusions: The results of the tests performed with short interval were relatively consistent, and when comparing the results of the afternoon and the next morning, there were significant differences in several indicators. In the future, the number of HRV measurements should be increased and a larger-scale follow-up study including more subjects will be needed.

• Animal Bioscience
• /
• v.34 no.9
• /
• pp.1451-1459
• /
• 2021

Objective: The objectives of the study were to evaluate reproductive performance and selection response through genetic trend of community-based breeding programs (CBBPs) of Bonga sheep. Methods: Reproduction traits data were collected between 2012 and 2018 from Bonga sheep CBBPs. Phenotypic performance was analyzed using the general linear model procedures of Statistical Analysis System. Genetic parameters were estimated by univariate animal model for age at first lambing (AFL) and repeatability models for lambing interval (LI), litter size (LS), and annual reproductive rate (ARR) traits using restricted maximum likelihood method of WOMBAT. For correlations bivariate animal model was used. Best model was chosen based on likelihood ratio test. The genetic trends were estimated by the weighted regression of the average breeding value of the animals on the year of birth/lambing. Results: The overall least squares mean±standard error of AFL, LI, LS, and ARR were 375±12.5, 284±9.9, 1.45±0.010, and 2.31±0.050, respectively. Direct heritability estimates for AFL, LI, LS, and ARR were 0.07±0.190, 0.06±0.120, 0.18±0.070, and 0.25±0.203, respectively. The low heritability for both AFL and LI showed that these traits respond little to selection programs but rather highly depend on animal management options. The annual genetic gains were -0.0281 days, -0.016 days, -0.0002 lambs and 0.0003 lambs for AFL, LI, LS, and ARR, respectively. Conclusion: Implications of the result to future improvement programs were improving management of animals, conservation of prolific flocks and out scaling the CBBP to get better results.

• Journal of People, Plants, and Environment
• /
• v.24 no.3
• /
• pp.285-300
• /
• 2021

Background and objective: Rural migrants are an important human resource in urban and rural exchange (URE) business, therefore it is necessary to enhance their awareness and intent-to-participate. This study was to analyze the rural migrants' recognition and intent-to-participate of URE business and to propose the enhancement of them both. Methods: The questionnaire was designed to analyze the socio-demographic background, motivations, satisfaction with settlement, intent-to-persist, and intent-to-participate of URE business including tourism. The data of 144 respondents was subject to the statistical analysis. Results: The motives of migration were to enjoy leisure life after retirement, increased tiredness of city life, health problems, etc. The satisfaction with settlement was 3.67 at 5-point Likert scale. The intent-to-recommend and intent-to-publicize were 3.40 and 3.46, respectively. The intent-to-participate was 3.45, which was affected by the necessity of URE business and the support of central/local governments, and also showed a significant correlation with the satisfaction with settlement, intent-to-recommend, intent-to-publicize, tourism resources for green tourism or rural tourism, driving a car in Namhae county, and the service and price of meals. They thought the missions that the Namhae county office must focus on were to establish an internal/external public relations systems, establish a support system of central/local governments, and foster/support local leaders. Conclusion: It is necessary to improve the satisfaction with settlement and intent-to-persist, expand exchanges with local people, improve internal/external public relations systems, foster/support leaders, improve transportation in the county, enhance the service and price of meals, and develop/operate URE programs including tourism.

• Journal of The Korean Society of Integrative Medicine
• /
• v.10 no.2
• /
• pp.61-72
• /
• 2022

Purpose : This study aimed to identify the educational effects of the International Development Cooperation and Healthcare course from 2018 to 2020. Methods : Changes in awareness of international development cooperation (understanding international development cooperation as well as government Official Development Assistance [ODA], thoughts on aid, and thoughts on government's aid scale) were analyzed using web-based surveys. The pre-course survey was conducted 1-2 weeks before the semester started, and the post-course survey was conducted 1-2 weeks after the semester ended. All data were analyzed using the SPSS 26.0 program, and statistical significance was set at p< .05. Results : A total of 314 people participated in the survey before taking the course, and 286 people participated in the survey after taking the course. Analysis of the changes in students' awareness of international development cooperation showed that all items (understanding international development cooperation and government ODA, as well as having thoughts on aid and government's aid scale) were improved. Regarding changes in awareness according to general characteristics, thoughts on aid were statistically significant according to all characteristics except for 2018. Regarding government's aid scale, awareness scores increased after taking the course in students who majored in healthcare, fine arts and athletics, broadcasting and media studies, and digital contents. Conclusion : This study showed that changes in awareness of international development cooperation were largest in second-year students. Compared to changes regarding international development cooperation, government ODA, and thoughts on aid, changes regarding thoughts on government's aid scale were minor. In the future, it is necessary to develop class content suitable for the first-year level and to supplement and operate content that can change the way of thinking on government's aid scale.

