• 제목/요약/키워드: spontaneous methods

검색결과 561건 처리시간 0.035초

Spontaneous bone regeneration after surgical extraction of a horizontally impacted mandibular third molar: a retrospective panoramic radiograph analysis

  • Kim, Eugene;Eo, Mi Young;Nguyen, Truc Thi Hoang;Yang, Hoon Joo;Myoung, Hoon;Kim, Soung Min
    • Maxillofacial Plastic and Reconstructive Surgery
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    • 제41권
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    • pp.4.1-4.10
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    • 2019
  • Background: The mandibular third molar (M3) is typically the last permanent tooth to erupt because of insufficient space and thick soft tissues covering its surface. Problems such as alveolar bone loss, development of a periodontal pocket, exposure of cementum, gingival recession, and dental caries can be found in the adjacent second molars (M2) following M3 extraction. The specific aims of the study were to assess the amount and rate of bone regeneration on the distal surface of M2 and to evaluate the aspects of bone regeneration in terms of varying degree of impaction. Methods: Four series of panoramic radiographic images were obtained from the selected cases, including images from the first visit, immediately after extraction, 6 weeks, and 6 months after extraction. ImageJ software® (NIH, USA) was used to measure linear distance from the region of interest to the distal root of the adjacent M2. Radiographic infrabony defect (RID) values were calculated from the measured radiographic bone height and cementoenamel junction with distortion compensation. Repeated measures of analysis of variance and one-way analysis of variance were conducted to analyze the statistical significant difference between RID and time, and a Spearman correlation test was conducted to assess the relationship between Pederson's difficulty index (DI) and RID. Results: A large RID (> 6 mm) can be reduced gradually and consistently over time. More than half of the samples recovered nearly to their normal healthy condition (RID ≤ 3 mm) by the 6-month follow-up. DI affected the first 6 weeks of post-extraction period and only showed a significant positive correlation with respect to the difference between baseline and final RID. Conclusions: Additional treatments on M2 for a minimum of 6 months after an M3 extraction could be recommended. Although DI may affect bone regeneration during the early healing period, further study is required to elucidate any possible factors associated with the healing process. The DI does not cause any long-term adverse effects on bone regeneration after surgical extraction.

약쑥엑스제 쑥뜸방식에 의한 체간 온도 변화와 당뇨병 임상에 관한 연구 (A Study on the Variations of the Trunk Temperature and the Clinical Test for the Diabetics by the Artemisia Extract Moxibustion Method)

  • 윤동업;조봉관;배종일;구자성;김종원;이현민;조훈석;신우진;서상호;박동일;홍상훈
    • 대한한의학회지
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    • 제27권1호
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    • pp.165-183
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    • 2006
  • Objectives : We implemented the Artemisia Extract Moxibustion Method and had the clinical tests for the diabetes with it. Methods : We implemented Artemisia extract made by extracting the vasodilator and antioxidant compounds from Artemisia-CH2C12 fraction and the moxibustion method constructed with DC Power supply, controller, Artemisia pad. single and multiple heating terminal with PTC(Positive Temperature Coefficient) thermistor. And we performed to estimate the efficiency on the questionnaire and the clinical tests with 23 cases of the diabetics. Results : We have estimated the improvement over 60% the symptoms that were the upper and lower limbs pain, frequent urination, spontaneous perspiration, thirst, decrease of body weight, and malaise after the moxibustion treatment on 5 cases among 23 cases. And the 19 cases took the biochemical check-up after the moxibustion treatment. From the results of biochemical check-up, the average HbAlc of before treatment was 8.400%, and after treatment 7.632%. The average HbAlc was decreased significantly after treatment (P<0.001). And the average urinary blood of before treatment was 0.73 and after treatment 0.27. The average urinary blood was decreased significantly after treatment (P<0.001). In addition the average FBS before treatment was 182.64 mg/dl, after treatment 161.77 mg/dl. Conclusions : We could estimate that our proposed moxibustion method was a significant treatment method for the diabetes.

