• Journal of Pharmaceutical Investigation
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• 제16권2호
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• pp.72-75
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• 1986

A convenient high performance liquid chromatographic method was established for the quantitative determination and content uniformity test of aclatonium napadisilate preparation. This method was more simple to make the sample solution for injection, and easy to determine the content in the preparation. Aclatonium napadisilate was chromatographed using a $Lichrosorb-NH_2$ column $(4mm\;{\times}\;25\;cm$, and acetonitrile-water mixture (83:17) as an eluent at a flow rate of 1.8 ml/min. RI-detector response was linear over a range of $0.5{\sim}2.0%$ aclatonium napadisilate under above conditions. Reproducibility studies gave relative standard deviation of 1.29%.

• Archives of Pharmacal Research
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• 제5권2호
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• pp.87-91
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• 1982

In order to develop an analytical method for amikacin and butirosin in presence of their parent antibiotics, kanamycin A and ribostamycin, high-performance liquid chromatographic technique and microbioassay method were evaluated and compared. Using high performance liquid chromatography, two acylated antibiotics, amikacin and butirosin was partially separated from their parent antibiotics, to provide a qualitative analytical method. In microbioassay using Pseudomonas aeruginosa TI-13, a producer of aminoglycoside-3-phosphotransferase I, only acylated antibiotics were selectively analyzed when paper disc-susceptibility assay was used. The standard curve showed a good correlation between the response and odse in semilogarithmic plat with correlation coefficients above 0.96, and analytical deviation from expected dose was within 10%.

• 품질경영학회지
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• 제38권3호
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• pp.313-321
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• 2010

The coefficient of variation represents the ratio of the standard deviation to the mean, and it is a useful statistic for comparing the degree of variation from one data series to another, even if the means are drastically different from each other. Recently, the CV control chart is developed for monitoring processes in such situations. However, the CV control chart has low performance in detecting small shift. Due to the development of equipment and technique, currently, small shift of process occurs more frequently than large shift. In this paper, we proposes the CV-CUSUM control chart using CUSUM scheme which is cumulative sum of the deviations between each data point and a target value to detect a small shift in the process. We also found that the FIR(fast initial response) CUSUM control chart is especially valuable at start-up or after a CV-CUSUM control chart has signaled out-of-control.

• 한국해안·해양공학회논문집
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• 제22권4호
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• pp.224-229
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• 2010

선박에 의한 해상교량의 충돌취약도 해석을 수행하였다. 확률변수를 충돌속도와 충돌각으로 하였으며 18,000DWT와 30,000DWT 설계선박에 대해 충돌해석을 수행하였다. 음함수 형태의 변위를 한계상태함수에 적용하기 위해 응답면 기법을 사용하여 충돌응답면을 구성하고 충돌속도를 2 m/s~7m/s까지 총 6개 CASE에 대해 신뢰성 해석을 수행하였다. 신뢰성 해석으로 계산한 파괴확률을 이용하여 충돌취약도 곡선을 표현하고 충돌속도에 대한 중간값과 대수표준편차를 계산하여 해상교량의 위험도를 나타내었다.

• 대한기계학회논문집A
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• 제31권4호
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• pp.490-495
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• 2007

This research aims to examine accuracy and efficiency of the first four moments corresponding to mean, standard deviation, skewness, and kurtosis, which are estimated by a function approximation moment method (FAMM). In FAMM, the moments are estimated from an approximating quadratic function of a system response function. The function approximation is performed on a specially selected experimental region for accuracy, and the number of function evaluations is taken equal to that of the unknown coefficients for efficiency. For this purpose, three error-minimizing conditions are utilized and corresponding canonical experimental regions constructed accordingly. An interpolation function is then obtained using a D-optimal design and then the first four moments of it are obtained as the estimates for the system response function. In order to verify accuracy and efficiency of FAMM, several non-linear examples are considered including a polynomial of order 4, an exponential function, and a rational function. The moments calculated from various coefficients of variation show very good accuracy and efficiency in comparison with those from analytic integration or the Monte Carlo simulation and the experimental design technique proposed by Taguchi and updated by D'Errico and Zaino.

• 지식경영연구
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• 제19권2호
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• pp.1-19
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• 2018

This study aims to identify the causal relationship among public technology transfer, technological performance, and research and development (R&D) productivity. Using the impulse-response function(IRF) of a panel vector autoregressive model (panel VAR), this study suggests the results of how long the factors such as technological performance (patent), public technology transfer, and R&D productivity takes and lasts if a one-unit shock of standard deviation occurs. As a result, first, the increase of public technology transfer activities has no power to increase the technology performance but improve the R&D productivity. If the public institute increases its technology transfer activities by one unit, the R&D productivity will increase within five years. Second, the impact of increasing technological performance on improvement of public technology transfer and R&D productivity is an insignificant. Third, the effect of R&D productivity on the public technology transfer creates a substantial reaction after a current time. Considering the structural relationships among public technology transfer, technological performance, and R&D productivity, if policy makers intend to construct the active R&D circumstance, technology suppliers should be motivated to run the active R&D mechanism because they achieve gains.

