• Asian Pacific Journal of Cancer Prevention
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• v.14 no.9
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• pp.5077-5083
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• 2013

Background: Breast cancer is the most frequent cancer in women globally and represents the second leading cause of cancer death among women (after lung cancer). India is going through epidemiologic transition. It is reported that the incidence of breast cancer is rising rapidly as a result of changes in reproductive risk factors, dietary habits and increasing life expectancy, acting in concert with genetic factors. Materials and Methods: In order to understand the existing epidemiological correlates of breast cancer in South India, a systematic review of evidence available on epidemiologic correlates of breast cancer addressing incidence, prevalence, and associated factors like age, reproductive factors, cultural and religious factors was performed with specific focus on screening procedures in southern India. Results: An increase in breast cancer incidence due to various modifiable risk factors was noted, especially in women over 40 years of age, with late stage of presentation, lack of awareness about screening, costs, fear and stigma associated with the disease serving as major barriers for early presentation. Conclusions: Educational strategies should be aimed at modifying the life style, early planning of pregnancy, promoting breast feeding and physical activity. It is very important to obtain reliable data for planning policies, decision-making and setting up the priorities.

• Journal of the Korea Safety Management & Science
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• v.10 no.4
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• pp.229-240
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• 2008

With the effectuation of Kyoto Protocol, one of the important movement throughout the world is reducing the emission of greenhouse gas which is the main reason of making global warming. The actual factor of greenhouse gas is CO2, and in year of 2002 20% of total CO2 emission was produced only through transportation throughout the South Korea. In the contrary, the recycling of municipal wastes in South Korea was 44.0% in 2002, but it will be targeted upto 53.5% in 2011. All of these show environment-conscious logistics should be implemented together throughout the each stage of distribution with the development of product and service. This study applied survey research for the activities affecting to the emission of CO2 and packaging wastes produced from transportation and packaging stages in logistics area. For this, survey questionary was constructed with five specific areas - strategy, transportation & distribution, custody, packaging, and information. Based on the 148 returned survey questionaries, this study analyzed 52 categories and finally suggests necessary modal shift, collaboration & co-operation in logistics, LCA(life-cycle assessment), and other promoting policies for the environment-conscious logistics in effective way.

• The Research Journal of the Costume Culture
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• v.27 no.6
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• pp.615-631
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• 2019

Smart healthcare clothing combines IoT, new technology, and clothing construction to perform specific care functions, and its utility has been expanding rapidly within aging and diversified societies. However, the related market remains at an early stage of development due to limited regulation, lack of consumer awareness, and the need for not only technical development but promotion plans for potential users. This paper aims to analyze factors influencing purchase intention for smart healthcare clothing with biosignal monitoring, including variables in the Technology Acceptance Model (TAM), clothing attributes, health-related lifestyle factors, and fashion innovativeness. A survey was conducted on a sample of 300 males and 300 females ranging in age from 20 to 50 years, and data were analyzed using SPSS 21.0. The results show that perceived usefulness, perceived aesthetic attributes, health responsibility, and fashion innovativeness were overall significant predictors of using smart healthcare clothing. Additionally, perceived ease of use and physical activity in the male subsample, and perceived compatibility within the female group, also had significant effects. Furthermore, age was a determining factor; for subjects in the 30s age group, perceived usefulness, compatibility, and health responsibility had significant positive associations. The results of this study can provide basic guidelines for designing merchandising plans to expand user acceptance of smart healthcare clothing.

• International conference on construction engineering and project management
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• 2011.02a
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• pp.550-555
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• 2011

Utilizing construction knowledge and experiences in design phase can reduce change orders and improve productivity in construction phase. To do so, information must be made available to the design team in time. Current approaches for effective utilization of constructability knowledge, however, only focus on the formalization of constructability knowledge such as a checklist, which lacks the consideration of the appropriate use at the proper point in time. The inadequate use of constructability knowledge can result in unnecessary reworks. To deal with this problem, the design team needs to know what constructability knowledge is required for specific design activities in the design process. This paper presents a constructability implementation model using the dependency structure matrix (DSM) that focuses on information flows between design activities and constructability knowledge. For this objective, design activities in the design process are modeled in a matrix form based on their dependency. Then, constructability knowledge, which needs to be considered in the design stage, is mapped into activities and incorporated into the matrix, creating Constructability-DSM (C-DSM). Next, the partitioning algorithm is applied to C-DSM for optimal information flow. The Partitioned C-DSM is then analyzed based on the relationship between activities. Finally, the optimal utilization of construction knowledge in the design process is determined by identifying what constructability knowledge is required for each design activity, and how and when it is reflected to design for constructability. Thus, this research can help provide robust control actions to reduce unnecessary iterative cycles in design process for efficient constructability implementation.