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소아 신경모세포종의 치료 후 조직소견의 변화와 예후와의 관계 (Pathologic Change and Prognosis after Combination Therapy in Advanced Neuroblastoma)

  • 서연경;정유진;김준식;김흥식;박우현;최순옥;이병육;권건영
    • Clinical and Experimental Pediatrics
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    • 제46권11호
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    • pp.1107-1111
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    • 2003
  • 목 적 : 진행된 신경모세포종 환아의 약물치료 후 수술한 예에서 조직변화를 관찰하여 예후와의 상관관계를 알아보고자 이 연구를 시행하였다. 방 법 : 1991년 1월부터 2000년 6월까지 계명대학교 동산병원 소아과에서 진단된 신경모세포종 환아 중 항암치료 후 종양절제를 시행한 6례를 대상으로 하였다. 진단 당시 침생검소견과 항암치료 후 조직소견에서 신경모세포의 분화정도와 핵 모양 및 간질조직의 기질화 양상과 석회와 유무 등을 비교하여 변형된 Shimada 분류에 따라 분류하였다 결 과 : 항암치료 전과 후에 조직소견의 변화를 관찰하였으며 변형된 Shimada 분류에 따라 2가지 예후군으로 분류하였으며, 좋은 예후군 3례 중 2명은 생존해 있으며, 1명은 추적되지 않고 사망한 것으로 추정하였으며, 나쁜 예후군의 3례는 각각 패혈증과 retinoic acid 복용 중 발생한 출혈성 췌장염으로 사망하였다. 결 론 : 항암치료 전과 후에 조직소견의 변화를 관찰하였으며 Shimada 분류에 따라 비교하고, 치료 후 종양세포의 성숙을 관찰하였으며, 좋은 예후군에서 생존수가 많은 것을 확인할 수 있었다.

소아에서의 일과성 소장형 장중첩증의 임상적 고찰 (Clinical features of transient small bowel intussusception in children)

  • 허지승;서은민;심은정;조도준;김덕하;민기식;유기양;이관섭
    • Clinical and Experimental Pediatrics
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    • 제51권5호
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    • pp.500-505
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    • 2008
  • 목 적 : 본 연구는 대장형 장중첩증과 비교하여 소아에서 일시적 소장형 장중첩증의 임상양상에 관하여 알아보고자 하였다. 방 법 : 2002년 1월부터 2005년 12월까지 한림대학교 성심병원 소아과에서 장중첩증으로 진단받은 210명의 환아를 대상으로 하여 소장형 장중첩증과 대장형 장중첩증으로 분류하여 후향적 연구를 통해서 이루어졌으며, 전체 210례 중 191례는 대장형이었고 19례에서 소장형이었다. 결 과 : 소장형 장중첩증은 평균 나이가 29.5개월로 대장형 장중첩증(21.2개월)보다 많았으며, 혈변이나 복부 종괴 등의 전형적인 증상은 드문 편이었다. 치료에 있어서 대장형 장중첩증은 공기 주입식 정복술이 92.2%, 수술적인 정복이 7.3%였던 반면, 소장형 장중첩증은 78.9%가 자연 정복되었으며 수술적인 처치를 한 예는 없었다. 결 론 : 성인과는 달리 소아에서의 소장형 장중첩증은 자연 정복이 많고 수술적 치료가 드물며 소아에서의 대장형 장중첩증에 비해 발생 연령이 많았다. 또한 전형적인 임상 양상을 보이는 경우가 적으므로 진단과 치료에 있어서 주의를 필요로 한다.

Do spontaneously decreasing estradiol levels prior to triggering of ovulation adversely impact in vitro fertilization outcomes?

