• Title/Summary/Keyword: spinal tumor

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Extraosseous Epidural Ewing's Sarcoma Arising in the Lumbar Area - A Case Report- (요추부에 발생한 경막외 유잉육종 - 증례 보고 -)

  • Ahn, Myun-Hwan;Shin, Duk-Seop;Jung, Kwang-Am;Hah, Jeong-Ok
    • The Journal of the Korean bone and joint tumor society
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    • v.5 no.3
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    • pp.183-189
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    • 1999
  • Ewing's sarcoma is an uncommon malignant neoplasm of the long bone and it has a poor prognosis due to its early metastasis and aggressive local spread. It is mostly found before the age of 30 and it is rare in extraskeletal sites. Extraskeletal Ewing's sarcoma has been reported to occur in various sites including the larynx, scalp, nasal fossa, neck, chest wall, lung, pelvis, perineum, arm, finger, leg and toe, but it is extremely rare as a primary epidural tumor of the spine. We experienced a case of extraosseous epidural Ewing's sarcoma arising in the lumbar spinal canal at L3-L5 level in a 9-year-old boy. Following total laminectomy from L3 to L5 with a lumbar vertebrae and mass excision, he received chemotherapy with complete remission.

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Intracisternal Cranial Root Accessory Nerve Schwannoma Associated with Recurrent Laryngeal Neuropathy

  • Jin, Sung-Won;Park, Kyung-Jae;Park, Dong-Hyuk;Kang, Shin-Hyuk
    • Journal of Korean Neurosurgical Society
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    • v.56 no.2
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    • pp.152-156
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    • 2014
  • Intracisternal accessory nerve schwannomas are very rare; only 18 cases have been reported in the literature. In the majority of cases, the tumor origin was the spinal root of the accessory nerve and the tumors usually presented with symptoms and signs of intracranial hypertension, cerebellar ataxia, and myelopathy. Here, we report a unique case of an intracisternal schwannoma arising from the cranial root of the accessory nerve in a 58-year-old woman. The patient presented with the atypical symptom of hoarseness associated with recurrent laryngeal neuropathy which is noted by needle electromyography, and mild hypesthesia on the left side of her body. The tumor was completely removed with sacrifice of the originating nerve rootlet, but no additional neurological deficits. In this report, we describe the anatomical basis for the patient's unusual clinical symptoms and discuss the feasibility and safety of sacrificing the cranial rootlet of the accessory nerve in an effort to achieve total tumor resection. To our knowledge, this is the first case of schwannoma originating from the cranial root of the accessory nerve that has been associated with the symptoms of recurrent laryngeal neuropathy.

Metastatic Brain Neuroendocrine Tumor Originating from the Liver

  • Lee, Guk Jin;Jo, Kwang Wook;Kim, Jeana;Park, Il Young
    • Journal of Korean Neurosurgical Society
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    • v.58 no.6
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    • pp.550-553
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    • 2015
  • A 67-year-old male presented with left temporal hemianopsia and left hemiparesis. A contrast-enhanced magnetic resonance image revealed a $4.5{\times}3.5{\times}5.0cm$ rim-enhancing mass with central necrosis and associated edema located in the left occipital lobe. Of positron emission tomography and abdominal computed tomography, a 9-cm mass with poor enhancement was found in the right hepatic lobe. Craniotomy and right hemihepatectomy was performed. The resected specimen showed histological features and immunochemical staining consistent with a metastatic neuroendocrine tumor (NET). Four months later, the tumors recurred in the brain, liverand spinal cord. Palliative chemotherapy with etoposide and cisplatin led to complete remission of recurred lesions, but the patient died for pneumonia. This is the first case of a metastatic brain NET originating from the liver. If the metastatic NET of brain is suspicious, investigation for primary lesion should be considered including liver.

