• Genomics & Informatics
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• v.20 no.2
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• pp.16.1-16.12
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• 2022

Various methodologies for the genetic analysis of longitudinal data have been proposed and applied to data from large-scale genome-wide association studies (GWAS) to identify single nucleotide polymorphisms (SNPs) associated with traits of interest and to detect SNP-time interactions. We recently proposed a grid-based Bayesian mixed model for longitudinal genetic data and showed that our Bayesian method increased the statistical power compared to the corresponding univariate method and well detected SNP-time interactions. In this paper, we further analyze longitudinal obesity-related traits such as body mass index, hip circumference, waist circumference, and waist-hip ratio from Korea Association Resource data to evaluate the proposed Bayesian method. We first conducted GWAS analyses of cross-sectional traits and combined the results of GWAS analyses through a meta-analysis based on a trajectory model and a random-effects model. We then applied our Bayesian method to a subset of SNPs selected by meta-analysis to further discover SNPs associated with traits of interest and SNP-time interactions. The proposed Bayesian method identified several novel SNPs associated with longitudinal obesity-related traits, and almost 25% of the identified SNPs had significant p-values for SNP-time interactions.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.16 no.12
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• pp.3960-3975
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• 2022

To analyze and compare the most influencing factors on cloud computing adoption (CCA) in the healthcare organization, a systematic review and meta-analyses of studies was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Cochrane collaboration recommendations. A search of PubMed, ScienceDirect, Springer, Wiley Online, and Taylor & Francis Online digital libraries (From inception to January 19, 2022) was performed. A total of 17 studies met the defined studies' inclusion and exclusion criteria. Statistical significance difference favoring most influencing factors on CCA were (MD 0.76, 95% CI -1.48 - 3.01, p <0.00001, I² = 90%), (MD 1.40, 95% CI -4.76 - 7.55, p < 0.00007, I² = 97%) (MD 0.17, 95% CI -2.69 - 3.03, p<0.00001, I² = 96%) for technology vs. organizational, technology vs. environmental and business vs. human factors, respectively. Organizational and environmental factors had greater impacts on CCA compared with technological factors. Moreover, business factors were more influential than the human factors.

• Journal of Korean Society on Water Environment
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• v.39 no.4
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• pp.261-268
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• 2023

The benthic macroinvertebrates index (BMI) was developed based on the 5-day biochemical oxygen demand (BOD₅), which is the amount of biodegradable organic matter in stream water. However, benthic macroinvertebrates mainly live in the streambed substrate and are affected by the interaction of water quality and substrate. This study was conducted to examine the interactive relationship between water quality items (BOD₅, total phosphorus (TP), total suspended solids (TSS)) and substrate with BMI by performing statistical analyses (four-way analysis of variance, Pearson's correlation analysis, partial correlation analysis and multiple regression analysis). The data used in the analyses were collected from 19,915 sampling units at 1,937 sites in South Korea from 2010 to 2020. The interaction effect between BOD₅ and substrate types was confirmed through a four-way analysis of variance. Partial correlation analysis and multiple regression analysis estimated the degree of influence on the change in BMI value in the order of mean grain size of the substrate as (𝜱_m) > BOD₅ > TP > TSS. BMI can be regarded as an index that evaluates the comprehensive effects of water quality and streambed status, although it is an index that was developed based on the amount of biodegradable organic matter in a water column.

• International Journal of Advanced Culture Technology
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• v.11 no.3
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• pp.156-162
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• 2023