  • Grin, Leonti;Berkovitz-Shperling, Roza;Zohav, Eyal;Namazov, Ahmet;Leyetes, Sophia;Friedler, Shevach
    • Clinical and Experimental Reproductive Medicine
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    • 제47권3호
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    • pp.213-220
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    • 2020
  • Objective: The aim of this study was to explore the potential adverse effect of spontaneously decreasing serum estradiol (SE) levels on in vitro fertilization (IVF) outcomes. Methods: This retrospective single-subject study analyzed IVF cycles conducted at a hospital IVF unit between 2010 and 2017. Overall, 2,417 cycles were analyzed. Only cycles with spontaneously decreasing SE before human chorionic gonadotropin (hCG) triggering were included. Each patient served as her own control, and subsequent cycles were analyzed for recurrent SE decreases. The main outcome was the number of oocytes retrieved. Results: Cycle characteristics were similar between the study (SE decrease) and control groups, with the exception of the median SE on the day of hCG triggering (899.7 pg/mL; interquartile range [IQR], 193-2,116 pg/mL vs. 1,566.8 pg/mL; IQR, 249-2,970 pg/mL; p< 0.001). The study group, relative to the control group, had significantly fewer total oocytes (5 [IQR, 2-9] vs. 7 [IQR, 3-11]; p= 0.002) and significantly fewer metaphase II (MII) oocytes (3 [IQR, 1-6] vs. 4 [IQR, 2-8]; p= 0.001) retrieved. The study group had fewer cleavage-stage embryos than the control cycles (3 [IQR, 1-6] vs. 4 [IQR, 2-7]; p= 0.012). Compared to cycles with a ≤ 20% SE decrease, cycles with a > 20% decrease had significantly fewer total and MII oocytes retrieved. SE decrease recurred in 12% of patients. Conclusion: A spontaneous decrease in SE levels adversely affected IVF outcomes, with a linear correlation between the percentage decrease and the number of oocytes retrieved. SE decrease can repeat in later cycles.

저체중아 출생과 관련된 산모의 특성 연구 (The Study of Maternal Characteristics of Low Birth-Weight Infant)

  • 홍필순;박형숙
    • 여성건강간호학회지
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    • 제5권1호
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    • pp.80-95
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    • 1999
  • The purpose of this study was to investigate the characteristics of low birth-weight infants and their's mothers, and to identify the factors which influenced to delivery of L.B.W infants. The data derived from K. General Hospital and J. obs & gyn clinic in pusan from January, 1998 to August, 1998, which were from mothers of having B. W infants. The factors used for this study were characteristics of general, obstetrical, environmental aspects and physical and psychological life experiences during pregnancy. Analysis of data obtained were computerized statistically by using SPSS 7.5 WIN program. the data were analysed as number, frequency, percentage, t-test and ANOVA. The major results obtained of this study were as follows : 1) Gender that L.B.W infants were male in 47.2% and female in 52.8%, body weight of 2001~2500gm was above 8 in 68.5%, and below 5 in 1.8%. The L.B.W infants with complications were 7, which were 6.5%. The kinds of malformations were the Cleft palate & lip, Hyper-kalemia, Hypoglycemia, Meningocele, CHD, Down syndrome and each of them marked 0.9%. 2) In the general characteristics of pregnant women, the age group of 25~29 years was the most common as 46.3%. Over 35 years of age, elderly gravidas were in 7.5%. the height of 156~160cm was the most common as 52.8%. pregnant women of below 150cm height was in 3.7%. body weight of 51~55kg was the most common as 38%. pregnant women of below 45kg were in 19.4%. The women with smoking and drinking episodes during pregnancy were 1.9% and 25%. In the status of marriage, married women were in 95.4%, unmarried ones were in 1.9%, and unmarried couples were in 2.8%. Iin he obstetrical characteristics of pregnant women, pregnant women with gestational age under 37wks were in 45.4%, and the ones over 38wks were 54.6%. At the methods of delivery, normal spontaneous vaginal deliveries were in 51.9%, which were the most common, cesarian section deliveries were in 47.2%, and breech deliveries were in 0.9%. In the environmental characteristics of pregnant women, 40.8% of pregnant women lived in house or apartments with stairs, 23.1% of them lived in the high altitude. the pregnant women who ran a household without a helper were in 65.7%. In the pregnant women who had underwent life experiences of physical and psychological stress during pregnancy. life experiences of physical stresses were described as persistent fatigue due to lifestyle, traumatic experience, illness, move away with an effort, physical impact caused by discord. life experiments of psychological stresses were describeded as trouble with their husbands, discord with one's husband family, family problems, and conflicts due to environmental factors, etc. The number of the pregnant women who had complications during pregnancy was 32, which was 29.6% totally. Among them, pre-eclampsia was in 12.1% and the premature rupture of membrane in 7.4%. 3) In the analysis of the general, obstetrical, and circumstantial characteristics and L.B.W infants. There were statistical difference significantly between the gestational age of pregnant women(F=12.035, P=.000), and the status of marriage(F=3.207, P=.044), and maternal complication(t=2.344, P=.021) etc.