The Early Detection of Recurrence of Malignant Peripheral Nerve Sheath Tumor by Frequent Magnetic Resonance Imaging

  • Lee, Chang-Sub;Huh, Ji-Soon;Chang, Jee-Won;Park, Ji-Kang
    • Journal of Korean Neurosurgical Society
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    • v.47 no.1
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    • pp.51-54
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    • 2010
  • Surgery has a key role in the treatment of malignant peripheral nerve sheath tumors (MPNSTs), but the resectability of paraspinal MPNSTs is only 20%. Therefore, spinal MPNSTs show frequent recurrence and poor prognosis. Local recurrence is much more common than metastasis for MPNSTs, and surgery still has a key role in the treatment of local recurrence. Therefore, it is important that recurrence must be detected before resectability is lost. However, no evidence-based follow-up protocol has been established for MPNST. The authors performed gross total resection in a 34-year-old woman presented with thoracic MPNST. Adjuvant radiotherapy and chemotherapy were not administered since these adjuvant therapies generally do not improve survival in MPNST and may cause additional neurovascular damage. Instead, the authors monitored the primary site every 3 months using magnetic resonance imaging to detect local recurrence at the earliest opportunity. The tumor recurred locally on two occasions without overt symptoms at 21 and 24 months postoperatively. These recurrences were treated successfully by gross total removal.

A Case of Tuberculous Spondylitis Combined with Schwannoma of Spinal Cord - A Case Report - (척수 신경초종을 동반한 결핵성 척추염 1례 - 증례보고 -)

  • Park, Jong Hoon;Kim, Kyu Hong;Lee, Woon Gi;Choi, Jeong Hoon;Lee, In Chang;Bae, Sang Do
    • Journal of Korean Neurosurgical Society
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    • v.30 no.10
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    • pp.1241-1244
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    • 2001
  • The authors report a very rare case of tuberculous spondylitis combined with a schwannoma of spinal cord. A 39- year-old man was admitted because of paraparesis(G1/G2). MRI showed severe cord compression at two different levels. One was by the bulged soft tissue and subligamentous abscess extending from T7 to T9 and the other was by an intradural extramedullary cord tumor at the level of T1-2. At first operation, T8 corpectomy and T7-9 plate fixation with autogenous iliac bone graft were performed. After then, Paraparesis was improved(G2/G3) postoperatively. The second operation underwent two weeks later. The tumor was totally removed and shortly after second operation, paraparesis was markedly improved(G3/G4). Histological diagnosis were tuberculous spondylitis and schwannoma, respectively. The authors reviewed this case where good surgical outcome was obtained by two stage operation.

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Giant Cell Tumor of the Cervical Spine - Case Report - (경추에 발생한 거대 세포종 - 증례 보고 -)

  • An, Ki-Chan;Chung, Kyung-Chil;Kim, Yoon-Jun
    • The Journal of the Korean bone and joint tumor society
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    • v.12 no.1
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    • pp.57-62
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    • 2006
  • Giant cell tumors are potentially malignant tumors in vertebrae, affecting frequently difficult to diagnose and are often inoperable. So it will be treated using radiation because of their high recurrence rate and the mechanical compression of spinal cord, but many surgeons described tumors of the vertebra, and the affected vertebral body can be treated using radical or near to total excision, with anteroposterior vertebral fusion or instrumentation of the spine. we report a case of giant cell tumor affecting the third cervical vertebra which caused neck pain and destroyed the vertebra body had treated using radical excison with fusion of posterior arch using instrumentation of the spine together with a literature review.

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Evaluation on Usefulness of Applying Body-fix to Four Dimensional Radiation Therapy (4차원 방사선 치료시 Body Fix의 유용성 평가)

  • Kim, Young-Jae;Jang, Young-Ill;Ji, Yeon-Sang;Han, Jae-Bok;Choi, Nam-Gil;Jang, Seong-Joo
    • The Journal of the Korea Contents Association
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    • v.13 no.10
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    • pp.419-426
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    • 2013
  • This study investigates the usefulness of body fix in 4DRT on Liver cancer trying to find tumor tissue's volume and located variations, absorbed dose on tumor and normal tissues. Test subjects 23 patients were agreed these test. These patient's have a 4 dimensional CT scan. We make an acquisition on patients CT image by two types -put on the body fix or not-. Average tumor volume reduced by 0.17% on GTV and 3.2% on CTV and PTV. Tumor's variation reduces 29.8%(anterior and posterior, AP) and 5.31% (upper and lower, UL). The absorbed tumor doses under put on the body fix was a little higher(1.3%) than other. Normal tissues'(normal liver, stomach, Rt. kidney, spinal cord) absorbed dose could be reduced approximately 5%. Therefore, using body fix on 4DRT for liver cancer patient is considered effectively.

