• Research in Community and Public Health Nursing
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• v.12 no.3
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• pp.773-784
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• 2001

The study was conducted to test the effectiveness of thermotherapy for high school girls who suffered from disruption in school activities through dysmenorrhea, and to study the extent of its availability in school infirmaries as one of the nursing methods. The test for the study was designed to make a contrast between half of the subjects (20) who did not receive the thermotherapy, and the rest (20) who did during the period from February 15th to April 14th, 2001. Measurements were taken of the subjects who complained of painful menstruation by a set of variables. The variables that were established and complemented by Hur, Mung-heang (1985) consist of 29 items that assess the dysmenorrhea and vitality through the symptoms of primary menstruation visually. Spsswin was used to analyze the data. The Cronbach-${\alpha}$ method was used for statistic confidence, and the test effect of both the subjects and the contrary ones was analyzed by way of T-test. The conclusions are as follow. (1) The hypothesis 1 states that the subjects with themotherapy have a lower degree of dysmenorrhea rather than the contrary ones without it. By the above assessment, there was a quantitative difference between the subjects at 39.40, and the contrary ones at 22.0. After the themotherapy, the degree of dysmenorrhea in the subjects was low indicating that there is a still 5% chance of statistic meaningful difference (t= 2.651. P= .012). As a result, the first hypothesis was accepted. (2) The hypothesis 2 states that the subjects with themotherapy have a different primary menstruation than those without. Data indicate that there was a difference of -5.95 and -4.80. The subjects showed low degrees. Since it was statistically insignificant (t=-1.398, P=.170), the second hypothesis was rejected. (3) The hypothesis 3 states that the subjects with themotherapy have a different vitality. The vitality was measured in three aspects. (1) pulse rate (/min) The hypothesis 3' states that the subjects with themotherapy have the different pulse rate from those without. Data indicate that there was no statistically meaningful difference between the two groups (t=.237, P=. 814). Therefore, the third 1st hypothesis was rejected. (2) Respiration rate The hypothesis 3' states that the subjects with themotherapy have a different respiration rate between pre-thermotherapy and post-thermotherapy. in contrast with the ones without it. The data show that there was no statistically meaningful difference (t=.133. P=.895). A little respiration rate difference was shown between pre-and post-. Likewise. the third 2nd hypothesis was rejected. (3) Blood pressure In the 3rd sub-hypothesis that there would be a difference between experimental and controlled groups was also rejected. because there was no statistically significant difference between the contracting blood pressure and the relaxing blood pressure. In terms of vitality. the pulse rate, respiration rate and blood pressure have no statistical meaning but the first two ones show the decreasing in the rate. In short, though exclusive studies focused on thermo therapy have not been conducted and the comparison can not be made, this study shows not only that the thermotherapy is very effective to dysmenorrhea, but also that it can be available in school infirmaries as one of the nursing methods.

• The Korean Journal of Emergency Medical Services
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• v.12 no.3
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• pp.115-127
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• 2008

Purpose : This study aimed to examine the effects of empowerment of the paramedics on critical thinking and provide the basic materials for the qualitative improvement of emergency medical service. Methods : This study collected data with the paramedics working at general hospital and hospital emergency room in G metropolitan city, B metropolitan city, U metropolitan city, D metropolitan city and J province from July 1 to 31, 2008. Total 180 questionnaires were collected and 152 were used for final analysis, and the following results were obtained through statistical analysis using SPSS 12.0 program. Results : 1) Average score of empowerment was 4.44 out of 6 and according to average score by areas, significance was 4.94, capacity 4.92, self-determination 4.28, and effective-ness 3.62. 2) Empowerment by general characteristics was statistically significant in age (F = 3.313, p < 0.05), the final scholastic attainments(F = 2.436, p < 0.05), and salary(F = 1.695, p < 0.01). 3) Average score of critical thinking was 3.12 out of 7 and according to scores by areas, maturity was highest as 3.71, followed by no prejudice as 3.70, systemicity as 3.14, pursuit of truth as 3.05, much curiosity as 2.93, critical thinking and self-confidence as 2.92, and analysis as 2.91. 4) Critical thinking by general characteristics was statistically significant in marital status (F = 15.695, p < 0.01) and the final scholastic attainments (F = 2.606, p < 0.05). 5) Correlations between empowerment and critical thinking showed positive correlations as Pearson's correlation coefficient r = 0.400 and positive correlation in all areas including empowerment and critical thinking were found (r = 0.116-0.710). 6) The effect of empowerment on critical thinking was statistically significant in p < 0.01 and was explained as $R^2=0.155$. In the effects of empowerment on critical thinking, significance, capacity and self-determination were statistically significant in p < 0.01, effectiveness in p < 0.05 and were explained as R2 = 0.244. Conclusion : From the above results, it was found that empowerment had the influence on critical thinking, so it was considered that hospital managers and emergency room chiefs must develop and operate education and training program based on the concept of empowerment, maintenance and management strategies.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• v.1
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• pp.235-240
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• 2006