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신생아 행동 특성과 Dopamine Transporter 유전자 및 Dopamine D2, D3, D4 수용체 유전자의 다형성 (NEONATAL BEHAVIORAL CHARACTERISTICS AND DOPAMINE TRANSPORTER GENE AND DOPAMINE D2, D3, D4 RECEPTOR GENE POLYMORPHISMS)

  • 박영남;김대광;김성욱
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • 제12권2호
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    • pp.179-191
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    • 2001
  • 연구목적:신생아의 행동 특성과 DAT1, DRD2, DRD3 및 DRD4 유전자 다형성 사이에 연관이 있는지 평가하였다. 방 법:2000년 4월 17일부터 2000년 6월 17일까지 출생한 정상 신생아 114명을 대상으로 하였다. 신생아 행동 평가는 Neonatal Behavioral Assessment Scale(NBAS)을 이용하여 생후 약 18시간에 평가하였으며, 출산시 제대혈액을 채취하여 DAT1, DRD2, DRD3 및 DRD4 유전자 다형성을 검사하였다. DAT1, DRD2, DRD3 및 DRD4 유전자의 유전자형에 따라서 집단 사이에 NBAS 7개 항목 점수를 비교하였다. 결 과:DAT1 유전자는 10/10 유전자형 집단과 비교해서 기타 유전자형 집단이 사회성-상호작용, 상태 조직력 및 상태 조절 능력 항목에서 유의하게 점수가 높았다. DRD2 유전자 Ser311/Cys311 유전자형은 Ser/Ser 유전자형 집단과 기타 유전자형 집단 사이에 NBAS 항목 점수에 유의한 차이가 없었다. DRD2 유전자는 TaqI A 및 TaqI B 유전자형에 의한 집단 사이에 NBAS 항목 점수에 유의한 차이가 없었다. DRD3 유전자는 유전자형에 의한 집단 사이에 NBAS 항목 점수에 유의한 차이가 없었다. DRD4 유전자 promoter 유전자형에 의한 집단 사이에 NBAS 항목 점수에 유의한 차이가 없었다. DRD4 유전자 반복배열이 긴 유전자형 집단은 짧은 유전자형 집단보다 습관화 항목 점수가 유의하게 높았다. 결 론:이러한 성적은 DAT1 및 DRD4 유전자 반복배열 다형성이 신생아 행동 특성에 영향을 미치는 유전적 기전일 가능성을 시사한다.

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Hilbert-Huang 변환을 이용한 제세동 성공 예측 (Prediction of the Successful Defibrillation using Hilbert-Huang Transform)

  • 장용구;장승진;황성오;윤영로
    • 전자공학회논문지SC
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    • 제44권5호
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    • pp.45-54
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    • 2007
  • 시/주파수 분석은 생체 신호 처리에서 널리 사용되어왔다. 전기 생리학적 신호로부터 중요한 특징들을 추출함으로써 이 방법들은 특정 질병의 임상 병리학적 기전 해석이 가능하다. 하지만 이 방법은 신호가 안정하다는 가정 아래 적용되었으며 불안정한 시스템에서의 적용은 제한이 되어 있다. 본 연구에서는 비선형적이고 비정상적인 심실세동 심전도 파형의 분석을 위해 Hilbert-Huang 변환을 사용한 새로운 신호처리 방법을 제안하였다. Hilbert-Huang 변환은 경험모드분리법(EMD)과 힐버트 변환으로 크게 두 가지로 구성된다. Hilbert-Huang 변환은 EMD를 사용하여 각각의 특성을 지니고 있는 독립적인 내부모드함수들로 나누어지며, 힐버트 변환에 의해 순간 주파수와 크기를 구할 수 있게 된다. 이런 특성으로 신호의 국부적인 작용에 대하여 정확하게 설명할 수 있게 된다. 본 연구에서는 Hilbert-Huang 변환을 기반으로 심실세동 심전도 파형으로부터 두 종류의 파라미터(EMD-IF, EMD-FFT)를 추출하고 서포트 벡터 머신(Support Vector Machine)을 이용하여 소생성공 및 실패 여부 예측에 관하여 연구하였다. 평균적으로 민감도와 특이도는 각각 87.57%와 76.92%로 나타났다. Hilbert-Huang 변환은 더욱 정확하게 심실세동에서의 소생성공 예측을 가능하게 하였다.