The purpose of this study was to examine the effects of peer scaffolding on the writing fluency of English language learners. This study was intended to confirm that peer scaffolding in English as a foreign language (EFL) writing classes can improve students' English proficiency. An analysis of 20 EFL learners studying at a university in Gyeonggi Province was conducted based on the English Proficiency Test. In this study, 20 intermediate learners with similar proficiency levels were included in the sample. Randomly, 10 students were designated as members of the control group, and 10 students were designated as members of the experimental group. In the experimental group, students practiced essay writing, while a skilled student provided scaffolding for a less skilled student. A variety of tools were used to gather data, including tests, questionnaires, and interviews Statistical analyses of quantitative data were conducted using t-tests for independent samples, whereas analyses of qualitative data were conducted based on themes. Pre-test results indicated a significant value of sig. =0.87, which was higher than α = 0.05. According to the results of this study, the writing performance of both experimental and control groups of students was equal and homogeneous prior to treatment. However, there were significant differences between the writing of students in the two groups after the completion of the program. Due to the post-test analysis of the writing test, the test resulted in a sig. =0 .043, a value lower than α = 0.05. As a result, the experimental group participants showed a marked improvement in their writing abilities after treatment.

• Steel and Composite Structures
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• v.44 no.5
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• pp.651-676
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• 2022

Most of the experimental, theoretical, and numerical studies on the stability of functionally graded composites are deterministic, while there are full of complex interactions of variables with an inherently probabilistic nature, this paper presents a non-intrusive framework to investigate the stochastic nonlinear buckling behaviors of porous functionally graded cylindrical shells exposed to inevitable source-uncertainties. Euler-Lagrange equations are theoretically derived based on the three variable refined shear deformation theory. Closed-form solutions for the shell buckling loads are achieved by solving the deterministic eigenvalue problems. The analytical results are verified with numerical results obtained from finite element analyses that are conducted in the commercial software ABAQUS. The non-intrusive framework is completed by integrating the Monte Carlo simulation with the verified closed-form solutions. The convergence studies are performed to determine the effective pseudorandom draws of the simulation. The accuracy and efficiency of the framework are verified with statistical results that are obtained from the first and second-order perturbation techniques. Eleven cases of individual and compound uncertainties are investigated. Sensitivity analyses are conducted to figure out the five cases that have profound perturbative effects on the shell buckling loads. Complete probability distributions of the first three critical buckling loads are completely presented for each profound uncertainty case. The effects of the shell thickness, volume fraction index, and stochasticity degree on the shell buckling load under compound uncertainties are studied. There is a high probability that the shell has non-unique buckling modes in stochastic environments, which should be known for reliable analysis and design of engineering structures.

• Earthquakes and Structures
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• v.25 no.6
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• pp.469-479
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• 2023

A probabilistic seismic damage analysis is an essential procedure to identify seismically vulnerable structures, prioritize the seismic retrofit, and ultimately minimize the overall seismic risk. To assess the seismic risk of multiple structures within a region, a large number of nonlinear time-history structural analyses must be conducted and studied. As a result, each assessment requires high computing resources. To overcome this limitation, we explore a deep learning-based metamodel to enable the prediction of the mean and the standard deviation of the seismic damage distribution of track-on steel-plate girder railway bridges in Korea considering the geometric variation. For machine learning training, nonlinear dynamic time-history analyses are performed to generate 800 high-fidelity datasets on the seismic response. Through intensive trial and error, the study is concentrated on developing an optimal machine learning architecture with the pre-identified variables of the physical configuration of the bridge. Additionally, the prediction performance of the proposed method is compared with a previous, well-defined, response surface model. Finally, the statistical testing results indicate that the overall performance of the deep-learning model is improved compared to the response surface model, as its errors are reduced by as much as 61%. In conclusion, the model proposed in this study can be effectively deployed for the seismic fragility and risk assessment of a region with a large number of structures.

• Korean Journal of Childcare and Education
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• v.19 no.6
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• pp.1-19
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• 2023

Objective: The aim of the present study was to develop and validate a recognition scale for childcare teachers' rights. Methods: Statistical methods for data analysis involved the use of SPSS 20.0 and AMOS 20.0. To confirm the reliability and validity of the developed scale, various analyses, including item quality assessment, item discrimination, exploratory factor analysis, confirmatory factor analysis, and Pearson correlation analysis, were conducted. The maximum likelihood estimation method was employed for model fitting. Goodness of fit was assessed using SRMR, RMSEA and its 90% confidence interval, CFI, and TLI. Through these analyses, the scale's reliability and validity exceeded the standard. Consequently, 5 factors and 30 questions were ultimately selected as the recognition scale for childcare teachers' rights. Results: First, a recognition scale for childcare teachers' rights was developed to reflect changes in childcare settings. Second, an objective measurement was incorporated into the recognition scale of childcare teachers' rights. Third, the analysis using the proposed scale revealed a correlation between the recognition of childcare teachers' rights and life satisfaction. Conclusion/Implications: The study developed a scale capable of objectively measuring the recognition of childcare teachers' rights.