• Journal of Fashion Business
• /
• v.26 no.5
• /
• pp.105-121
• /
• 2022

To improve the discrepancy between consumer attitude and actual consumption behavior despite the expansion of consumer perception of sustainable fashion, this study attempted to identify the factors influencing the purchase intention and behavior of sustainable fashion consumers. The extended theory of planned behavior, which adds prior knowledge and consumer inertia, was used to predict purchase intention and factors affecting purchase behavior for sustainable fashion, and to verify the influence of knowledge and inertia on consumers' attitudes, subjective norms, and perceived behavioral control. The results of this study were derived from SPSS and AMOS statistical analysis based on response data of 323 domestic male and female consumers, 20 years or older with experience in sustainable fashion consumption. The results showed that consumers' prior knowledge and inertia about sustainable fashion have a significant influence on their attitude toward sustainable fashion consumption, subjective norms, and perceived behavioral control. Implications were derived based on this quantitative verification. The higher the level of consumers' knowledge of sustainable fashion, the greater the impact on attitude, subjective norms, and perceived behavioral control, but inertia decreases the impact. Therefore, to grow consumers' knowledge, not only a shopping environment should be established but also inertia should be suppressed as much as possible through sustainable fashion marketing activities.

• Journal of Animal Science and Technology
• /
• v.64 no.4
• /
• pp.727-739
• /
• 2022

Mycotoxin contamination in pig feeds has a negative impact on growth performance, the immune system, and major body organs. Arginine (Arg) plays an important role in animals' body biochemistry and physiology. This study aimed to determine the effect of dietary Arg supplementation on mitigating the negative effects of mycotoxins in growing pigs. A total of 72 growing pigs (Landrace × Large white) with initial mean body weight (BW) = 55 ± 2.5 kg were allotted to four treatment groups with three replicates per group of six pigs per replicate in a completely randomized design. The treatments included a non-toxin diet with 1.2% Arg (NT1.2) and mycotoxin-challenged treatments supplemented with 1.2% Arg (TX1.2), 1.3% Arg (TX1.3), and 1.4% Arg (TX1.4). Statistical analysis of data included the effects of dietary level of Arg. The results indicated a significantly higher BW (p < 0.05), average daily gain (p < 0.05), and gain-to-feed ratio (p < 0.05) in the NT1.2 group than in the TX1.2, TX1.3, and TX1.4 groups. The relative weight of the liver was higher (p < 0.05) in the TX1.2 compared to that of the NT1.2 group, although it was not different from that of TX1.3 and TX1.4. The level of tumor necrosis factor-alpha was significantly up-regulated (p < 0.05) in the liver tissue of the TX1.2 group compared to that of the other treatments. Overall, dietary Arg supplementation remedied liver injury and alleviated the compromised immune system caused by mycotoxin toxicity.

• Physical Therapy Korea
• /
• v.29 no.3
• /
• pp.215-224
• /
• 2022

Background: The presence of the lumbopelvic-hip neuromuscular chain is essential for dynamic spinal stabilization; its therapeutic effects on dynamic movements of the distal extremity segment and underpinning motor mechanism remain unknown and warrant further study on participants with low back pain (LBP). Objects: We aim to compare the effects of the broken chain exercise (BCE) and connected chain exercise (CCE) on electromyography (EMG) amplitude and onset time in participants with and without LBP. Methods: Randomized controlled clinical trial. A convenience sample of 40 nonathletic participants (mean age: 24.78 ± 1.70) with and without LBP participated in this study. All participants underwent CCE for 30 minutes, 30-minute daily. We measured EMG amplitude and onset times on bilateral erector spinae (ES), gluteus maximus (GM), hamstring (HAM), transverse abdominis (TrA), internal oblique (IO), and external oblique (EO) during the prone hip extension (PHE) test before and after the BCE and CCE. We used multivariate analysis of variance (MANOVA) to analyze the amplitude and onset time difference between exercises (BCE and CCE) and Pearson's correlations to determine any synergistic relationship among the HAM, GM, bilateral TrA/IO, and ES muscles. The statistical analyses were used at p < 0.05. Results: MANOVA showed that CCE was more decreased on EMG amplitude in HAM and bilateral ES, while increased GM and contralateral TrA/IO than BCE (p < 0.05). MANOVA EMG onset time data analyses revealed that the main effect of the conditions was significant for all HAM, GM, and bilateral ES muscles, whereas the main effect for the group was significant only for GM and contralateral ES in healthy and LBP groups. Pearson's correlation coefficient was computed to assess the relationship between BCE and CCE on dependent variables. In most of the muscles, there was a strong, positive correlation between the two variables, and there was a significant relationship (p < 0.001). Conclusion: CCE produced more effective and coordinated core stabilization and motor control mechanism in the lumbopelvic-hip muscles in participants with and without LBP during PHE than BCE.