비디오 흉강경을 이용한 흉부수술 31예 (Video Assisted Thoracoscopic Surgery, 31 Cases)

  • 성숙환;김관민;김주현
    • Tuberculosis and Respiratory Diseases
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    • 제40권5호
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    • pp.468-473
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    • 1993
  • 연구배경 : 최근의 비디오 영상기술, 내시경 수술기구 및 내시경 수술기법의 눈부신 발달에 힘입어 흉강경의 영역이 단순한 늑막질환 진단에서 여러가지 흉부질환의 치료 방법으로 넓어졌다. 비디오 흉강경 수술(VATS) 방법은 3년전에 개발된 새롭고 가히 매력적이라 할 만한 흉부질환 수술방법으로 서울대학교병원에서도 1992년 7월에 도입하여서 비록 짧은 기간이지만 여러가지 임상경험을 하였기에 그 결과를 분석한다. 방법 : 1992년 7월부터 1993년 4월까지 10개월간 30명 환자에게 31예의 비디오 흉강경 수술을 시행하였다. 폐기포 절제술이 18명(19예), 종격동 종양 절제술이 4예, 폐실질 폐조직 생검 3예, 늑막생검 3예, 늑막종괴제거술 1예 그리고 늑막심낭창형성술 1예였다. 결과 : 사망예는 없으며 8예의 합병증이 발생하였다. 장기간공기누출이 3예, 장기간 늑막액 유출이 2예, 기흉재발 1예, 호너씨 증후군 1예, 애성 1예였다. 31예 모두 비디오흉강경 자체로 수술을 완료하였다. 합병증이 없었던 자연기흉 환자들의 술후 입원기간은 5일정도로 평상적인 개흉술로 수술받은 환자보다 입원기간이 약간 짧았다. 결론 : 비록 비디오 흉강경 수술은 초기단계라서 비교적 술후 합병증 빈도가 높았지만 이러한 술식이 통증감소, 입원기간단축, 빠른 회복, 미용적으로 우수한 작은 수술 상처 등의 여러가지 장점을 갖고 있어 환자들에게 매우 유익하다고 확신한다. 비디오 흉강경수술의 영역은 앞으로 흉곽내 여러가지 질환의 진단과 치료에 사용되고 심지어 심장병질환에도 응용될 것이라 생각된다.

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데이터마이닝 분석을 이용한 노인약물유해반응과 원인약물의 연관성연구 (Study for Association between Adverse Drug Reactions and Causative Drugs in the Elderly Using Data-mining Analysis)

  • 이미우;이정선;한옥연;최인영;정승희;임현우;이동건;나현오;박영민
    • 한국임상약학회지
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    • 제24권1호
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    • pp.39-44
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    • 2014
  • Purpose: To investigate adverse drug reactions (ADR) and causative drugs in the elderly 65 years of age or older, using Korean spontaneous reporting adverse events reporting database from June 2009 to December 2010. Methods: We estimated the association between ADRs and implicated medications by calculating a proportional reporting ratio (PRR), reporting odds ratio (ROR), and information component (IC). We reexamined the most frequently implicated medications and ADRs, and the seriousness of ADRs. Then, we assessed reports and concordant rate of ADRs due to medications designated as "high-risk" in elderly by 2012 healthcare effectiveness data and information set (HEDIS) or "potentially inappropriate" by 2012 American Geriatrics Society updated Beers criteria for potentially inappropriate medications (PIMs). Results: Among 15,484 elderly reports, data-mining analysis by PRR, ROR and IC showed that 421 drug-ADR pairs were detected as signals (3,189). The most frequently reported ADR and causative drug were urticaria (470) and contrast media agents (647), respectively. One hundred eighty nine ADR cases were graded as serious. Twenty-two kinds of high-risk medications were shown to be implicated in only 0.9% of ADRs. Only thirty-nine cases were consistent with 2012 Beers criteria or HEDIS. Conclusion: These results suggest that management of the other medications including contrast media agents as well as close monitoring of PIMs are necessary for reducing ADRs in the elderly.