• Journal of Pharmaceutical Investigation
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• v.19 no.1
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• pp.29-37
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• 1989

For the prevention of the aggregation during microencapsulation, the effects and role of polyisobutylene(PIB), as a protective colloid, were studied. The effects of sealant treatment on the microencapsulation were studied. Methyldopa was microencapsulated with ethylcellulose (EC) by polymer deposition from cyclohexane by temperature change using PIB. The EC-microencapsulated methyldopa was sealed with spermaceti. The dissolution of methyldopa was influenced by the drug to wall ratio. When PIB was used, low aggregation of microcapsules occurred and the surface was smooth with a few pores. Treatment of microcapsules with spermaceti retarded the release of methyldopa, the release being affected by the percentage of sealant used and the particle size of the product.

• Journal of Pharmaceutical Investigation
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• v.21 no.4
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• pp.253-262
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• 1991

Microencapsulation of sodium ascorbate with cellulose acetate phthalate(CAP) by coacervation/ phase separation method were carried out. Various factors affecting microencapsulation, i.e., surfactant concentration. CAP concentration, stirring speed and treatment of spermaceti as a sealing agent were studied. Dissolution rate. particle size distribution, surface feature and stability test were investigated. CAP microcapsules prepared using 0.5% span 80 as a surfactant showed smooth and round surfaces. The release of sodium ascorbate was retarded by microencapsulation with CAP and by sealant treatment with spermaceti. When triturated with sodium bicarbonate, CAP microcapsules were more stable than unencapsulated sodium ascorbate under various RH conditions at $37^{\circ}C$.

• The Journal of the Acoustical Society of Korea
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• v.39 no.6
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• pp.533-540
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• 2020

A total length of sperm whales can be estimated by measuring the Inter-Pulse Interval(IPI) of their clicks composed by multiple pulses. The IPI is caused by the two-way travel time of the sound transmission in the spermaceti within the whale head. Therefore, the IPI can be used to measure the whale's total length based on allometric relationships between head and body length. In this paper, the click signals recorded in the East Sea, Korea in 2017 were analyzed to estimate the size of sperm whales. The size of sperm whales calculated by the relationship between IPI and body length was 9.9 m to 10.9 m, which is corresponding to the size of an adult female or a juvenile male sperm whale. This non-lethal acoustic method has been demonstrated to accurately estimate the sperm whale size, and can provide useful information for domestic sperm whale monitoring.