The paper will give an overview of the mission of GalTeC and then concentrate on two main aspects. The first more detailed aspect, is the analysis of the key performance parameters for the Galileo system services and presenting a technical overview of methods and algorithms used. The second more detailed aspect, is the service volume prediction including service dimensioning using the Prediction tool. In order to monitor and validate the Galileo SIS performance for Open Service (OS) and Safety Of Life services (SOL) regarding the key performance parameters, different analyses in the SIS domain and User domain are considered. In the SIS domain, the validation of Signal-in-Space Accuracy SISA and Signal-in-Space Monitoring Accuracy SISMA is performed. For this purpose first of all an independent OD&TS and Integrity determination and processing software is developed to generate the key reference performance parameters named as SISRE (Signal In Space Reference Errors) and related over-bounding statistical information SISRA (Signal In Space Reference Accuracy) based on raw measurements from independent sites (e.g. IGS), Galileo Ground Sensor Stations (GSS) or an own regional monitoring network. Secondly, the differences of orbits and satellite clock corrections between Galileo broadcast ephemeris and the precise reference ephemeris generated by GalTeC will also be compared to check the SIS accuracy. Thirdly, in the user domain, SIS based navigation solution PVT on reference sites using Galileo broadcast ephemeris and the precise ephemeris generated by GalTeC are also used to check key performance parameters. In order to demonstrate the GalTeC performance and the methods mentioned above, the paper presents an initial test result using GPS raw data and GPS broadcast ephemeris. In the tests, some Galileo typical performance parameters are used for GPS system. For example, the maximum URA for one day for one GPS satellite from GPS broadcast ephemeris is used as substitution of SISA to check GPS ephemeris accuracy. Using GalTeC OD&TS and GPS raw data from IGS reference sites, a 10 cm-level of precise orbit determination can be reached. Based on these precise GPS orbits from GalTeC, monitoring and validation of GPS performance can be achieved with a high confidence level. It can be concluded that one of the GalTeC missions is to provide the capability to assess Galileo and general GNSS performance and prediction methods based on a regional and global monitoring networks. Some capability, of which first results are shown in the paper, will be demonstrated further during the planned Galileo IOV phase, the Full Galileo constellation phase and for the different services particularly the Open Services and the Safety Of Life services based on the Galileo Integrity concept.

• Journal of Navigation and Port Research
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• v.33 no.3
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• pp.181-191
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• 2009

In general, seafarer's human error is considered to be the preponderant muse for the majority of maritime transportation accidents in a merchant ship. The implementation techniques for Human Error Model (HEM) to assess possible accident risk by deck officers including captain, chief officer, second mate and third mate are described in this study. The scope of this work is focused to 642 deck officers in the ship management company with 130 vessels. At first, HEM can be constructed through the statistical analysis and expert's brainstorming process with human data to 642 deck officers. Then the variables $\upsilon$ for the human factors, the evaluation level EP($\upsilon$) for $\upsilon$, the weight $\alpha$ of $\upsilon$, and the title weight $\beta$ of each deck officers can be decided. In addition, through the analysis of ship's accident history, the accident causation ratios by human error ${\gamma}_H$ and by external error ${\gamma}_B$ can be found as 0.517(51.7%) and 0.483(48.3%), respectively. The correlation coefficients to $\upsilon$ are also shown significant for a 95% confidence interval (p < 0.05) for each coefficient. And the validity of HEM is also surveyed by the analysis of normal probability distribution of risk level RL to each deck officer.

• Journal of Pharmaceutical Investigation
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• v.30 no.2
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• pp.133-138
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• 2000