Expression of Endoplasmic Reticulum Chaperone ERp29 in the Injured Spinal Cord

  • Park, Soojung;Hwang, Ho-Myung;Lee, Young-Ho;You, Kwan-Hee;Shin, Kee-Sun;Kwon, O-Yu
    • Animal cells and systems
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    • v.7 no.3
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    • pp.265-269
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    • 2003
  • Vascular endothelial growth factor (VEGF) is a potent regulator of normal and abnormal angiogenesis. Recent literature suggests that VEGF has several activities that may amplify acute inflammation reactions. Dysregulated VEGF expression has been implicated as a major contributor to the development of a number of common disease pathologies. One of common mutations in the 3'- untranslated region of the VEGF gene, a C\longrightarrowT exchange at nucleotide position 936, has been found to be significantly associated with VEGF expression levels in the plasma from a previous Austrian study. The frequency of this mutation could be important genetic information regarding tumor growth and angiogenesis related diseases. The aim of this study was to investigate the frequency distribution of this mutation in general Korean population. We examined the statistical data from 207 healthy Korean subjects. Observed numbers (%) of 936T were 28.5 (CT) and 3.9 (TT), respectively. The mutant allele frequency of 936T in Korean subjects was 0.18, which appeared somewhat higher than that in Austrian subjects.

Three Cases of Intracranial Clear Cell Meningioma

  • Kim, Yeon-Seong;Kim, In-Young;Jung, Shin;Lee, Min-Cheol
    • Journal of Korean Neurosurgical Society
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    • v.38 no.1
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    • pp.54-60
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    • 2005
  • The clear cell meningioma[CCM] is a rare and recently described as a histologic variant of meningioma. It has been identified and included in new World Health Organization[WHO] classification of the Central Nervous System[CNS] tumors recently. The CCMs are histologically characterized by sheets of spindled to polygonal cells with clear cytoplasm, which is the expression of high glycogen concentration. The CCMs occur in younger patients and usually are located in the spinal canal and posterior fossa. The most interesting aspect of CCM is the high recurrence rate and aggressiveness. Poor outcome has been shown in intracranial and spinal tumor location, but the indicators that predict outcome have not been established. Until now 22 intracranial CCM cases had been reported in English literature and 3 cases in Korean. The authors report two cases of CCM located at cerebral convexity and one at cavernous sinus those were totally removed [Simpson Grade $I{\sim}II$] by subfrontal, frontal and orbitocranial approaches. The clinical, radiological, histopathological, and neurosurgical features of these cases are discussed with the relevant literatures.

Percutaneous osteoplasty for painful bony lesions: a technical survey

  • Kim, Won-Sung;Kim, Kyung-Hoon
    • The Korean Journal of Pain
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    • v.34 no.4
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    • pp.375-393
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    • 2021
  • Percutaneous osteoplasty (POP) is defined as the injection of bone cement into various painful bony lesions, refractory to conventional therapy, as an extended technique of percutaneous vertebroplasty (PVP). POP can be applied to benign osteochondral lesions and malignant metastatic lesions throughout the whole skeleton, whereas PVP is restricted to the vertebral body. Common spinal metastases occur in the thoracic (70%), lumbosacral (20%), and cervical (10%) vertebrae, in order of frequency. Extraspinal metastases into the ribs, scapulae, sternum, and humeral head commonly originate from lung and breast cancers; extraspinal metastases into the pelvis and femoral head come from prostate, urinary bladder, colon, and uterine cervical cancers. Pain is aggravated in the dependent (or weight bearing) position, or during movement (or respiration). The tenderness and imaging diagnosis should match. The supposed mechanism of pain relief in POP is the augmentation of damaged bones, thermal and chemical ablation of the nociceptive nerves, and local inhibition of tumor invasion. Adjacent (facet) joint injections may be needed prior to POP (PVP). The length and thickness of the applied needle should be chosen according to the targeted bone. Bone cement is also selected by its osteoconduction, osteoinduction, and osteogenesis. Needle route should be chosen as a shortcut to reach the target bony lesions, without damage to the nerves and vessels. POP is a promising minimally invasive procedure for immediate pain relief. This review provides a technical survey for POPs in painful bony lesions.