• Geomechanics and Engineering
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• v.37 no.4
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• pp.371-382
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• 2024

Measurement or prediction of compression index (C_c) of soils is essential for assessment of total and differential settlement of structures. It is a well-known fact that this parameter is controlled by several index identifiers of soil including initial void ratio, Atterberg limits, overconsolidation ratio, specific gravity, etc. Many studies in the past proposed relationships for prediction of C_c based on different index properties. Therefore, this study aims to present a comparison of previously proposed equations for estimation of C_c. Data from literature was compiled, and a total of 90 and 623 test results on remolded and undisturbed specimens were used to question the validity of previously proposed equations. Nevertheless, the modeling ability of 7 and 12 equations for estimation of C_c of remolded and undisturbed soils were questioned by use of compiled data. Moreover, new empirical relationships based on initial void ratio and toughness limit for prediction of C_c was proposed by use of nonlinear multivariable regression and evolutionary based regression analyses. The results are promising-the performances of models established are quite acceptable, which are verified by statistical analyses.

• Journal of the Korea Safety Management & Science
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• v.26 no.2
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• pp.79-86
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• 2024

Scientific exploration of how occupational health risks relate with occupational illnesses are essential for mitigating health-related issues in industries. This study analyzed the risk scores obtained by occupational health risk assessments at 3,172 manufacturing companies and examined their effects on occupational illness. Statistical analyses revealed that companies with an occupational health manager (scored 89.1 out of 100) had significantly higher activity scores of health management compared to those without (78.2). However, companies with a history of occupational illness (79.1) or those classified as high-risk industries (85.2) had significantly lower activity scores than their counterparts (81.7, 87.3). In addition, regression analyses using factor analysis showed that latent risk factors such as cardiovascular disease/job stress, health management, and musculoskeletal problem significantly influenced the risk of occupational illness. The activity factors such as health management, work environment management, and regulatory complaisance significant impacted the reduction of occupational illness. The findings of this study can be used to improve the occupational health risk assessment method and utilized in effectively managing occupational risks in industries.

• Food Science of Animal Resources
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• v.23 no.2
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• pp.137-144
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• 2003

This study was carried out to investigate safety evaluation of IGEs separated and refined from bovine milk and commercial recombinant human IGFs. In order to evaluate toxicity of these samples, acute toxicity test and short term toxicity test were investigated with IGF-I separated and refined from colostrum and commercial recombinant human IGF-I from R&D systems company. for acute toxicity test, we selected recombinant human IGF-I from R&D systems company and establish one control group and three dose-level groups(0, 10, 20 and 50 $\mu\textrm{g}$ per rat). We have intravenously injected tail of rats with selected sample once. After 20 days, pathological cellular tissue analyses were investigated with liver, kidney and spleen of 12 rats in all test groups. However, Morbid tissue and abnormal statistical results were not discovered in all cellular tissues. For short term toxicity test, we selected IGF-I separated and refined from colostrum and establish one control group and three dose-level groups(0, 5, 10 and 15 $\mu\textrm{g}$/day per rat). Rats were orally injected with selected sample once a day during two weeks. After short term toxicity test period, Pathological cellular tissue analyses were investigate with liver, kidney and spleen of 12 rats in all test groups. However, Morbid tissue and abnormal statistical results were not discovered in all cellular tissues. These results suggest that IGF-I treated groups show no significant toxicological findings with changes of body weight, food consumption, water consumption, and pathological findings compared with control groups.