• 대한기계학회논문집A
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• 제30권8호
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• pp.1001-1007
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• 2006

In this paper we present robust optimal supporting positions for large glass panels used for TFT-LCD monitors when they are stored in a cassette during manufacturing process. The criterion taken is to minimize their maximum deflection. Since they are supported by some supports and have large deformations, contact analysis with a geometrically nonlinear effect is necessary. In addition, the center of a panel can not be positioned exactly as intended and should be considered as uncertainties. To take into account of these effects, the mean and the standard deviation of system response functions, particularly the deflection of the panels, need be calculated. A function approximation moment method (FAMM) is utilized to estimate them. It is a special type of response surface methodology for structural reliability analysis and can be efficiently used to estimate the two stochastic properties, that is, the system performance and the perturbations caused by uncertainties. For a design purpose, they are to be minimized simultaneously by some optimization algorithm to obtain robust optimal supporting positions.

• 대한통합의학회지
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• 제8권4호
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• pp.59-66
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• 2020

Purpose : This study aimed to present normative data for older Korean adults completing the Yonsei dual task cognitive screening test (Y-DuCog) and identify changes in cognitive function on the Montreal Cognitive Assessment - Korean (MoCA-K) with age. Methods : From May 2019 to August 2019, 195 healthy adults aged ≥60 years participated in this study. All participants completed the Y-DuCog to assess their dual-task performance and the MoCA-K to assess their cognitive function. Participants were divided into three groups based on their age: 60~69 years, 70~79 years, and ≥80 years. Results : The results of the Y-DuCog showed that dual-task performance time, effect, and correct response rate decreased significantly with age (p<.001). Scores from the three groups showed differences on all items (p<.001). Cognitive function on the MoCA-K also decreased significantly with age (mean score ± standard deviation [SD]; 27.33 ± 2.61 in subjects aged 60~69 years; 24.82 ± 3.20 in subjects aged 70~79 years; and 22.10 ± 4.91 in subjects aged ≥80 years; p<.001). Conclusions : Occupational therapists should be aware of the decline in cognitive function and dual-task performance time, effect, and correct response rate in older adults and consider interventions to treat this decline. Further studies are needed with larger groups of participants to examine factors, such as sex and education, that may impact dual-task performance and cognitive function.

• 아태비즈니스연구
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• 제13권4호
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• pp.109-121
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• 2022

Purpose - This study investigates how earnings volatility influences current stock price informativeness about expectations of future earnings. Design/methodology/approach - I adopt the FERC model developed by Collins et al. (1994) and modified by Lundholm and Myers (2002) to investigate the connection between earnings volatility and future earnings reflected in current returns. I define five-year rolling standard deviations of earnings and components as earnings volatility measures and the degree of deviation of earnings from cash flows over the same five-year, which is developed by Jayaraman (2008). Finding - My results show that earnings volatility delays current stock price response to future operation expectations. They also verify that as earnings are more divergent from cash flows, current returns are less timely incorporating value-relevant future operation. Research implications or Originality This study shows that when volatile earnings deliver obscure and unreliable information about future operation expectations, they cause the market to be conflicting in understandings their implications and make it difficult in attaining correct future cashflow estimates.

• 한국해양공학회지
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• 제27권4호
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• pp.83-89
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• 2013

A numerical scheme based on a mode superposition method is presented for the dynamic response analysis of a top-tensioned riser (TTR) under sheared current loads. The natural frequencies and mode shapes of the TTR have been calculated analytically for a beam with a slowly varying tension and pinned-pinned boundary conditions at the top and bottom ends. The lift coefficients and corresponding amplitudes used to estimate the vortex-induced modal force and damping for each mode were predicted via iterative calculations based on the input and output power balancing concept. Here, the power-in regions were controlled by the normal distribution function, for which the center was coincident with the lock -in location by local vortex-shedding, and the range was defined by the constant standard deviation for the reduced velocity by the local current speed. Finally, dynamic responses such as root-mean-squared displacement and stress were calculated using the mode superposition technique. In order to verify the presented scheme, a numerical calculation was performed for a TTR under an arbitrary linearly sheared current and linearly varying tension. A comparison with the results of the existing software showed that the presented scheme could give reliable and feasible solutions. Case studies were performed to investigate the effects of various current loads and tensions.