Terbinafine is an orally active antifungal agent as it inhibits the fungal enzyme squalene epoxidase, which is important in the early biosynthetic pathway of ergosterol. This leads to abnormal development of the fungal cell membrane. Bioequivalence of two terbinafine tablets, $Lamisil^{TM}$ (Novartis Korea Ltd.) and $Terbina^{TM}$ (Korean Drug Co., Ltd.), was evaluated according to the guidelines of Korea Food and Drug Administration (KFDA). Sixteen normal male volunteers, $23.56{\pm}1.75$ years old and $65.60{\pm}8.54\;kg$ of body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one tablet containing 125 mg of terbinafine was orally administered, blood was taken at predetermined time intervals and the serum concentrations of terbinafine were determined using an HPLC method with UV detector. The pharmacokinetic parameters $(AUC_t,\;C_{max}\;and\;T_{max})$ were calculated and ANOVA test was utilized for the statistical analysis of parameters. The results showed that the differences in $AUC_t,\;C_{max}\;and\;T_{max}$ between two tablets based on $Lamisil^{TM}$, tablet were -2.53%, -2.98% and 8.13%, respectively. The powers $(1-{\beta})$ for $AUC_t,\;C_{max}\;and\;T_{max}$ were 85.21%, 98.21% and 93.11%, respectively. Minimum detectable differences $({\Delta})$ at ${\alpha}=0.1\;and\;1-{\beta}=0.8$ were all less than 20%. The 90% confidence intervals were all within ${\pm}20%$. All the parameters above met the criteria of KFDA for bioequivalence, indicating that $Terbina^{TM}$ tablet is bioequivalent to $Lamisil^{TM}$ tablet.

• Journal of Pharmaceutical Investigation
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• v.34 no.2
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• pp.147-153
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• 2004

The purpose of the present study was to evaluate the bioequivalence of two glimepiride tablets, $Amaryl^{\circledR}$ (Handok/Aventis Pharm. Co., Ltd.) and Glimed (Kuhn II Pharm. Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The glimepiride release from the two glimepiride formulations in vitro was tested using KP VIII Apparatus II method with a variety of dissolution media (pH 1.2, 4.0, 6.8 buffer solution, water and blend of PSB 80 into each dissolution medium). Twenty six healthy male subjects, $22.65{\pm}2.19$ years in age and $66.55{\pm}8.85$ kg in body weight, were divided into two groups and a randomized $2\;{\times}\;2$ cross-over study was employed. After one tablet containing 2 mg as glimepiride was orally administered, blood was taken at predetermined time intervals and the concentrations of glimepiride in serum were determined using HPLC method with UV detector. The dissolution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as $AUC_t$, $C_{max}$ and $T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$, $C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the Amaryl were -3.70, -8.28 and 0.61% for $AUC_t$, $C_{max}$ and $T_{max}$, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g., $log(0.84){\sim}log(1.04)$ for $log(0.82){\sim}log(1.03)$ for $AUC_t$ and $C_{max}$, respectively). Thus, the criteria of the KFDA guideline for the bioequivalence were satisfied, indicating Glimed tablet and Amaryl tablet were bioequivalent.

• Journal of Pharmaceutical Investigation
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• v.34 no.6
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• pp.521-527
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• 2004

Cimetidine is a histamine $H_2-receptor$ antagonist, used for the treatment of endoscopically or radiographically comfirmed duodenal ulcer, pathologic GI hypersecretory conditions, and active, benign and gastric ulcer. Simple method for determining cimetidine in human plasma has been developed and validated. The analytical procedure for cimetidine showed a linear relationship in the concentration ranges from $0.05\;to\;5\;{\mu}g/ml$. Coefficient of variance (CV, %) for intraday and interday validation and relative error (RE, %) were less than ${\pm}15%$. Based on this analytical method, the bioequivalence of two cimetidine 400 mg tablets, reference (Tagamet 400 mg) and test drug (Sinil CIMETIDINE 400 mg) was evaluated according to the guidelines set by the Korea Food and Drug Administration (KFDA). Release of cimetidine from the tablets in vitro was tested using KP VIII Apparatus II with various dissolution media (pH 1.2, 4.0, 6.8 buffer solutions and water). Twenty-four healthy volunteers, $21.38{\pm}1.86$ years in age and $68.71{\pm}8.68\;kg$ in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was performed. After oral administration of a tablet containing 400 mg of cimetidine, blood samples were taken at predetermined time intervals and concentrations of cimetidine in plasma were determined using HPLC equipped with UV detector. The dissolution profiles of the two tablet formulations were very similar at all dissolution media. In addition, pharmacokinetic parameters such as $AUC_t$ and $C_{max}$ were calculated and ANOVA was employed for the statistical analysis of parameters. The results were revealed that the differences in $AUC_t$ and $C_{max}$ between the two tablets were 4.17 % and 0.97% respectively. At 90% confidence intervals, the differences in these parameters were also within ${\pm}20%$. All of the above mentioned parameters have met the criteria of KFDA guidelines for bioequivalence, indicating that the test drug tablet (Sinil CIMETIDINE tablet) is bioequivalent to Tagamet 400 mg tablet.