• Asian-Australasian Journal of Animal Sciences
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• v.25 no.1
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• pp.37-43
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• 2012

We have investigated the effect of melatonin (MLT) on specific growth rate (SGR% $day^{-1}$), condition factor (k), gonado-somatic-index (GSI), histological structures of gonads, serum as well as gonadal protein and lipid in Nile tilapia Oreochromis niloticus. MLT treatment in the dose of 25 ${\mu}g/L$ for three weeks reduced SGR% $day^{-1}$ ($0.9{\pm}0.04$) as compared to control ($1.23{\pm}0.026$). The GSI value was significantly (p<0.05) reduced to $1.77{\pm}0.253$ from control where it was $2.56{\pm}0.25$. Serum protein level increased from $9.33{\pm}2.90$ mg/ml (control) to $11.67{\pm}1.45$ mg/ml after MLT treatment while there was depressed serum triglycerides ($86.16{\pm}1.078$ mg/dl) and cholesterol ($126.66{\pm}0.88$ mg/dl) as compared to control values where these were $123.0{\pm}1.23$ mg/dl and $132.0{\pm}1.65$ mg/dl respectively. Histological structure of ovary showed small eggs of early perinucleolus stage after MLT treatment while testicular structure of control and MLT treated fish was more or less similar. It is concluded that exogenous melatonin suppressed SGR% $day^{-1}$, GSI, ovarian cellular activity, protein and lipid biosynthesis, in tilapia suggesting that melatonin is useful in manipulating the gonadal maturity in fishes.

• Journal of Microbiology and Biotechnology
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• v.25 no.10
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• pp.1634-1639
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• 2015

Cytochrome P450 hydroxylase (CYP) in actinomycetes plays an important role in the biosynthesis and bioconversion of various secondary metabolites. Two unique CYPs named CYP-sb21 and CYP-pa1, which were identified from Sebekia benihana and Pseudonocardia autotrophica, respectively, were proven to transfer a hydroxyl group at the 4^th or 9^th N-methyl leucine position of immunosuppressive agent cyclosporin A (CsA). Interestingly, these two homologous CYPs showed different CsA regio-selectivities. CYP-sb21 exhibited preferential hydroxylation activity at the 4^th position over the 9^th position, whereas CYP-pa1 showed the opposite preference. To narrow down the CYP domain critical for CsA regio-selectivity, each CYP was divided into four domains, and each domain was swapped with its counterpart from the other CYP. A total of 18 hybrid CYPs were then individually tested for CsA regio-selectivity. Although most of the hybrid CYPs failed to exhibit a significant change in regio-selectivity in the context of CsA hydroxylation, hybrid CYP-pa1 swapped with the second domain of CYP-sb21 showed a higher preference for the 9^th position. Moreover, hybrid CYPsb21 containing seven amino acids from the 2nd domain of CYP-pa1 showed higher preference for the 4^th position. These results imply that the 2nd domain of CsA-specific CYP plays a critical role in CsA regio-selectivity, thereby setting the stage for biotechnological application of CsA regio-selective hydroxylation.

• The Journal of the Korea Contents Association
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• v.11 no.3
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• pp.241-253
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• 2011

The present thesis is to concretize process stages and methods for effective use of online CGTS(creative group thinking system), or the web-storming program, in space design and to propose a support system for idea generation specific to space design. For the purpose of this study, activity factors in space design process and functional factors of the web-storming program were written into an interaction matrix, which was used for a questionnaire survey on correlations. Then, the results of the interaction matrix were visualized and analyzed following the procedure of observation-interpretation-application. The analysis found that the schematic design stage is most correlated where close collaboration is performed in the process of space design and that differences in correlation arise upon division of work. As such, the present study proposed 'provision of media for ideas in accordance with specific process and UI optimization' as a means of improving usability in schematic design that is closely correlated and suggested an idea to enhance the applicability of web-storming system in division of work.

