• BMB Reports
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• v.55 no.1
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• pp.30-38
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• 2022

Cardiovascular disease, especially ischemic heart disease, is a major cause of mortality worldwide. Cardiac repair is one of the most promising strategies to address advanced cardiovascular diseases. Despite moderate improvement in heart function via stem cell therapy, there is no evidence of significant improvement in mortality and morbidity beyond standard therapy. The most salutary effect of stem cell therapy are attributed to the paracrine effects and the stem cell-derived exosomes are known as a major contributor. Hence, exosomes are emerging as a promising therapeutic agent and potent biomarkers of cardiovascular disease. Furthermore, they play a role as cellular cargo and facilitate intercellular communication. However, the clinical use of exosomes is hindered by the absence of a standard operating procedures for exosome isolation and characterization, problems related to yield, and heterogeneity. In addition, the successful clinical application of exosomes requires strategies to optimize cargo, improve targeted delivery, and reduce the elimination of exosomes. In this review, we discuss the basic concept of exosomes and stem cell-derived exosomes in cardiovascular disease, and introduce current efforts to overcome the limitations and maximize the benefit of exosomes including engineered biomimetic exosomes.

• Journal of information and communication convergence engineering
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• v.20 no.2
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• pp.137-142
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• 2022

Monolithic three-dimensional (M3D) logics such as M3D-NAND, M3D-NOR, M3D-buffer, M3D 2×1 multiplexer, and M3D D flip-flop, consisting of modularized M3D inverters (M3D-INVs), have been proposed. In the previous M3D logic, each M3D logic had to be designed separately for a standard cell library. The proposed M3D logic is designed by placing modularized M3D-INVs and connecting interconnects such as metal lines or monolithic inter-tier-vias between M3D-INVs. The electrical characteristics of the previous and proposed M3D logics were simulated using the technology computer-aided design and Simulation Program with Integrated Circuit Emphasis with the extracted parameters of the previously developed LETI-UTSOI MOSFET model for n- and p-type MOSFETs and the extracted external capacitances. The area, propagation delay, falling/rising times, and dynamic power consumption of the proposed M3D logic are lower than those of previous versions. Despite the larger space and lower performance of the proposed M3D logic in comparison to the previous versions, it can be easily designed with a single modularized M3D-INV and without having to design all layouts of the logic gates separately.

• Transactions of the Korean hydrogen and new energy society
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• v.33 no.4
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• pp.284-292
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• 2022

Hydrogen is promising a candidate for energy supporting the carbon neutrality policy for greenhouse gas reduction, which is being promoted in several countries, including Korea. Although challenging efforts-such as lowering the costs of green hydrogen production and fuel cells-remain, hydrogen fuel cell electric vehicles (FCEVs) are expected to play a significant role in the energy transition from fossil fuels to renewable energy. In line with this objective, the hydrogen FCEV working group in the International Organization for Standardization (ISO) compiled and revised international standards related to hydrogen refueling stations as of 2019. A well-established hydrogen quality management system based on the standard documents will increase the reliability of hydrogen charging stations and accelerate the use of FCEVs. In this study, among the published ISO standards and other references, the main requirements for managing charging stations and developing related techniques were summarized and explained. To respond preemptively to the growing FCEV market, a continuous hydrogen quality monitoring method suitable for use at hydrogen charging stations was proposed.

• The Korean Journal of Nuclear Medicine
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• v.7 no.1
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• pp.1-13
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• 1973

• The Journal of Korean Institute of Communications and Information Sciences
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• v.41 no.8
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• pp.903-910
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• 2016

This paper investigates an advanced receiver for interference mitigation of downlink control channel in the 3GPP Rel-13 standard. There are several features for downlink throughput performance improvement with inter-cell interference management such as network coordination and advanced receivers during Rel-10~Rel-12. These features can be operated always under the assumption that UE perfectly decodes control channels (PCFICH and PDCCH) of serving cell. However, the performance of control channels could be deteriorated in the cell edge region due to inter-cell interference. In this paper, we introduce the advanced receivers and analyze performance for control channel interference mitigation (CCIM) based on 3GPP Rel-13 standard. Additionally, we propose UE behavior depending on network condition.