• Journal of Pharmaceutical Investigation
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• v.38 no.2
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• pp.135-142
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• 2008

The present study describes the evaluation of the bioequivalence of two atorvastatin tablets, Lipitor $Tablet^{(R)}$ (Pfizer, reference drug) and Atorva $Tablet^{(R)}$ (Yuhan, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Forty-nine healthy male Korean volunteers received each medicine at the atorvastatin dose of 40 mg in a $2{\times}2$ crossover study with a two weeks washout interval. After drug administration, serial blood samples were collected at a specific time interval from 0-48 hours. The plasma atorvastatin concentrations were monitored by an high performance liquid chromatography -tandem mass spectrometer (LC-MS/MS) employing electrospray ionization technique and operating in multiple reaction monitoring (MRM) and positive ion mode. The total chromatographic run time was 4.5 min and calibration curves were linear over the concentration range of 0.1-100 ng/mL for atorvastatin. The method was validated for selectivity, sensitivity, linearity, accuracy and precision. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 48hr) was calculated by the linear log trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were complied trom the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for Atorva $Tablet^{(R)}$ / Lipitor $Tablet^{(R)}$ were ${\log}\;0.9413{\sim}{\log}\;1.0179$ and ${\log}\;0.831{\sim}{\log}\;1.0569$, respectively. These values were within the acceptable bioequivalence intervals of ${\log}\;0.8{\sim}{\log}\;1.25$. Based on these statistical considerations, it was concluded that the test drug, Atorva $Tablet^{(R)}$ was bioequivalent to the reference drug, Lipitor $Tablet^{(R)}$.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.20 no.6
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• pp.564-574
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• 2008

This study investigates a long-term variation of annual maximum surge heights(AMSH) and main characteristics of high surge events, which is influenced by the global warming and intensifying typhoons, using sea level data at Sokcho and Mukho tidal stations over 34 years ($1974{\sim}2007$). It is found that the there is a longterm uptrend of the AMSH at Sokcho (8.3 cm/34yrs) and at Mukho (8.7 cm/34yrs), which is significant within 95% confidence level based on the linear regression. The statistical analysis reveals that 53% of the AMSH occurs during typhoon's event in both tidal stations and the highest surge records are mostly produced by the typhoon. It is concluded that the uptrend in the AMSH is attributed by the increasing typhoon activities globally as well as locally in Korea due to the increased sea surface temperature in tropical oceans. The continuous efforts monitering and predicting the extreme surge events in the future warm environments are required to prevent the growing storm surge damage by the intensified typhoon.

• Environmental Analysis Health and Toxicology
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• v.27
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• pp.13.1-13.10
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• 2012

Objectives: We aimed to investigate the acute effects of heat stress on body temperature and blood pressure of elderly individuals living in poor housing conditions. Methods: Repeated measurements of the indoor temperature, relative humidity, body temperature, and blood pressure were conducted for 20 elderly individuals living in low-cost dosshouses in Seoul during hot summer days in 2010. Changes in the body temperature, systolic blood pressure (SBP) and diastolic blood pressure (DBP) according to variations in the indoor and outdoor temperature and humidity were analyzed using a repeated-measures ANOVA controlling for age, sex, alcohol, and smoking. Results: Average indoor and outdoor temperatures were $31.47^{\circ}C$ (standard deviation [SD], $0.97^{\circ}C$) and $28.15^{\circ}C$ (SD, $2.03^{\circ}C$), respectively. Body temperature increased by $0.21^{\circ}C$ (95% confidence interval [CI], 0.16 to $0.26^{\circ}C$) and $0.07^{\circ}C$ (95% CI, 0.04 to $0.10^{\circ}C$) with an increase in the indoor and outdoor temperature of $1^{\circ}C$. DBP decreased by 2.05 mmHg (95% CI, 0.05 to 4.05 mmHg), showing a statistical significance, as the indoor temperature increased by $1^{\circ}C$, while it increased by 0.20 mmHg (95% CI, -0.83 to 1.22 mmHg) as outdoor temperature increased by $1^{\circ}C$. SBP decreased by 1.75 mmHg (95% CI, -1.11 to 4.61 mmHg) and 0.35 mmHg (95% CI, -1.04 to 1.73 mmHg), as the indoor and outdoor temperature increased by $1^{\circ}C$, respectively. The effects of relative humidity on SBP and DBP were not statistically significant for both indoor and outdoor. Conclusions: The poor and elderly are directly exposed to heat waves, while their vital signs respond sensitively to increase in temperature. Careful adaptation strategies to climate change considering socioeconomic status are therefore necessary.