• Biomolecules & Therapeutics
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• v.32 no.2
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• pp.205-213
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• 2024

Hydroxychavicol, a primary active phenolic compound of betel leaves, previously inhibited bone loss in vivo by stimulating osteogenesis. However, the effect of hydroxychavicol on bone remodeling induced by osteoclasts is unknown. In this study, the anti-osteoclastogenic effects of hydroxychavicol and its mechanism were investigated in receptor activator of nuclear factor kappa-B ligand (RANKL)-induced osteoclasts. Hydroxychavicol reduced the number of tartrate resistance acid phosphatase (TRAP)-positive multinucleated, F-actin ring formation and bone-resorbing activity of osteoclasts differentiated from RAW264.7 cells in a concentration-dependent manner. Furthermore, hydroxychavicol decreased the expression of osteoclast-specific genes, including cathepsin K, MMP-9, and dendritic cell-specific transmembrane protein (DC-STAMP). For mechanistic studies, hydroxychavicol suppressed RANKL-induced expression of major transcription factors, including the nuclear factor of activated T-cells 1 (NFATc1), c-Fos, and c-Jun. At the early stage of osteoclast differentiation, hydroxychavicol blocked the phosphorylation of NF-κB subunits (p65 and Iκβα). This blockade led to the decrease of nuclear translocation of p65 induced by RANKL. In addition, the anti-osteoclastogenic effect of hydroxychavicol was confirmed by the inhibition of TRAP-positive multinucleated differentiation from human peripheral mononuclear cells (PBMCs). In conclusion, hydroxychavicol inhibits osteoclastogenesis by abrogating RANKL-induced NFATc1 expression by suppressing the NF-κB signaling pathway in vitro.

• Asian-Australasian Journal of Animal Sciences
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• v.23 no.7
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• pp.855-862
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• 2010

Among the known interferon-induced antiviral mechanisms, the Mx pathway is one of the most powerful pathways. The Mx protein has direct antiviral activity and inhibits a wide range of viruses by blocking an early stage of the viral replication cycle. Cloning, characterization, and expression of Mx in vivo and in vitro have been conducted. The chicken Mx gene spans 21 kb and is made up of 14 exons and 13 introns, of which the promoter region was analyzed. The real-time PCR results showed that Mx expression was increased in chicken embryo fibroblasts (CEF) after 12- and 24-h induction with polyI: C. Induction of Mx expression by poly I: C in vivo revealed tissue-specific patterns among the chicken tissues tested. A trace expression of Mx was detected in healthy chicken liver tissues from adult chickens without inducement; the expression levels in the liver, heart, and gizzard were higher than in the muscle and kidney. This is the first report to demonstrate the expression of a glutathione-S-transferase-tagged-Mx fusion protein of 75 KDa, as well as the biological activity tested by SDS-PAGE and western blotting.

• Journal of Microbiology and Biotechnology
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• v.17 no.11
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• pp.1789-1796
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• 2007

A ${\beta}$-glucosidase with the molecular mass of 160,000 Da was purified to homogeneity from cell extract of a cellulolytic bacterium, Cellulomonas uda CS1-1. The kinetic parameters ($K_m$ and $V_{max}$) of the enzyme were determined with pNP-cellooligosccharides (DP 1-5) and cellobiose. The molecular orbital theoretical studies on the cellulolytic reactivity between the pNP-cellooligosaccharides as substrate (S) molecules and the purified ${\beta}$-glucosidase (E) were conducted by applying the frontier molecular orbital (FMO) interaction theory. The results of the FMO interaction between E and S molecules verified that the first stage of the reaction was induced by exocyclic cleavage, which occurred in an electrophilic reaction based on a strong charge-controlled reaction between the highest occupied molecular orbital (HOMO) energy of the S molecule and the lowest occupied molecular orbital (LUMO) energy of the hydronium ion ($H_3O^+$), more than endocyclic cleavage, whereas a nucleophilic substitution reaction was induced by an orbital-controlled reaction between the LUMO energy of the oxonium ion ($SH^+$) protonated to the S molecule and the HOMO energy of the $H_2O_2$ molecule. A hypothetic reaction route was proposed with the experimental results in which the enzymatic acid-catalyst hydrolysis reaction of E and S molecules would be progressed via $SN_1$ and $SN_2$ reactions. In addition, the quantitative structure-activity relationships (QSARs) between these kinetic parameters showed that $K_m$ has a significant correlation with hydrophobicity (logP), and specific activity has with dipole moment, respectively.