• The Korean Journal of Malacology
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• v.27 no.4
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• pp.387-393
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• 2011

The objective of this study was to develop a real-time PCR method for the rapid detection and quantification of the protozoan pathogen Perkinsus olseni using a TaqMan probe. For the standard, genomic DNA was extracted from $10^5$ in vitro-cultured P. olseni trophozoites, and then 10-fold serial dilutions to the level of a single cell were prepared. To test the reliability of the technique, triplicates of genomic DNA were extracted from $5{\times}10^4$ cells and 10-fold serial dilutions to the level of 5 cells were prepared. The standards and samples were analyzed in duplicate using an $Exicycler^{TM}$ 96 real-time quantitative thermal block. For quantification, the threshold cycle ($C_T$) values of samples were compared with those obtained from standard dilutions. There was a strong linear relationship between the $C_T$ value and the log concentration of cells in the standard ($r^2$ = 0.996). Detection of DNA at a concentration as low as the equivalent of a single cell showed that the assay was sensitive enough to detect a single cell of P. olseni. The estimated number of P. olseni cells was similar to the original cell concentrations, indicating the reliability of P. olseni quantification by real-time PCR. Accordingly, the designed primers and probe may be used for the rapid detection and quantification of P. olseni from clam tissue, environmental water, and sediment samples.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.27 no.8B
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• pp.809-818
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• 2002

In this paper, we propose a fast cell search algorithm keeping compatible with the standard cell search algorithm of the WCDMA system. The proposed algorithm can acquire the synchronization of slot and frame times, and the code group identification using only one synchronization channel while the standard algorithm employs two synchronization channels called P-SCH and S-SCH. The proposed synchronization channel structure is the same as the P-SCH structure of the WCDMA system. However, the P-SCH is modulated with a specific polarization code, which is one element of new code group codes. The proposed algorithm can reduce both the BS' transmission power and the complexity of receiver as compared with the conventional one since only on synchronization channel is used. It is shown through the computer simulation that the proposed algorithm yields a significant improvement in terms of cell search time compared with the standard especially in low SNR environments.

• Journal of the Korean Geotechnical Society
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• v.27 no.10
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• pp.45-54
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• 2011

In this study, the consolidation characteristics are investigated on the artificial soil mixture of kaolinite, fine soils representing dredged soils and reclaimed coal ash from the ash ponds. A large sedimentation chamber was designed and manufactured to produce the artificial soil mixture with uniform stress history. In order to examine the consolidation characteristics in lateral and vertical directions, standard consolidation and Rowe Cell tests were performed. From the results of standard consolidation tests, the artificial soil mixture with coal ash showed lower compressibility and the larger consolidation coefficients enough to aid in early stabilization of the reclaimed sites compared with the kaolinite only. Also, in order to examine the consolidation characteristics when applying vertical drains, the drainage material was installed and tested in the Rowe Cell. The Rowe Cell test results show that the artificial soil mixture yields higher coefficient of consolidation. Thus, the application of artificial soil mixture on the reclaimed sites can shorten the consolidation time.

• Journal of the Korean Institute of Gas
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• v.22 no.5
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• pp.124-132
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• 2018

The supply of renewable energy has become more vigorous due to Paris Agreement. In Korea, supply policies of renewable energy is being promoted with priority given to public buildings, so, the supply of fuel cell system that are relatively easy to install in buildings is expected to expand, so it is important that study on anti-islanding evaluation of grid-connected power conditioning system(PCS) for fuel cell. In this study, we consider that KGS AB934 PC53 in domestic certification standard of PCS for fuel cell correspond with abroad standard and analyze anti-islanding evaluation that important safety performance when connected grid. Additionally, we constructed a prototype for anti-islanding evaluation of PCS for fuel cell connected in parallel and carried out the demonstration evaluation, so, we have conducted ways that ensure safety performance in accordance with the circumstances where several fuel cell systems are installed.

• Asian-Australasian Journal of Animal Sciences
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• v.17 no.10
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• pp.1338-1343
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• 2004

The Debao pony ear marginal tissue fibroblast cell line (NDPEM 2/2) was uccessfully established using either primary explant technique or collagenase technique. The characterizations of the cell line were identified as following: the cells were adherent and of density limitation; population doubling time (PDT) of cells made with the two techniques were 35.9 h and 48 h, respectively; chromosome analysis showed that the frequency of cell chromosome number to be 2n=64 was 91.3%-92.8%. Confirmed by isoenzyme analysis, this cell line had no cross- contamination. Tests for microbial contamination from bacteria, fungi, virus or mycoplasma were negative. This newly established cell line meets all the standard quality controls of ATCC. It will provide a precious genetic resource for the conservation of the Debao pony breed, as well as effective experimental material for genetic studies on Debao ponies.